Class information for:
Level 2: CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
483 15640 46.4 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
483 2             CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5 15640
2300 1                   E2F//P107//E2F1 2289
2551 1                   MPF//CDC2//GREATWALL 2210
4549 1                   P16//CDKN2A//P16INK4A 1767
5472 1                   CYCLIN D1//CCND1//CYCLIN D3 1619
5545 1                   SKP2//P27KIP1//P27 1608
7118 1                   FLAVOPIRIDOL//CYCLIN DEPENDENT KINASE//ROSCOVITINE 1403
9064 1                   P21//P21WAF1 CIP1//P21WAF1 1190
11551 1                   CDK5//P35//CYCLIN DEPENDENT KINASE 5 973
15937 1                   CDC25B//CDC25 PHOSPHATASE//CDC25A 683
16420 1                   PEDIAT CHILDREN SURG//SOMATIC GENOME VARIATIONS//CELL CYCLE RE ENTRY 654
16686 1                   CYCLIN E//CYCLIN A1//CYCLIN B1 641
23606 1                   CAK//SPY1//CDK ACTIVATING KINASE 340
34552 1                   CCNG2//CYCLIN G2//CYCLIN G 110
36554 1                   CDK2AP1//P12CDK2 AP1//DOC 1 79
36779 1                   CDK11P58//PITSLRE//CDK11 74

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CYCLIN DEPENDENT KINASE authKW 430625 3% 44% 504
2 CELL CYCLE authKW 426260 12% 11% 1948
3 CDK5 authKW 311847 2% 58% 278
4 CYCLIN D1 authKW 287532 4% 25% 594
5 E2F authKW 281597 2% 48% 302
6 CYCLIN authKW 245151 3% 30% 415
7 P27KIP1 authKW 242899 2% 36% 343
8 P27 authKW 233595 2% 34% 349
9 SKP2 authKW 189725 1% 61% 160
10 CDK authKW 169534 1% 40% 215

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 64574 33% 1% 5236
2 Oncology 56105 32% 1% 4983
3 Biochemistry & Molecular Biology 19997 32% 0% 5015
4 Genetics & Heredity 9049 11% 0% 1756
5 Developmental Biology 7110 5% 1% 725
6 Pathology 2236 4% 0% 636
7 Biophysics 758 4% 0% 574
8 Reproductive Biology 741 2% 0% 267
9 Medicine, Research & Experimental 527 3% 0% 532
10 Chemistry, Medicinal 527 3% 0% 394

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CELL CYCLE REGULAT GRP 38384 0% 62% 32
2 PATHOL 14478 12% 0% 1937
3 SBARRO CANC MOL MED 14419 0% 11% 65
4 MOLEC BIOL MB7 13653 0% 100% 7
5 DTP CLIN TRIALS UNIT 11945 0% 88% 7
6 MOL THER EUT UNIT 11758 0% 46% 13
7 TUMOR CELL BIOL 11226 0% 8% 69
8 CANC 10829 4% 1% 656
9 FUNCT GENOM SECT 10332 0% 25% 21
10 VECTOROL EXPT GENE THER Y 10186 0% 35% 15

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 68294 5% 4% 800
2 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 38556 2% 6% 314
3 MOLECULAR AND CELLULAR BIOLOGY 15482 3% 2% 429
4 CANCER RESEARCH 12037 3% 1% 506
5 CELL GROWTH & DIFFERENTIATION 7869 0% 5% 76
6 CLINICAL CANCER RESEARCH 7234 2% 2% 241
7 GENES & DEVELOPMENT 6190 1% 2% 157
8 INTERNATIONAL JOURNAL OF ONCOLOGY 6043 1% 2% 176
9 MOLECULAR AND CELLULAR DIFFERENTIATION 5664 0% 36% 8
10 CELL DIVISION 5411 0% 12% 24

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 CYCLIN DEPENDENT KINASE 430625 3% 44% 504 Search CYCLIN+DEPENDENT+KINASE Search CYCLIN+DEPENDENT+KINASE
2 CELL CYCLE 426260 12% 11% 1948 Search CELL+CYCLE Search CELL+CYCLE
3 CDK5 311847 2% 58% 278 Search CDK5 Search CDK5
4 CYCLIN D1 287532 4% 25% 594 Search CYCLIN+D1 Search CYCLIN+D1
5 E2F 281597 2% 48% 302 Search E2F Search E2F
6 CYCLIN 245151 3% 30% 415 Search CYCLIN Search CYCLIN
7 P27KIP1 242899 2% 36% 343 Search P27KIP1 Search P27KIP1
8 P27 233595 2% 34% 349 Search P27 Search P27
9 SKP2 189725 1% 61% 160 Search SKP2 Search SKP2
10 CDK 169534 1% 40% 215 Search CDK Search CDK

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RUAS, M , PETERS, G , (1998) THE P16(INK4A)/CDKN2A TUMOR SUPPRESSOR AND ITS RELATIVES.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1378. ISSUE 2. P. F115 -F177 382 72% 528
2 DYSON, N , (1998) THE REGULATION OF E2F BY PRB-FAMILY PROTEINS.GENES & DEVELOPMENT. VOL. 12. ISSUE 15. P. 2245-2262 161 88% 1660
3 ASGHAR, U , WITKIEWICZ, AK , TURNER, NC , KNUDSEN, ES , (2015) THE HISTORY AND FUTURE OF TARGETING CYCLIN-DEPENDENT KINASES IN CANCER THERAPY.NATURE REVIEWS DRUG DISCOVERY. VOL. 14. ISSUE 2. P. 130 -146 131 74% 97
4 SHERR, CJ , (1996) CANCER CELL CYCLES.SCIENCE. VOL. 274. ISSUE 5293. P. 1672 -1677 120 67% 4122
5 DIMOVA, DK , DYSON, NJ , (2005) THE E2F TRANSCRIPTIONAL NETWORK: OLD ACQUAINTANCES WITH NEW FACES.ONCOGENE. VOL. 24. ISSUE 17. P. 2810-2826 169 79% 396
6 SHAPIRO, GI , (2006) CYCLIN-DEPENDENT KINASE PATHWAYS AS TARGETS FOR CANCER TREATMENT.JOURNAL OF CLINICAL ONCOLOGY. VOL. 24. ISSUE 11. P. 1770-1783 145 78% 524
7 CHU, IM , HENGST, L , SLINGERLAND, JM , (2008) THE CDK INHIBITOR P27 IN HUMAN CANCER: PROGNOSTIC POTENTIAL AND RELEVANCE TO ANTICANCER THERAPY.NATURE REVIEWS CANCER. VOL. 8. ISSUE 4. P. 253 -267 136 68% 472
8 MOLLER, MB , (2003) MOLECULAR CONTROL OF THE CELL CYCLE IN CANCER: BIOLOGICAL AND CLINICAL ASPECTS.DANISH MEDICAL BULLETIN. VOL. 50. ISSUE 2. P. 118-138 317 60% 18
9 DEGREGORI, J , JOHNSON, DG , (2006) DISTINCT AND OVERLAPPING ROLES FOR E2F FAMILY MEMBERS IN TRANSCRIPTION, PROLIFERATION AND APOPTOSIS.CURRENT MOLECULAR MEDICINE. VOL. 6. ISSUE 7. P. 739-748 154 80% 262
10 MUSGROVE, EA , CALDON, CE , BARRACLOUGH, J , STONE, A , SUTHERLAND, RL , (2011) CYCLIN D AS A THERAPEUTIC TARGET IN CANCER.NATURE REVIEWS CANCER. VOL. 11. ISSUE 8. P. 558 -572 118 65% 381

Classes with closest relation at Level 2


Rank Class id link
1 2853 RETINOBLASTOMA//OPHTHALM ONCOL SERV//CHEMOREDUCTION
2 2913 CELLULAR SENESCENCE//SENESCENCE//ST PETERSBURG BIOREGULAT GERONTOL
3 2346 EGG ACTIVATION//OOCYTE ACTIVATION//SPERM FACTOR
4 2682 DNA REPLICATION//GEMININ//CDC6
5 936 P53//MDM2//P73
6 2754 MYC//MAX//C MYC
7 540 KINETOCHORE//MITOSIS//CENTROSOME
8 1195 JNK//ERK5//MAP KINASE
9 3037 KLF4//KRUPPEL LIKE FACTOR//GADD45
10 3108 FOXM1//FOXO1//FOXO

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