Class information for:
Level 1: PACLITAXEL//CREMOPHOR EL//DOCETAXEL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7277 1386 33.7 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
216 3       NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG 51214
1102 2             PACLITAXEL//TAXANES//EPOTHILONES 9807
7277 1                   PACLITAXEL//CREMOPHOR EL//DOCETAXEL 1386

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PACLITAXEL authKW 777304 33% 8% 464
2 CREMOPHOR EL authKW 387858 3% 39% 45
3 DOCETAXEL authKW 183984 12% 5% 172
4 NEW MAT BIOL address 154207 1% 100% 7
5 LAROTAXEL authKW 137256 1% 69% 9
6 TAXOL authKW 135841 6% 7% 89
7 ORAL PACLITAXEL authKW 132178 0% 100% 6
8 PACLITAXEL TAXOLR authKW 89210 1% 45% 9
9 DHP107 authKW 88118 0% 100% 4
10 SHR110008 authKW 88118 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 11756 48% 0% 661
2 Pharmacology & Pharmacy 6453 40% 0% 560
3 Chemistry, Analytical 782 11% 0% 159
4 Biochemical Research Methods 638 8% 0% 111
5 Chemistry, Medicinal 140 4% 0% 52
6 Radiology, Nuclear Medicine & Medical Imaging 48 4% 0% 50
7 Materials Science, Biomaterials 34 1% 0% 15
8 Toxicology 22 2% 0% 28
9 Chemistry, Multidisciplinary 20 6% 0% 81
10 Spectroscopy 17 2% 0% 23

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEW MAT BIOL 154207 1% 100% 7
2 PHARMACEUT ANAL TOXICOL 77572 1% 39% 9
3 DRUG TOXICOL 75043 2% 12% 28
4 SLOTERVAART HOSP 71648 2% 14% 24
5 DANIEL DE HOED KLIN 44059 0% 100% 2
6 EXPT THER EUT PHASE I PROGRAMS 44059 0% 100% 2
7 NUCL MED CLINDAVID GEFFEN MED 44059 0% 100% 2
8 PHARM PHARMACOL 37803 5% 2% 74
9 DANIEL DEN HOED KLIN 35957 1% 12% 14
10 GENOME QUEBEC MONTREAL HEART 28320 0% 43% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 27041 7% 1% 95
2 ANTI-CANCER DRUGS 12429 3% 1% 43
3 CLINICAL CANCER RESEARCH 6007 5% 0% 64
4 SEMINARS IN ONCOLOGY 4562 2% 1% 33
5 INVESTIGATIONAL NEW DRUGS 4143 2% 1% 22
6 SEMINARS IN RADIATION ONCOLOGY 2232 1% 1% 9
7 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2196 3% 0% 35
8 JOURNAL OF CLINICAL ONCOLOGY 2011 3% 0% 39
9 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 1648 2% 0% 29
10 PHARMACOGENOMICS 1485 1% 1% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PACLITAXEL 777304 33% 8% 464 Search PACLITAXEL Search PACLITAXEL
2 CREMOPHOR EL 387858 3% 39% 45 Search CREMOPHOR+EL Search CREMOPHOR+EL
3 DOCETAXEL 183984 12% 5% 172 Search DOCETAXEL Search DOCETAXEL
4 LAROTAXEL 137256 1% 69% 9 Search LAROTAXEL Search LAROTAXEL
5 TAXOL 135841 6% 7% 89 Search TAXOL Search TAXOL
6 ORAL PACLITAXEL 132178 0% 100% 6 Search ORAL+PACLITAXEL Search ORAL+PACLITAXEL
7 PACLITAXEL TAXOLR 89210 1% 45% 9 Search PACLITAXEL+TAXOLR Search PACLITAXEL+TAXOLR
8 DHP107 88118 0% 100% 4 Search DHP107 Search DHP107
9 SHR110008 88118 0% 100% 4 Search SHR110008 Search SHR110008
10 BMS 184476 70493 0% 80% 4 Search BMS+184476 Search BMS+184476

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HENDRIKX, JJMA , ROSING, H , SCHINKEL, AH , SCHELLENS, JHM , BEIJNEN, JH , (2014) QUANTIFICATION OF TAXANES IN BIOLOGICAL MATRICES: A REVIEW OF BIOANALYTICAL ASSAYS AND RECOMMENDATIONS FOR DEVELOPMENT OF NEW ASSAYS.BIOANALYSIS. VOL. 6. ISSUE 7. P. 993 -1010 100 74% 2
2 SPARREBOOM, A , VAN TELLINGEN, O , NOOIJEN, WJ , BEIJNEN, JH , (1998) PRECLINICAL PHARMACOKINETICS OF PACLITAXEL AND DOCETAXEL.ANTI-CANCER DRUGS. VOL. 9. ISSUE 1. P. 1 -17 93 71% 78
3 HERTZ, DL , MCLEOD, HL , KRENS, SD , (2013) PHARMACOGENETICS, ENZYME PROBES AND THERAPEUTIC DRUG MONITORING AS POTENTIAL TOOLS FOR INDIVIDUALIZING TAXANE THERAPY.PHARMACOGENOMICS. VOL. 14. ISSUE 5. P. 555 -574 69 55% 4
4 GELDERBLOM, H , VERWEIJ, J , NOOTER, K , SPARREBOOM, A , (2001) CREMOPHOR EL: THE DRAWBACKS AND ADVANTAGES OF VEHICLE SELECTION FOR DRUG FORMULATION.EUROPEAN JOURNAL OF CANCER. VOL. 37. ISSUE 13. P. 1590 -1598 41 69% 705
5 TEN TIJE, AJ , VERWEIJ, J , LOOS, WJ , SPARREBOOM, A , (2003) PHARMACOLOGICAL EFFECTS OF FORMULATION VEHICLES - IMPLICATIONS FOR CANCER CHEMOTHERAPY.CLINICAL PHARMACOKINETICS. VOL. 42. ISSUE 7. P. 665-685 72 43% 246
6 VAN ZUYLEN, L , VERWEIJ, J , SPARREBOOM, A , (2001) ROLE OF FORMULATION VEHICLES IN TAXANE PHARMACOLOGY.INVESTIGATIONAL NEW DRUGS. VOL. 19. ISSUE 2. P. 125 -141 61 55% 157
7 BULITTA, JB , ZHAO, P , ARNOLD, RD , KESSLER, DR , DAIFUKU, R , PRATT, J , LUCIANO, G , HANAUSKE, AR , GELDERBLOM, H , AWADA, A , ET AL (2009) MECHANISTIC POPULATION PHARMACOKINETICS OF TOTAL AND UNBOUND PACLITAXEL FOR A NEW NANODROPLET FORMULATION VERSUS TAXOL IN CANCER PATIENTS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 63. ISSUE 6. P. 1049-1063 35 88% 17
8 NIEUWEBOER, AJM , DE MORREE, ES , DE GRAAN, AJM , SPARREBOOM, A , DE WIT, R , MATHIJSSEN, RHJ , (2015) INTER-PATIENT VARIABILITY IN DOCETAXEL PHARMACOKINETICS: A REVIEW.CANCER TREATMENT REVIEWS. VOL. 41. ISSUE 7. P. 605 -613 48 48% 4
9 GERRITSEN-VAN SCHIEVEEN, P , ROYER, B , (2011) LEVEL OF EVIDENCE FOR THERAPEUTIC DRUG MONITORING OF TAXANES.FUNDAMENTAL & CLINICAL PHARMACOLOGY. VOL. 25. ISSUE 4. P. 414 -424 49 53% 3
10 DE JONGE, ME , HUITEMA, AD , SCHELLENS, JH , RODENHUIS, S , BEIJNEN, JH , (2005) POPULATION PHARMACOKINETICS OF ORALLY ADMINISTERED PACLITAXEL FORMULATED IN CREMOPHOR EL.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 59. ISSUE 3. P. 325-334 33 89% 13

Classes with closest relation at Level 1


Rank Class id link
1 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION
2 2951 TAXACEAE//TAXOIDS//TAXUS CUSPIDATA
3 2966 METASTATIC BREAST CANCER//VINORELBINE//DOCETAXEL
4 20800 HYPERSENSITIVITY REACTION//HYPERSENSITIVITY//RAPID DESENSITIZATION
5 16519 NAB PACLITAXEL//ALBUMIN NANOPARTICLES//ABRAXANE
6 33987 LIPID NANOCAPSULES//U646//U1066
7 9553 CANCER NANOTECHNOLOGY//SHENZHEN GENE ANTIBODY THER Y//NANOSCI NANOENGN INITIAT NUSNNI
8 10628 EPOTHILONES//IXABEPILONE//PATUPILONE
9 6731 CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY//GOSHAJINKIGAN//CIPN
10 1615 OVARIAN CANCER//RECURRENT OVARIAN CANCER//PEGYLATED LIPOSOMAL DOXORUBICIN

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