Class information for:
Level 1: COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5476 1619 40.9 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
2644 2             COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS 3490
5476 1                   COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS 1619

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COMBRETASTATIN authKW 2254507 8% 87% 137
2 COMBRETASTATIN A 4 authKW 1644270 7% 75% 117
3 VASCULAR DISRUPTING AGENTS authKW 1124946 6% 59% 101
4 PHENSTATIN authKW 396037 1% 100% 21
5 CANC TREATMENT DIAGFREDERICK CANC address 394091 2% 65% 32
6 ZD6126 authKW 381880 2% 75% 27
7 SCREENING TECHNOL BRANCH address 369410 4% 29% 68
8 TUBULIN POLYMERIZATION authKW 328055 3% 36% 49
9 COMBRETASTATIN A4 PHOSPHATE authKW 327976 1% 87% 20
10 TUBULIN INHIBITOR authKW 315921 2% 49% 34

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 33321 42% 0% 686
2 Oncology 3905 27% 0% 430
3 Chemistry, Organic 2716 20% 0% 317
4 Pharmacology & Pharmacy 1593 20% 0% 327
5 Biochemistry & Molecular Biology 354 16% 0% 267
6 Chemistry, Multidisciplinary 81 8% 0% 126
7 Radiology, Nuclear Medicine & Medical Imaging 49 3% 0% 56
8 Biochemical Research Methods 7 2% 0% 28
9 Crystallography 3 1% 0% 17
10 Cell Biology 3 3% 0% 48

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC TREATMENT DIAGFREDERICK CANC 394091 2% 65% 32
2 SCREENING TECHNOL BRANCH 369410 4% 29% 68
3 CANC TREATMENT DIAGNIH 221348 2% 31% 38
4 DEV THER EUT PROGRAMNIH 207900 1% 53% 21
5 UNITE BIOTECHNOL BIOINGN 134090 1% 44% 16
6 ONCOEMATOL 104789 1% 33% 17
7 LP4 78577 0% 83% 5
8 UNITA ONCOL SPERIMENTALE IMMUNOL 75436 0% 100% 4
9 TUMOR MICROCIRCULAT GRP 67101 1% 32% 11
10 GRAY CANC 66034 2% 12% 29

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY 21532 8% 1% 122
2 JOURNAL OF MEDICINAL CHEMISTRY 18388 9% 1% 145
3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 13872 5% 1% 83
4 CHEMMEDCHEM 6410 2% 1% 28
5 MEDCHEMCOMM 6128 1% 2% 21
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5693 5% 0% 88
7 INVESTIGATIONAL NEW DRUGS 4954 2% 1% 26
8 ANTI-CANCER DRUG DESIGN 2988 1% 2% 10
9 LETTERS IN DRUG DESIGN & DISCOVERY 2342 1% 1% 13
10 CHEMICAL BIOLOGY & DRUG DESIGN 2214 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 COMBRETASTATIN 2254507 8% 87% 137 Search COMBRETASTATIN Search COMBRETASTATIN
2 COMBRETASTATIN A 4 1644270 7% 75% 117 Search COMBRETASTATIN+A+4 Search COMBRETASTATIN+A+4
3 VASCULAR DISRUPTING AGENTS 1124946 6% 59% 101 Search VASCULAR+DISRUPTING+AGENTS Search VASCULAR+DISRUPTING+AGENTS
4 PHENSTATIN 396037 1% 100% 21 Search PHENSTATIN Search PHENSTATIN
5 ZD6126 381880 2% 75% 27 Search ZD6126 Search ZD6126
6 TUBULIN POLYMERIZATION 328055 3% 36% 49 Search TUBULIN+POLYMERIZATION Search TUBULIN+POLYMERIZATION
7 COMBRETASTATIN A4 PHOSPHATE 327976 1% 87% 20 Search COMBRETASTATIN+A4+PHOSPHATE Search COMBRETASTATIN+A4+PHOSPHATE
8 TUBULIN INHIBITOR 315921 2% 49% 34 Search TUBULIN+INHIBITOR Search TUBULIN+INHIBITOR
9 COLCHICINE BINDING SITE 305511 1% 90% 18 Search COLCHICINE+BINDING+SITE Search COLCHICINE+BINDING+SITE
10 CA 4 286850 1% 89% 17 Search CA+4 Search CA+4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GREENE, LM , MEEGAN, MJ , ZISTERER, DM , (2015) COMBRETASTATINS: MORE THAN JUST VASCULAR TARGETING AGENTS?.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 355. ISSUE 2. P. 212 -227 159 83% 8
2 PEREZ-PEREZ, MJ , PRIEGO, EM , BUENO, O , MARTINS, MS , CANELA, MD , LIEKENS, S , (2016) BLOCKING BLOOD FLOW TO SOLID TUMORS BY DESTABILIZING TUBULIN: AN APPROACH TO TARGETING TUMOR GROWTH.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 19. P. 8685 -8711 138 70% 3
3 RAJAK, H , DEWANGAN, PK , PATEL, V , JAIN, DK , SINGH, A , VEERASAMY, R , SHARMA, PC , DIXIT, A , (2013) DESIGN OF COMBRETASTATIN A-4 ANALOGS AS TUBULIN TARGETED VASCULAR DISRUPTING AGENT WITH SPECIAL EMPHASIS ON THEIR CIS-RESTRICTED ISOMERS.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 10. P. 1923-1955 111 78% 18
4 LU, Y , CHEN, JJ , XIAO, M , LI, W , MILLER, DD , (2012) AN OVERVIEW OF TUBULIN INHIBITORS THAT INTERACT WITH THE COLCHICINE BINDING SITE.PHARMACEUTICAL RESEARCH. VOL. 29. ISSUE 11. P. 2943 -2971 97 64% 122
5 TRON, GC , PIRALI, T , SORBA, G , PAGLIAI, F , BUSACCA, S , GENAZZANI, AA , (2006) MEDICINAL CHEMISTRY OF COMBRETASTATIN A4: PRESENT AND FUTURE DIRECTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 11. P. 3033-3044 81 84% 344
6 PATIL, PO , PATIL, AG , RANE, RA , PATIL, PC , DESHMUKH, PK , BARI, SB , PATIL, DA , NAPHADE, SS , (2015) RECENT ADVANCEMENT IN DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCT COMBRETASTATIN-INSPIRED ANTICANCER AGENTS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 8. P. 955 -969 81 94% 5
7 CHAUDHARY, A , PANDEYA, SN , KUMAR, P , SHARMA, P , GUPTA, S , SONI, N , VERMA, KK , BHARDWAJ, G , (2007) COMBRETASTATIN A-4 ANALOGS AS ANTICANCER AGENTS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 7. ISSUE 12. P. 1186-1205 97 88% 80
8 NAM, NH , (2003) COMBRETASTATIN A-4 ANALOGUES AS ANTIMITOTIC ANTITUMOR AGENTS.CURRENT MEDICINAL CHEMISTRY. VOL. 10. ISSUE 17. P. 1697-1722 98 76% 232
9 ALVAREZ, R , ARAMBURU, L , PUEBLA, P , CABALLERO, E , GONZALEZ, M , VICENTE, A , MEDARDE, M , PELAEZ, R , (2016) PYRIDINE BASED ANTITUMOUR COMPOUNDS ACTING AT THE COLCHICINE SITE.CURRENT MEDICINAL CHEMISTRY. VOL. 23. ISSUE 11. P. 1100 -1130 125 54% 0
10 MARRELLI, M , CONFORTI, F , STATTI, GA , CACHET, X , MICHEL, S , TILLEQUIN, F , MENICHINI, F , (2011) BIOLOGICAL POTENTIAL AND STRUCTURE-ACTIVITY RELATIONSHIPS OF MOST RECENTLY DEVELOPED VASCULAR DISRUPTING AGENTS: AN OVERVIEW OF NEW DERIVATIVES OF NATURAL COMBRETASTATIN A-4.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 20. P. 3035 -3081 76 83% 39

Classes with closest relation at Level 1


Rank Class id link
1 22006 DMXAA//FLAVONE ACETIC ACID//5 6 DIMETHYLXANTHENONE 4 ACETIC ACID
2 14569 THIOCOLCHICOSIDE//COLCHICINOIDS//THIOCOLCHICINE
3 34573 CI 980//1 ACETYLINDOLINE//ALPHA AMINOALKYL ARYL KETONE
4 25516 SULOFENUR//INDISULAM//E7070
5 33929 TUBULYSIN//PYRROLO 1 5 BENZOXAZEPINES//PBOX
6 14510 DOLASTATIN 10//DIDEMNIN B//CRYPTOPHYCIN
7 10628 EPOTHILONES//IXABEPILONE//PATUPILONE
8 17351 DISCODERMOLIDE//LAULIMALIDE//ELEUTHEROBIN
9 33515 DINITROANILINE//PHOSPHOROTHIOAMIDATE//2R 3S N BENZOYL 3 PHENYLISOSERINE
10 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION

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