Class information for:
Level 1: PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30791 163 38.9 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
30791 1                   PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA 163

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PUMA authKW 1640913 34% 16% 56
2 PUMA GENE authKW 374669 1% 100% 2
3 P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA authKW 249778 1% 67% 2
4 2 3 DCPE authKW 187334 1% 100% 1
5 ADENOVIRUS EXPRESSING P53 authKW 187334 1% 100% 1
6 AKT FOXO3A SIGNALING authKW 187334 1% 100% 1
7 C JUN N TERMINAL KINASE JNK ACTIVATION authKW 187334 1% 100% 1
8 C4ORF7 authKW 187334 1% 100% 1
9 CANCER BCL 2 FAMILY PROTEINS authKW 187334 1% 100% 1
10 CIB BIM NANOMED VHIR address 187334 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1318 47% 0% 76
2 Cell Biology 465 28% 0% 46
3 Biochemistry & Molecular Biology 100 24% 0% 39
4 Genetics & Heredity 91 11% 0% 18
5 Medicine, Research & Experimental 46 7% 0% 12
6 Gastroenterology & Hepatology 15 4% 0% 6
7 Biophysics 12 4% 0% 7
8 Hematology 9 3% 0% 5
9 Pharmacology & Pharmacy 8 7% 0% 11
10 Cell & Tissue Engineering 5 1% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CIB BIM NANOMED VHIR 187334 1% 100% 1
2 COMITE URO GYNECOL ONCOL 187334 1% 100% 1
3 EA 1773 187334 1% 100% 1
4 HAEMATOL SA PATHOL HEAMATOL ONCOL 187334 1% 100% 1
5 HILLMAN CANC PAVIL PATHOL 187334 1% 100% 1
6 HILLMAN CANC PAVIL PHARMACOL 187334 1% 100% 1
7 HILLMAN CANC PHARMACOL 187334 1% 100% 1
8 HILMAN CANC 187334 1% 100% 1
9 INNOVAT ENGAGEMENTS 187334 1% 100% 1
10 JOHNS HOPKINS ONCOL HOWARD HUGHES MED 187334 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 2686 4% 0% 7
2 CANCER BIOLOGY & THERAPY 2397 4% 0% 6
3 ONCOGENE 1246 7% 0% 11
4 MOLECULAR CANCER THERAPEUTICS 1145 3% 0% 5
5 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 943 3% 0% 5
6 IRANIAN JOURNAL OF BIOTECHNOLOGY 939 1% 1% 1
7 TRANSLATIONAL CANCER RESEARCH 556 1% 0% 1
8 ONCOTARGET 542 4% 0% 6
9 CELL DEATH AND DIFFERENTIATION 528 2% 0% 3
10 CANCER CELL 487 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PUMA 1640913 34% 16% 56 Search PUMA Search PUMA
2 PUMA GENE 374669 1% 100% 2 Search PUMA+GENE Search PUMA+GENE
3 P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA 249778 1% 67% 2 Search P53+UPREGULATED+MODULATOR+OF+APOPTOSIS+PUMA Search P53+UPREGULATED+MODULATOR+OF+APOPTOSIS+PUMA
4 2 3 DCPE 187334 1% 100% 1 Search 2+3+DCPE Search 2+3+DCPE
5 ADENOVIRUS EXPRESSING P53 187334 1% 100% 1 Search ADENOVIRUS+EXPRESSING+P53 Search ADENOVIRUS+EXPRESSING+P53
6 AKT FOXO3A SIGNALING 187334 1% 100% 1 Search AKT+FOXO3A+SIGNALING Search AKT+FOXO3A+SIGNALING
7 C JUN N TERMINAL KINASE JNK ACTIVATION 187334 1% 100% 1 Search C+JUN+N+TERMINAL+KINASE+JNK+ACTIVATION Search C+JUN+N+TERMINAL+KINASE+JNK+ACTIVATION
8 C4ORF7 187334 1% 100% 1 Search C4ORF7 Search C4ORF7
9 CANCER BCL 2 FAMILY PROTEINS 187334 1% 100% 1 Search CANCER+BCL+2+FAMILY+PROTEINS Search CANCER+BCL+2+FAMILY+PROTEINS
10 GASTRO INTESTINAL SYNDROME 187334 1% 100% 1 Search GASTRO+INTESTINAL+SYNDROME Search GASTRO+INTESTINAL+SYNDROME

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SUN, J , SUN, QH , BROWN, MF , DUDGEON, C , CHANDLER, J , XU, X , SHU, YQ , ZHANG, L , YU, J , (2012) THE MULTI-TARGETED KINASE INHIBITOR SUNITINIB INDUCES APOPTOSIS IN COLON CANCER CELLS VIA PUMA.PLOS ONE. VOL. 7. ISSUE 8. P. - 18 40% 11
2 ZHANG, XL , LU, HF , WANG, YB , LIU, CJ , ZHU, WF , ZHENG, SY , WAN, FS , (2015) TAURINE INDUCES THE APOPTOSIS OF BREAST CANCER CELLS BY REGULATING APOPTOSIS-RELATED PROTEINS OF MITOCHONDRIA.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. VOL. 35. ISSUE 1. P. 218 -226 15 42% 5
3 ZHANG, LL , WANG, HA , LI, W , ZHONG, JC , YU, RC , HUANG, XF , WANG, HH , TAN, ZK , WANG, JG , ZHANG, YJ , (2017) PAZOPANIB, A NOVEL MULTI-KINASE INHIBITOR, SHOWS POTENT ANTITUMOR ACTIVITY IN COLON CANCER THROUGH PUMA-MEDIATED APOPTOSIS.ONCOTARGET. VOL. 8. ISSUE 2. P. 3289 -3303 20 32% 0
4 HE, K , ZHENG, XN , ZHANG, L , YU, J , (2013) HSP90 INHIBITORS PROMOTE P53-DEPENDENT APOPTOSIS THROUGH PUMA AND BAX.MOLECULAR CANCER THERAPEUTICS. VOL. 12. ISSUE 11. P. 2559-2568 18 36% 10
5 YU, J , ZHANG, L , (2008) PUMA, A POTENT KILLER WITH OR WITHOUT P53.ONCOGENE. VOL. 27. ISSUE . P. S71 -S83 28 19% 181
6 ZHENG, XN , HE, K , ZHANG, L , YU, J , (2013) CRIZOTINIB INDUCES PUMA-DEPENDENT APOPTOSIS IN COLON CANCER CELLS.MOLECULAR CANCER THERAPEUTICS. VOL. 12. ISSUE 5. P. 777-786 16 37% 7
7 CHEN, DS , WEI, L , YU, J , ZHANG, L , (2014) REGORAFENIB INHIBITS COLORECTAL TUMOR GROWTH THROUGH PUMA-MEDIATED APOPTOSIS.CLINICAL CANCER RESEARCH. VOL. 20. ISSUE 13. P. 3472 -3484 15 33% 21
8 CARPENTER, RL , HAN, W , PAW, I , LO, HW , (2013) HER2 PHOSPHORYLATES AND DESTABILIZES PRO-APOPTOTIC PUMA, LEADING TO ANTAGONIZED APOPTOSIS IN CANCER CELLS.PLOS ONE. VOL. 8. ISSUE 11. P. - 15 36% 1
9 HIKISZ, P , KILIANSKA, ZM , (2012) PUMA, A CRITICAL MEDIATOR OF CELL DEATH - ONE DECADE ON FROM ITS DISCOVERY.CELLULAR & MOLECULAR BIOLOGY LETTERS. VOL. 17. ISSUE 4. P. 646 -669 21 23% 28
10 MUSTATA, G , LI, M , ZEVOLA, N , BAKAN, A , ZHANG, L , EPPERLY, M , GREENBERGER, JS , YU, J , BAHAR, I , (2011) DEVELOPMENT OF SMALL-MOLECULE PUMA INHIBITORS FOR MITIGATING RADIATION-INDUCED CELL DEATH.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 3. P. 281-290 16 33% 13

Classes with closest relation at Level 1


Rank Class id link
1 640 MCL 1//BCL 2 FAMILY//BH3 MIMETIC
2 31852 GS NITROXIDE//MNSOD PL//MNSOD PL GENE THERAPY
3 1860 MDM2//MDMX//MDM4
4 16830 RAD P53//RECOMBINANT ADENOVIRUS P53//ADENOVIRAL MEDIATED INTERFERON ALPHA
5 6028 LGR5//INTESTINAL STEM CELLS//LGR4
6 36785 GRAPTOPETALUM PARAGUAYENSE E WALTHER//GRAPTOPETALUM PARAGUAYENSE//3 HYDROXYL 3 METHYLGLUTAROYL HMG
7 8010 MUTANT P53//PRIMA 1//CP 31398
8 25613 UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251
9 33061 CITED2//CITED//MELANOCYTE SPECIFIC GENE MSG1
10 25856 BNIP3//BCH DOMAIN//HGTD P

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