Class information for:
Level 1: RAF//LEO JENKINS CANC//KSR1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11748 957 51.6 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
11748 1                   RAF//LEO JENKINS CANC//KSR1 957

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RAF authKW 568480 9% 21% 86
2 LEO JENKINS CANC address 291665 3% 29% 32
3 KSR1 authKW 229713 1% 60% 12
4 RAF 1 authKW 225959 4% 16% 43
5 A RAF authKW 212699 1% 67% 10
6 C RAF 1 authKW 203181 1% 58% 11
7 MED STRAHLENKUNDE ZELLFOR address 162126 3% 20% 26
8 KSR authKW 159519 1% 50% 10
9 B RAF authKW 120212 3% 13% 28
10 ARAF authKW 95718 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 7576 45% 0% 435
2 Biochemistry & Molecular Biology 4895 59% 0% 561
3 Oncology 2015 25% 0% 239
4 Genetics & Heredity 548 11% 0% 107
5 Virology 123 3% 0% 31
6 Developmental Biology 119 3% 0% 25
7 Biophysics 88 5% 0% 44
8 Hematology 83 4% 0% 35
9 Biology 48 3% 0% 26
10 Medicine, Research & Experimental 27 3% 0% 31

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEO JENKINS CANC 291665 3% 29% 32
2 MED STRAHLENKUNDE ZELLFOR 162126 3% 20% 26
3 FREDERICK CANC IL VIRAL CARCINOGENESIS 63812 0% 100% 2
4 MEMBER LEO JENKINS CANC 63812 0% 100% 2
5 110 63808 0% 50% 4
6 INTRACELLULAR SIGNALING 48606 1% 19% 8
7 VIRAL PATHOL SECT 42540 0% 67% 2
8 CELL DEV SIGNALING 40888 1% 13% 10
9 ESCUELA QUIM FARM 34797 1% 18% 6
10 SIGNAL TRANSDUCT TEAM 32559 1% 15% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 9625 8% 0% 74
2 MOLECULAR AND CELLULAR BIOLOGY 8224 8% 0% 76
3 LEUKEMIA 2606 3% 0% 25
4 JOURNAL OF BIOLOGICAL CHEMISTRY 2529 12% 0% 112
5 CANCER JOURNAL FROM SCIENTIFIC AMERICAN 2277 0% 7% 1
6 CELLULAR SIGNALLING 1624 2% 0% 15
7 EMBO JOURNAL 1527 3% 0% 29
8 CELL GROWTH & DIFFERENTIATION 1436 1% 1% 8
9 ADVANCES IN ENZYME REGULATION 1328 1% 1% 5
10 CANCER CELLS-A MONTHLY REVIEW 1325 0% 2% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RAF 568480 9% 21% 86 Search RAF Search RAF
2 KSR1 229713 1% 60% 12 Search KSR1 Search KSR1
3 RAF 1 225959 4% 16% 43 Search RAF+1 Search RAF+1
4 A RAF 212699 1% 67% 10 Search A+RAF Search A+RAF
5 C RAF 1 203181 1% 58% 11 Search C+RAF+1 Search C+RAF+1
6 KSR 159519 1% 50% 10 Search KSR Search KSR
7 B RAF 120212 3% 13% 28 Search B+RAF Search B+RAF
8 ARAF 95718 0% 100% 3 Search ARAF Search ARAF
9 RAF KINASE 75924 1% 18% 13 Search RAF+KINASE Search RAF+KINASE
10 CNK 71787 0% 75% 3 Search CNK Search CNK

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LAVOIE, H , THERRIEN, M , (2015) REGULATION OF RAF PROTEIN KINASES IN ERK SIGNALLING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 16. ISSUE 5. P. 281 -298 123 53% 34
2 UDELL, CM , RAJAKULENDRAN, T , SICHERI, F , THERRIEN, M , (2011) MECHANISTIC PRINCIPLES OF RAF KINASE SIGNALING.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 68. ISSUE 4. P. 553-565 96 60% 38
3 LEICHT, DT , BALAN, V , KAPLUN, A , SINGH-GUPTA, V , KAPLUN, L , DOBSON, M , TZIVION, G , (2007) RAF KINASES: FUNCTION, REGULATION AND ROLE IN HUMAN CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1773. ISSUE 8. P. 1196-1212 106 57% 95
4 CHONG, H , VIKIS, HG , GUAN, KL , (2003) MECHANISMS OF REGULATING THE RAF KINASE FAMILY.CELLULAR SIGNALLING. VOL. 15. ISSUE 5. P. 463-469 62 71% 257
5 CLAPERON, A , THERRIEN, M , (2007) KSR AND CNK: TWO SCAFFOLDS REGULATING RAS-MEDIATED RAF ACTIVATION.ONCOGENE. VOL. 26. ISSUE 22. P. 3143-3158 69 61% 74
6 ZHANG, H , KOO, CY , STEBBING, J , GIAMAS, G , (2013) THE DUAL FUNCTION OF KSR1: A PSEUDOKINASE AND BEYOND.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 41. ISSUE . P. 1078-1082 42 86% 14
7 KOLCH, W , (2000) MEANINGFUL RELATIONSHIPS: THE REGULATION OF THE RAS/RAF/MEK/ERK PATHWAY BY PROTEIN INTERACTIONS.BIOCHEMICAL JOURNAL. VOL. 351. ISSUE . P. 289-305 67 39% 935
8 BEERAM, M , PATNAIK, A , ROWINSKY, EK , (2005) RAF: A STRATEGIC TARGET FOR THERAPEUTIC DEVELOPMENT AGAINST CANCER.JOURNAL OF CLINICAL ONCOLOGY. VOL. 23. ISSUE 27. P. 6771-6790 85 41% 168
9 BALJULS, A , SCHMITZ, W , MUELLER, T , ZAHEDI, RP , SICKMANN, A , HEKMAN, M , RAPP, UR , (2008) POSITIVE REGULATION OF A-RAF BY PHOSPHORYLATION OF ISOFORM-SPECIFIC HINGE SEGMENT AND IDENTIFICATION OF NOVEL PHOSPHORYLATION SITES.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 283. ISSUE 40. P. 27239-27254 48 65% 15
10 NIAULT, TS , BACCARINI, M , (2010) TARGETS OF RAF IN TUMORIGENESIS.CARCINOGENESIS. VOL. 31. ISSUE 7. P. 1165 -1174 61 40% 47

Classes with closest relation at Level 1


Rank Class id link
1 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
2 36872 FAM83D//FAM83B//ANAT DEV REGENERAT BIOL
3 4031 RAS//RAS PROTEINS//ONCOGENIC RAS P21
4 1284 VEMURAFENIB//BRAF INHIBITOR//BRAF
5 25822 V ERBB//HD3 CELLS//CANC SCI PK
6 35107 DIARYLAMIDE//DIARYLUREA//A375P
7 22024 RKIP//RAF KINASE INHIBITOR PROTEIN//HIPPOCAMPAL CHOLINERGIC NEUROSTIMULATING PEPTIDE
8 35409 ANRIBELTSVILLE AGR//IMMUNO DIS ISTANCE//ONCOGENE V MYC
9 7863 14 3 3 PROTEIN//14 3 3//14 3 3 SIGMA
10 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE

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