Class information for:
Level 3: PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
204 52492 46.8 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
677 2             PROTEASOME//UBIQUITIN//PROTEASOME INHIBITOR 13186
1195 2             JNK//ERK5//MAP KINASE 9252
1548 2             UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS 7418
1709 2             C FOS//EGR 1//IMMEDIATE EARLY GENE 6679
2158 2             NF KAPPA B//I KAPPA B//IKK 4991
3037 2             KLF4//KRUPPEL LIKE FACTOR//GADD45 2468
3159 2             YAP//HIPPO PATHWAY//TAZ 2202
3177 2             PROTEIN KINASE CK2//CK2//CASEIN KINASE 2 2149
3564 2             14 3 3 PROTEIN//14 3 3//14 3 3 SIGMA 1319
3713 2             A20//LAPTM4B//WWP1 1079
3833 2             CITED2//BRANCHIO OCULO FACIAL SYNDROME//AP 2 ALPHA 911
3893 2             PRL 3//ATF3//ATF5 838

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 PROTEASOME authKW 262586 3% 32% 1405
2 UBIQUITIN authKW 251329 3% 31% 1398
3 UNFOLDED PROTEIN RESPONSE authKW 165550 1% 46% 624
4 CELL BIOLOGY WoSSC 152837 28% 2% 14955
5 BIOCHEMISTRY & MOLECULAR BIOLOGY WoSSC 151118 45% 1% 23808
6 ENDOPLASMIC RETICULUM STRESS authKW 142172 1% 35% 715
7 ER STRESS authKW 136286 1% 34% 703
8 PROTEIN KINASE CK2 authKW 110894 0% 76% 251
9 NF KAPPA B authKW 89636 3% 11% 1475
10 YAP authKW 85401 0% 66% 224

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 152837 28% 2% 14955
2 Biochemistry & Molecular Biology 151118 45% 1% 23808
3 Oncology 27817 14% 1% 7209
4 Biophysics 13914 7% 1% 3641
5 Genetics & Heredity 9678 7% 1% 3693
6 Neurosciences 4414 8% 0% 4194
7 Developmental Biology 4287 2% 1% 1151
8 Medicine, Research & Experimental 1524 3% 0% 1706
9 Immunology 1520 5% 0% 2392
10 Chemistry, Medicinal 1327 2% 0% 1204

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 BIOCHEM 20642 6% 1% 3036
2 MED 20141 24% 1% 12714
3 GENE REGULAT SIGNAL TRANSDUCT 18720 0% 25% 133
4 CELLULAR MOL BIOCHEM 151 16812 0% 100% 29
5 BIOCHEM MOL BIOL 16445 3% 2% 1590
6 IWAWAKI INITIAT UNIT 15092 0% 96% 27
7 HOWARD HUGHES MED 11982 2% 3% 931
8 CANC 9536 2% 2% 1186
9 CELL GROWTH PROLIFERAT 9508 0% 86% 19
10 PHARMACOL 9318 4% 1% 1854

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 64825 8% 3% 4279
2 ONCOGENE 43122 2% 7% 1182
3 MOLECULAR AND CELLULAR BIOLOGY 34124 2% 5% 1174
4 EMBO JOURNAL 14062 1% 4% 669
5 MOLECULAR CELL 13845 1% 7% 369
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 13194 3% 2% 1335
7 CELLULAR SIGNALLING 9522 1% 6% 274
8 FEBS LETTERS 8119 2% 2% 815
9 MOLECULAR BRAIN RESEARCH 7228 0% 5% 244
10 ONCOTARGET 7158 1% 3% 408

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 PROTEASOME 262586 3% 32% 1405 Search PROTEASOME Search PROTEASOME
2 UBIQUITIN 251329 3% 31% 1398 Search UBIQUITIN Search UBIQUITIN
3 UNFOLDED PROTEIN RESPONSE 165550 1% 46% 624 Search UNFOLDED+PROTEIN+RESPONSE Search UNFOLDED+PROTEIN+RESPONSE
4 ENDOPLASMIC RETICULUM STRESS 142172 1% 35% 715 Search ENDOPLASMIC+RETICULUM+STRESS Search ENDOPLASMIC+RETICULUM+STRESS
5 ER STRESS 136286 1% 34% 703 Search ER+STRESS Search ER+STRESS
6 PROTEIN KINASE CK2 110894 0% 76% 251 Search PROTEIN+KINASE+CK2 Search PROTEIN+KINASE+CK2
7 NF KAPPA B 89636 3% 11% 1475 Search NF+KAPPA+B Search NF+KAPPA+B
8 YAP 85401 0% 66% 224 Search YAP Search YAP
9 HIPPO PATHWAY 82306 0% 81% 176 Search HIPPO+PATHWAY Search HIPPO+PATHWAY
10 CALRETICULIN 78391 1% 45% 305 Search CALRETICULIN Search CALRETICULIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HERDEGEN, T , LEAH, JD , (1998) INDUCIBLE AND CONSTITUTIVE TRANSCRIPTION FACTORS IN THE MAMMALIAN NERVOUS SYSTEM: CONTROL OF GENE EXPRESSION BY JUN, FOS AND KROX, AND CREB/ATF PROTEINS.BRAIN RESEARCH REVIEWS. VOL. 28. ISSUE 3. P. 370 -490 707 52% 952
2 PEARSON, G , ROBINSON, F , GIBSON, TB , XU, BE , KARANDIKAR, M , BERMAN, K , COBB, MH , (2001) MITOGEN-ACTIVATED PROTEIN (MAP) KINASE PATHWAYS: REGULATION AND PHYSIOLOGICAL FUNCTIONS.ENDOCRINE REVIEWS. VOL. 22. ISSUE 2. P. 153 -183 297 68% 2398
3 MENG, ZP , MOROISHI, T , GUAN, KL , (2016) MECHANISMS OF HIPPO PATHWAY REGULATION.GENES & DEVELOPMENT. VOL. 30. ISSUE 1. P. 1 -17 172 87% 28
4 VOGES, D , ZWICKL, P , BAUMEISTER, W , (1999) THE 26S PROTEASOME: A MOLECULAR MACHINE DESIGNED FOR CONTROLLED PROTEOLYSIS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 1015-1068 309 78% 1241
5 HAYDEN, MS , GHOSH, S , (2004) SIGNALING TO NF-KAPPA B.GENES & DEVELOPMENT. VOL. 18. ISSUE 18. P. 2195-2224 226 65% 2376
6 HAYDEN, MS , GHOSH, S , (2012) NF-KAPPA B, THE FIRST QUARTER-CENTURY: REMARKABLE PROGRESS AND OUTSTANDING QUESTIONS.GENES & DEVELOPMENT. VOL. 26. ISSUE 3. P. 203-234 235 65% 452
7 CARGNELLO, M , ROUX, PP , (2011) ACTIVATION AND FUNCTION OF THE MAPKS AND THEIR SUBSTRATES, THE MAPK-ACTIVATED PROTEIN KINASES.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 75. ISSUE 1. P. 50 -83 262 61% 501
8 MCCONNELL, BB , YANG, VW , (2010) MAMMALIAN KRUPPEL-LIKE FACTORS IN HEALTH AND DISEASES.PHYSIOLOGICAL REVIEWS. VOL. 90. ISSUE 4. P. 1337 -1381 329 66% 265
9 GLICKMAN, MH , CIECHANOVER, A , (2002) THE UBIQUITIN-PROTEASOME PROTEOLYTIC PATHWAY: DESTRUCTION FOR THE SAKE OF CONSTRUCTION.PHYSIOLOGICAL REVIEWS. VOL. 82. ISSUE 2. P. 373 -428 283 55% 2238
10 JOHNSON, R , HALDER, G , (2014) THE TWO FACES OF HIPPO: TARGETING THE HIPPO PATHWAY FOR REGENERATIVE MEDICINE AND CANCER TREATMENT.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 1. P. 63-79 184 85% 149

Classes with closest relation at Level 3


Rank Class id link
1 441 TRAIL//SURVIVIN//APOPTOSIS
2 262 AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR
3 304 P53//RETINOBLASTOMA//MDM2
4 269 CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE
5 103 O GLCNACYLATION//O GLCNAC TRANSFERASE//O GLCNACASE
6 27 DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2
7 584 POMPE DISEASE//PIN1//CYCLOPHILIN
8 410 HEAT SHOCK PROTEIN//HSP90//HSP70
9 447 TCTP//TRANSLATIONALLY CONTROLLED TUMOR PROTEIN//GENETIC EPIDEMIOLOGY
10 636 TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN

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