Class information for:
Level 1: S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14515 765 42.0 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1220 2             PTEN//MTOR//COWDEN SYNDROME 9128
14515 1                   S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2 765

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 S6K2 authKW 255447 1% 80% 8
2 P70 S6 KINASE authKW 126363 2% 17% 19
3 RIBOSOMAL S6 KINASE 2 S6K2 authKW 119742 0% 100% 3
4 S6 KINASE authKW 108643 2% 15% 18
5 S6K1 authKW 93680 2% 13% 18
6 P70S6K authKW 91364 3% 10% 23
7 RIBOSOMAL S6 KINASES authKW 89805 0% 75% 3
8 DISORDERS METAB address 79828 0% 100% 2
9 LY2584702 TOSYLATE authKW 79828 0% 100% 2
10 MTOR S6K PATHWAY authKW 79828 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 4400 62% 0% 473
2 Cell Biology 1866 26% 0% 201
3 Biophysics 624 11% 0% 86
4 Oncology 239 11% 0% 85
5 Physiology 88 5% 0% 36
6 CYTOLOGY & HISTOLOGY 42 0% 0% 3
7 Biology 34 3% 0% 20
8 Developmental Biology 33 2% 0% 13
9 Genetics & Heredity 29 4% 0% 31
10 Endocrinology & Metabolism 25 4% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DISORDERS METAB 79828 0% 100% 2
2 POB 2543 63858 1% 40% 4
3 TOXICOL INSPECT 53217 0% 67% 2
4 BIOCHEM PROT PHOSPHORYLAT UNIT MRC 39914 0% 100% 1
5 BREAST CANC TRANSLAT Y7 5824 39914 0% 100% 1
6 CANC GENET PROGRAM PATHOL MED 39914 0% 100% 1
7 CANCER S 39914 0% 100% 1
8 HARAS NATIONAUXUNITE MIXTE RECH 6175 39914 0% 100% 1
9 HEMATOL MALIGNANCIES CLIN 39914 0% 100% 1
10 HLTH CARE GRP 0151 39914 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPERIMENTAL ONCOLOGY 4207 1% 1% 8
2 JOURNAL OF BIOLOGICAL CHEMISTRY 4036 16% 0% 125
3 SECOND MESSENGERS AND PHOSPHOPROTEINS 2657 0% 3% 2
4 EUROPEAN JOURNAL OF BIOCHEMISTRY 1901 4% 0% 31
5 MOLECULAR AND CELLULAR BIOLOGY 1367 4% 0% 28
6 FEBS LETTERS 676 4% 0% 27
7 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 674 5% 0% 35
8 EXPERIMENTAL CELL RESEARCH 592 2% 0% 14
9 CELL GROWTH & DIFFERENTIATION 446 1% 0% 4
10 CELLULAR SIGNALLING 437 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 S6K2 255447 1% 80% 8 Search S6K2 Search S6K2
2 P70 S6 KINASE 126363 2% 17% 19 Search P70+S6+KINASE Search P70+S6+KINASE
3 RIBOSOMAL S6 KINASE 2 S6K2 119742 0% 100% 3 Search RIBOSOMAL+S6+KINASE+2+S6K2 Search RIBOSOMAL+S6+KINASE+2+S6K2
4 S6 KINASE 108643 2% 15% 18 Search S6+KINASE Search S6+KINASE
5 S6K1 93680 2% 13% 18 Search S6K1 Search S6K1
6 P70S6K 91364 3% 10% 23 Search P70S6K Search P70S6K
7 RIBOSOMAL S6 KINASES 89805 0% 75% 3 Search RIBOSOMAL+S6+KINASES Search RIBOSOMAL+S6+KINASES
8 LY2584702 TOSYLATE 79828 0% 100% 2 Search LY2584702+TOSYLATE Search LY2584702+TOSYLATE
9 MTOR S6K PATHWAY 79828 0% 100% 2 Search MTOR+S6K+PATHWAY Search MTOR+S6K+PATHWAY
10 P70S6 KINASE ALPHA 79828 0% 100% 2 Search P70S6+KINASE+ALPHA Search P70S6+KINASE+ALPHA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FERRARI, S , THOMAS, G , (1994) S6 PHOSPHORYLATION AND THE P70(S6K)/P85(S6K).CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 29. ISSUE 6. P. 385-413 79 70% 108
2 MAGNUSON, B , EKIM, B , FINGAR, DC , (2012) REGULATION AND FUNCTION OF RIBOSOMAL PROTEIN S6 KINASE (S6K) WITHIN MTOR SIGNALLING NETWORKS.BIOCHEMICAL JOURNAL. VOL. 441. ISSUE . P. 1 -21 63 28% 254
3 DUFNER, A , THOMAS, G , (1999) RIBOSOMAL S6 KINASE SIGNALING AND THE CONTROL OF TRANSLATION.EXPERIMENTAL CELL RESEARCH. VOL. 253. ISSUE 1. P. 100 -109 48 53% 492
4 FENTON, TR , GOUT, IT , (2011) FUNCTIONS AND REGULATION OF THE 70 KDA RIBOSOMAL S6 KINASES.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 43. ISSUE 1. P. 47 -59 52 40% 124
5 VOLAREVIC, S , THOMAS, G , (2001) ROLE OF S6 PHOSPHORYLATION AND S6 KINASE IN CELL GROWTH.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 65. VOL. 65. ISSUE . P. 101 -127 65 50% 110
6 JASTRZEBSKI, K , HANNAN, KM , TCHOUBRIEVA, EB , HANNAN, RD , PEARSON, RB , (2007) COORDINATE REGULATION OF RIBOSOME BIOGENESIS AND FUNCTION BY THE RIBOSOMAL PROTEIN S6 KINASE, A KEY MEDIATOR OF MTOR FUNCTION.GROWTH FACTORS. VOL. 25. ISSUE 4. P. 209-226 64 36% 115
7 SHIMA, H , PENDE, M , CHEN, Y , FUMAGALLI, S , THOMAS, G , KOZMA, SC , (1998) DISRUPTION OF THE P70(S6K)/P85(S6K) GENE REVEALS A SMALL MOUSE PHENOTYPE AND A NEW FUNCTIONAL S6 KINASE.EMBO JOURNAL. VOL. 17. ISSUE 22. P. 6649 -6659 36 62% 445
8 PHIN, S , KUPFERWASSER, D , LAM, J , LEE-FRUMAN, KK , (2003) MUTATIONAL ANALYSIS OF RIBOSOMAL S6 KINASE 2 SHOWS DIFFERENTIAL REGULATION OF ITS KINASE ACTIVITY FROM THAT OF RIBOSOMAL S6 KINASE 1.BIOCHEMICAL JOURNAL. VOL. 373. ISSUE . P. 583 -591 30 91% 15
9 MEYUHAS, O , (2008) PHYSIOLOGICAL ROLES OF RIBOSOMAL PROTEIN S6: ONE OF ITS KIND.INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 268. VOL. 268. ISSUE . P. 1-37 55 34% 103
10 IIJIMA, Y , LASER, M , SHIRAISHI, H , WILLEY, CD , SUNDARAVADIVEL, B , XU, L , MCDERMOTT, PJ , KUPPUSWAMY, D , (2002) C-RAF/MEK/ERK PATHWAY CONTROLS PROTEIN KINASE C-MEDIATED P70S6K ACTIVATION IN ADULT CARDIAC MUSCLE CELLS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 277. ISSUE 25. P. 23065 -23075 41 57% 105

Classes with closest relation at Level 1


Rank Class id link
1 6422 RHEB//RICTOR//REDD1
2 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
3 4399 RIBOSOMAL PROTEIN//ACIDIC RIBOSOMAL PROTEIN//RIBOSOMAL PROTEIN S3
4 3885 EIF4E//EIF4F//CAP ANALOG
5 16660 COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3
6 6528 PDK1//AKT//AKT2
7 24668 ATG8//CHLOROPHAGY//ATATG18
8 34692 PKN//PRK1//PKN ALPHA
9 37223 DIPARTIMENTO CARDIO TORACO VASCOLARE//ENVIRONM GENET ENVIRONM HLTH//IL17A SIGNALING PATHWAY
10 1300 MTOR//PIK3CA//PI3K INHIBITOR

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