Class information for:
Level 1: DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9419 1157 48.4 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
9419 1                   DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE 1157

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DUAL SPECIFICITY PHOSPHATASE authKW 631441 4% 46% 52
2 MKP 1 authKW 540302 5% 35% 59
3 MAP KINASE PHOSPHATASE authKW 384745 2% 54% 27
4 MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1 authKW 251315 2% 48% 20
5 PTP INHIBITOR authKW 224880 1% 61% 14
6 DUSP authKW 222988 1% 65% 13
7 DUSP6 authKW 191527 1% 48% 15
8 MAPK PHOSPHATASE authKW 178347 1% 48% 14
9 MKP 2 authKW 178130 1% 75% 9
10 DUSP26 authKW 158341 1% 100% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 4884 54% 0% 622
2 Cell Biology 3558 29% 0% 338
3 Oncology 559 13% 0% 153
4 Biophysics 426 8% 0% 92
5 Genetics & Heredity 137 6% 0% 69
6 Immunology 94 6% 0% 72
7 Biochemical Research Methods 47 3% 0% 36
8 Chemistry, Medicinal 35 2% 0% 28
9 Endocrinology & Metabolism 30 3% 0% 38
10 Medicine, Research & Experimental 15 3% 0% 30

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK ST S PONSE 142500 1% 60% 9
2 CR UK ST S PONSE 131951 0% 100% 5
3 PROGRAM PHARM 118747 1% 50% 9
4 STRUCT BASED DRUG DESIGN DEV 59377 0% 75% 3
5 KARMANOS CANC PROGRAM MOL BIOL HUMAN GENET 52780 0% 100% 2
6 MED GENET BIOCHEM ONCOL IMMUNOL 52780 0% 100% 2
7 BIOCHEM ONCOL IMMUNOL 45635 1% 22% 8
8 ELA KODESZ CANC DEV PREVENT 41228 0% 31% 5
9 PROGRAM MOL BIOL GENETKARMANOS CANC 39582 0% 50% 3
10 PITTSBURGH MOL LIB SCREENING 38802 0% 29% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 5205 15% 0% 175
2 CELLULAR SIGNALLING 4712 2% 1% 28
3 ONCOGENE 2056 3% 0% 38
4 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 1147 2% 0% 24
5 SCIENCE SIGNALING 604 1% 0% 6
6 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 566 1% 0% 10
7 BMB REPORTS 395 0% 0% 4
8 MOLECULAR AND CELLULAR BIOCHEMISTRY 386 1% 0% 12
9 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 373 3% 0% 33
10 MOLECULAR CELL 295 1% 0% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DUAL SPECIFICITY PHOSPHATASE 631441 4% 46% 52 Search DUAL+SPECIFICITY+PHOSPHATASE Search DUAL+SPECIFICITY+PHOSPHATASE
2 MKP 1 540302 5% 35% 59 Search MKP+1 Search MKP+1
3 MAP KINASE PHOSPHATASE 384745 2% 54% 27 Search MAP+KINASE+PHOSPHATASE Search MAP+KINASE+PHOSPHATASE
4 MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1 251315 2% 48% 20 Search MITOGEN+ACTIVATED+PROTEIN+KINASE+PHOSPHATASE+1 Search MITOGEN+ACTIVATED+PROTEIN+KINASE+PHOSPHATASE+1
5 PTP INHIBITOR 224880 1% 61% 14 Search PTP+INHIBITOR Search PTP+INHIBITOR
6 DUSP 222988 1% 65% 13 Search DUSP Search DUSP
7 DUSP6 191527 1% 48% 15 Search DUSP6 Search DUSP6
8 MAPK PHOSPHATASE 178347 1% 48% 14 Search MAPK+PHOSPHATASE Search MAPK+PHOSPHATASE
9 MKP 2 178130 1% 75% 9 Search MKP+2 Search MKP+2
10 DUSP26 158341 1% 100% 6 Search DUSP26 Search DUSP26

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 NUNES-XAVIER, C , ROMA-MATEO, C , RIOS, P , TARREGA, C , CEJUDO-MARIN, R , TABERNERO, L , PULIDO, R , (2011) DUAL-SPECIFICITY MAP KINASE PHOSPHATASES AS TARGETS OF CANCER TREATMENT.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 1. P. 109 -132 190 65% 29
2 CAUNT, CJ , KEYSE, SM , (2013) DUAL-SPECIFICITY MAP KINASE PHOSPHATASES (MKPS): SHAPING THE OUTCOME OF MAP KINASE SIGNALLING.FEBS JOURNAL. VOL. 280. ISSUE 2. P. 489 -504 89 67% 102
3 BOUTROS, T , CHEVET, E , METRAKOS, P , (2008) MITOGEN-ACTIVATED PROTEIN (MAP) KINASE/MAP KINASE PHOSPHATASE REGULATION: ROLES IN CELL GROWTH, DEATH, AND CANCER.PHARMACOLOGICAL REVIEWS. VOL. 60. ISSUE 3. P. 261 -310 184 35% 276
4 KONDOH, K , NISHIDA, E , (2007) REGULATION OF MAP KINASES BY MAP KINASE PHOSPHATASES.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1773. ISSUE 8. P. 1227-1237 107 79% 99
5 JEFFREY, KL , CAMPS, M , ROMMEL, C , MACKAY, CR , (2007) TARGETING DUAL-SPECIFICITY PHOSPHATASES: MANIPULATING MAP KINASE SIGNALLING AND IMMUNE RESPONSES.NATURE REVIEWS DRUG DISCOVERY. VOL. 6. ISSUE 5. P. 391-403 98 59% 210
6 WANCKET, LM , FRAZIER, WJ , LIU, YS , (2012) MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE (MKP)-1 IN IMMUNOLOGY, PHYSIOLOGY, AND DISEASE.LIFE SCIENCES. VOL. 90. ISSUE 7-8. P. 237 -248 99 59% 39
7 PATTERSON, KI , BRUMMER, T , O'BRIEN, PM , DALY, RJ , (2009) DUAL-SPECIFICITY PHOSPHATASES: CRITICAL REGULATORS WITH DIVERSE CELLULAR TARGETS.BIOCHEMICAL JOURNAL. VOL. 418. ISSUE . P. 475-489 90 49% 293
8 OWENS, DM , KEYSE, SM , (2007) DIFFERENTIAL REGULATION OF MAP KINASE SIGNALLING BY DUAL-SPECIFICITY PROTEIN PHOSPHATASES.ONCOGENE. VOL. 26. ISSUE 22. P. 3203-3213 56 80% 414
9 HUANG, CY , TAN, TH , (2012) DUSPS, TO MAP KINASES AND BEYOND.CELL AND BIOSCIENCE. VOL. 2. ISSUE . P. - 71 78% 47
10 PRABHAKAR, S , ASUTHKAR, S , LEE, W , CHIGURUPATI, S , ZAKHARIAN, E , TSUNG, AJ , VELPULA, KK , (2014) TARGETING DUSPS IN GLIOBLASTOMAS - WIELDING A DOUBLE-EDGED SWORD?.CELL BIOLOGY INTERNATIONAL. VOL. 38. ISSUE 2. P. 145-153 64 82% 6

Classes with closest relation at Level 1


Rank Class id link
1 36872 FAM83D//FAM83B//ANAT DEV REGENERAT BIOL
2 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
3 31962 PEA 15//IST ENDOCRINOL ONCOL SPERIMENTALE GAETANO SALVA//BIKDD
4 5457 JNK//MKK4//C JUN N TERMINAL KINASE
5 5307 MK2//P38 INHIBITORS//P38 ALPHA
6 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5
7 33806 MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY
8 1580 PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B
9 36490 VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM
10 15937 CDC25B//CDC25 PHOSPHATASE//CDC25A

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