Class information for:
Level 1: 2 METHOXYESTRADIOL//2 METHOXYOESTRADIOL//2 METHOXYESTRADIOL BIS SULPHAMATE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18998 527 38.1 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
159 3       MENOPAUSE//ISOFLAVONES//TAMOXIFEN 61134
1407 2             2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE 8029
18998 1                   2 METHOXYESTRADIOL//2 METHOXYOESTRADIOL//2 METHOXYESTRADIOL BIS SULPHAMATE 527

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 2 METHOXYESTRADIOL authKW 7869036 35% 73% 185
2 2 METHOXYOESTRADIOL authKW 500769 2% 79% 11
3 2 METHOXYESTRADIOL BIS SULPHAMATE authKW 347644 1% 100% 6
4 STERIX LTD address 340661 4% 28% 21
5 2 METHOXYESTRADIOL 2ME2 authKW 297979 1% 86% 6
6 MED CHEM STERIX LTD address 283905 1% 70% 7
7 ENDOCRINOL METAB MED STERIX LTD address 276062 2% 53% 9
8 2 METHOXYESTRADIOL ANALOGS authKW 231763 1% 100% 4
9 ESE 16 authKW 231763 1% 100% 4
10 2 ETHYL 3 O SULPHAMOYL ESTRA 1 3 51016 TETRAENE authKW 173822 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1703 30% 0% 160
2 Endocrinology & Metabolism 487 13% 0% 67
3 Chemistry, Medicinal 355 8% 0% 44
4 Biochemistry & Molecular Biology 220 21% 0% 109
5 Pharmacology & Pharmacy 192 13% 0% 71
6 Cell Biology 121 10% 0% 51
7 Reproductive Biology 86 3% 0% 15
8 Medicine, Research & Experimental 85 6% 0% 31
9 Peripheral Vascular Diseases 64 4% 0% 21
10 Obstetrics & Gynecology 51 4% 0% 20

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STERIX LTD 340661 4% 28% 21
2 MED CHEM STERIX LTD 283905 1% 70% 7
3 ENDOCRINOL METAB MED STERIX LTD 276062 2% 53% 9
4 PHARM PHARMACOL STERIX LTD 130365 1% 75% 3
5 CELLULAR DIFFERENTIAT TRANSFORMAT 115881 0% 100% 2
6 SCEENING TECHNOL BRANCH 115881 0% 100% 2
7 ONCOL DRUG DISCOVERY WOMENS HLTH GRP 92700 1% 40% 4
8 SECT ENDOCRINOL MENOPAUSE 67586 1% 17% 7
9 ABBOTT PROD GMBH 57941 0% 100% 1
10 ALBERT BONNIOT CRIINSERMUJFU823 57941 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STEROIDS 3840 3% 0% 17
2 CANCER CELL INTERNATIONAL 1881 1% 1% 5
3 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 1835 3% 0% 17
4 MOLECULAR CANCER THERAPEUTICS 1409 2% 0% 10
5 BIOCELL 1113 1% 1% 3
6 CELL BIOCHEMISTRY AND FUNCTION 1072 1% 0% 6
7 REPRODUCTIVE SCIENCES 1025 1% 0% 5
8 HYPERTENSION 968 3% 0% 14
9 VASCULAR PHARMACOLOGY 814 1% 0% 4
10 BIOMEDICAL RESEARCH-INDIA 751 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 2 METHOXYESTRADIOL 7869036 35% 73% 185 Search 2+METHOXYESTRADIOL Search 2+METHOXYESTRADIOL
2 2 METHOXYOESTRADIOL 500769 2% 79% 11 Search 2+METHOXYOESTRADIOL Search 2+METHOXYOESTRADIOL
3 2 METHOXYESTRADIOL BIS SULPHAMATE 347644 1% 100% 6 Search 2+METHOXYESTRADIOL+BIS+SULPHAMATE Search 2+METHOXYESTRADIOL+BIS+SULPHAMATE
4 2 METHOXYESTRADIOL 2ME2 297979 1% 86% 6 Search 2+METHOXYESTRADIOL+2ME2 Search 2+METHOXYESTRADIOL+2ME2
5 2 METHOXYESTRADIOL ANALOGS 231763 1% 100% 4 Search 2+METHOXYESTRADIOL+ANALOGS Search 2+METHOXYESTRADIOL+ANALOGS
6 ESE 16 231763 1% 100% 4 Search ESE+16 Search ESE+16
7 2 ETHYL 3 O SULPHAMOYL ESTRA 1 3 51016 TETRAENE 173822 1% 100% 3 Search 2+ETHYL+3+O+SULPHAMOYL+ESTRA+1+3+51016+TETRAENE Search 2+ETHYL+3+O+SULPHAMOYL+ESTRA+1+3+51016+TETRAENE
8 ESE 15 OL 173822 1% 100% 3 Search ESE+15+OL Search ESE+15+OL
9 2 METHOXYESTRADIOL ANALOGUES 115881 0% 100% 2 Search 2+METHOXYESTRADIOL+ANALOGUES Search 2+METHOXYESTRADIOL+ANALOGUES
10 2 METHOXYOESTRADIOL BIS SULPHAMATE 115881 0% 100% 2 Search 2+METHOXYOESTRADIOL+BIS+SULPHAMATE Search 2+METHOXYOESTRADIOL+BIS+SULPHAMATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KUMAR, BS , RAGHUVANSHI, DS , HASANAIN, M , ALAM, S , SARKAR, J , MITRA, K , KHAN, F , NEGI, AS , (2016) RECENT ADVANCES IN CHEMISTRY AND PHARMACOLOGY OF 2-METHOXYESTRADIOL: AN ANTICANCER INVESTIGATIONAL DRUG.STEROIDS. VOL. 110. ISSUE . P. 9 -34 118 68% 2
2 PEYRAT, JF , BRION, JD , ALAMI, M , (2012) SYNTHETIC 2-METHOXYESTRADIOL DERIVATIVES: STRUCTURE-ACTIVITY RELATIONSHIPS.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 24. P. 4142-4156 109 83% 15
3 SOLUM, EJ , AKSELSEN, OW , VIK, A , HANSEN, TV , (2015) SYNTHESIS AND PHARMACOLOGICAL EFFECTS OF THE ANTI-CANCER AGENT 2-METHOXYESTRADIOL.CURRENT PHARMACEUTICAL DESIGN. VOL. 21. ISSUE 38. P. 5453 -5466 59 86% 0
4 MUECK, AO , SEEGER, H , (2010) 2-METHOXYESTRADIOL-BIOLOGY AND MECHANISM OF ACTION.STEROIDS. VOL. 75. ISSUE 10. P. 625-631 56 74% 82
5 PINTO, MP , MEDINA, RA , OWEN, GI , (2014) 2-METHOXYESTRADIOL AND DISORDERS OF FEMALE REPRODUCTIVE TISSUES.HORMONES & CANCER. VOL. 5. ISSUE 5. P. 274 -283 57 64% 4
6 GORSKA, M , KUBAN-JANKOWSKA, A , SLAWEK, J , WOZNIAK, M , (2016) NEW INSIGHT INTO 2-METHOXYESTRADIOL- A POSSIBLE PHYSIOLOGICAL LINK BETWEEN NEURODEGENERATION AND CANCER CELL DEATH.CURRENT MEDICINAL CHEMISTRY. VOL. 23. ISSUE 15. P. 1513 -1527 67 53% 0
7 PARKS, M , TILLHON, M , DONA, F , PROSPERI, E , SCOVASSI, AI , (2011) 2-METHOXYESTRADIOL: NEW PERSPECTIVES IN COLON CARCINOMA TREATMENT.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 331. ISSUE 1. P. 119-128 47 75% 9
8 PARADA-BUSTAMANTE, A , VALENCIA, C , REUQUEN, P , DIAZ, P , RINCON-RODRIGUEZ, R , ORIHUELA, PA , (2015) ROLE OF 2-METHOXYESTRADIOL, AN ENDOGENOUS ESTROGEN METABOLITE, IN HEALTH AND DISEASE.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 5. P. 427 -438 66 45% 4
9 SUTHERLAND, TE , ANDERSON, RL , HUGHES, RA , ALTMANN, E , SCHULIGA, M , ZIOGAS, J , STEWART, AG , (2007) 2-METHOXYESTRADIOL - A UNIQUE BLEND OF ACTIVITIES GENERATING A NEW CLASS OF ANTI-TUMOUR/ANTI-INFLAMMATORY AGENTS.DRUG DISCOVERY TODAY. VOL. 12. ISSUE 13-14. P. 577-584 40 74% 56
10 MARAIS, S , MQOCO, T , STANDER, A , VAN PAPENDORP, D , JOUBERT, A , (2012) THE IN VITRO EFFECTS OF A SULPHAMOYLATED DERIVATIVE OF 2-METHOXYESTRADIOL ON CELL NUMBER, MORPHOLOGY AND ALPHA-TUBULIN DISRUPTION IN CERVICAL ADENOCARCINOMA (HELA) CELLS.BIOMEDICAL RESEARCH-INDIA. VOL. 23. ISSUE 3. P. 357-362 29 85% 4

Classes with closest relation at Level 1


Rank Class id link
1 5815 CATECHOLESTROGENS//16 ALPHA HYDROXYESTRONE//ESTROGEN METABOLITES
2 12125 STEROID SULFATASE//X LINKED ICHTHYOSIS//ESTRONE SULFATASE
3 5476 COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS
4 13518 STEROIDS//STEROIDAL OXIMES//HETEROSTEROIDS
5 35959 CARBOXYAMIDOTRIAZOLE//PROOFREADING STIMULATION//EQUIMOLAR COMBINATIONS OF NUCLEOTIDES PRECURSORS
6 24531 DUBLIN MED//2D GEL CLECTROPHORESIS//ANGIOGENIC ACTIVATOR
7 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION
8 2104 ESTROGEN//HORMONE REPLACEMENT THERAPY//CATEDRA BIOQUIM CLIN 2
9 17195 STUDY SEX DIFFERENCES HLTH AGING DIS//STUDY SEX DIFFERENCE HLTH AGING DIS//SEX GENDER DIFFERENCES HLTH DIS
10 16557 FLUOROESTRADIOL//F 18 FES PET//F 18FES

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