Class information for:
Level 1: IGF 1R//IGF IR//INSULIN LIKE GROWTH FACTOR 1 RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1648 2555 46.7 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
144 3       ENDOCRINOLOGY & METABOLISM//PITUITARY ADENOMA//GROWTH HORMONE 64198
92 2             GROWTH HORMONE//GROWTH HORMONE & IGF RESEARCH//ENDOCRINOLOGY & METABOLISM 26472
1648 1                   IGF 1R//IGF IR//INSULIN LIKE GROWTH FACTOR 1 RECEPTOR 2555

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IGF 1R authKW 680702 7% 32% 178
2 IGF IR authKW 396590 3% 42% 79
3 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR authKW 353850 3% 36% 82
4 CIXUTUMUMAB authKW 199150 1% 83% 20
5 IGFBP 3 authKW 175043 4% 15% 98
6 INSULIN LIKE GROWTH FACTOR authKW 142986 6% 8% 158
7 FIGITUMUMAB authKW 139039 1% 73% 16
8 IGF I RECEPTOR authKW 134622 2% 23% 49
9 IGF 1R INHIBITOR authKW 120488 0% 92% 11
10 INSULIN LIKE GROWTH FACTOR I RECEPTOR authKW 120219 2% 25% 41

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 30142 56% 0% 1426
2 Endocrinology & Metabolism 3562 15% 0% 391
3 Cell Biology 1261 13% 0% 335
4 Medicine, Research & Experimental 269 5% 0% 128
5 Public, Environmental & Occupational Health 235 5% 0% 136
6 Biochemistry & Molecular Biology 230 13% 0% 321
7 Pathology 111 3% 0% 66
8 Genetics & Heredity 82 4% 0% 99
9 Urology & Nephrology 66 2% 0% 58
10 Chemistry, Medicinal 47 2% 0% 53

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OSI ONCOL 49787 0% 83% 5
2 IGF GRP 38236 0% 80% 4
3 CANC PREVENT UNIT 36559 1% 15% 21
4 N GLAMORGAN TRUST 35848 0% 100% 3
5 SECT CANC PREVENT CONTROL 34434 0% 41% 7
6 ONCOLCANC PREVENT UNIT 27309 0% 57% 4
7 COMPREHENS GUIDANCE WOMENS HLTH 26885 0% 75% 3
8 CANC TREATMENT EPIDEMIOL CANC PREVENT 23899 0% 100% 2
9 GENOM EPIDEMIOL GRP C055 23899 0% 100% 2
10 INSURANCE TESTING 23899 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GROWTH HORMONE & IGF RESEARCH 23584 2% 4% 47
2 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 14268 3% 1% 87
3 BREAST CANCER RESEARCH AND TREATMENT 7537 3% 1% 68
4 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 7000 1% 3% 19
5 CANCER RESEARCH 6896 6% 0% 152
6 MOLECULAR CANCER THERAPEUTICS 6417 2% 1% 47
7 CLINICAL CANCER RESEARCH 5838 3% 1% 86
8 ENDOCRINE-RELATED CANCER 4842 1% 2% 26
9 INTERNATIONAL JOURNAL OF CANCER 2480 3% 0% 66
10 FRONTIERS IN ENDOCRINOLOGY 2034 0% 2% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 IGF 1R 680702 7% 32% 178 Search IGF+1R Search IGF+1R
2 IGF IR 396590 3% 42% 79 Search IGF+IR Search IGF+IR
3 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR 353850 3% 36% 82 Search INSULIN+LIKE+GROWTH+FACTOR+1+RECEPTOR Search INSULIN+LIKE+GROWTH+FACTOR+1+RECEPTOR
4 CIXUTUMUMAB 199150 1% 83% 20 Search CIXUTUMUMAB Search CIXUTUMUMAB
5 IGFBP 3 175043 4% 15% 98 Search IGFBP+3 Search IGFBP+3
6 INSULIN LIKE GROWTH FACTOR 142986 6% 8% 158 Search INSULIN+LIKE+GROWTH+FACTOR Search INSULIN+LIKE+GROWTH+FACTOR
7 FIGITUMUMAB 139039 1% 73% 16 Search FIGITUMUMAB Search FIGITUMUMAB
8 IGF I RECEPTOR 134622 2% 23% 49 Search IGF+I+RECEPTOR Search IGF+I+RECEPTOR
9 IGF 1R INHIBITOR 120488 0% 92% 11 Search IGF+1R+INHIBITOR Search IGF+1R+INHIBITOR
10 INSULIN LIKE GROWTH FACTOR I RECEPTOR 120219 2% 25% 41 Search INSULIN+LIKE+GROWTH+FACTOR+I+RECEPTOR Search INSULIN+LIKE+GROWTH+FACTOR+I+RECEPTOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 OZKAN, EE , (2011) PLASMA AND TISSUE INSULIN-LIKE GROWTH FACTOR-I RECEPTOR (IGF-IR) AS A PROGNOSTIC MARKER FOR PROSTATE CANCER AND ANTI-IGF-IR AGENTS AS NOVEL THERAPEUTIC STRATEGY FOR REFRACTORY CASES: A REVIEW.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 344. ISSUE 1-2. P. 1 -24 186 63% 43
2 KING, H , ALEKSIC, T , HALUSKA, P , MACAULAY, VM , (2014) CAN WE UNLOCK THE POTENTIAL OF IGF-1R INHIBITION IN CANCER THERAPY?.CANCER TREATMENT REVIEWS. VOL. 40. ISSUE 9. P. 1096 -1105 119 83% 22
3 SAMANI, AA , YAKAR, S , LEROITH, D , BRODT, P , (2007) THE ROLE OF THE IGF SYSTEM IN CANCER GROWTH AND METASTASIS: OVERVIEW AND RECENT INSIGHTS.ENDOCRINE REVIEWS. VOL. 28. ISSUE 1. P. 20-47 132 41% 541
4 VISHWAMITRA, D , GEORGE, SK , SHI, P , KASEB, AO , AMIN, HM , (2017) TYPE I INSULIN-LIKE GROWTH FACTOR RECEPTOR SIGNALING IN HEMATOLOGICAL MALIGNANCIES.ONCOTARGET. VOL. 8. ISSUE 1. P. 1814 -1844 145 49% 0
5 SINGH, P , ALEX, JM , BAST, F , (2014) INSULIN RECEPTOR (IR) AND INSULIN-LIKE GROWTH FACTOR RECEPTOR 1 (IGF-1R) SIGNALING SYSTEMS: NOVEL TREATMENT STRATEGIES FOR CANCER.MEDICAL ONCOLOGY. VOL. 31. ISSUE 1. P. - 89 66% 31
6 BOWERS, LW , ROSSI, EL , O'FLANAGAN, CH , DEGRAFFENRIED, LA , HURSTING, SD , (2015) THE ROLE OF THE INSULIN/IGF SYSTEM IN CANCER: LESSONS LEARNED FROM CLINICAL TRIALS AND THE ENERGY BALANCE-CANCER LINK.FRONTIERS IN ENDOCRINOLOGY. VOL. 6. ISSUE . P. - 114 59% 4
7 ARCARO, A , (2013) TARGETING THE INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR IN HUMAN CANCER.FRONTIERS IN PHARMACOLOGY. VOL. 4. ISSUE . P. - 71 90% 18
8 BRUCHIM, I , WERNER, H , (2013) TARGETING IGF-1 SIGNALING PATHWAYS IN GYNECOLOGIC MALIGNANCIES.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 17. ISSUE 3. P. 307 -320 81 72% 24
9 BRUCHIM, I , ATTIAS, Z , WERNER, H , (2009) TARGETING THE IGF1 AXIS IN CANCER PROLIFERATION.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 13. ISSUE 10. P. 1179-1192 88 77% 28
10 NOVELLO, S , SCAGLIOTTI, GV , (2012) THE ROLE OF THE INSULIN-LIKE GROWTH FACTOR SIGNALING PATHWAY IN NON-SMALL CELL LUNG CANCER AND OTHER SOLID TUMORS.CANCER TREATMENT REVIEWS. VOL. 38. ISSUE 4. P. 292 -302 66 84% 45

Classes with closest relation at Level 1


Rank Class id link
1 980 INSULIN LIKE GROWTH FACTOR BINDING PROTEINS//IGFBP//IGFBP 2
2 25012 PL MOL MED IMMA BOADILLA DEL MONTE//DIPARTIMENTO SCI MED DIAGNOST//INSULIN LIKE GROWTH FACTOR II
3 9406 INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1
4 6777 COLORECTAL ADENOMA//ADVANCED ADENOMATOUS POLYPS//BREAST ONCODIABETOLOGY
5 14751 INSULIN LIKE GROWTH FACTOR 1//MED 0613B//INTERNAL MED CARDIOVASC SCI
6 28712 ENDOCRINE POLYPEPTIDE CANC//GHRH ANTAGONISTS//GROWTH HORMONE RELEASING HORMONE ANTAGONIST
7 20061 ALTERNATE DAY FASTING//INTERMITTENT FASTING//LONGEV
8 25876 MECHANO GROWTH FACTOR//E PEPTIDE//MECHANO GROWTH FACTOR MGF
9 1594 INSULIN RECEPTOR//LEPRECHAUNISM//DONOHUE SYNDROME
10 9158 69 BUTLER ST SE//DIABET BRANCHMOLEC CELLULAR PHYSIOL SECT//IGF IA

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