Class information for:
Level 2: FARNESYLTRANSFERASE//RAS//RAL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1911 5888 47.0 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
1911 2             FARNESYLTRANSFERASE//RAS//RAL 5888
2877 1                   FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE 2125
4031 1                   RAS//RAS PROTEINS//ONCOGENIC RAS P21 1860
11178 1                   RAP1//EPAC//EPAC1 1002
14252 1                   RAL//EXOCYST//RLIP76 781
33764 1                   FARNESYLTHIOSALICYLIC ACID//SALIRASIB//FTS 120

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FARNESYLTRANSFERASE authKW 382557 2% 65% 113
2 RAS authKW 369612 8% 15% 490
3 RAL authKW 207907 1% 70% 57
4 FARNESYLTRANSFERASE INHIBITOR authKW 205028 1% 67% 59
5 RAP1 authKW 180532 2% 36% 97
6 EXOCYST authKW 176296 1% 55% 62
7 RLIP76 authKW 171402 1% 85% 39
8 RAS PROTEINS authKW 161242 1% 45% 69
9 EPAC authKW 155762 1% 43% 70
10 PROTEIN FARNESYLTRANSFERASE authKW 141126 1% 83% 33

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 22294 51% 0% 3015
2 Cell Biology 15844 27% 0% 1618
3 Oncology 4174 16% 0% 913
4 Chemistry, Medicinal 2951 7% 0% 431
5 Biophysics 1950 8% 0% 448
6 Biochemical Research Methods 512 4% 0% 240
7 Genetics & Heredity 462 5% 0% 303
8 Chemistry, Organic 345 5% 0% 305
9 Hematology 213 3% 0% 158
10 Pharmacology & Pharmacy 83 5% 0% 298

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ABT STRUKTURELLE BIOL 55505 1% 36% 30
2 KENTUCKY STRUCT BIOL 48314 0% 55% 17
3 ABT STRUKT BIOL 22606 0% 36% 12
4 DENT ORAL MAXILLO IAL SURG PLAST RECON 20736 0% 100% 4
5 BIOMED GENET 20250 1% 5% 75
6 MED CELL BIOL PHARMACOL 18658 0% 60% 6
7 INTEGRAT BIOL PHARMACOL 16908 1% 6% 51
8 NEUROBIOCHEM 16616 1% 7% 49
9 LEHRSTUHL BIOPHYS 16255 0% 14% 22
10 MOL BIOLCHUO KU 16211 0% 26% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 12224 10% 0% 614
2 MOLECULAR AND CELLULAR BIOLOGY 9880 4% 1% 209
3 ONCOGENE 9144 3% 1% 181
4 METHODS IN ENZYMOLOGY 3735 2% 1% 111
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3532 2% 1% 135
6 CELLULAR SIGNALLING 3506 1% 1% 55
7 BIOCHEMISTRY 3142 3% 0% 188
8 MOLECULAR BIOLOGY OF THE CELL 2846 1% 1% 69
9 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1637 3% 0% 188
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1421 2% 0% 147

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FARNESYLTRANSFERASE 382557 2% 65% 113 Search FARNESYLTRANSFERASE Search FARNESYLTRANSFERASE
2 RAS 369612 8% 15% 490 Search RAS Search RAS
3 RAL 207907 1% 70% 57 Search RAL Search RAL
4 FARNESYLTRANSFERASE INHIBITOR 205028 1% 67% 59 Search FARNESYLTRANSFERASE+INHIBITOR Search FARNESYLTRANSFERASE+INHIBITOR
5 RAP1 180532 2% 36% 97 Search RAP1 Search RAP1
6 EXOCYST 176296 1% 55% 62 Search EXOCYST Search EXOCYST
7 RLIP76 171402 1% 85% 39 Search RLIP76 Search RLIP76
8 RAS PROTEINS 161242 1% 45% 69 Search RAS+PROTEINS Search RAS+PROTEINS
9 EPAC 155762 1% 43% 70 Search EPAC Search EPAC
10 PROTEIN FARNESYLTRANSFERASE 141126 1% 83% 33 Search PROTEIN+FARNESYLTRANSFERASE Search PROTEIN+FARNESYLTRANSFERASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LU, SY , JANG, H , MURATCIOGLU, S , GURSOY, A , KESKIN, O , NUSSINOV, R , ZHANG, J , (2016) RAS CONFORMATIONAL ENSEMBLES, ALLOSTERY, AND SIGNALING.CHEMICAL REVIEWS. VOL. 116. ISSUE 11. P. 6607 -6665 256 62% 5
2 SOUSA, SF , FERNANDES, PA , RAMOS, MJ , (2008) FARNESYLTRANSFERASE INHIBITORS: A DETAILED CHEMICAL VIEW ON AN ELUSIVE BIOLOGICAL PROBLEM.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 15. P. 1478-1492 193 86% 70
3 ZHANG, FL , CASEY, PJ , (1996) PROTEIN PRENYLATION: MOLECULAR MECHANISMS AND FUNCTIONAL CONSEQUENCES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 241-269 147 74% 1329
4 BERNDT, N , HAMILTON, AD , SEBTI, SM , (2011) TARGETING PROTEIN PRENYLATION FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 11. ISSUE 11. P. 775 -791 138 64% 163
5 MOORTHY, NSHN , SOUSA, SF , RAMOS, MJ , FERNANDES, PA , (2013) FARNESYLTRANSFERASE INHIBITORS: A COMPREHENSIVE REVIEW BASED ON QUANTITATIVE STRUCTURAL ANALYSIS.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 38. P. 4888-4923 164 74% 9
6 BENETKA, W , KORANDA, M , EISENHABER, F , (2006) PROTEIN PRENYLATION: AN (ALMOST) COMPREHENSIVE OVERVIEW ON DISCOVERY HISTORY, ENZYMOLOGY, AND SIGNIFICANCE IN PHYSIOLOGY AND DISEASE.MONATSHEFTE FUR CHEMIE. VOL. 137. ISSUE 10. P. 1241 -1281 230 63% 17
7 AYRAL-KALOUSTIAN, S , SALASKI, EJ , (2002) PROTEIN FARNESYLTRANSFERASE INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 9. ISSUE 10. P. 1003 -1032 191 81% 35
8 LU, SY , JANG, H , GU, S , ZHANG, J , NUSSINOV, R , (2016) DRUGGING RAS GTPASE: A COMPREHENSIVE MECHANISTIC AND SIGNALING STRUCTURAL VIEW.CHEMICAL SOCIETY REVIEWS. VOL. 45. ISSUE 18. P. 4929 -4952 141 64% 3
9 PRAKASH, P , GORFE, AA , (2013) LESSONS FROM COMPUTER SIMULATIONS OF RAS PROTEINS IN SOLUTION AND IN MEMBRANE.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1830. ISSUE 11. P. 5211-5218 124 83% 13
10 GIBBS, RA , ZAHN, TJ , SEBOLT-LEOPOLD, JS , (2001) NON-PEPTIDIC PRENYLTRANSFERASE INHIBITORS: DIVERSE STRUCTURAL CLASSES AND SURPRISING ANTI-CANCER MECHANISMS.CURRENT MEDICINAL CHEMISTRY. VOL. 8. ISSUE 12. P. 1437 -1465 169 87% 30

Classes with closest relation at Level 2


Rank Class id link
1 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN
2 2803 GAP 43//PALMITOYLATION//MARCKS
3 1195 JNK//ERK5//MAP KINASE
4 1143 GENOMICS//CYTOGENETICS AND CELL GENETICS//MINISATELLITE
5 447 TRAFFIC//ENDOCYTOSIS//CLATHRIN
6 3960 IMP3//DLC1//DELETED IN LIVER CANCER 1
7 2254 PHOSPHOLIPASE D//DIACYLGLYCEROL KINASE//PHOSPHATIDIC ACID
8 1585 ISOPRENOID BIOSYNTHESIS//ISOPRENOIDS//TERPENE SYNTHASE
9 2998 RGS PROTEINS//GIRDIN//RGS
10 2436 LAMIN//LAMINOPATHY//NUCLEAR ENVELOPE

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