Class information for:
Level 2: P53//MDM2//P73

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
936 10991 45.8 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
936 2             P53//MDM2//P73 10991
1581 1                   P53//P53 GENE//ONCOGENE 2584
1860 1                   MDM2//MDMX//MDM4 2454
4381 1                   P73//P63//EEC SYNDROME 1795
8010 1                   MUTANT P53//PRIMA 1//CP 31398 1303
9053 1                   P53 POLYMORPHISM//P53 CODON 72//CODON 72 1191
13947 1                   P53//AREA BIOPATOL//BCL 2 803
19114 1                   LI FRAUMENI SYNDROME//LI FRAUMENI//GERMLINE TP53 MUTATION 521
29487 1                   PINK EYED UNSTABLE//RADIAT ON AB MOL CELLULAR RADIAT BIOL//3 5 EXONUCLEASE 185
31291 1                   IASPP//ASPP2//53BP2 155

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 P53 authKW 1326543 27% 16% 2940
2 MDM2 authKW 1148862 7% 51% 815
3 P73 authKW 847662 4% 70% 439
4 P63 authKW 512020 4% 44% 417
5 MDMX authKW 287433 1% 93% 111
6 LI FRAUMENI SYNDROME authKW 277581 1% 68% 148
7 MUTANT P53 authKW 210124 1% 60% 127
8 TP53 authKW 162639 2% 23% 256
9 MDM4 authKW 153836 1% 83% 67
10 NUTLIN 3 authKW 134487 1% 65% 74

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 70565 42% 1% 4595
2 Cell Biology 35822 30% 0% 3298
3 Biochemistry & Molecular Biology 15653 34% 0% 3686
4 Genetics & Heredity 13091 15% 0% 1694
5 Pathology 2226 5% 0% 516
6 Biophysics 657 4% 0% 433
7 Hematology 525 3% 0% 324
8 Medicine, Research & Experimental 365 3% 0% 372
9 Developmental Biology 302 1% 0% 158
10 Dermatology 151 1% 0% 158

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 P53 56872 0% 50% 41
2 TRANSCRIPT NETWORKS 37086 0% 64% 21
3 TOXICOL UNIT 28247 1% 8% 128
4 IDI IRCCS 28232 0% 36% 28
5 BIOCHEM IDI IRCCS 19191 0% 43% 16
6 GRP MOL CARCINOGENESIS 16646 0% 50% 12
7 COMPARAT ONCOL 16281 0% 24% 24
8 SURG MOL ONCOL 15486 0% 14% 41
9 CHROMOSOME STABIL GRP 14594 0% 48% 11
10 MOL ONCOGENESIS 12002 0% 16% 27

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 91545 7% 4% 774
2 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 25712 2% 4% 215
3 CELL DEATH AND DIFFERENTIATION 15307 1% 4% 133
4 CANCER RESEARCH 7331 3% 1% 332
5 INTERNATIONAL JOURNAL OF ONCOLOGY 7291 1% 2% 161
6 MOLECULAR AND CELLULAR BIOLOGY 6977 2% 1% 243
7 MOLECULAR CARCINOGENESIS 5068 1% 3% 72
8 BRITISH JOURNAL OF CANCER 3556 1% 1% 157
9 ONCOTARGET 3543 1% 1% 129
10 CELL DEATH & DISEASE 3463 1% 2% 55

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 P53 1326543 27% 16% 2940 Search P53 Search P53
2 MDM2 1148862 7% 51% 815 Search MDM2 Search MDM2
3 P73 847662 4% 70% 439 Search P73 Search P73
4 P63 512020 4% 44% 417 Search P63 Search P63
5 MDMX 287433 1% 93% 111 Search MDMX Search MDMX
6 LI FRAUMENI SYNDROME 277581 1% 68% 148 Search LI+FRAUMENI+SYNDROME Search LI+FRAUMENI+SYNDROME
7 MUTANT P53 210124 1% 60% 127 Search MUTANT+P53 Search MUTANT+P53
8 TP53 162639 2% 23% 256 Search TP53 Search TP53
9 MDM4 153836 1% 83% 67 Search MDM4 Search MDM4
10 NUTLIN 3 134487 1% 65% 74 Search NUTLIN+3 Search NUTLIN+3

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FREED-PASTOR, WA , PRIVES, C , (2012) MUTANT P53: ONE NAME, MANY PROTEINS.GENES & DEVELOPMENT. VOL. 26. ISSUE 12. P. 1268 -1286 157 81% 263
2 MULLER, PAJ , VOUSDEN, KH , (2014) MUTANT P53 IN CANCER: NEW FUNCTIONS AND THERAPEUTIC OPPORTUNITIES.CANCER CELL. VOL. 25. ISSUE 3. P. 304-317 124 77% 206
3 KARNI-SCHMIDT, O , LOKSHIN, M , PRIVES, C , (2016) THE ROLES OF MDM2 AND MDMX IN CANCER.ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11. VOL. 11. ISSUE . P. 617 -644 165 83% 6
4 MEEK, DW , (2015) REGULATION OF THE P53 RESPONSE AND ITS RELATIONSHIP TO CANCER.BIOCHEMICAL JOURNAL. VOL. 469. ISSUE . P. 325 -346 182 66% 45
5 MULLER, PAJ , VOUSDEN, KH , (2013) P53 MUTATIONS IN CANCER.NATURE CELL BIOLOGY. VOL. 15. ISSUE 1. P. 2-8 89 93% 386
6 KO, LJ , PRIVES, C , (1996) P53: PUZZLE AND PARADIGM.GENES & DEVELOPMENT. VOL. 10. ISSUE 9. P. 1054-1072 160 68% 1985
7 WADE, M , LI, YC , WAHL, GM , (2013) MDM2, MDMX AND P53 IN ONCOGENESIS AND CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 13. ISSUE 2. P. 83-96 121 71% 283
8 OZBUN, MA , BUTEL, JS , (1995) TUMOR-SUPPRESSOR P53 MUTATIONS AND BREAST-CANCER - A CRITICAL ANALYSIS.ADVANCES IN CANCER RESEARCH, VOL 66. VOL. 66. ISSUE . P. 71-141 319 79% 95
9 HOE, KK , VERMA, CS , LANE, DP , (2014) DRUGGING THE P53 PATHWAY: UNDERSTANDING THE ROUTE TO CLINICAL EFFICACY.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 3. P. 217 -236 158 69% 58
10 NAG, S , ZHANG, X , SRIVENUGOPAL, KS , WANG, MH , WANG, W , ZHANG, R , (2014) TARGETING MDM2-P53 INTERACTION FOR CANCER THERAPY: ARE WE THERE YET?.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 5. P. 553 -574 196 66% 25

Classes with closest relation at Level 2


Rank Class id link
1 483 CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5
2 2913 CELLULAR SENESCENCE//SENESCENCE//ST PETERSBURG BIOREGULAT GERONTOL
3 2853 RETINOBLASTOMA//OPHTHALM ONCOL SERV//CHEMOREDUCTION
4 3037 KLF4//KRUPPEL LIKE FACTOR//GADD45
5 306 TRAIL//SURVIVIN//APOPTOSIS
6 2606 FHIT//WWOX//FRAGILE SITES
7 2754 MYC//MAX//C MYC
8 3177 PROTEIN KINASE CK2//CK2//CASEIN KINASE 2
9 3713 A20//LAPTM4B//WWP1
10 900 BRCA1//BRCA2//FANCONI ANEMIA

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