Class information for:
Level 2: UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1548 7418 48.7 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1548 2             UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS 7418
415 1                   UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS 3496
7695 1                   PROTEIN DISULFIDE ISOMERASE//PROTEIN DISULPHIDE ISOMERASE//ERP29 1339
11673 1                   DSBA//CYTOCHROME C MATURATION//DSBD 963
12856 1                   CALRETICULIN//CALNEXIN//CALNEXIN HOMOLOGUE 877
16599 1                   GRP78//GLUCOSE REGULATED PROTEIN 78//CELL SURFACE GRP78 645
35375 1                   ORP150//OXYGEN REGULATED PROTEIN 150//150 KD OXYGEN REGULATED PROTEIN 98

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNFOLDED PROTEIN RESPONSE authKW 987173 8% 42% 571
2 ENDOPLASMIC RETICULUM STRESS authKW 890922 9% 32% 670
3 ER STRESS authKW 803719 9% 31% 639
4 CALRETICULIN authKW 547479 4% 44% 302
5 PROTEIN DISULFIDE ISOMERASE authKW 527932 3% 53% 243
6 GRP78 authKW 451548 3% 51% 215
7 XBP1 authKW 285228 1% 67% 103
8 UPR authKW 272991 2% 44% 152
9 IRE1 authKW 269535 1% 70% 93
10 ENDOPLASMIC RETICULUM authKW 247755 7% 12% 492

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 23678 47% 0% 3521
2 Cell Biology 17626 26% 0% 1926
3 Biophysics 2240 7% 0% 543
4 Endocrinology & Metabolism 1148 6% 0% 447
5 Oncology 973 8% 0% 597
6 Medicine, Research & Experimental 567 4% 0% 331
7 Microbiology 238 4% 0% 289
8 Biochemical Research Methods 191 3% 0% 200
9 Neurosciences 154 5% 0% 406
10 Hematology 131 2% 0% 159

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IWAWAKI INITIAT UNIT 107121 0% 96% 27
2 MOL STUDIES CELL 43845 0% 33% 32
3 IWAWAKI 36589 0% 68% 13
4 DEGENERAT DIS PROGRAM 35755 0% 43% 20
5 BIOMED NEUROSCI 29798 1% 17% 42
6 CORE IL DEV BIOL 29383 0% 71% 10
7 USC NORRIS COMPREHENS CANC 20096 0% 14% 34
8 LI KA SHING MED SCI 18323 0% 64% 7
9 BIOORGAN CHEM 1 16458 0% 100% 4
10 CENPAR 16458 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIOXIDANTS & REDOX SIGNALING 17486 2% 4% 115
2 JOURNAL OF BIOLOGICAL CHEMISTRY 10061 9% 0% 632
3 CELL STRESS & CHAPERONES 3001 0% 3% 29
4 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2680 3% 0% 223
5 CELL DEATH AND DIFFERENTIATION 2111 1% 1% 41
6 CELL DEATH & DISEASE 1840 0% 1% 33
7 EMBO JOURNAL 1793 1% 1% 90
8 MOLECULAR BIOLOGY OF THE CELL 1559 1% 1% 58
9 BIOCHEMICAL JOURNAL 1460 1% 0% 108
10 PEZCOLLER FOUNDATION SYMPOSIA 1329 0% 1% 26

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 UNFOLDED PROTEIN RESPONSE 987173 8% 42% 571 Search UNFOLDED+PROTEIN+RESPONSE Search UNFOLDED+PROTEIN+RESPONSE
2 ENDOPLASMIC RETICULUM STRESS 890922 9% 32% 670 Search ENDOPLASMIC+RETICULUM+STRESS Search ENDOPLASMIC+RETICULUM+STRESS
3 ER STRESS 803719 9% 31% 639 Search ER+STRESS Search ER+STRESS
4 CALRETICULIN 547479 4% 44% 302 Search CALRETICULIN Search CALRETICULIN
5 PROTEIN DISULFIDE ISOMERASE 527932 3% 53% 243 Search PROTEIN+DISULFIDE+ISOMERASE Search PROTEIN+DISULFIDE+ISOMERASE
6 GRP78 451548 3% 51% 215 Search GRP78 Search GRP78
7 XBP1 285228 1% 67% 103 Search XBP1 Search XBP1
8 UPR 272991 2% 44% 152 Search UPR Search UPR
9 IRE1 269535 1% 70% 93 Search IRE1 Search IRE1
10 ENDOPLASMIC RETICULUM 247755 7% 12% 492 Search ENDOPLASMIC+RETICULUM Search ENDOPLASMIC+RETICULUM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HETZ, C , (2012) THE UNFOLDED PROTEIN RESPONSE: CONTROLLING CELL FATE DECISIONS UNDER ER STRESS AND BEYOND.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 2. P. 89 -102 109 89% 727
2 HATAHET, F , RUDDOCK, LW , (2009) PROTEIN DISULFIDE ISOMERASE: A CRITICAL EVALUATION OF ITS FUNCTION IN DISULFIDE BOND FORMATION.ANTIOXIDANTS & REDOX SIGNALING. VOL. 11. ISSUE 11. P. 2807 -2850 222 71% 236
3 RON, D , WALTER, P , (2007) SIGNAL INTEGRATION IN THE ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 8. ISSUE 7. P. 519 -529 83 83% 2652
4 HETZ, C , CHEVET, E , HARDING, HP , (2013) TARGETING THE UNFOLDED PROTEIN RESPONSE IN DISEASE.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 9. P. 703 -719 143 79% 197
5 WANG, M , KAUFMAN, RJ , (2016) PROTEIN MISFOLDING IN THE ENDOPLASMIC RETICULUM AS A CONDUIT TO HUMAN DISEASE.NATURE. VOL. 529. ISSUE 7586. P. 326 -335 90 74% 32
6 WANG, M , KAUFMAN, RJ , (2014) THE IMPACT OF THE ENDOPLASMIC RETICULUM PROTEIN-FOLDING ENVIRONMENT ON CANCER DEVELOPMENT.NATURE REVIEWS CANCER. VOL. 14. ISSUE 9. P. 581 -597 129 66% 134
7 WANG, SY , KAUFMAN, RJ , (2012) THE IMPACT OF THE UNFOLDED PROTEIN RESPONSE ON HUMAN DISEASE.JOURNAL OF CELL BIOLOGY. VOL. 197. ISSUE 7. P. 857-867 111 76% 309
8 HETZ, C , MARTINON, F , RODRIGUEZ, D , GLIMCHER, LH , (2011) THE UNFOLDED PROTEIN RESPONSE: INTEGRATING STRESS SIGNALS THROUGH THE STRESS SENSOR IRE1 ALPHA.PHYSIOLOGICAL REVIEWS. VOL. 91. ISSUE 4. P. 1219 -1243 149 75% 156
9 HETZ, C , CHEVET, E , OAKES, SA , (2015) PROTEOSTASIS CONTROL BY THE UNFOLDED PROTEIN RESPONSE.NATURE CELL BIOLOGY. VOL. 17. ISSUE 7. P. 829 -838 112 80% 43
10 DUFEY, E , SEPULVEDA, D , ROJAS-RIVERA, D , HETZ, C , (2014) CELLULAR MECHANISMS OF ENDOPLASMIC RETICULUM STRESS SIGNALING IN HEALTH AND DISEASE. 1. AN OVERVIEW.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. VOL. 307. ISSUE 7. P. C582 -C594 136 81% 34

Classes with closest relation at Level 2


Rank Class id link
1 3893 PRL 3//ATF3//ATF5
2 1632 EIF4E//TRANSLATION INITIATION//IRES
3 677 PROTEASOME//UBIQUITIN//PROTEASOME INHIBITOR
4 1128 AUTOPHAGY//BECLIN 1//LC3
5 870 PEROXIREDOXIN//THIOREDOXIN//GLUTATHIONE
6 290 HEAT SHOCK PROTEIN//HSP90//HSP70
7 1764 STIM1//ORAI1//STORE OPERATED CALCIUM ENTRY
8 3177 PROTEIN KINASE CK2//CK2//CASEIN KINASE 2
9 1480 MOLECULAR FARMING//EDIBLE VACCINE//SEED STORAGE PROTEIN
10 892 PROTEIN TRANSLOCATION//PROTEIN IMPORT//SECA

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