Class information for:
Level 1: RAS//RAS PROTEINS//ONCOGENIC RAS P21

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4031 1860 49.2 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
1911 2             FARNESYLTRANSFERASE//RAS//RAL 5888
4031 1                   RAS//RAS PROTEINS//ONCOGENIC RAS P21 1860

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RAS authKW 264793 13% 7% 233
2 RAS PROTEINS authKW 198314 2% 28% 43
3 ONCOGENIC RAS P21 authKW 180566 1% 100% 11
4 CDC25MM authKW 131321 0% 100% 8
5 K RAS4B authKW 117245 1% 71% 10
6 RAS GRF authKW 109427 1% 67% 10
7 ABT STRUKTURELLE BIOL address 94550 1% 26% 22
8 GTP HYDROLYSIS authKW 90753 1% 22% 25
9 EFFECTOR DOMAIN authKW 90272 1% 50% 11
10 HSOS1 authKW 82076 0% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 11765 65% 0% 1201
2 Cell Biology 8985 36% 0% 670
3 Biophysics 1208 10% 0% 189
4 Oncology 926 13% 0% 249
5 Genetics & Heredity 415 8% 0% 141
6 Biochemical Research Methods 187 4% 0% 80
7 Chemistry, Medicinal 41 2% 0% 41
8 Developmental Biology 13 1% 0% 17
9 Biology 11 1% 0% 27
10 Mathematical & Computational Biology 2 1% 0% 10

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ABT STRUKTURELLE BIOL 94550 1% 26% 22
2 LEHRSTUHL BIOPHYS 51553 1% 14% 22
3 MAX PLANCK PARTNER 49245 0% 100% 3
4 FREDERICK CANC CANC INFLAMMAT PROG 32830 0% 100% 2
5 MOL STUDIES CELL REGULAT 32830 0% 100% 2
6 SIR ALASTAIR CURRIE CANC UK 32830 0% 100% 2
7 INTEGRAT BIOL PHARMACOL 31411 2% 5% 39
8 IBMCC CSIC USAL 26259 0% 40% 4
9 MED CELL BIOL PHARMACOL 26259 0% 40% 4
10 BIOPHYS PHYS BIOCHEM 25684 1% 6% 27

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND CELLULAR BIOLOGY 8329 6% 0% 107
2 ONCOGENE 5863 4% 0% 81
3 JOURNAL OF BIOLOGICAL CHEMISTRY 4560 11% 0% 210
4 JOURNAL OF PROTEIN CHEMISTRY 3527 1% 1% 18
5 BIOCHEMISTRY 2368 5% 0% 90
6 STRUCTURE 1528 1% 1% 19
7 CELLULAR SIGNALLING 1473 1% 0% 20
8 CELL GROWTH & DIFFERENTIATION 1391 1% 1% 11
9 METHODS IN ENZYMOLOGY 1107 2% 0% 34
10 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1099 5% 0% 84

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RAS 264793 13% 7% 233 Search RAS Search RAS
2 RAS PROTEINS 198314 2% 28% 43 Search RAS+PROTEINS Search RAS+PROTEINS
3 ONCOGENIC RAS P21 180566 1% 100% 11 Search ONCOGENIC+RAS+P21 Search ONCOGENIC+RAS+P21
4 CDC25MM 131321 0% 100% 8 Search CDC25MM Search CDC25MM
5 K RAS4B 117245 1% 71% 10 Search K+RAS4B Search K+RAS4B
6 RAS GRF 109427 1% 67% 10 Search RAS+GRF Search RAS+GRF
7 GTP HYDROLYSIS 90753 1% 22% 25 Search GTP+HYDROLYSIS Search GTP+HYDROLYSIS
8 EFFECTOR DOMAIN 90272 1% 50% 11 Search EFFECTOR+DOMAIN Search EFFECTOR+DOMAIN
9 HSOS1 82076 0% 100% 5 Search HSOS1 Search HSOS1
10 RASGRF1 81577 1% 38% 13 Search RASGRF1 Search RASGRF1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LU, SY , JANG, H , MURATCIOGLU, S , GURSOY, A , KESKIN, O , NUSSINOV, R , ZHANG, J , (2016) RAS CONFORMATIONAL ENSEMBLES, ALLOSTERY, AND SIGNALING.CHEMICAL REVIEWS. VOL. 116. ISSUE 11. P. 6607 -6665 236 57% 5
2 PRAKASH, P , GORFE, AA , (2013) LESSONS FROM COMPUTER SIMULATIONS OF RAS PROTEINS IN SOLUTION AND IN MEMBRANE.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1830. ISSUE 11. P. 5211-5218 124 83% 13
3 LU, SY , JANG, H , GU, S , ZHANG, J , NUSSINOV, R , (2016) DRUGGING RAS GTPASE: A COMPREHENSIVE MECHANISTIC AND SIGNALING STRUCTURAL VIEW.CHEMICAL SOCIETY REVIEWS. VOL. 45. ISSUE 18. P. 4929 -4952 136 62% 3
4 MARCUS, K , MATTOS, C , (2015) DIRECT ATTACK ON RAS: INTRAMOLECULAR COMMUNICATION AND MUTATION-SPECIFIC EFFECTS.CLINICAL CANCER RESEARCH. VOL. 21. ISSUE 8. P. 1810 -1818 65 88% 18
5 PRAKASH, P , GORFE, AA , (2014) OVERVIEW OF SIMULATION STUDIES ON THE ENZYMATIC ACTIVITY AND CONFORMATIONAL DYNAMICS OF THE GTPASE RAS.MOLECULAR SIMULATION. VOL. 40. ISSUE 10-11. P. 839 -847 78 71% 6
6 BUDAY, L , DOWNWARD, J , (2008) MANY FACES OF RAS ACTIVATION.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1786. ISSUE 2. P. 178-187 92 61% 83
7 HENNIG, A , MARKWART, R , ESPARZA-FRANCO, MA , LADDS, G , RUBIO, I , (2015) RAS ACTIVATION REVISITED: ROLE OF GEF AND GAP SYSTEMS.BIOLOGICAL CHEMISTRY. VOL. 396. ISSUE 8. P. 831 -848 94 50% 5
8 SPIEGEL, J , CROMM, PM , ZIMMERMANN, G , GROSSMANN, TN , WALDMANN, H , (2014) SMALL-MOLECULE MODULATION OF RAS SIGNALING.NATURE CHEMICAL BIOLOGY. VOL. 10. ISSUE 8. P. 613 -622 60 60% 41
9 PRIOR, IA , HANCOCK, JF , (2012) RAS TRAFFICKING, LOCALIZATION AND COMPARTMENTALIZED SIGNALLING.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 23. ISSUE 2. P. 145-153 67 60% 51
10 HOBBS, GA , DER, CJ , ROSSMAN, KL , (2016) RAS ISOFORMS AND MUTATIONS IN CANCER AT A GLANCE.JOURNAL OF CELL SCIENCE. VOL. 129. ISSUE 7. P. 1287 -1292 46 65% 6

Classes with closest relation at Level 1


Rank Class id link
1 33764 FARNESYLTHIOSALICYLIC ACID//SALIRASIB//FTS
2 14252 RAL//EXOCYST//RLIP76
3 35582 RASGAP//G3BP1//G3BP
4 17419 INFORMAT GENET DEV//BCY1//CDC25P
5 11748 RAF//LEO JENKINS CANC//KSR1
6 11178 RAP1//EPAC//EPAC1
7 2802 N RAS//RAS GENES//RAS ONCOGENE
8 2877 FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE
9 1558 RHO GTPASES//TIAM1//RHOB
10 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR

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