Class information for:
Level 1: UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
415 3496 54.1 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1548 2             UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS 7418
415 1                   UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS 3496

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNFOLDED PROTEIN RESPONSE authKW 1731462 15% 38% 519
2 ENDOPLASMIC RETICULUM STRESS authKW 1614755 18% 30% 619
3 ER STRESS authKW 1445138 17% 28% 588
4 XBP1 authKW 605443 3% 67% 103
5 IRE1 authKW 572123 3% 70% 93
6 UPR authKW 470812 4% 39% 137
7 ATF6 authKW 446863 2% 69% 74
8 PERK authKW 442605 3% 43% 117
9 CHOP authKW 201925 3% 21% 108
10 SALUBRINAL authKW 195099 1% 62% 36

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 13510 32% 0% 1135
2 Biochemistry & Molecular Biology 6337 37% 0% 1298
3 Endocrinology & Metabolism 1292 9% 0% 299
4 Medicine, Research & Experimental 778 7% 0% 234
5 Neurosciences 565 10% 0% 347
6 Biophysics 444 5% 0% 181
7 Oncology 328 7% 0% 251
8 Physiology 140 3% 0% 113
9 Gastroenterology & Hepatology 108 3% 0% 88
10 Peripheral Vascular Diseases 98 2% 0% 82

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IWAWAKI INITIAT UNIT 194917 1% 89% 25
2 MOL STUDIES CELL 87374 1% 32% 31
3 DEGENERAT DIS PROGRAM 75912 1% 43% 20
4 IWAWAKI 66174 0% 63% 12
5 CORE IL DEV BIOL 62369 0% 71% 10
6 BIOMED NEUROSCI 51828 1% 16% 38
7 MOL SIGNALING 30806 1% 12% 29
8 NEUROSCI AGING STEM CELL 29389 0% 21% 16
9 ADV SCI LEADERS DEV UNIT 27573 0% 20% 16
10 PROGRAM BIOCHEM MOL CELL BIOL 26603 0% 38% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPERIMENTAL DIABETES RESEARCH 2744 0% 3% 10
2 ANTIOXIDANTS & REDOX SIGNALING 2670 1% 1% 31
3 CELL METABOLISM 2609 1% 1% 21
4 CELL DEATH AND DIFFERENTIATION 2598 1% 1% 31
5 CELL DEATH & DISEASE 2458 1% 1% 26
6 JOURNAL OF BIOLOGICAL CHEMISTRY 1639 5% 0% 182
7 APOPTOSIS 1608 0% 4% 5
8 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1590 3% 0% 117
9 PEZCOLLER FOUNDATION SYMPOSIA 1527 1% 1% 19
10 CELL STRESS & CHAPERONES 1484 0% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 UNFOLDED PROTEIN RESPONSE 1731462 15% 38% 519 Search UNFOLDED+PROTEIN+RESPONSE Search UNFOLDED+PROTEIN+RESPONSE
2 ENDOPLASMIC RETICULUM STRESS 1614755 18% 30% 619 Search ENDOPLASMIC+RETICULUM+STRESS Search ENDOPLASMIC+RETICULUM+STRESS
3 ER STRESS 1445138 17% 28% 588 Search ER+STRESS Search ER+STRESS
4 XBP1 605443 3% 67% 103 Search XBP1 Search XBP1
5 IRE1 572123 3% 70% 93 Search IRE1 Search IRE1
6 UPR 470812 4% 39% 137 Search UPR Search UPR
7 ATF6 446863 2% 69% 74 Search ATF6 Search ATF6
8 PERK 442605 3% 43% 117 Search PERK Search PERK
9 CHOP 201925 3% 21% 108 Search CHOP Search CHOP
10 SALUBRINAL 195099 1% 62% 36 Search SALUBRINAL Search SALUBRINAL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HETZ, C , (2012) THE UNFOLDED PROTEIN RESPONSE: CONTROLLING CELL FATE DECISIONS UNDER ER STRESS AND BEYOND.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 2. P. 89 -102 108 88% 727
2 RON, D , WALTER, P , (2007) SIGNAL INTEGRATION IN THE ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 8. ISSUE 7. P. 519 -529 82 82% 2652
3 HETZ, C , CHEVET, E , HARDING, HP , (2013) TARGETING THE UNFOLDED PROTEIN RESPONSE IN DISEASE.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 9. P. 703 -719 132 73% 197
4 WANG, M , KAUFMAN, RJ , (2016) PROTEIN MISFOLDING IN THE ENDOPLASMIC RETICULUM AS A CONDUIT TO HUMAN DISEASE.NATURE. VOL. 529. ISSUE 7586. P. 326 -335 90 74% 32
5 HETZ, C , CHEVET, E , OAKES, SA , (2015) PROTEOSTASIS CONTROL BY THE UNFOLDED PROTEIN RESPONSE.NATURE CELL BIOLOGY. VOL. 17. ISSUE 7. P. 829 -838 111 79% 43
6 HETZ, C , MARTINON, F , RODRIGUEZ, D , GLIMCHER, LH , (2011) THE UNFOLDED PROTEIN RESPONSE: INTEGRATING STRESS SIGNALS THROUGH THE STRESS SENSOR IRE1 ALPHA.PHYSIOLOGICAL REVIEWS. VOL. 91. ISSUE 4. P. 1219 -1243 145 73% 156
7 WANG, SY , KAUFMAN, RJ , (2012) THE IMPACT OF THE UNFOLDED PROTEIN RESPONSE ON HUMAN DISEASE.JOURNAL OF CELL BIOLOGY. VOL. 197. ISSUE 7. P. 857-867 106 72% 309
8 DUFEY, E , SEPULVEDA, D , ROJAS-RIVERA, D , HETZ, C , (2014) CELLULAR MECHANISMS OF ENDOPLASMIC RETICULUM STRESS SIGNALING IN HEALTH AND DISEASE. 1. AN OVERVIEW.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. VOL. 307. ISSUE 7. P. C582 -C594 135 81% 34
9 WANG, M , KAUFMAN, RJ , (2014) THE IMPACT OF THE ENDOPLASMIC RETICULUM PROTEIN-FOLDING ENVIRONMENT ON CANCER DEVELOPMENT.NATURE REVIEWS CANCER. VOL. 14. ISSUE 9. P. 581 -597 119 61% 134
10 MOORE, KA , HOLLIEN, J , (2012) THE UNFOLDED PROTEIN RESPONSE IN SECRETORY CELL FUNCTION.ANNUAL REVIEW OF GENETICS, VOL 46. VOL. 46. ISSUE . P. 165-183 130 88% 55

Classes with closest relation at Level 1


Rank Class id link
1 31233 BZIP28//MEMBRANE ASSOCIATED TRANSCRIPTION FACTOR//BZIP60
2 16599 GRP78//GLUCOSE REGULATED PROTEIN 78//CELL SURFACE GRP78
3 35375 ORP150//OXYGEN REGULATED PROTEIN 150//150 KD OXYGEN REGULATED PROTEIN
4 27975 MOL CELLULAR SIGNALING//TAT BH4//2 EPI 2 O ACETYLTHEVETIN BGHSC 74
5 21300 ATF3//ACTIVATING TRANSCRIPTION FACTOR 3//ACTIVATING TRANSCRIPTION FACTOR 3 ATF3
6 24808 TRIBBLES//TRB3//TRIB3
7 5128 ERAD//VALOSIN CONTAINING PROTEIN//P97
8 28679 GERIATR MED NEPHROL B6//AUTOPHAGY//ADENOVIRAL BCL XL
9 13751 GLUCOLIPOTOXICITY//LIPOTOXICITY//BETA CELL BIOCHEM
10 7695 PROTEIN DISULFIDE ISOMERASE//PROTEIN DISULPHIDE ISOMERASE//ERP29

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