Class information for:
Level 1: EPOTHILONES//IXABEPILONE//PATUPILONE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10628 1047 43.0 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
216 3       NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG 51214
1102 2             PACLITAXEL//TAXANES//EPOTHILONES 9807
10628 1                   EPOTHILONES//IXABEPILONE//PATUPILONE 1047

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPOTHILONES authKW 4872001 21% 75% 222
2 IXABEPILONE authKW 1697977 8% 66% 88
3 PATUPILONE authKW 785858 3% 84% 32
4 EPOTHILONE B authKW 524911 3% 60% 30
5 SAGOPILONE authKW 472438 2% 90% 18
6 CLASS III BETA TUBULIN authKW 273776 2% 36% 26
7 BMS 247550 authKW 265117 1% 91% 10
8 KOS 862 authKW 204141 1% 100% 7
9 ANTINEOPLAST PHARMACOL address 164024 1% 38% 15
10 PRECLIN PHARMACOL CORE IL address 143566 1% 62% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 7196 43% 0% 452
2 Chemistry, Organic 753 13% 0% 141
3 Pharmacology & Pharmacy 477 15% 0% 154
4 Chemistry, Medicinal 441 7% 0% 71
5 Chemistry, Multidisciplinary 196 12% 0% 123
6 Cell Biology 51 6% 0% 60
7 Biotechnology & Applied Microbiology 41 4% 0% 44
8 Biochemistry & Molecular Biology 34 10% 0% 102
9 Obstetrics & Gynecology 11 2% 0% 19
10 Pathology 10 2% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTINEOPLAST PHARMACOL 164024 1% 38% 15
2 PRECLIN PHARMACOL CORE IL 143566 1% 62% 8
3 ANALYT PHARMACOL CORE IL 104151 0% 71% 5
4 GLOBAL MED DEV ONCOL 87489 0% 100% 3
5 TA ONCOL 74984 1% 43% 6
6 ONCOL DA 65615 0% 75% 3
7 IMMUNOL HEMOPATHIES 52491 0% 60% 3
8 ABT NAT STOFFCHEM 45560 0% 31% 5
9 ABT NATURSTOFFCHEM 33132 0% 23% 5
10 ANALYT CHEM CORE S 29163 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL BREAST CANCER 7425 1% 2% 14
2 MOLECULAR CANCER THERAPEUTICS 4810 2% 1% 26
3 INVESTIGATIONAL NEW DRUGS 3275 2% 1% 17
4 CLINICAL CANCER RESEARCH 2498 3% 0% 36
5 CANCER CHEMOTHERAPY AND PHARMACOLOGY 2447 2% 0% 25
6 CHEMMEDCHEM 1255 1% 0% 10
7 EXPERT OPINION ON INVESTIGATIONAL DRUGS 1084 1% 0% 9
8 JOURNAL OF CLINICAL ONCOLOGY 999 2% 0% 24
9 ANNALS OF ONCOLOGY 997 2% 0% 17
10 DRUGS IN R&D 808 0% 3% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 EPOTHILONES 4872001 21% 75% 222 Search EPOTHILONES Search EPOTHILONES
2 IXABEPILONE 1697977 8% 66% 88 Search IXABEPILONE Search IXABEPILONE
3 PATUPILONE 785858 3% 84% 32 Search PATUPILONE Search PATUPILONE
4 EPOTHILONE B 524911 3% 60% 30 Search EPOTHILONE+B Search EPOTHILONE+B
5 SAGOPILONE 472438 2% 90% 18 Search SAGOPILONE Search SAGOPILONE
6 CLASS III BETA TUBULIN 273776 2% 36% 26 Search CLASS+III+BETA+TUBULIN Search CLASS+III+BETA+TUBULIN
7 BMS 247550 265117 1% 91% 10 Search BMS+247550 Search BMS+247550
8 KOS 862 204141 1% 100% 7 Search KOS+862 Search KOS+862
9 TUBB3 140800 1% 37% 13 Search TUBB3 Search TUBB3
10 EPOTHILONE A 129903 1% 64% 7 Search EPOTHILONE+A Search EPOTHILONE+A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KAISER, S , MULLER, JJ , FROEHLICH, PE , GNOATTO, SCB , BERGOLD, AM , (2013) FROM BACTERIA TO ANTINEOPLASTIC: EPOTHILONES A SUCCESSFUL HISTORY.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 7. P. 1057-1068 100 85% 6
2 ALTMANN, KH , PFEIFFER, B , ARSENIYADIS, S , PRATT, BA , NICOLAOU, KC , (2007) THE CHEMISTRY AND BIOLOGY OF EPOTHILONES - THE WHEEL KEEPS TURNING.CHEMMEDCHEM. VOL. 2. ISSUE 4. P. 396 -423 114 79% 65
3 ALTMANN, KH , (2004) THE MERGER OF NATURAL PRODUCT SYNTHESIS AND MEDICINAL CHEMISTRY: ON THE CHEMISTRY AND CHEMICAL BIOLOGY OF EPOTHILONES.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 2. ISSUE 15. P. 2137-2152 77 85% 48
4 TRIVEDI, M , BUDIHARDJO, I , LOUREIRO, K , REID, TR , MA, JD , (2008) EPOTHILONES: A NOEL CLASS OF MICROTUBULE-STABILIZING DRUGS FOR THE TREATMENT OF CANCER.FUTURE ONCOLOGY. VOL. 4. ISSUE 4. P. 483-500 63 91% 22
5 ALTMANN, KH , (2005) RECENT DEVELOPMENTS IN THE CHEMICAL BIOLOGY OF EPOTHILONES.CURRENT PHARMACEUTICAL DESIGN. VOL. 11. ISSUE 13. P. 1595-1613 74 79% 65
6 BROGDON, CF , LEE, FY , CANETTA, RM , (2014) DEVELOPMENT OF OTHER MICROTUBULE-STABILIZER FAMILIES: THE EPOTHILONES AND THEIR DERIVATIVES.ANTI-CANCER DRUGS. VOL. 25. ISSUE 5. P. 599 -609 59 76% 10
7 LIU, XX , QIN, W , ZHENG, YS , (2007) TOTAL SYNTHESES OF EPOTHIOLONES.CHINESE JOURNAL OF ORGANIC CHEMISTRY. VOL. 27. ISSUE 3. P. 298-312 56 97% 1
8 KAVALLARIS, M , (2010) MICROTUBULES AND RESISTANCE TO TUBULIN-BINDING AGENTS.NATURE REVIEWS CANCER. VOL. 10. ISSUE 3. P. 194 -204 55 50% 346
9 WATKINS, EB , CHITTIBOYINA, AG , JUNG, JC , AVERY, MA , (2005) THE EPOTHILONES AND RELATED ANALOGUES - A REVIEW OF THEIR SYNTHESES AND ANTI-CANCER ACTIVITIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 11. ISSUE 13. P. 1615-1653 71 74% 36
10 FERRANDINA, G , MARIANI, M , ANDREOLI, M , SHAHABI, S , SCAMBIA, G , FERLINI, C , (2012) NOVEL DRUGS TARGETING MICROTUBULES: THE ROLE OF EPOTHILONES.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 19. P. 2793-2803 55 77% 18

Classes with closest relation at Level 1


Rank Class id link
1 17351 DISCODERMOLIDE//LAULIMALIDE//ELEUTHEROBIN
2 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION
3 5367 DETYROSINATION//GLUTAMYLATION//TUBULIN TYROSINE LIGASE
4 5476 COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS
5 13007 ERCC1//RRM1//MED OVARIAN CANC SECT
6 19264 ERIBULIN//ERIBULIN MESYLATE//HALICHONDRIN B
7 2966 METASTATIC BREAST CANCER//VINORELBINE//DOCETAXEL
8 7277 PACLITAXEL//CREMOPHOR EL//DOCETAXEL
9 36821 SIPHOLANES//1 ACETYLVINYL P NITROBENZOYLOXY//24 BETA METHYLCHOLASTA 1 8 14 22 25 PENTEN 3 ONE 5 ALPHA OL 1 1H INDOL 3 YL 2 3 DIHYDROXY 5 METHYL HEXANE
10 33929 TUBULYSIN//PYRROLO 1 5 BENZOXAZEPINES//PBOX

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