Class information for:
Level 1: MDM2//MDMX//MDM4

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1860 2454 51.0 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
936 2             P53//MDM2//P73 10991
1860 1                   MDM2//MDMX//MDM4 2454

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MDM2 authKW 2875951 25% 38% 609
2 MDMX authKW 1219435 4% 91% 108
3 MDM4 authKW 590394 3% 77% 62
4 NUTLIN 3 authKW 570706 3% 64% 72
5 HDM2 authKW 535418 3% 54% 79
6 P53 authKW 525642 36% 5% 874
7 NUTLIN authKW 399006 2% 76% 42
8 HDMX authKW 253127 1% 88% 23
9 P53 MDM2 INTERACTION authKW 139957 1% 75% 15
10 MDM2 INHIBITOR authKW 121916 1% 70% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 13425 38% 0% 937
2 Oncology 10251 34% 0% 839
3 Biochemistry & Molecular Biology 5956 42% 0% 1033
4 Genetics & Heredity 1474 11% 0% 280
5 Chemistry, Medicinal 1071 7% 0% 169
6 Biophysics 286 5% 0% 123
7 Pathology 140 3% 0% 70
8 Hematology 102 3% 0% 69
9 Developmental Biology 101 2% 0% 41
10 Medicine, Research & Experimental 38 3% 0% 67

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 P53 136513 1% 37% 30
2 MCARDLE CANC 207A 49765 0% 100% 4
3 STATE KAY MOL REACT DYNAM 49765 0% 100% 4
4 CRUK SIGNAL TRANSDUCT GRP P53 40711 0% 55% 6
5 ROCHE 30109 1% 12% 21
6 BARRY ASHBEE LEUKEMIA S 24883 0% 100% 2
7 BIOL CELLULAR MOL PHARMACOL 24883 0% 100% 2
8 EDINBURGH CHEM BIOL 24883 0% 100% 2
9 IFOM JOINT P53 24883 0% 100% 2
10 INSERM UNITE 940 24883 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 20335 4% 2% 90
2 ONCOGENE 18166 7% 1% 163
3 CELL DEATH AND DIFFERENTIATION 3974 1% 1% 32
4 MOLECULAR CANCER RESEARCH 3797 1% 1% 24
5 MOLECULAR AND CELLULAR BIOLOGY 3200 3% 0% 77
6 CURRENT CANCER DRUG TARGETS 2539 1% 1% 14
7 CANCER CELL 2056 1% 1% 16
8 MOLECULAR CANCER THERAPEUTICS 2023 1% 1% 26
9 ONCOTARGET 1891 2% 0% 44
10 CELL CYCLE 1874 0% 2% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MDM2 2875951 25% 38% 609 Search MDM2 Search MDM2
2 MDMX 1219435 4% 91% 108 Search MDMX Search MDMX
3 MDM4 590394 3% 77% 62 Search MDM4 Search MDM4
4 NUTLIN 3 570706 3% 64% 72 Search NUTLIN+3 Search NUTLIN+3
5 HDM2 535418 3% 54% 79 Search HDM2 Search HDM2
6 P53 525642 36% 5% 874 Search P53 Search P53
7 NUTLIN 399006 2% 76% 42 Search NUTLIN Search NUTLIN
8 HDMX 253127 1% 88% 23 Search HDMX Search HDMX
9 P53 MDM2 INTERACTION 139957 1% 75% 15 Search P53+MDM2+INTERACTION Search P53+MDM2+INTERACTION
10 MDM2 INHIBITOR 121916 1% 70% 14 Search MDM2+INHIBITOR Search MDM2+INHIBITOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WADE, M , LI, YC , WAHL, GM , (2013) MDM2, MDMX AND P53 IN ONCOGENESIS AND CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 13. ISSUE 2. P. 83-96 118 69% 283
2 KARNI-SCHMIDT, O , LOKSHIN, M , PRIVES, C , (2016) THE ROLES OF MDM2 AND MDMX IN CANCER.ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11. VOL. 11. ISSUE . P. 617 -644 149 75% 6
3 MEEK, DW , (2015) REGULATION OF THE P53 RESPONSE AND ITS RELATIONSHIP TO CANCER.BIOCHEMICAL JOURNAL. VOL. 469. ISSUE . P. 325 -346 146 53% 45
4 NAG, S , ZHANG, X , SRIVENUGOPAL, KS , WANG, MH , WANG, W , ZHANG, R , (2014) TARGETING MDM2-P53 INTERACTION FOR CANCER THERAPY: ARE WE THERE YET?.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 5. P. 553 -574 175 59% 25
5 ZHAO, YJ , AGUILAR, A , BERNARD, D , WANG, SM , (2015) SMALL-MOLECULE INHIBITORS OF THE MDM2-P53 PROTEIN-PROTEIN INTERACTION (MDM2 INHIBITORS) IN CLINICAL TRIALS FOR CANCER TREATMENT.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 3. P. 1038 -1052 65 88% 68
6 CARR, MI , JONES, SN , (2016) REGULATION OF THE MDM2-P53 SIGNALING AXIS IN THE DNA DAMAGE RESPONSE AND TUMORIGENESIS.TRANSLATIONAL CANCER RESEARCH. VOL. 5. ISSUE 6. P. 707 -724 159 62% 0
7 LESLIE, PL , ZHANG, Y , (2016) MDM2 OLIGOMERS: ANTAGONIZERS OF THE GUARDIAN OF THE GENOME.ONCOGENE. VOL. 35. ISSUE 48. P. 6157 -6165 104 82% 1
8 LEMOS, A , LEAO, M , SOARES, J , PALMEIRA, A , PINTO, M , SARAIVA, L , SOUSA, ME , (2016) MEDICINAL CHEMISTRY STRATEGIES TO DISRUPT THE P53-MDM2/MDMX INTERACTION.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 5. P. 789 -844 118 70% 1
9 HOE, KK , VERMA, CS , LANE, DP , (2014) DRUGGING THE P53 PATHWAY: UNDERSTANDING THE ROUTE TO CLINICAL EFFICACY.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 3. P. 217 -236 119 52% 58
10 HOCK, AK , VOUSDEN, KH , (2014) THE ROLE OF UBIQUITIN MODIFICATION IN THE REGULATION OF P53.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1843. ISSUE 1. P. 137 -149 129 50% 42

Classes with closest relation at Level 1


Rank Class id link
1 8010 MUTANT P53//PRIMA 1//CP 31398
2 9053 P53 POLYMORPHISM//P53 CODON 72//CODON 72
3 1581 P53//P53 GENE//ONCOGENE
4 22276 SIGNALING SYST//INTRACELLULAR DYNAMIC//NF KAPPA B SIGNAL TRANSDUCTION NETWORK
5 13568 NUCLEOPHOSMIN//B23//NUCLEOPHOSMIN B23
6 31291 IASPP//ASPP2//53BP2
7 30791 PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA
8 36490 VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM
9 29487 PINK EYED UNSTABLE//RADIAT ON AB MOL CELLULAR RADIAT BIOL//3 5 EXONUCLEASE
10 15710 ALPHA HELIX MIMETICS//STAPLED PEPTIDES//PROTEOMIMETICS

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