Class information for:
Level 2: PHOSPHODIESTERASE//ROLIPRAM//PDE4

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1338 8346 43.1 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
343 3       NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE 36678
1338 2             PHOSPHODIESTERASE//ROLIPRAM//PDE4 8346
658 1                   ROLIPRAM//PHOSPHODIESTERASE//PDE4 3202
3603 1                   CELLULAR BIOCHEM SECT//CAMP DEPENDENT PROTEIN KINASE//8 CHLORO ADENOSINE 1946
10086 1                   YC 1//SOLUBLE GUANYLYL CYCLASE//BAY 41 2272 1093
11840 1                   AKAP//A KINASE ANCHORING PROTEIN//GRAVIN 950
16151 1                   CGMP DEPENDENT PROTEIN KINASE//TYPE II CGMP DEPENDENT PROTEIN KINASE//CANC MOL BIOL SECT 670
19890 1                   SILDENAFIL//PDE5//PDE 5 INHIBITION 485

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHOSPHODIESTERASE authKW 627601 6% 32% 536
2 ROLIPRAM authKW 480294 3% 55% 241
3 PDE4 authKW 349569 2% 72% 133
4 ROFLUMILAST authKW 227223 1% 72% 86
5 PDE4 INHIBITOR authKW 213436 1% 70% 83
6 PDE10A authKW 210331 1% 91% 63
7 CGMP authKW 202107 5% 15% 378
8 AKAP authKW 165320 1% 54% 84
9 YC 1 authKW 162740 1% 60% 74
10 PHOSPHODIESTERASE 4 authKW 139682 1% 56% 68

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 16877 39% 0% 3247
2 Pharmacology & Pharmacy 7358 19% 0% 1609
3 Cell Biology 3999 13% 0% 1081
4 Chemistry, Medicinal 3052 6% 0% 532
5 Biophysics 1798 6% 0% 532
6 Peripheral Vascular Diseases 791 4% 0% 302
7 Cardiac & Cardiovascular System 755 5% 0% 422
8 Physiology 686 4% 0% 346
9 Neurosciences 559 7% 0% 622
10 Respiratory System 472 3% 0% 215

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR BIOCHEM SECT 74629 0% 58% 35
2 MOL PHARMACOL GRP 28269 1% 14% 55
3 PHARMACOMETR PHARMACOKINET 26114 0% 71% 10
4 DIPARTIMENTO BIOL PATOL MOL CELLULARE 20585 0% 43% 13
5 MED FAK MA N1 18284 0% 100% 5
6 PULM CRIT CARE MED BRANCH 18002 0% 14% 35
7 CANC MOL BIOL SECT 15235 0% 83% 5
8 PHARMACOL TOXICOL CLIN PHARM 15230 0% 30% 14
9 CARDIAC SIGNAL TRANSDUCT CELLULAR BIOL 14926 0% 58% 7
10 VOLLUM 14211 1% 6% 69

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 16219 0% 19% 23
2 ADVANCES IN SECOND MESSENGER AND PHOSPHOPROTEIN RESEARCH 14774 0% 13% 31
3 ADVANCES IN CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 12977 0% 16% 22
4 JOURNAL OF BIOLOGICAL CHEMISTRY 12814 9% 1% 754
5 CELLULAR SIGNALLING 11701 1% 3% 119
6 SECOND MESSENGERS AND PHOSPHOPROTEINS 6078 0% 17% 10
7 BRITISH JOURNAL OF PHARMACOLOGY 5966 2% 1% 174
8 ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 5697 0% 16% 10
9 PULMONARY PHARMACOLOGY & THERAPEUTICS 4718 1% 3% 44
10 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 4358 2% 1% 179

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHOSPHODIESTERASE 627601 6% 32% 536 Search PHOSPHODIESTERASE Search PHOSPHODIESTERASE
2 ROLIPRAM 480294 3% 55% 241 Search ROLIPRAM Search ROLIPRAM
3 PDE4 349569 2% 72% 133 Search PDE4 Search PDE4
4 ROFLUMILAST 227223 1% 72% 86 Search ROFLUMILAST Search ROFLUMILAST
5 PDE4 INHIBITOR 213436 1% 70% 83 Search PDE4+INHIBITOR Search PDE4+INHIBITOR
6 PDE10A 210331 1% 91% 63 Search PDE10A Search PDE10A
7 CGMP 202107 5% 15% 378 Search CGMP Search CGMP
8 AKAP 165320 1% 54% 84 Search AKAP Search AKAP
9 YC 1 162740 1% 60% 74 Search YC+1 Search YC+1
10 PHOSPHODIESTERASE 4 139682 1% 56% 68 Search PHOSPHODIESTERASE+4 Search PHOSPHODIESTERASE+4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FRANCIS, SH , BLOUNT, MA , CORBIN, JD , (2011) MAMMALIAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR MECHANISMS AND PHYSIOLOGICAL FUNCTIONS.PHYSIOLOGICAL REVIEWS. VOL. 91. ISSUE 2. P. 651 -690 275 69% 167
2 LUGNIER, C , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PDE) SUPERFAMILY: A NEW TARGET FOR THE DEVELOPMENT OF SPECIFIC THERAPEUTIC AGENTS.PHARMACOLOGY & THERAPEUTICS. VOL. 109. ISSUE 3. P. 366-398 249 75% 437
3 BENDER, AT , BEAVO, JA , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR REGULATION TO CLINICAL USE.PHARMACOLOGICAL REVIEWS. VOL. 58. ISSUE 3. P. 488-520 183 74% 805
4 FRANCIS, SH , BUSCH, JL , CORBIN, JD , (2010) CGMP-DEPENDENT PROTEIN KINASES AND CGMP PHOSPHODIESTERASES IN NITRIC OXIDE AND CGMP ACTION.PHARMACOLOGICAL REVIEWS. VOL. 62. ISSUE 3. P. 525 -563 248 54% 289
5 MAURICE, DH , KE, HM , AHMAD, F , WANG, YS , CHUNG, J , MANGANIELLO, VC , (2014) ADVANCES IN TARGETING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 4. P. 290 -314 159 65% 120
6 AZEVEDO, MF , FAUCZ, FR , BIMPAKI, E , HORVATH, A , LEVY, I , DE ALEXANDRE, RB , AHMAD, F , MANGANIELLO, V , STRATAKIS, CA , (2014) CLINICAL AND MOLECULAR GENETICS OF THE PHOSPHODIESTERASES (PDES).ENDOCRINE REVIEWS. VOL. 35. ISSUE 2. P. 195 -233 258 59% 20
7 OMORI, K , KOTERA, J , (2007) OVERVIEW OF PDES AND THEIR REGULATION.CIRCULATION RESEARCH. VOL. 100. ISSUE 3. P. 309-327 147 88% 324
8 FRANCIS, SH , TURKO, IV , CORBIN, JD , (2001) CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: RELATING STRUCTURE AND FUNCTION.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 65. VOL. 65. ISSUE . P. 1 -52 196 69% 339
9 FRANCIS, SH , CORBIN, JD , (1999) CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES: INTRACELLULAR RECEPTORS FOR CAMP AND CGMP ACTION.CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. VOL. 36. ISSUE 4. P. 275 -328 186 85% 184
10 DERBYSHIRE, ER , MARLETTA, MA , (2012) STRUCTURE AND REGULATION OF SOLUBLE GUANYLATE CYCLASE.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81. VOL. 81. ISSUE . P. 533-559 122 74% 126

Classes with closest relation at Level 2


Rank Class id link
1 2535 NADPH DIAPHORASE//NITRIC OXIDE//NITRIC OXIDE SYNTHASE
2 2676 LEVOSIMENDAN//CALCIUM SENSITIZER//MILRINONE
3 3554 CU GNRH//DNA COUPLED COLUMN//STREPTOVERTICILLIUM RIMOFACIENS
4 1079 BETA3 ADRENOCEPTOR//ADENYLYL CYCLASE//G PROTEIN
5 3412 PENTOXIFYLLINE//PROPENTOFYLLINE//BUFLOMEDIL
6 3177 PROTEIN KINASE CK2//CK2//CASEIN KINASE 2
7 2821 NITRATE TOLERANCE//NITROGLYCERIN//ORGANIC NITRATES
8 295 NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE-BIOLOGY AND CHEMISTRY
9 711 ERECTILE DYSFUNCTION//IMPOTENCE//INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
10 1911 FARNESYLTRANSFERASE//RAS//RAL

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