Class information for:
Level 1: SILDENAFIL//PDE5//PDE 5 INHIBITION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19890 485 41.8 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
343 3       NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE 36678
1338 2             PHOSPHODIESTERASE//ROLIPRAM//PDE4 8346
19890 1                   SILDENAFIL//PDE5//PDE 5 INHIBITION 485

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SILDENAFIL authKW 556306 25% 7% 119
2 PDE5 authKW 205854 5% 15% 22
3 PDE 5 INHIBITION authKW 201465 1% 80% 4
4 TRANSGENES CARDIOVASC CONTROL address 192802 1% 44% 7
5 PHOSPHODIESTERASE 5 authKW 186263 4% 16% 19
6 OSU 03012 authKW 143082 1% 45% 5
7 AMINOPYRAZINONE authKW 125917 0% 100% 2
8 BEIJING YOU YI HOSP address 125917 0% 100% 2
9 EXPT RENAL P ERVAT UNIT address 125917 0% 100% 2
10 TRANSGENES address 125917 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cardiac & Cardiovascular System 2267 27% 0% 133
2 Peripheral Vascular Diseases 1157 15% 0% 72
3 Pharmacology & Pharmacy 340 18% 0% 85
4 Physiology 289 9% 0% 45
5 Urology & Nephrology 213 7% 0% 33
6 Cell Biology 124 10% 0% 49
7 Oncology 73 8% 0% 41
8 Medicine, Research & Experimental 68 6% 0% 27
9 Chemistry, Medicinal 41 4% 0% 17
10 Transplantation 39 2% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSGENES CARDIOVASC CONTROL 192802 1% 44% 7
2 BEIJING YOU YI HOSP 125917 0% 100% 2
3 EXPT RENAL P ERVAT UNIT 125917 0% 100% 2
4 TRANSGENES 125917 0% 100% 2
5 PHARMACEUT SCI PROGRAM 83585 2% 15% 9
6 ANAT HISTOL LEGAL MED LOCOMOTOR SYST 62958 0% 100% 1
7 BIOL BIOL CELLULAIRE VIELLISSEMENT 62958 0% 100% 1
8 CELL BIOLGUANGDONG PROV BIOENGN MED 62958 0% 100% 1
9 CENTRO CARDIOL MONZINO 62958 0% 100% 1
10 CREATE TRANSLAT SCI 62958 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CIRCULATION-HEART FAILURE 2617 1% 1% 6
2 CANCER BIOLOGY & THERAPY 1804 2% 0% 9
3 EUROPEAN JOURNAL OF HEART FAILURE 1697 2% 0% 8
4 LIPIDS IN HEALTH AND DISEASE 1491 1% 0% 6
5 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 1443 4% 0% 17
6 CIRCULATION 910 4% 0% 19
7 JOURNAL OF TRANSLATIONAL MEDICINE 671 1% 0% 5
8 VASCULAR PHARMACOLOGY 496 1% 0% 3
9 JOURNAL OF CELLULAR PHYSIOLOGY 493 2% 0% 9
10 ACTA CIRURGICA BRASILEIRA 469 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SILDENAFIL 556306 25% 7% 119 Search SILDENAFIL Search SILDENAFIL
2 PDE5 205854 5% 15% 22 Search PDE5 Search PDE5
3 PDE 5 INHIBITION 201465 1% 80% 4 Search PDE+5+INHIBITION Search PDE+5+INHIBITION
4 PHOSPHODIESTERASE 5 186263 4% 16% 19 Search PHOSPHODIESTERASE+5 Search PHOSPHODIESTERASE+5
5 OSU 03012 143082 1% 45% 5 Search OSU+03012 Search OSU+03012
6 AMINOPYRAZINONE 125917 0% 100% 2 Search AMINOPYRAZINONE Search AMINOPYRAZINONE
7 PHOSPHODIESTERASE 5 INHIBITION 113323 1% 60% 3 Search PHOSPHODIESTERASE+5+INHIBITION Search PHOSPHODIESTERASE+5+INHIBITION
8 TADALAFIL 95420 6% 5% 28 Search TADALAFIL Search TADALAFIL
9 ENDOTHELIN 1 RECEPTOR BLOCKERS 83943 0% 67% 2 Search ENDOTHELIN+1+RECEPTOR+BLOCKERS Search ENDOTHELIN+1+RECEPTOR+BLOCKERS
10 PDE5A 80943 1% 43% 3 Search PDE5A Search PDE5A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 POFI, R , GIANFRILLI, D , BADAGLIACCA, R , DI DATO, C , VENNERI, MA , GIANNETTA, E , (2016) EVERYTHING YOU EVER WANTED TO KNOW ABOUT PHOSPHODIESTERASE 5 INHIBITORS AND THE HEART (BUT NEVER DARED ASK): HOW DO THEY WORK?.JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. VOL. 39. ISSUE 2. P. 131 -142 51 55% 3
2 DAS, A , DURRANT, D , SALLOUM, FN , XI, L , KUKREJA, RC , (2015) PDE5 INHIBITORS AS THERAPEUTICS FOR HEART DISEASE, DIABETES AND CANCER.PHARMACOLOGY & THERAPEUTICS. VOL. 147. ISSUE . P. 12 -21 50 38% 22
3 KUKREJA, RC , SALLOUM, FN , DAS, A , KOKA, S , OCKAILI, RA , XI, L , (2011) EMERGING NEW USES OF PHOSPHODIESTERASE-5 INHIBITORS IN CARDIOVASCULAR DISEASES.EXPERIMENTAL & CLINICAL CARDIOLOGY. VOL. 16. ISSUE 4. P. E30-E35 33 48% 26
4 ZHANG, ML , KASS, DA , (2011) PHOSPHODIESTERASES AND CARDIAC CGMP: EVOLVING ROLES AND CONTROVERSIES.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 32. ISSUE 6. P. 360-365 30 52% 31
5 SCHWARTZ, BG , LEVINE, LA , COMSTOCK, G , STECHER, VJ , KLONER, RA , (2012) CARDIAC USES OF PHOSPHODIESTERASE-5 INHIBITORS.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. VOL. 59. ISSUE 1. P. 9-15 26 53% 44
6 LEE, DI , KASS, DA , (2012) PHOSPHODIESTERASES AND CYCLIC GMP REGULATION IN HEART MUSCLE.PHYSIOLOGY. VOL. 27. ISSUE 4. P. 248-258 37 39% 14
7 SALLOUM, FN , CHAU, VQ , HOKE, NN , KUKREJA, RC , (2014) TADALAFIL PREVENTS ACUTE HEART FAILURE WITH REDUCED EJECTION FRACTION IN MICE.CARDIOVASCULAR DRUGS AND THERAPY. VOL. 28. ISSUE 6. P. 493 -500 19 66% 5
8 VASQUEZ, EC , GAVA, AL , GRACELI, JB , BALARINI, CM , CAMPAGNARO, BP , PEREIRA, TMC , MEYRELLES, SS , (2016) NOVEL THERAPEUTIC TARGETS FOR PHOSPHODIESTERASE 5 INHIBITORS: CURRENT STATE-OF-THE-ART ON SYSTEMIC ARTERIAL HYPERTENSION AND ATHEROSCLEROSIS.CURRENT PHARMACEUTICAL BIOTECHNOLOGY. VOL. 17. ISSUE 4. P. 347 -364 36 30% 2
9 KUKREJA, RC , (2013) SILDENAFIL AND CARDIOPROTECTION.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 39. P. 6842-6847 23 49% 4
10 KUKREJA, RC , SALLOUM, FN , DAS, A , (2012) CYCLIC GUANOSINE MONOPHOSPHATE SIGNALING AND PHOSPHODIESTERASE-5 INHIBITORS IN CARDIOPROTECTION.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. VOL. 59. ISSUE 22. P. 1921-1927 26 41% 23

Classes with closest relation at Level 1


Rank Class id link
1 16151 CGMP DEPENDENT PROTEIN KINASE//TYPE II CGMP DEPENDENT PROTEIN KINASE//CANC MOL BIOL SECT
2 839 ERECTILE DYSFUNCTION//INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH//SILDENAFIL
3 658 ROLIPRAM//PHOSPHODIESTERASE//PDE4
4 10086 YC 1//SOLUBLE GUANYLYL CYCLASE//BAY 41 2272
5 11840 AKAP//A KINASE ANCHORING PROTEIN//GRAVIN
6 2977 RIGHT VENTRICLE//RIGHT VENTRICULAR FUNCTION//PULMONARY HYPERTENSION
7 1299 PULMONARY ARTERIAL HYPERTENSION//PULMONARY HYPERTENSION//TREPROSTINIL
8 7532 HEART FAILURE WITH PRESERVED EJECTION FRACTION//PRESERVED EJECTION FRACTION//DIASTOLIC HEART FAILURE
9 7511 HEART BRAIN CIRCULAT//MYOCARDIAL O 2 CONSUMPTION//ENDOCARDIAL ENDOTHELIUM
10 32714 ALPHA BETA ADRENOCEPTOR BLOCKADE//KMUP 1//ACHYRANTHES BIDENTATA POLYPEPTIDES

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