Class information for:
Level 2: JNK//ERK5//MAP KINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1195 9252 46.2 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
5307 1                   MK2//P38 INHIBITORS//P38 ALPHA 1643
5457 1                   JNK//MKK4//C JUN N TERMINAL KINASE 1621
9419 1                   DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE 1157
9970 1                   MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR 1103
11748 1                   RAF//LEO JENKINS CANC//KSR1 957
16660 1                   COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3 642
22274 1                   ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5 388
22795 1                   ASK1//PP5//PROTEIN PHOSPHATASE 5 368
24101 1                   MIXED LINEAGE KINASE//RPM 1//DLK 323
24258 1                   TAK1//TAB1//TGF BETA ACTIVATED KINASE 1 318
28520 1                   MAP4K4//TNIK//MST3 205
29236 1                   TPL2//TPL 2//COT TPL2 190
31962 1                   PEA 15//IST ENDOCRINOL ONCOL SPERIMENTALE GAETANO SALVA//BIKDD 145
33806 1                   MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY 120
36872 1                   FAM83D//FAM83B//ANAT DEV REGENERAT BIOL 72

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JNK authKW 217676 4% 16% 412
2 ERK5 authKW 192135 1% 69% 85
3 MAP KINASE authKW 158696 4% 13% 362
4 COFFIN LOWRY SYNDROME authKW 130958 0% 88% 45
5 P38 authKW 127249 3% 15% 256
6 ASK1 authKW 104409 1% 40% 80
7 MK2 authKW 97115 1% 63% 47
8 TAK1 authKW 96042 1% 39% 75
9 RAF authKW 89147 1% 26% 106
10 DUAL SPECIFICITY PHOSPHATASE authKW 81938 1% 47% 53

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 28317 29% 0% 2697
2 Biochemistry & Molecular Biology 27844 46% 0% 4279
3 Oncology 4405 13% 0% 1216
4 Chemistry, Medicinal 2794 6% 0% 543
5 Biophysics 1823 6% 0% 569
6 Genetics & Heredity 1264 6% 0% 581
7 Neurosciences 992 9% 0% 799
8 Immunology 391 5% 0% 469
9 Developmental Biology 309 2% 0% 143
10 Pharmacology & Pharmacy 200 6% 0% 514

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK ST S PONSE 43098 0% 93% 14
2 LEO JENKINS CANC 32025 0% 29% 33
3 MED STRAHLENKUNDE ZELLFOR 23786 0% 23% 31
4 PROGRAM PHARM 22164 0% 61% 11
5 PROT PHOSPHORYLAT UNIT 21505 1% 12% 53
6 CELL SIGNALING 18924 1% 6% 92
7 PROGRAM MOL SIGNAL TRANSDUCT 18455 0% 40% 14
8 ANTIBIOT BIOARCHITECT GRP 16492 0% 100% 5
9 CR UK ST S PONSE 16492 0% 100% 5
10 INVITROGEN DISCOVERY SERV 16492 0% 100% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 21053 11% 1% 1008
2 ONCOGENE 12727 3% 1% 268
3 CELLULAR SIGNALLING 12398 1% 3% 129
4 MOLECULAR AND CELLULAR BIOLOGY 12125 3% 1% 291
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5222 2% 1% 206
6 EMBO JOURNAL 2942 1% 1% 128
7 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2472 3% 0% 242
8 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1924 1% 1% 55
9 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1732 1% 1% 50
10 BIOCHEMICAL JOURNAL 1578 1% 0% 126

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 JNK 217676 4% 16% 412 Search JNK Search JNK
2 ERK5 192135 1% 69% 85 Search ERK5 Search ERK5
3 MAP KINASE 158696 4% 13% 362 Search MAP+KINASE Search MAP+KINASE
4 COFFIN LOWRY SYNDROME 130958 0% 88% 45 Search COFFIN+LOWRY+SYNDROME Search COFFIN+LOWRY+SYNDROME
5 P38 127249 3% 15% 256 Search P38 Search P38
6 ASK1 104409 1% 40% 80 Search ASK1 Search ASK1
7 MK2 97115 1% 63% 47 Search MK2 Search MK2
8 TAK1 96042 1% 39% 75 Search TAK1 Search TAK1
9 RAF 89147 1% 26% 106 Search RAF Search RAF
10 DUAL SPECIFICITY PHOSPHATASE 81938 1% 47% 53 Search DUAL+SPECIFICITY+PHOSPHATASE Search DUAL+SPECIFICITY+PHOSPHATASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PEARSON, G , ROBINSON, F , GIBSON, TB , XU, BE , KARANDIKAR, M , BERMAN, K , COBB, MH , (2001) MITOGEN-ACTIVATED PROTEIN (MAP) KINASE PATHWAYS: REGULATION AND PHYSIOLOGICAL FUNCTIONS.ENDOCRINE REVIEWS. VOL. 22. ISSUE 2. P. 153 -183 277 63% 2398
2 CARGNELLO, M , ROUX, PP , (2011) ACTIVATION AND FUNCTION OF THE MAPKS AND THEIR SUBSTRATES, THE MAPK-ACTIVATED PROTEIN KINASES.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 75. ISSUE 1. P. 50 -83 241 56% 501
3 KYRIAKIS, JM , AVRUCH, J , (2012) MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE.PHYSIOLOGICAL REVIEWS. VOL. 92. ISSUE 2. P. 689 -737 189 57% 294
4 BOUTROS, T , CHEVET, E , METRAKOS, P , (2008) MITOGEN-ACTIVATED PROTEIN (MAP) KINASE/MAP KINASE PHOSPHATASE REGULATION: ROLES IN CELL GROWTH, DEATH, AND CANCER.PHARMACOLOGICAL REVIEWS. VOL. 60. ISSUE 3. P. 261 -310 266 51% 276
5 CHEN, Z , GIBSON, TB , ROBINSON, F , SILVESTRO, L , PEARSON, G , XU, BE , WRIGHT, A , VANDERBILT, C , COBB, MH , (2001) MAP KINASES.CHEMICAL REVIEWS. VOL. 101. ISSUE 8. P. 2449 -2476 256 55% 575
6 KYRIAKIS, JM , AVRUCH, J , (2001) MAMMALIAN MITOGEN-ACTIVATED PROTEIN KINASE SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION.PHYSIOLOGICAL REVIEWS. VOL. 81. ISSUE 2. P. 807 -869 168 48% 2205
7 LEWIS, TS , SHAPIRO, PS , AHN, NG , (1998) SIGNAL TRANSDUCTION THROUGH MAP KINASE CASCADES.ADVANCES IN CANCER RESEARCH, VOL 74. VOL. 74. ISSUE . P. 49 -139 295 37% 1195
8 NUNES-XAVIER, C , ROMA-MATEO, C , RIOS, P , TARREGA, C , CEJUDO-MARIN, R , TABERNERO, L , PULIDO, R , (2011) DUAL-SPECIFICITY MAP KINASE PHOSPHATASES AS TARGETS OF CANCER TREATMENT.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 1. P. 109 -132 211 72% 29
9 RUBINFELD, H , SEGER, R , (2005) THE ERK CASCADE - A PROTOTYPE OF MAPK SIGNALING.MOLECULAR BIOTECHNOLOGY. VOL. 31. ISSUE 2. P. 151-174 170 69% 240
10 LAVOIE, H , THERRIEN, M , (2015) REGULATION OF RAF PROTEIN KINASES IN ERK SIGNALLING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 16. ISSUE 5. P. 281 -298 136 59% 34

Classes with closest relation at Level 2


Rank Class id link
1 1709 C FOS//EGR 1//IMMEDIATE EARLY GENE
2 3564 14 3 3 PROTEIN//14 3 3//14 3 3 SIGMA
3 1911 FARNESYLTRANSFERASE//RAS//RAL
4 3948 SPROUTY//LRIG1//MIG 6
5 2998 RGS PROTEINS//GIRDIN//RGS
6 2158 NF KAPPA B//I KAPPA B//IKK
7 3893 PRL 3//ATF3//ATF5
8 1220 PTEN//MTOR//COWDEN SYNDROME
9 2172 PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B
10 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN

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