Class information for:
Level 1: SQUALENE SYNTHASE//SQUALENE SYNTHASE INHIBITOR//ZARAGOZIC ACIDS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19834 487 33.5 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
3 4 PLANT SCIENCES//AGRONOMY//FOOD SCIENCE & TECHNOLOGY 1882812
680 3       HEVEA BRASILIENSIS//ISOPRENOID BIOSYNTHESIS//GUAYULE 8761
1585 2             ISOPRENOID BIOSYNTHESIS//ISOPRENOIDS//TERPENE SYNTHASE 7221
19834 1                   SQUALENE SYNTHASE//SQUALENE SYNTHASE INHIBITOR//ZARAGOZIC ACIDS 487

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SQUALENE SYNTHASE authKW 1520173 12% 43% 57
2 SQUALENE SYNTHASE INHIBITOR authKW 1318249 6% 73% 29
3 ZARAGOZIC ACIDS authKW 1210990 5% 74% 26
4 SQUALESTATINS authKW 438899 1% 100% 7
5 YM 53601 authKW 250800 1% 100% 4
6 HUMAN SQUALENE SYNTHASE authKW 188100 1% 100% 3
7 PETROLEUM PLANT authKW 141073 1% 75% 3
8 TAK 475 authKW 141073 1% 75% 3
9 4 1 BENZOXAZEPINE 3 ACETIC ACID authKW 125400 0% 100% 2
10 ALPHA D XYLOFURANURONIC ACID authKW 125400 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 3208 37% 0% 180
2 Chemistry, Medicinal 2025 20% 0% 95
3 Pharmacology & Pharmacy 348 18% 0% 86
4 Biochemistry & Molecular Biology 222 21% 0% 104
5 Biotechnology & Applied Microbiology 218 10% 0% 50
6 Chemistry, Multidisciplinary 115 13% 0% 62
7 Microbiology 100 7% 0% 36
8 Biophysics 54 5% 0% 24
9 Plant Sciences 48 6% 0% 29
10 Immunology 28 6% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG DISVOCERY 62700 0% 100% 1
2 FOOD CULINARY 62700 0% 100% 1
3 GEN ENGLAND 62700 0% 100% 1
4 LIPID DIABET ATHEROSCLEROSIS GRP 62700 0% 100% 1
5 LIPID DIABETES ATHEROSCLEROSIS GRP 62700 0% 100% 1
6 MONTREAL UNIV COMMUN GENOM LIPID CLIN 62700 0% 100% 1
7 MONTREAL UNIV COMMUNITYGENOM 62700 0% 100% 1
8 PEDIAT INFECT DIS IMMUNOBIOL 62700 0% 100% 1
9 PLANNING MANAGEMENT MANAGEMENT 62700 0% 100% 1
10 RECEPTORS MEDIATORS MECH GRP 62700 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ANTIBIOTICS 6347 5% 0% 26
2 TETRAHEDRON LETTERS 2648 11% 0% 56
3 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1783 6% 0% 27
4 JOURNAL OF MEDICINAL CHEMISTRY 1653 5% 0% 24
5 BIOORGANIC & MEDICINAL CHEMISTRY 796 3% 0% 13
6 JOURNAL OF ORGANIC CHEMISTRY 733 5% 0% 25
7 EXPERT OPINION ON THERAPEUTIC PATENTS 444 1% 0% 4
8 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 429 2% 0% 11
9 SYNLETT 428 2% 0% 10
10 ACS CENTRAL SCIENCE 383 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SQUALENE SYNTHASE 1520173 12% 43% 57 Search SQUALENE+SYNTHASE Search SQUALENE+SYNTHASE
2 SQUALENE SYNTHASE INHIBITOR 1318249 6% 73% 29 Search SQUALENE+SYNTHASE+INHIBITOR Search SQUALENE+SYNTHASE+INHIBITOR
3 ZARAGOZIC ACIDS 1210990 5% 74% 26 Search ZARAGOZIC+ACIDS Search ZARAGOZIC+ACIDS
4 SQUALESTATINS 438899 1% 100% 7 Search SQUALESTATINS Search SQUALESTATINS
5 YM 53601 250800 1% 100% 4 Search YM+53601 Search YM+53601
6 HUMAN SQUALENE SYNTHASE 188100 1% 100% 3 Search HUMAN+SQUALENE+SYNTHASE Search HUMAN+SQUALENE+SYNTHASE
7 PETROLEUM PLANT 141073 1% 75% 3 Search PETROLEUM+PLANT Search PETROLEUM+PLANT
8 TAK 475 141073 1% 75% 3 Search TAK+475 Search TAK+475
9 4 1 BENZOXAZEPINE 3 ACETIC ACID 125400 0% 100% 2 Search 4+1+BENZOXAZEPINE+3+ACETIC+ACID Search 4+1+BENZOXAZEPINE+3+ACETIC+ACID
10 ALPHA D XYLOFURANURONIC ACID 125400 0% 100% 2 Search ALPHA+D+XYLOFURANURONIC+ACID Search ALPHA+D+XYLOFURANURONIC+ACID

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KOUROUNAKIS, AP , KATSELOU, MG , MATRALIS, AN , LADOPOULOU, EM , BAVAVEA, E , (2011) SQUALENE SYNTHASE INHIBITORS: AN UPDATE ON THE SEARCH FOR NEW ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 29. P. 4418 -4439 79 63% 13
2 BILLER, SA , NEUENSCHWANDER, K , PONPIPOM, MM , POULTER, CD , (1996) SQUALENE SYNTHASE INHIBITORS.CURRENT PHARMACEUTICAL DESIGN. VOL. 2. ISSUE 1. P. 1 -40 98 70% 64
3 NAKAMURA, S , SATO, H , HIRATA, Y , WATANABE, N , HASHIMOTO, S , (2005) TOTAL SYNTHESIS OF ZARAGOZIC ACID C BY AN ALDOL-BASED STRATEGY.TETRAHEDRON. VOL. 61. ISSUE 47. P. 11078 -11106 69 71% 16
4 HIRATA, Y , NAKAMURA, S , WATANABE, N , HASHIMOTO, S , SHIRO, M , KITAGAKI, S , ANADA, M , KUROSAKI, T , KATAOKA, O , (2006) TOTAL SYNTHESES OF ZARAGOZIC ACIDS A AND C BY A CARBONYL YLIDE CYCLOADDITION STRATEGY.CHEMISTRY-A EUROPEAN JOURNAL. VOL. 12. ISSUE 35. P. 8898 -8925 73 57% 31
5 NADIN, A , NICOLAOU, KC , (1996) CHEMISTRY AND BIOLOGY OF THE ZARAGOZIC ACIDS (SQUALESTATINS).ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 35. ISSUE 15. P. 1623 -1656 77 63% 13
6 JOTTERAND, N , VOGEL, P , (2001) RECENT PROGRESS IN THE SYNTHESIS OF ZARAGOZIC ACIDS AND ANALOGS.CURRENT ORGANIC CHEMISTRY. VOL. 5. ISSUE 6. P. 637 -661 62 61% 19
7 RIZZACASA, MA , STURGESS, D , (2014) TOTAL SYNTHESIS OF ALKYL CITRATE NATURAL PRODUCTS.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 12. ISSUE 9. P. 1367-1382 39 67% 0
8 ARMSTRONG, A , BLENCH, TJ , (2002) RECENT SYNTHETIC STUDIES ON THE ZARAGOZIC ACIDS (SQUALESTATINS).TETRAHEDRON. VOL. 58. ISSUE 46. P. 9321-9349 43 74% 26
9 BUNTE, JO , CUZZUPE, AN , DALY, AM , RIZZACASA, MA , (2006) FORMAL TOTAL SYNTHESIS OF (+)-ZARAGOZIC ACID C THROUGH AN IRELAND-CLAISEN REARRANGEMENT.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 45. ISSUE 38. P. 6376 -6380 31 79% 25
10 FREEMAN-COOK, KD , HALCOMB, RL , (2000) A SYMMETRY-BASED FORMAL SYNTHESIS OF ZARAGOZIC ACID A.JOURNAL OF ORGANIC CHEMISTRY. VOL. 65. ISSUE 19. P. 6153 -6159 33 85% 18

Classes with closest relation at Level 1


Rank Class id link
1 19056 PRENYLTRANSFERASE//FARNESYL DIPHOSPHATE SYNTHASE//GERANYLGERANYL DIPHOSPHATE SYNTHASE
2 12077 OXIDOSQUALENE CYCLASE//TRITERPENE SYNTHASE//SQUALENE HOPENE CYCLASE
3 13816 HMG COA REDUCTASE//APOMINE//FOOD FUS COMPLEX
4 20995 BOTRYOCOCCUS BRAUNII//BOTRYOCOCCENE//ALGAENAN
5 6968 STEROL METHYLTRANSFERASE//STEROL C24 METHYLTRANSFERASE//ERGOSTEROL BIOSYNTHESIS
6 27552 MEFLOQUINE DERIVATIVES//1 AZABICYCLO331NONADIENES//CINCHONA ALKALOIDS
7 29993 PALE SULFONATED SHALE OIL//GAMMA 2 AMINOETHYLAMINO 2 BUTYROTHIENONE PHARMACOLOGY//ICHTHYOLR
8 2877 FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE
9 37256 PACTAMYCIN//TROP DISMINATO KU//JOGYAMYCIN
10 18720 THRAUSTOCHYTRIDS//QPX//SCHIZOCHYTRIUM SP

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