Class information for:
Level 2: PROTEASOME//UBIQUITIN//PROTEASOME INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
677 13186 48.2 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
677 2             PROTEASOME//UBIQUITIN//PROTEASOME INHIBITOR 13186
1429 1                   PROTEASOME//MULTICATALYTIC PROTEINASE//IMMUNOPROTEASOME 2670
3837 1                   DEUBIQUITINATING ENZYME//UBIQUITIN//DEUBIQUITINASE 1898
5128 1                   ERAD//VALOSIN CONTAINING PROTEIN//P97 1669
5140 1                   PROTEASOME INHIBITOR//BORTEZOMIB//PROTEASOME 1666
8269 1                   UBIQUITIN//POLYUBIQUITIN GENE//UBIQUITIN CONJUGATING ENZYME 1273
9078 1                   NEDD8//COP9 SIGNALOSOME//NEDDYLATION 1190
18772 1                   UCH L1//UBIQUITIN CARBOXY TERMINAL HYDROLASE L1//DEGENERAT NEUROL DIS 536
19492 1                   FBXW7//FBW7//FBXO7 503
19896 1                   U BOX//RING H2//SAUL1 485
22295 1                   ISG15//ISGYLATION//USP18 387
22758 1                   ARGINYLATION//JOHANSON BLIZZARD SYNDROME//N END RULE 370
31973 1                   PUPYLATION//PROKARYOTIC UBIQUITIN LIKE PROTEIN//PAFA 145
34066 1                   MULIBREY NANISM//3 M SYNDROME//TRIM37 116
35314 1                   UBIQUILIN//UBIQUILIN 1//UBQLN1 99
35756 1                   UFM1//UBA5//UBE1DC1 92
36059 1                   UBCH10//UBE2C//UBE2Q1 87

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 PROTEASOME authKW 914425 10% 30% 1309
2 UBIQUITIN authKW 874848 10% 29% 1302
3 PROTEASOME INHIBITOR authKW 266090 2% 35% 328
4 NEDD8 authKW 198742 1% 77% 112
5 BORTEZOMIB authKW 179295 3% 22% 359
6 IMMUNOPROTEASOME authKW 177829 1% 67% 115
7 DEUBIQUITINATING ENZYME authKW 160481 1% 61% 113
8 26S PROTEASOME authKW 157549 1% 52% 130
9 COP9 SIGNALOSOME authKW 155549 1% 82% 82
10 ERAD authKW 152095 1% 49% 135

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 49878 51% 0% 6749
2 Cell Biology 39544 29% 1% 3808
3 Biophysics 6483 9% 0% 1187
4 Oncology 5273 12% 0% 1615
5 Genetics & Heredity 1773 6% 0% 823
6 Biochemical Research Methods 722 3% 0% 455
7 Developmental Biology 521 2% 0% 217
8 Plant Sciences 494 4% 0% 575
9 Chemistry, Medicinal 311 2% 0% 296
10 Hematology 192 2% 0% 267

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 PROT METAB 31886 0% 28% 50
2 CELL BIOL METAB GRP 23861 0% 74% 14
3 BIOMOL STRUCT ORG 21213 0% 26% 36
4 DEGENERAT NEUROL DIS 20211 0% 19% 45
5 PROT PROC SECT 17035 0% 82% 9
6 BIOCHEM CCM 15613 0% 75% 9
7 ACUTE LUNG INJURY EXCELLENCE 14376 0% 33% 19
8 GRP MOL MISREADING 11569 0% 100% 5
9 MED SPECIALTY SERV LINE 10761 0% 27% 17
10 BIOCHEM 10280 8% 1% 1038

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 MOLECULAR CELL 20371 2% 4% 221
2 JOURNAL OF BIOLOGICAL CHEMISTRY 16223 8% 1% 1073
3 ENZYME & PROTEIN 6555 0% 18% 16
4 CELL DIVISION 5397 0% 11% 22
5 MOLECULAR BIOLOGY OF THE CELL 5055 1% 2% 138
6 EMBO JOURNAL 4971 2% 1% 198
7 FEBS LETTERS 3915 2% 1% 277
8 EMBO REPORTS 3870 0% 3% 61
9 NATURE CELL BIOLOGY 3514 0% 2% 65
10 NATURE STRUCTURAL & MOLECULAR BIOLOGY 3495 0% 3% 58

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 PROTEASOME 914425 10% 30% 1309 Search PROTEASOME Search PROTEASOME
2 UBIQUITIN 874848 10% 29% 1302 Search UBIQUITIN Search UBIQUITIN
3 PROTEASOME INHIBITOR 266090 2% 35% 328 Search PROTEASOME+INHIBITOR Search PROTEASOME+INHIBITOR
4 NEDD8 198742 1% 77% 112 Search NEDD8 Search NEDD8
5 BORTEZOMIB 179295 3% 22% 359 Search BORTEZOMIB Search BORTEZOMIB
6 IMMUNOPROTEASOME 177829 1% 67% 115 Search IMMUNOPROTEASOME Search IMMUNOPROTEASOME
7 DEUBIQUITINATING ENZYME 160481 1% 61% 113 Search DEUBIQUITINATING+ENZYME Search DEUBIQUITINATING+ENZYME
8 26S PROTEASOME 157549 1% 52% 130 Search 26S+PROTEASOME Search 26S+PROTEASOME
9 COP9 SIGNALOSOME 155549 1% 82% 82 Search COP9+SIGNALOSOME Search COP9+SIGNALOSOME
10 ERAD 152095 1% 49% 135 Search ERAD Search ERAD

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VOGES, D , ZWICKL, P , BAUMEISTER, W , (1999) THE 26S PROTEASOME: A MOLECULAR MACHINE DESIGNED FOR CONTROLLED PROTEOLYSIS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 1015-1068 305 77% 1241
2 GLICKMAN, MH , CIECHANOVER, A , (2002) THE UBIQUITIN-PROTEASOME PROTEOLYTIC PATHWAY: DESTRUCTION FOR THE SAKE OF CONSTRUCTION.PHYSIOLOGICAL REVIEWS. VOL. 82. ISSUE 2. P. 373 -428 268 52% 2238
3 MARQUES, AJ , PALANIMURUGAN, R , MATIAS, AC , RAMOS, PC , DOHMEN, RJ , (2009) CATALYTIC MECHANISM AND ASSEMBLY OF THE PROTEASOME.CHEMICAL REVIEWS. VOL. 109. ISSUE 4. P. 1509 -1536 323 82% 91
4 FINLEY, D , (2009) RECOGNITION AND PROCESSING OF UBIQUITIN-PROTEIN CONJUGATES BY THE PROTEASOME.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 78. ISSUE . P. 477 -513 169 79% 663
5 FINLEY, D , CHEN, X , WALTERS, KJ , (2016) GATES, CHANNELS, AND SWITCHES: ELEMENTS OF THE PROTEASOME MACHINE.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 41. ISSUE 1. P. 77 -93 126 86% 19
6 COUX, O , TANAKA, K , GOLDBERG, AL , (1996) STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 801-847 195 72% 1712
7 XOLALPA, W , PEREZ-GALAN, P , RODRIGUEZ, MS , ROUE, G , (2013) TARGETING THE UBIQUITIN PROTEASOME SYSTEM: BEYOND PROTEASOME INHIBITION.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 22. P. 4053 -4093 348 63% 5
8 FINLEY, D , ULRICH, HD , SOMMER, T , KAISER, P , (2012) THE UBIQUITIN-PROTEASOME SYSTEM OF SACCHAROMYCES CEREVISIAE.GENETICS. VOL. 192. ISSUE 2. P. 319 -360 280 59% 70
9 XIA, D , TANG, WK , YE, YH , (2016) STRUCTURE AND FUNCTION OF THE AAA + ATPASE P97/CDC48P.GENE. VOL. 583. ISSUE 1. P. 64 -77 130 90% 10
10 KOMANDER, D , RAPE, M , (2012) THE UBIQUITIN CODE.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81. VOL. 81. ISSUE . P. 203-229 116 64% 593

Classes with closest relation at Level 2


Rank Class id link
1 3713 A20//LAPTM4B//WWP1
2 1843 ACUTE PROMYELOCYTIC LEUKEMIA//ARSENIC TRIOXIDE//SUMO
3 2158 NF KAPPA B//I KAPPA B//IKK
4 1548 UNFOLDED PROTEIN RESPONSE//ENDOPLASMIC RETICULUM STRESS//ER STRESS
5 2687 METHIONINE SULFOXIDE REDUCTASE//SPIN TRAPPING//PROTEIN OXIDATION
6 1128 AUTOPHAGY//BECLIN 1//LC3
7 1297 RIBOSOME//TRANSLATION TERMINATION//TMRNA
8 483 CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5
9 2994 NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT
10 713 MULTIPLE MYELOMA//MYELOMA//LENALIDOMIDE

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