Class information for:
Level 1: MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9970 1103 45.0 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
9970 1                   MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR 1103

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MAP KINASE KINASE authKW 154037 1% 35% 16
2 MAP KINASE authKW 123252 10% 4% 110
3 MAP KINASE ACTIVATOR authKW 110729 0% 100% 4
4 MICROTUBULE ASSOCIATED PROTEIN 2 KINASE authKW 110729 0% 100% 4
5 MED MED CLIN IMMUNOL ALLERGY address 63270 0% 57% 4
6 MITOGEN ACTIVATED PROTEIN KINASE authKW 56088 7% 3% 80
7 10833 LE CONTE AVE52175 CHS address 55365 0% 100% 2
8 MYELIN BASIC PROTEIN KINASE authKW 41521 0% 50% 3
9 ERK1 AND ERK2 authKW 36908 0% 67% 2
10 KINASE CASCADE authKW 35582 1% 21% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5086 56% 0% 617
2 Cell Biology 3787 31% 0% 339
3 Biophysics 551 9% 0% 100
4 Oncology 180 9% 0% 96
5 Neurosciences 176 10% 0% 109
6 CYTOLOGY & HISTOLOGY 82 0% 0% 5
7 Physiology 67 4% 0% 41
8 Urology & Nephrology 40 3% 0% 28
9 Genetics & Heredity 34 4% 0% 42
10 Endocrinology & Metabolism 25 3% 0% 35

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED MED CLIN IMMUNOL ALLERGY 63270 0% 57% 4
2 10833 LE CONTE AVE52175 CHS 55365 0% 100% 2
3 10833 LE CONTE AVEROOM 52175 CHS 27682 0% 100% 1
4 2222 HLTH SCI MALL 27682 0% 100% 1
5 ABT ALLGEMEINE CHIRURG POLKLIN 27682 0% 100% 1
6 BECKMAN NEUROSCI W M KECK STRUCT BIOL 27682 0% 100% 1
7 BIOCHEM LEAD DISCOVERY 27682 0% 100% 1
8 CELL REGURAT 27682 0% 100% 1
9 CELLULAR DEV ONCOL MOLEC SIGNALLING UNIT 27682 0% 100% 1
10 CHAIR CLIN SURG 3 27682 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL REGULATION 3671 0% 3% 5
2 JOURNAL OF BIOLOGICAL CHEMISTRY 3299 12% 0% 137
3 CELL GROWTH & DIFFERENTIATION 2811 1% 1% 12
4 CELLULAR SIGNALLING 1810 2% 0% 17
5 BIOCHEMICAL JOURNAL 1776 4% 0% 44
6 MOLECULAR AND CELLULAR BIOLOGY 1472 3% 0% 35
7 ONCOGENE 1159 3% 0% 28
8 FEBS LETTERS 877 3% 0% 37
9 MOLECULAR BIOLOGY OF THE CELL 824 1% 0% 16
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 729 4% 0% 44

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MAP KINASE KINASE 154037 1% 35% 16 Search MAP+KINASE+KINASE Search MAP+KINASE+KINASE
2 MAP KINASE 123252 10% 4% 110 Search MAP+KINASE Search MAP+KINASE
3 MAP KINASE ACTIVATOR 110729 0% 100% 4 Search MAP+KINASE+ACTIVATOR Search MAP+KINASE+ACTIVATOR
4 MICROTUBULE ASSOCIATED PROTEIN 2 KINASE 110729 0% 100% 4 Search MICROTUBULE+ASSOCIATED+PROTEIN+2+KINASE Search MICROTUBULE+ASSOCIATED+PROTEIN+2+KINASE
5 MITOGEN ACTIVATED PROTEIN KINASE 56088 7% 3% 80 Search MITOGEN+ACTIVATED+PROTEIN+KINASE Search MITOGEN+ACTIVATED+PROTEIN+KINASE
6 MYELIN BASIC PROTEIN KINASE 41521 0% 50% 3 Search MYELIN+BASIC+PROTEIN+KINASE Search MYELIN+BASIC+PROTEIN+KINASE
7 ERK1 AND ERK2 36908 0% 67% 2 Search ERK1+AND+ERK2 Search ERK1+AND+ERK2
8 KINASE CASCADE 35582 1% 21% 6 Search KINASE+CASCADE Search KINASE+CASCADE
9 MEK 30359 2% 4% 25 Search MEK Search MEK
10 3CH134 27682 0% 100% 1 Search 3CH134 Search 3CH134

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SEGER, R , KREBS, EG , (1995) PROTEIN KINASES .7. THE MAPK SIGNALING CASCADE.FASEB JOURNAL. VOL. 9. ISSUE 9. P. 726-735 48 55% 2467
2 BLENIS, J , (1993) SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 90. ISSUE 13. P. 5889-5892 38 58% 1224
3 MORIGUCHI, T , GOTOH, Y , NISHIDA, E , (1995) ACTIVATION OF 2 ISOFORMS OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN RESPONSE TO EPIDERMAL GROWTH-FACTOR AND NERVE GROWTH-FACTOR.EUROPEAN JOURNAL OF BIOCHEMISTRY. VOL. 234. ISSUE 1. P. 32-38 53 85% 12
4 COBB, MH , GOLDSMITH, EJ , (1995) HOW MAP KINASES ARE REGULATED.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 270. ISSUE 25. P. 14843-14846 31 56% 1490
5 ROBBINS, DJ , ZHEN, EH , CHENG, MG , XU, SC , EBERT, D , COBB, MH , (1994) MAP KINASES ERK1 AND ERK2 - PLEIOTROPIC ENZYMES IN A UBIQUITOUS SIGNALING NETWORK.ADVANCES IN CANCER RESEARCH, VOL 63. VOL. 63. ISSUE . P. 93-116 75 54% 55
6 NISHIDA, E , GOTOH, Y , (1993) THE MAP KINASE CASCADE IS ESSENTIAL FOR DIVERSE SIGNAL TRANSDUCTION PATHWAYS.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 18. ISSUE 4. P. 128-131 29 76% 899
7 MORDRET, G , (1993) MAP KINASE KINASE - A NODE CONNECTING MULTIPLE PATHWAYS.BIOLOGY OF THE CELL. VOL. 79. ISSUE 3. P. 193-207 80 50% 65
8 MANSOUR, SJ , MATTEN, WT , HERMANN, AS , CANDIA, JM , RONG, S , FUKASAWA, K , VANDEWOUDE, GF , AHN, NG , (1994) TRANSFORMATION OF MAMMALIAN-CELLS BY CONSTITUTIVELY ACTIVE MAP KINASE KINASE.SCIENCE. VOL. 265. ISSUE 5174. P. 966-970 29 63% 1195
9 LALLEMAIN, G , HER, JH , WU, J , STURGILL, TW , WEBER, MJ , (1992) GROWTH FACTOR-INDUCED ACTIVATION OF A KINASE-ACTIVITY WHICH CAUSES REGULATORY PHOSPHORYLATION OF P42/MICROTUBULE-ASSOCIATED PROTEIN-KINASE.MOLECULAR AND CELLULAR BIOLOGY. VOL. 12. ISSUE 5. P. 2222-2229 44 92% 53
10 ROSEN, LB , GINTY, DD , WEBER, MJ , GREENBERG, ME , (1994) MEMBRANE DEPOLARIZATION AND CALCIUM INFLUX STIMULATE MEK AND MAP KINASE VIA ACTIVATION OF RAS.NEURON. VOL. 12. ISSUE 6. P. 1207-1221 46 51% 517

Classes with closest relation at Level 1


Rank Class id link
1 11748 RAF//LEO JENKINS CANC//KSR1
2 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
3 17092 RUFFLE//PROTEIN KINASE N//GROWTH TORS SECT NIH
4 36872 FAM83D//FAM83B//ANAT DEV REGENERAT BIOL
5 33806 MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY
6 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
7 16892 GENISTEIN INHIBITION//TYROSINE KINASE//ANGIOTENSIN II
8 26062 LOE 908//G ALPHA12//VOLTAGE INDEPENDENT CALCIUM CHANNEL
9 5457 JNK//MKK4//C JUN N TERMINAL KINASE
10 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5

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