Class information for:
Level 1: EIF4E//EIF4F//CAP ANALOG

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3885 1887 47.8 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
153 3       BIOCHEMISTRY & MOLECULAR BIOLOGY//RIBOSOME//RNA 62593
1632 2             EIF4E//TRANSLATION INITIATION//IRES 6984
3885 1                   EIF4E//EIF4F//CAP ANALOG 1887

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EIF4E authKW 1838846 11% 54% 210
2 EIF4F authKW 312588 2% 60% 32
3 CAP ANALOG authKW 308193 1% 95% 20
4 EUKARYOTIC INITIATION FACTOR 4E authKW 217313 2% 45% 30
5 4E BP1 authKW 201329 2% 27% 46
6 EIF4G authKW 192784 2% 35% 34
7 INITIATION FACTOR authKW 176122 2% 26% 42
8 MCGILL CANC address 169944 3% 16% 65
9 CAPPING EFFICIENCY authKW 161802 1% 100% 10
10 TRANSLATION INITIATION authKW 154237 4% 11% 83

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 9572 58% 0% 1102
2 Cell Biology 5638 29% 0% 544
3 Oncology 1419 16% 0% 300
4 Biophysics 559 7% 0% 137
5 Genetics & Heredity 273 6% 0% 121
6 Developmental Biology 242 3% 0% 50
7 Virology 204 3% 0% 57
8 Chemistry, Medicinal 92 3% 0% 54
9 Medicine, Research & Experimental 15 2% 0% 44
10 Reproductive Biology 14 1% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MCGILL CANC 169944 3% 16% 65
2 POSTTRANSCRIPT CONTROL GRP 101291 1% 52% 12
3 EQUIPE TRADUCT CYCLE CELLULAIRE DEV 72070 0% 64% 7
4 TRANSLAT CONTROL GRP 60980 0% 54% 7
5 CELLULAR MOL SCI GRP 57521 0% 44% 8
6 GOODMAN CANC 55320 2% 8% 41
7 ROSALIND MORRIS GOODMAN CANC 26049 1% 9% 18
8 UMR 7150 24014 0% 21% 7
9 EXCELLENCE TOULOUSE CANC 21572 0% 67% 2
10 HEME ONC TRANSPLANT 21572 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 4624 11% 0% 213
2 MOLECULAR AND CELLULAR BIOLOGY 4097 4% 0% 76
3 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 3074 2% 1% 30
4 RNA-A PUBLICATION OF THE RNA SOCIETY 2835 1% 1% 15
5 RNA 2270 1% 1% 19
6 ONCOGENE 1665 2% 0% 44
7 EMBO JOURNAL 1376 2% 0% 39
8 COMPREHENSIVE VIROLOGY 1154 0% 7% 1
9 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1151 1% 0% 19
10 SECOND MESSENGERS AND PHOSPHOPROTEINS 1075 0% 3% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 EIF4E 1838846 11% 54% 210 Search EIF4E Search EIF4E
2 EIF4F 312588 2% 60% 32 Search EIF4F Search EIF4F
3 CAP ANALOG 308193 1% 95% 20 Search CAP+ANALOG Search CAP+ANALOG
4 EUKARYOTIC INITIATION FACTOR 4E 217313 2% 45% 30 Search EUKARYOTIC+INITIATION+FACTOR+4E Search EUKARYOTIC+INITIATION+FACTOR+4E
5 4E BP1 201329 2% 27% 46 Search 4E+BP1 Search 4E+BP1
6 EIF4G 192784 2% 35% 34 Search EIF4G Search EIF4G
7 INITIATION FACTOR 176122 2% 26% 42 Search INITIATION+FACTOR Search INITIATION+FACTOR
8 CAPPING EFFICIENCY 161802 1% 100% 10 Search CAPPING+EFFICIENCY Search CAPPING+EFFICIENCY
9 TRANSLATION INITIATION 154237 4% 11% 83 Search TRANSLATION+INITIATION Search TRANSLATION+INITIATION
10 CAP DEPENDENT TRANSLATION 139052 1% 45% 19 Search CAP+DEPENDENT+TRANSLATION Search CAP+DEPENDENT+TRANSLATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PELLETIER, J , GRAFF, J , RUGGERO, D , SONENBERG, N , (2015) TARGETING THE EIF4F TRANSLATION INITIATION COMPLEX: A CRITICAL NEXUS FOR CANCER DEVELOPMENT.CANCER RESEARCH. VOL. 75. ISSUE 2. P. 250 -263 136 70% 33
2 GINGRAS, AC , RAUGHT, B , SONENBERG, N , (1999) EIF4 INITIATION FACTORS: EFFECTORS OF MRNA RECRUITMENT TO RIBOSOMES AND REGULATORS OF TRANSLATION.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 913 -963 161 47% 1331
3 PETTERSSON, F , DEL RINCON, SV , MILLER, WH , (2014) EUKARYOTIC TRANSLATION INITIATION FACTOR 4E AS A NOVEL THERAPEUTIC TARGET IN HEMATOLOGICAL MALIGNANCIES AND BEYOND.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 18. ISSUE 9. P. 1035 -1048 128 81% 5
4 BHAT, M , ROBICHAUD, N , HULEA, L , SONENBERG, N , PELLETIER, J , TOPISIROVIC, I , (2015) TARGETING THE TRANSLATION MACHINERY IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 14. ISSUE 4. P. 261 -278 121 44% 46
5 KARAKI, S , ANDRIEU, C , ZIOUZIOU, H , ROCCHI, P , (2015) THE EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF4E) AS A THERAPEUTIC TARGET FOR CANCER.ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 101. VOL. 101. ISSUE . P. 1 -26 92 77% 1
6 CARROLL, M , BORDEN, KLB , (2013) THE ONCOGENE EIF4E: USING BIOCHEMICAL INSIGHTS TO TARGET CANCER.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. VOL. 33. ISSUE 5. P. 227-238 89 71% 20
7 KORNEEVA, NL , SONG, AR , GRAM, H , EDENS, MA , RHOADS, RE , (2016) INHIBITION OF MITOGEN-ACTIVATED PROTEIN KINASE (MAPK)-INTERACTING KINASE (MNK) PREFERENTIALLY AFFECTS TRANSLATION OF MRNAS CONTAINING BOTH A 5-TERMINAL CAP AND HAIRPIN.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 291. ISSUE 7. P. 3455 -3467 76 75% 1
8 SLEPENKOV, SV , DARZYNKIEWICZ, E , RHOADS, RE , (2006) STOPPED-FLOW KINETIC ANALYSIS OF EIF4E AND PHOSPHORYLATED EIF4E BINDING TO CAP ANALOGS AND CAPPED OLIGORIBONUCLEOTIDES - EVIDENCE FOR A ONE-STEP BINDING MECHANISM.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 281. ISSUE 21. P. 14927-14938 73 91% 33
9 PELLETIER, J , MALINA, A , CENCIC, R , (2011) TARGETING TRANSLATION DEPENDENCE IN CANCER.ONCOTARGET. VOL. 2. ISSUE 1-2. P. 76 -88 81 66% 27
10 LU, CW , MAKALA, L , WU, DQ , CAI, YF , (2016) TARGETING TRANSLATION: EIF4E AS AN EMERGING ANTICANCER DRUG TARGET.EXPERT REVIEWS IN MOLECULAR MEDICINE. VOL. 18. ISSUE . P. - 82 55% 2

Classes with closest relation at Level 1


Rank Class id link
1 6259 GENE REGULAT DEV//EIF3//EIF2
2 5844 IRES//INTERNAL RIBOSOME ENTRY SITE//INTERNAL RIBOSOME ENTRY SITE IRES
3 11961 CYTOPLASMIC POLYADENYLATION//CPEB//POLYA BINDING PROTEIN
4 14173 RIBOSOME PROFILING//UORF//UPSTREAM OPEN READING FRAME
5 12218 RNA HELICASE//DEAD BOX PROTEIN//DEAD BOX
6 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
7 30959 WATER MEDIATED RECOGNITION IN BIOLOGY//AMINO ACID NUCLEOTIDE INTERACTION//AMINO ACIDS URACIL INTERACTION THERMODYNAMICS
8 6422 RHEB//RICTOR//REDD1
9 25230 PDCD4//PROGRAMMED CELL DEATH 4//MICRORNA 183
10 6198 P BODIES//STRESS GRANULES//DECAPPING

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