Class information for:
Level 1: EXON SKIPPING//MC LOCKWOOD MUSCULAR DYSTROPHY//NEUROMUSCULAR ALS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17872 578 48.1 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
180 3       DUCHENNE MUSCULAR DYSTROPHY//DYSTROPHIN//MUSCULAR DYSTROPHY 56784
991 2             DUCHENNE MUSCULAR DYSTROPHY//DYSTROPHIN//MUSCULAR DYSTROPHY 10483
17872 1                   EXON SKIPPING//MC LOCKWOOD MUSCULAR DYSTROPHY//NEUROMUSCULAR ALS 578

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXON SKIPPING authKW 1199100 16% 24% 93
2 MC LOCKWOOD MUSCULAR DYSTROPHY address 491403 3% 47% 20
3 NEUROMUSCULAR ALS address 396196 3% 50% 15
4 DMD GENET THER Y GRP address 323571 1% 88% 7
5 EXPT MOL MED GRP address 287617 1% 78% 7
6 SPLICE SWITCHING authKW 211309 1% 67% 6
7 ANTISENSE OLIGONUCLEOTIDES authKW 203145 13% 5% 78
8 NEUROMUSCULAR NEUROL DISORDERS address 195449 6% 11% 35
9 PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER authKW 190177 1% 60% 6
10 PPMO authKW 184892 1% 50% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Research & Experimental 4368 33% 0% 189
2 Biotechnology & Applied Microbiology 1942 25% 0% 146
3 Genetics & Heredity 1932 25% 0% 143
4 Biochemistry & Molecular Biology 599 29% 0% 170
5 Pharmacology & Pharmacy 166 12% 0% 71
6 Clinical Neurology 135 8% 0% 47
7 Chemistry, Medicinal 111 5% 0% 28
8 Developmental Biology 50 2% 0% 13
9 Biochemical Research Methods 47 4% 0% 23
10 Chemistry, Organic 42 6% 0% 32

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MC LOCKWOOD MUSCULAR DYSTROPHY 491403 3% 47% 20
2 NEUROMUSCULAR ALS 396196 3% 50% 15
3 DMD GENET THER Y GRP 323571 1% 88% 7
4 EXPT MOL MED GRP 287617 1% 78% 7
5 NEUROMUSCULAR NEUROL DISORDERS 195449 6% 11% 35
6 BIOTHER IES MALAD NEUROMUSCULAI UNITE MIXTE U 158484 1% 100% 3
7 FRIENDS GARRETT CUMMING MUSCULAR DYSTROPHY 158484 1% 100% 3
8 NEUROMUSCULAR AMYOTROPH LATERAL SCLEROSIS 158484 1% 100% 3
9 CANC ENDOCRINE 105656 0% 100% 2
10 DNA GENET 105656 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEIC ACID THERAPEUTICS 60076 3% 7% 17
2 MOLECULAR THERAPY-NUCLEIC ACIDS 56643 3% 6% 18
3 MOLECULAR THERAPY 23825 7% 1% 40
4 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT 14182 2% 3% 10
5 CURRENT OPINION IN MOLECULAR THERAPEUTICS 11833 2% 2% 14
6 OLIGONUCLEOTIDES 7058 1% 2% 6
7 CURRENT GENE THERAPY 4710 1% 1% 7
8 NEUROMUSCULAR DISORDERS 3777 2% 1% 13
9 JOURNAL OF GENE MEDICINE 3743 2% 1% 10
10 HUMAN GENE THERAPY 3543 3% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 EXON SKIPPING 1199100 16% 24% 93 Search EXON+SKIPPING Search EXON+SKIPPING
2 SPLICE SWITCHING 211309 1% 67% 6 Search SPLICE+SWITCHING Search SPLICE+SWITCHING
3 ANTISENSE OLIGONUCLEOTIDES 203145 13% 5% 78 Search ANTISENSE+OLIGONUCLEOTIDES Search ANTISENSE+OLIGONUCLEOTIDES
4 PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER 190177 1% 60% 6 Search PHOSPHORODIAMIDATE+MORPHOLINO+OLIGOMER Search PHOSPHORODIAMIDATE+MORPHOLINO+OLIGOMER
5 PPMO 184892 1% 50% 7 Search PPMO Search PPMO
6 DUCHENNE MUSCULAR DYSTROPHY 180214 13% 4% 78 Search DUCHENNE+MUSCULAR+DYSTROPHY Search DUCHENNE+MUSCULAR+DYSTROPHY
7 2 O METHYL PHOSPHOROTHIOATE 158484 1% 100% 3 Search 2+O+METHYL+PHOSPHOROTHIOATE Search 2+O+METHYL+PHOSPHOROTHIOATE
8 MORPHOLINO OLIGOMER 158478 1% 50% 6 Search MORPHOLINO+OLIGOMER Search MORPHOLINO+OLIGOMER
9 PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS 140872 1% 67% 4 Search PHOSPHORODIAMIDATE+MORPHOLINO+OLIGOMERS Search PHOSPHORODIAMIDATE+MORPHOLINO+OLIGOMERS
10 MORPHOLINO 124584 5% 9% 27 Search MORPHOLINO Search MORPHOLINO

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 AARTSMA-RUS, A , (2010) ANTISENSE-MEDIATED MODULATION OF SPLICING THERAPEUTIC IMPLICATIONS FOR DUCHENNE MUSCULAR DYSTROPHY.RNA BIOLOGY. VOL. 7. ISSUE 4. P. 453-461 60 78% 27
2 KOO, T , WOOD, MJ , (2013) CLINICAL TRIALS USING ANTISENSE OLIGONUCLEOTIDES IN DUCHENNE MUSCULAR DYSTROPHY.HUMAN GENE THERAPY. VOL. 24. ISSUE 5. P. 479-488 51 65% 56
3 ECHIGOYA, Y , YOKOTA, T , (2014) SKIPPING MULTIPLE EXONS OF DYSTROPHIN TRANSCRIPTS USING COCKTAIL ANTISENSE OLIGONUCLEOTIDES.NUCLEIC ACID THERAPEUTICS. VOL. 24. ISSUE 1. P. 57-68 58 57% 11
4 MOULTON, HM , (2013) IN VIVO DELIVERY OF MORPHOLINO OLIGOS BY CELL-PENETRATING PEPTIDES.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 16. P. 2963-2969 46 71% 10
5 WILTON, SD , VEEDU, RN , FLETCHER, S , (2015) THE EMPEROR'S NEW DYSTROPHIN: FINDING SENSE IN THE NOISE.TRENDS IN MOLECULAR MEDICINE. VOL. 21. ISSUE 7. P. 417 -426 51 48% 7
6 KOLE, R , KRAINER, AR , ALTMAN, S , (2012) RNA THERAPEUTICS: BEYOND RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 2. P. 125 -140 36 40% 334
7 WILTON, SD , FLETCHER, S , (2010) SPLICE MODIFICATION TO RESTORE FUNCTIONAL DYSTROPHIN SYNTHESIS IN DUCHENNE MUSCULAR DYSTROPHY.CURRENT PHARMACEUTICAL DESIGN. VOL. 16. ISSUE 8. P. 988-1001 56 52% 7
8 JARVER, P , O'DONOVAN, L , GAIT, MJ , (2014) A CHEMICAL VIEW OF OLIGONUCLEOTIDES FOR EXON SKIPPING AND RELATED DRUG APPLICATIONS.NUCLEIC ACID THERAPEUTICS. VOL. 24. ISSUE 1. P. 37-47 43 54% 15
9 LU, QL , YOKOTA, T , TAKEDA, S , GARCIA, L , MUNTONI, F , PARTRIDGE, T , (2011) THE STATUS OF EXON SKIPPING AS A THERAPEUTIC APPROACH TO DUCHENNE MUSCULAR DYSTROPHY.MOLECULAR THERAPY. VOL. 19. ISSUE 1. P. 9-15 33 73% 41
10 AOKI, Y , YOKOTA, T , WOOD, MJA , (2013) DEVELOPMENT OF MULTIEXON SKIPPING ANTISENSE OLIGONUCLEOTIDE THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY.BIOMED RESEARCH INTERNATIONAL. VOL. . ISSUE . P. - 39 63% 4

Classes with closest relation at Level 1


Rank Class id link
1 3773 MDX MOUSE//DUCHENNE MUSCULAR DYSTROPHY//MDX
2 1302 DYSTROPHIN//DUCHENNE MUSCULAR DYSTROPHY//BECKER MUSCULAR DYSTROPHY
3 25066 SINGLE STRANDED OLIGONUCLEOTIDES//GENE REPAIR//CHIMERAPLASTY
4 2407 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE OLIGONUCLEOTIDES//ANTISENSE RESEARCH AND DEVELOPMENT
5 8253 DUCHENNE MUSCULAR DYSTROPHY//DUCHENNE//MUSCULAR DYSTROPHY
6 4600 NUCLE ACID//SYNTHET BIOORGAN CHEM//NUCL ACID
7 6706 PEPTIDE NUCLEIC ACID//PNA//BIOMOL RECOGNIT
8 2061 CELL PENETRATING PEPTIDE//PROTEIN TRANSDUCTION DOMAIN//PROTEIN TRANSDUCTION
9 4018 SPINAL MUSCULAR ATROPHY//SMN//SURVIVAL MOTOR NEURON
10 34765 BROWN TROUT FARMING//DIL C18//IN VIVO THROMBOSIS MODEL

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