Class information for:
Level 1: FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2877 2125 43.7 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
1911 2             FARNESYLTRANSFERASE//RAS//RAL 5888
2877 1                   FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE 2125

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FARNESYLTRANSFERASE authKW 1023190 5% 64% 111
2 FARNESYLTRANSFERASE INHIBITOR authKW 568306 3% 67% 59
3 PROTEIN FARNESYLTRANSFERASE authKW 391152 2% 83% 33
4 FARNESYLTRANSFERASE INHIBITORS authKW 389735 2% 59% 46
5 PROTEIN PRENYLATION authKW 324492 2% 47% 48
6 LONAFARNIB authKW 317968 1% 76% 29
7 TIPIFARNIB authKW 284456 2% 60% 33
8 PRENYLATION authKW 273263 4% 24% 79
9 FARNESYL TRANSFERASE INHIBITOR authKW 216478 2% 42% 36
10 GERANYLGERANYLTRANSFERASE authKW 213786 1% 60% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 7043 18% 0% 372
2 Biochemistry & Molecular Biology 5570 44% 0% 925
3 Oncology 1940 17% 0% 367
4 Chemistry, Organic 1465 13% 0% 281
5 Cell Biology 580 10% 0% 220
6 Biochemical Research Methods 384 5% 0% 115
7 Biophysics 382 6% 0% 126
8 Pharmacology & Pharmacy 187 8% 0% 173
9 Hematology 167 4% 0% 75
10 Mycology 32 1% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KENTUCKY STRUCT BIOL 133930 1% 55% 17
2 ANTICANC PROGRAM 43103 0% 100% 3
3 DRUG DISCOVERY PROGRAM 41618 2% 6% 46
4 GLENOLDEN 29827 0% 23% 9
5 IDB CTEP 28736 0% 100% 2
6 LUTTE CONTRE CANC CLAUDIUS REGAUD 28736 0% 100% 2
7 PROGRAM CANC STEM CELL BIOL 28421 1% 14% 14
8 ABT CHEM BIOL 26429 1% 10% 19
9 ZENTRUM PHARMAFOR 22135 1% 9% 18
10 PROGRAM PROTEASES 19156 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 9350 6% 1% 129
2 JOURNAL OF BIOLOGICAL CHEMISTRY 2847 8% 0% 180
3 JOURNAL OF MEDICINAL CHEMISTRY 2818 3% 0% 66
4 BIOORGANIC & MEDICINAL CHEMISTRY 2579 2% 0% 49
5 METHODS IN ENZYMOLOGY 1954 2% 0% 48
6 BIOCHEMISTRY 1865 4% 0% 86
7 CLINICAL CANCER RESEARCH 1062 2% 0% 34
8 CANCER RESEARCH 671 2% 0% 45
9 MEDCHEMCOMM 666 0% 1% 8
10 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 523 1% 0% 19

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FARNESYLTRANSFERASE 1023190 5% 64% 111 Search FARNESYLTRANSFERASE Search FARNESYLTRANSFERASE
2 FARNESYLTRANSFERASE INHIBITOR 568306 3% 67% 59 Search FARNESYLTRANSFERASE+INHIBITOR Search FARNESYLTRANSFERASE+INHIBITOR
3 PROTEIN FARNESYLTRANSFERASE 391152 2% 83% 33 Search PROTEIN+FARNESYLTRANSFERASE Search PROTEIN+FARNESYLTRANSFERASE
4 FARNESYLTRANSFERASE INHIBITORS 389735 2% 59% 46 Search FARNESYLTRANSFERASE+INHIBITORS Search FARNESYLTRANSFERASE+INHIBITORS
5 PROTEIN PRENYLATION 324492 2% 47% 48 Search PROTEIN+PRENYLATION Search PROTEIN+PRENYLATION
6 LONAFARNIB 317968 1% 76% 29 Search LONAFARNIB Search LONAFARNIB
7 TIPIFARNIB 284456 2% 60% 33 Search TIPIFARNIB Search TIPIFARNIB
8 PRENYLATION 273263 4% 24% 79 Search PRENYLATION Search PRENYLATION
9 FARNESYL TRANSFERASE INHIBITOR 216478 2% 42% 36 Search FARNESYL+TRANSFERASE+INHIBITOR Search FARNESYL+TRANSFERASE+INHIBITOR
10 GERANYLGERANYLTRANSFERASE 213786 1% 60% 25 Search GERANYLGERANYLTRANSFERASE Search GERANYLGERANYLTRANSFERASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SOUSA, SF , FERNANDES, PA , RAMOS, MJ , (2008) FARNESYLTRANSFERASE INHIBITORS: A DETAILED CHEMICAL VIEW ON AN ELUSIVE BIOLOGICAL PROBLEM.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 15. P. 1478-1492 192 85% 70
2 ZHANG, FL , CASEY, PJ , (1996) PROTEIN PRENYLATION: MOLECULAR MECHANISMS AND FUNCTIONAL CONSEQUENCES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 241-269 139 70% 1329
3 MOORTHY, NSHN , SOUSA, SF , RAMOS, MJ , FERNANDES, PA , (2013) FARNESYLTRANSFERASE INHIBITORS: A COMPREHENSIVE REVIEW BASED ON QUANTITATIVE STRUCTURAL ANALYSIS.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 38. P. 4888-4923 162 73% 9
4 BERNDT, N , HAMILTON, AD , SEBTI, SM , (2011) TARGETING PROTEIN PRENYLATION FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 11. ISSUE 11. P. 775 -791 133 62% 163
5 AYRAL-KALOUSTIAN, S , SALASKI, EJ , (2002) PROTEIN FARNESYLTRANSFERASE INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 9. ISSUE 10. P. 1003 -1032 181 77% 35
6 GIBBS, RA , ZAHN, TJ , SEBOLT-LEOPOLD, JS , (2001) NON-PEPTIDIC PRENYLTRANSFERASE INHIBITORS: DIVERSE STRUCTURAL CLASSES AND SURPRISING ANTI-CANCER MECHANISMS.CURRENT MEDICINAL CHEMISTRY. VOL. 8. ISSUE 12. P. 1437 -1465 167 86% 30
7 BENETKA, W , KORANDA, M , EISENHABER, F , (2006) PROTEIN PRENYLATION: AN (ALMOST) COMPREHENSIVE OVERVIEW ON DISCOVERY HISTORY, ENZYMOLOGY, AND SIGNIFICANCE IN PHYSIOLOGY AND DISEASE.MONATSHEFTE FUR CHEMIE. VOL. 137. ISSUE 10. P. 1241 -1281 212 58% 17
8 LANE, KT , BEESE, LS , (2006) STRUCTURAL BIOLOGY OF PROTEIN FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE TYPE I.JOURNAL OF LIPID RESEARCH. VOL. 47. ISSUE 4. P. 681-699 131 77% 128
9 PALSULEDESAI, CC , DISTEFANO, MD , (2015) PROTEIN PRENYLATION: ENZYMES, THERAPEUTICS, AND BIOTECHNOLOGY APPLICATIONS.ACS CHEMICAL BIOLOGY. VOL. 10. ISSUE 1. P. 51 -62 87 76% 18
10 BASSO, AD , KIRSCHMEIER, P , BISHOP, WR , (2006) FARNESYL TRANSFERASE INHIBITORS.JOURNAL OF LIPID RESEARCH. VOL. 47. ISSUE 1. P. 15-31 126 60% 193

Classes with closest relation at Level 1


Rank Class id link
1 33764 FARNESYLTHIOSALICYLIC ACID//SALIRASIB//FTS
2 19056 PRENYLTRANSFERASE//FARNESYL DIPHOSPHATE SYNTHASE//GERANYLGERANYL DIPHOSPHATE SYNTHASE
3 4031 RAS//RAS PROTEINS//ONCOGENIC RAS P21
4 20076 PERILLYL ALCOHOL//CIRURGIA GERAL ESPECIALIZADA//DIETARY ISOPRENOIDS
5 8340 STATINS//LOVASTATIN//SIMVASTATIN
6 7252 PALMITOYLATION//N MYRISTOYLTRANSFERASE//PALMITOYL ACYLTRANSFERASE
7 32385 ACHLYA AMBISEXUALIS//A FACTORASE//ACHLYA AMERICANA
8 2031 RAB//RAB PROTEINS//RAB27A
9 19834 SQUALENE SYNTHASE//SQUALENE SYNTHASE INHIBITOR//ZARAGOZIC ACIDS
10 13816 HMG COA REDUCTASE//APOMINE//FOOD FUS COMPLEX

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