Class information for:
Level 1: MUTANT P53//PRIMA 1//CP 31398

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8010 1303 52.0 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
936 2             P53//MDM2//P73 10991
8010 1                   MUTANT P53//PRIMA 1//CP 31398 1303

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MUTANT P53 authKW 1013785 7% 45% 96
2 PRIMA 1 authKW 483445 2% 74% 28
3 CP 31398 authKW 338602 1% 85% 17
4 P53 ISOFORMS authKW 292908 1% 83% 15
5 GAIN OF FUNCTION authKW 241243 3% 23% 44
6 PRIMA 1MET authKW 180249 1% 77% 10
7 P53 authKW 168733 28% 2% 361
8 TRANSCRIPT NETWORKS address 159754 1% 45% 15
9 APR 246 authKW 143525 1% 88% 7
10 CHROMOSOME STABIL GRP address 123267 1% 48% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 6487 37% 0% 476
2 Oncology 5913 36% 0% 463
3 Biochemistry & Molecular Biology 4930 51% 0% 667
4 Genetics & Heredity 1504 15% 0% 198
5 Biophysics 280 6% 0% 83
6 Medicine, Research & Experimental 28 3% 0% 39
7 Developmental Biology 27 1% 0% 17
8 Biochemical Research Methods 27 3% 0% 33
9 Biotechnology & Applied Microbiology 17 3% 0% 41
10 Mathematical & Computational Biology 5 1% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSCRIPT NETWORKS 159754 1% 45% 15
2 CHROMOSOME STABIL GRP 123267 1% 48% 11
3 CAMBRIDGE PROT ENGN 76138 1% 25% 13
4 CHROMOSOME STABIL SECT 74976 1% 40% 8
5 UNIT MOL MUTAGENESIS DNA REPAIR 62485 0% 67% 4
6 BIOPHYS CHEM MOL ONCOL 54668 1% 33% 7
7 MOL MUTAGENESIS UNIT 52723 0% 75% 3
8 GRP MOL CARCINOGENESIS 47832 1% 29% 7
9 CANC THER EUT S 46866 0% 100% 2
10 INSERM EUROPEAN ASSOCIATED U858 46866 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 13700 8% 1% 103
2 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 4821 2% 1% 32
3 CELL DEATH AND DIFFERENTIATION 4591 2% 1% 25
4 ONCOTARGET 2288 3% 0% 35
5 CANCER CELL 1516 1% 1% 10
6 HUMAN MUTATION 1484 1% 0% 16
7 COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY 1440 1% 1% 8
8 MOLECULAR CANCER RESEARCH 1237 1% 1% 10
9 CELL DEATH & DISEASE 1183 1% 0% 11
10 JOURNAL OF MOLECULAR BIOLOGY 1109 3% 0% 34

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MUTANT P53 1013785 7% 45% 96 Search MUTANT+P53 Search MUTANT+P53
2 PRIMA 1 483445 2% 74% 28 Search PRIMA+1 Search PRIMA+1
3 CP 31398 338602 1% 85% 17 Search CP+31398 Search CP+31398
4 P53 ISOFORMS 292908 1% 83% 15 Search P53+ISOFORMS Search P53+ISOFORMS
5 GAIN OF FUNCTION 241243 3% 23% 44 Search GAIN+OF+FUNCTION Search GAIN+OF+FUNCTION
6 PRIMA 1MET 180249 1% 77% 10 Search PRIMA+1MET Search PRIMA+1MET
7 P53 168733 28% 2% 361 Search P53 Search P53
8 APR 246 143525 1% 88% 7 Search APR+246 Search APR+246
9 DELTA 133P53 105446 0% 75% 6 Search DELTA+133P53 Search DELTA+133P53
10 MUTANT P53 REACTIVATION 97636 0% 83% 5 Search MUTANT+P53+REACTIVATION Search MUTANT+P53+REACTIVATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MULLER, PAJ , VOUSDEN, KH , (2014) MUTANT P53 IN CANCER: NEW FUNCTIONS AND THERAPEUTIC OPPORTUNITIES.CANCER CELL. VOL. 25. ISSUE 3. P. 304-317 104 64% 206
2 MULLER, PAJ , VOUSDEN, KH , (2013) P53 MUTATIONS IN CANCER.NATURE CELL BIOLOGY. VOL. 15. ISSUE 1. P. 2-8 59 61% 386
3 FREED-PASTOR, WA , PRIVES, C , (2012) MUTANT P53: ONE NAME, MANY PROTEINS.GENES & DEVELOPMENT. VOL. 26. ISSUE 12. P. 1268 -1286 89 46% 263
4 BISIO, A , CIRIBILLI, Y , FRONZA, G , INGA, A , MONTI, P , (2014) TP53 MUTANTS IN THE TOWER OF BABEL OF CANCER PROGRESSION.HUMAN MUTATION. VOL. 35. ISSUE 6. P. 689 -701 100 68% 7
5 OREN, M , ROTTER, V , (2010) MUTANT P53 GAIN-OF-FUNCTION IN CANCER.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 2. ISSUE 2. P. - 60 58% 212
6 JOERGER, AC , FERSHT, AR , (2008) STRUCTURAL BIOLOGY OF THE TUMOR SUPPRESSOR P53.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 77. ISSUE . P. 557-582 76 49% 237
7 ASCHAUER, L , MULLER, PAJ , (2016) NOVEL TARGETS AND INTERACTION PARTNERS OF MUTANT P53 GAIN-OF-FUNCTION.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 44. ISSUE . P. 460 -466 49 72% 3
8 JOERGER, AC , FERSHT, AR , (2007) STRUCTURE-FUNCTION-RESCUE: THE DIVERSE NATURE OF COMMON P53 CANCER MUTANTS.ONCOGENE. VOL. 26. ISSUE 15. P. 2226-2242 68 57% 182
9 JOERGER, AC , FERSHT, AR , (2016) THE P53 PATHWAY: ORIGINS, INACTIVATION IN CANCER, AND EMERGING THERAPEUTIC APPROACHES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85. VOL. 85. ISSUE . P. 375 -404 74 41% 3
10 BRAZDOVA, M , NAVRATILOVA, L , TICHY, V , NEMCOVA, K , LEXA, M , HRSTKA, R , PECINKA, P , ADAMIK, M , VOJTESEK, B , PALECEK, E , ET AL (2013) PREFERENTIAL BINDING OF HOT SPOT MUTANT P53 PROTEINS TO SUPERCOILED DNA IN VITRO AND IN CELLS.PLOS ONE. VOL. 8. ISSUE 3. P. - 55 66% 11

Classes with closest relation at Level 1


Rank Class id link
1 1860 MDM2//MDMX//MDM4
2 1581 P53//P53 GENE//ONCOGENE
3 19114 LI FRAUMENI SYNDROME//LI FRAUMENI//GERMLINE TP53 MUTATION
4 31291 IASPP//ASPP2//53BP2
5 4381 P73//P63//EEC SYNDROME
6 29487 PINK EYED UNSTABLE//RADIAT ON AB MOL CELLULAR RADIAT BIOL//3 5 EXONUCLEASE
7 13947 P53//AREA BIOPATOL//BCL 2
8 16830 RAD P53//RECOMBINANT ADENOVIRUS P53//ADENOVIRAL MEDIATED INTERFERON ALPHA
9 9053 P53 POLYMORPHISM//P53 CODON 72//CODON 72
10 30791 PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA

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