Class information for:
Level 1: FARNESYLTHIOSALICYLIC ACID//SALIRASIB//FTS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
33764 120 40.6 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
1911 2             FARNESYLTRANSFERASE//RAS//RAL 5888
33764 1                   FARNESYLTHIOSALICYLIC ACID//SALIRASIB//FTS 120

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FARNESYLTHIOSALICYLIC ACID authKW 3925999 15% 86% 18
2 SALIRASIB authKW 1717622 8% 75% 9
3 FTS authKW 956857 16% 20% 19
4 RAS RELATED SIGNALING PATHWAY authKW 763390 3% 100% 3
5 GW 5074 authKW 508926 2% 100% 2
6 S FARNESYLTHIOSALICYLIC ACID FTS authKW 508926 2% 100% 2
7 NEUROBIOCHEM address 493142 32% 5% 38
8 GEORGE WEISE LIFE SCI address 339283 2% 67% 2
9 6 CEPN authKW 254463 1% 100% 1
10 ELT3 authKW 254463 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 401 31% 0% 37
2 Cell Biology 93 16% 0% 19
3 Biochemistry & Molecular Biology 83 25% 0% 30
4 Chemistry, Medicinal 80 8% 0% 10
5 Pharmacology & Pharmacy 57 15% 0% 18
6 Chemistry, Organic 20 8% 0% 9
7 Immunology 17 8% 0% 9
8 Medicine, Research & Experimental 13 5% 0% 6
9 Biochemical Research Methods 11 4% 0% 5
10 Materials Science, Biomaterials 9 2% 0% 2

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROBIOCHEM 493142 32% 5% 38
2 GEORGE WEISE LIFE SCI 339283 2% 67% 2
3 PHASE CLIN TRIAS PROGRAM 1 254463 1% 100% 1
4 SKIP VIRAGH PANCREAT CANC PATIENT CARE 254463 1% 100% 1
5 ST UNIV HOSP 254463 1% 100% 1
6 GEORGE S WISE LIFE SCI 224535 40% 2% 48
7 INTERNAL MEDHOLDEN COMPREHENS CANC 84820 1% 33% 1
8 THORAC ONCOL SERV MED 84820 1% 33% 1
9 VGH 67853 2% 13% 2
10 GASTROENEROL 63614 1% 25% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 996 3% 0% 4
2 CELL DEATH & DISEASE 967 3% 0% 3
3 MOLECULAR MEDICINE TODAY 767 1% 0% 1
4 MOLECULAR PHARMACEUTICS 723 3% 0% 3
5 INTERNATIONAL JOURNAL OF CANCER 611 6% 0% 7
6 DRUG RESISTANCE UPDATES 524 1% 0% 1
7 BIOCONJUGATE CHEMISTRY 455 3% 0% 3
8 INFLAMMATION 389 2% 0% 2
9 CURRENT GENOMICS 374 1% 0% 1
10 CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 332 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FARNESYLTHIOSALICYLIC ACID 3925999 15% 86% 18 Search FARNESYLTHIOSALICYLIC+ACID Search FARNESYLTHIOSALICYLIC+ACID
2 SALIRASIB 1717622 8% 75% 9 Search SALIRASIB Search SALIRASIB
3 FTS 956857 16% 20% 19 Search FTS Search FTS
4 RAS RELATED SIGNALING PATHWAY 763390 3% 100% 3 Search RAS+RELATED+SIGNALING+PATHWAY Search RAS+RELATED+SIGNALING+PATHWAY
5 GW 5074 508926 2% 100% 2 Search GW+5074 Search GW+5074
6 S FARNESYLTHIOSALICYLIC ACID FTS 508926 2% 100% 2 Search S+FARNESYLTHIOSALICYLIC+ACID+FTS Search S+FARNESYLTHIOSALICYLIC+ACID+FTS
7 6 CEPN 254463 1% 100% 1 Search 6+CEPN Search 6+CEPN
8 ELT3 254463 1% 100% 1 Search ELT3 Search ELT3
9 F FTS 254463 1% 100% 1 Search F+FTS Search F+FTS
10 FARNESYL ANALOG 254463 1% 100% 1 Search FARNESYL+ANALOG Search FARNESYL+ANALOG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 WOLFSON, E , SCHMUKLER, E , SCHOKOROY, ST , KLOOG, Y , PINKAS-KRAMARSKI, R , (2015) ENHANCING FTS (SALIRASIB) EFFICIENCY VIA COMBINATORIAL TREATMENT.BIOLOGY OF THE CELL. VOL. 107. ISSUE 5. P. 130 -143 27 35% 1
2 MOR, A , AIZMAN, E , CHAPMAN, J , KLOOG, Y , (2013) IMMUNOMODULATORY PROPERTIES OF FARNESOIDS: THE NEW STEROIDS?.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 10. P. 1218-1224 19 45% 8
3 HAKLAI, R , ELAD-SFADIA, G , EGOZI, Y , KLOOG, Y , (2008) ORALLY ADMINISTERED FTS (SALIRASIB) INHIBITS HUMAN PANCREATIC TUMOR GROWTH IN NUDE MICE.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 61. ISSUE 1. P. 89 -96 16 53% 33
4 ZHANG, XL , HUANG, YX , GHAZWANI, M , ZHANG, P , LI, J , THORNE, SH , LI, S , (2015) TUNABLE PH-RESPONSIVE POLYMERIC MICELLE FOR CANCER TREATMENT.ACS MACRO LETTERS. VOL. 4. ISSUE 6. P. 620 -623 13 54% 4
5 ROTBLAT, B , EHRLICH, M , HAKLAI, R , KLOOG, Y , (2008) THE RAS INHIBITOR FARNESYLTHIOSALICYLIC ACID (SALIRASIB) DISRUPTS THE SPATIOTEMPORAL LOCALIZATION OF ACTIVE RAS: A POTENTIAL TREATMENT FOR CANCER.SMALL GTPASES IN DISEASE, PT B. VOL. 439. ISSUE . P. 467-489 25 31% 36
6 BUSTINZA-LINARES, E , KURZROCK, R , TSIMBERIDOU, AM , (2010) SALIRASIB IN THE TREATMENT OF PANCREATIC CANCER.FUTURE ONCOLOGY. VOL. 6. ISSUE 6. P. 885-891 18 39% 20
7 SUN, JJ , CHEN, YC , LI, K , HUANG, YX , FU, XF , ZHANG, XL , ZHAO, WC , WEI, Y , XU, L , ZHANG, PJ , ET AL (2016) A PRODRUG MICELLAR CARRIER ASSEMBLED FROM POLYMERS WITH PENDANT FARNESYL THIOSALICYLIC ACID MOIETIES FOR IMPROVED DELIVERY OF PACLITAXEL.ACTA BIOMATERIALIA. VOL. 43. ISSUE . P. 282 -291 16 39% 0
8 MOR, A , HAKLAI, R , BEN-MOSHE, O , MEKORI, YA , KLOOG, Y , (2011) INHIBITION OF CONTACT SENSITIVITY BY FARNESYLTHIOSALICYLIC ACID-AMIDE, A POTENTIAL RAP1 INHIBITOR.JOURNAL OF INVESTIGATIVE DERMATOLOGY. VOL. 131. ISSUE 10. P. 2040 -2048 13 45% 4
9 WANG, ZQ , CHANG, RA , HUANG, HY , WANG, XM , WANG, XY , CHEN, L , LING, Y , (2014) SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL FARNESYLTHIOSALICYLIC ACID/SALICYLIC ACID HYBRIDS AS POTENTIAL ANTI-TUMOR AGENTS.CHINESE CHEMICAL LETTERS. VOL. 25. ISSUE 12. P. 1545 -1549 11 48% 1
10 GOLDBERG, L , OCHERASHVILLI, A , DANIELS, D , LAST, D , COHEN, ZR , TAMAR, G , KLOOG, Y , MARDOR, Y , (2008) SALIRASIB (FARNESYL THIOSALICYLIC ACID) FOR BRAIN TUMOR TREATMENT: A CONVECTION-ENHANCED DRUG DELIVERY STUDY IN RATS.MOLECULAR CANCER THERAPEUTICS. VOL. 7. ISSUE 11. P. 3609-3616 14 41% 13

Classes with closest relation at Level 1


Rank Class id link
1 4031 RAS//RAS PROTEINS//ONCOGENIC RAS P21
2 2877 FARNESYLTRANSFERASE//FARNESYLTRANSFERASE INHIBITOR//PROTEIN FARNESYLTRANSFERASE
3 25971 EMBELIN//EMBELIA RIBES//EMBELIA ANGUSTIFOLIA
4 21364 NUCLEOLIN//SURFACE NUCLEOLIN//AS1411
5 34473 BOROPINIC ACID//4 GERANYLOXYFERULIC ACID//PRENYLOXYPHENYLPROPANOIDS
6 35221 CANARIUM ODONTOPHYLLUM//CHINESE OLIVE//CANARIUM ALBUM
7 14252 RAL//EXOCYST//RLIP76
8 25798 2 DEOXY D GLUCOSE//CELL BIOL R 124//METABOLIC OXIDATIVE STRESS
9 21370 NO NSAIDS//NCX 4016//NO ASPIRIN
10 2802 N RAS//RAS GENES//RAS ONCOGENE

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