Class information for:
Level 2: TRAIL//SURVIVIN//APOPTOSIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
306 18497 46.2 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
640 1                   MCL 1//BCL 2 FAMILY//BH3 MIMETIC 3219
1157 1                   TRAIL//DR5//TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND 2815
1319 1                   FAS//FAS LIGAND//FASL 2720
1845 1                   APAF 1//CASPASE 2//CASPASE 2462
3854 1                   SURVIVIN//YM155//SURVIVIN EXPRESSION 1894
6794 1                   XIAP//LIVIN//SMAC 1443
10004 1                   NECROPTOSIS//RIP3//RIP1 1099
14699 1                   C FLIP//FADD//DEATH EFFECTOR DOMAIN 755
19375 1                   OBLIMERSEN//G3139//ANTISENSE BCL 2 508
23365 1                   AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME//ALPS UNIT//DN T CELLS 348
25040 1                   APOPTOSIS INDUCING FACTOR//AIF//AMID 293
27700 1                   JOINT SERV BIOMARKER EVALUAT ONCOL//KI67 SCORE//LOCDIR 223
28260 1                   CASP8 652 6N DEL//CASPASE8//CASP8 211
29102 1                   M65//M30//CYTOKERATIN 18 193
30791 1                   PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA 163
35782 1                   ALTERNOL//DELISHENG//AND TUMOR INVASION 92
37421 1                   BCL2L12//BCL2L12A//BRAIN TUMOR GENET MED 59

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 TRAIL authKW 1119422 6% 58% 1171
2 SURVIVIN authKW 1068974 6% 56% 1150
3 APOPTOSIS authKW 602412 32% 6% 5989
4 FAS authKW 335487 4% 28% 719
5 NECROPTOSIS authKW 299854 2% 65% 282
6 DEATH RECEPTOR authKW 229224 2% 48% 289
7 CASPASE authKW 219208 5% 14% 962
8 BCL 2 authKW 209903 5% 13% 976
9 XIAP authKW 181695 1% 47% 233
10 MCL 1 authKW 181665 1% 42% 262

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 52642 29% 1% 5298
2 Cell Biology 44283 26% 1% 4819
3 Biochemistry & Molecular Biology 21467 31% 0% 5699
4 Immunology 5922 10% 0% 1902
5 Hematology 4549 6% 0% 1029
6 Medicine, Research & Experimental 3491 6% 0% 1159
7 Biophysics 1540 4% 0% 819
8 Pathology 1376 3% 0% 582
9 Genetics & Heredity 1364 5% 0% 932
10 Chemistry, Medicinal 542 2% 0% 445

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT CANC PEDIAT 79710 0% 61% 79
2 PROGRAM OPTOSIS CELL DEATH 56826 0% 49% 70
3 TUMOR IMMUNOL PROGRAM 21970 0% 21% 64
4 OPTOSIS REGULAT 21409 0% 50% 26
5 PATTERN RECOGNIT RECEPTOR DISCOVERY PERFORMANCE U 21254 0% 56% 23
6 IMMUNOINFLAMMAT THER EUT AREA 19117 0% 55% 21
7 MORPHOL EMBRYOL 18055 0% 18% 60
8 MOL GENET CANC 16997 0% 33% 31
9 ALPS UNIT 16489 0% 100% 10
10 OPTOSIS 16266 0% 17% 58

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL DEATH AND DIFFERENTIATION 143127 3% 17% 525
2 PEZCOLLER FOUNDATION SYMPOSIA 49089 1% 12% 246
3 CELL DEATH & DISEASE 31704 1% 9% 214
4 ONCOGENE 15991 2% 2% 427
5 MOLECULAR CANCER THERAPEUTICS 9977 1% 4% 159
6 CANCER BIOLOGY & THERAPY 7047 1% 4% 111
7 CANCER RESEARCH 6705 2% 1% 418
8 CLINICAL CANCER RESEARCH 6632 1% 2% 252
9 JOURNAL OF BIOLOGICAL CHEMISTRY 6457 5% 1% 843
10 INTERNATIONAL JOURNAL OF ONCOLOGY 5237 1% 2% 179

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 TRAIL 1119422 6% 58% 1171 Search TRAIL Search TRAIL
2 SURVIVIN 1068974 6% 56% 1150 Search SURVIVIN Search SURVIVIN
3 APOPTOSIS 602412 32% 6% 5989 Search APOPTOSIS Search APOPTOSIS
4 FAS 335487 4% 28% 719 Search FAS Search FAS
5 NECROPTOSIS 299854 2% 65% 282 Search NECROPTOSIS Search NECROPTOSIS
6 DEATH RECEPTOR 229224 2% 48% 289 Search DEATH+RECEPTOR Search DEATH+RECEPTOR
7 CASPASE 219208 5% 14% 962 Search CASPASE Search CASPASE
8 BCL 2 209903 5% 13% 976 Search BCL+2 Search BCL+2
9 XIAP 181695 1% 47% 233 Search XIAP Search XIAP
10 MCL 1 181665 1% 42% 262 Search MCL+1 Search MCL+1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CZABOTAR, PE , LESSENE, G , STRASSER, A , ADAMS, JM , (2014) CONTROL OF APOPTOSIS BY THE BCL-2 PROTEIN FAMILY: IMPLICATIONS FOR PHYSIOLOGY AND THERAPY.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 15. ISSUE 1. P. 49 -63 176 83% 433
2 YOULE, RJ , STRASSER, A , (2008) THE BCL-2 PROTEIN FAMILY: OPPOSING ACTIVITIES THAT MEDIATE CELL DEATH.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 9. ISSUE 1. P. 47 -59 123 76% 2030
3 FULDA, S , VUCIC, D , (2012) TARGETING IAP PROTEINS FOR THERAPEUTIC INTERVENTION IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 2. P. 109 -124 179 80% 235
4 DE MIGUEL, D , LEMKE, J , ANEL, A , WALCZAK, H , MARTINEZ-LOSTAO, L , (2016) ONTO BETTER TRAILS FOR CANCER TREATMENT.CELL DEATH AND DIFFERENTIATION. VOL. 23. ISSUE 5. P. 733 -747 166 83% 10
5 GALLUZZI, L , BRAVO-SAN PEDRO, JM , VITALE, I , AARONSON, SA , ABRAMS, JM , ADAM, D , ALNEMRI, ES , ALTUCCI, L , ANDREWS, D , ANNICCHIARICO-PETRUZZELLI, M , ET AL (2015) ESSENTIAL VERSUS ACCESSORY ASPECTS OF CELL DEATH: RECOMMENDATIONS OF THE NCCD 2015.CELL DEATH AND DIFFERENTIATION. VOL. 22. ISSUE 1. P. 58 -73 163 52% 147
6 JOHNSTONE, RW , FREW, AJ , SMYTH, MJ , (2008) THE TRAIL APOPTOTIC PATHWAY IN CANCER ONSET, PROGRESSION AND THERAPY.NATURE REVIEWS CANCER. VOL. 8. ISSUE 10. P. 782 -798 164 85% 462
7 LEMKE, J , VON KARSTEDT, S , ZINNGREBE, J , WALCZAK, H , (2014) GETTING TRAIL BACK ON TRACK FOR CANCER THERAPY.CELL DEATH AND DIFFERENTIATION. VOL. 21. ISSUE 9. P. 1350 -1364 134 88% 100
8 DELBRIDGE, ARD , GRABOW, S , STRASSER, A , VAUX, DL , (2016) THIRTY YEARS OF BCL-2: TRANSLATING CELL DEATH DISCOVERIES INTO NOVEL CANCER THERAPIES.NATURE REVIEWS CANCER. VOL. 16. ISSUE 2. P. 99 -109 135 73% 16
9 EARNSHAW, WC , MARTINS, LM , KAUFMANN, SH , (1999) MAMMALIAN CASPASES: STRUCTURE, ACTIVATION, SUBSTRATES, AND FUNCTIONS DURING APOPTOSIS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 383 -424 203 54% 1865
10 PASPARAKIS, M , VANDENABEELE, P , (2015) NECROPTOSIS AND ITS ROLE IN INFLAMMATION.NATURE. VOL. 517. ISSUE 7534. P. 311 -320 96 79% 135

Classes with closest relation at Level 2


Rank Class id link
1 2106 GAS6//AXL//MFG E8
2 3417 DEOXYRIBONUCLEASE I//MED GENET BIOCHEM//DEOXYRIBONUCLEASE
3 2158 NF KAPPA B//I KAPPA B//IKK
4 3606 TRIPTOLIDE//CELASTROL//PDCD5
5 854 CD40//BAFF//CD40 LIGAND
6 3713 A20//LAPTM4B//WWP1
7 3350 VDAC//VOLTAGE DEPENDENT ANION CHANNEL//HEXOKINASE
8 936 P53//MDM2//P73
9 1128 AUTOPHAGY//BECLIN 1//LC3
10 2683 NEUTROPHIL EXTRACELLULAR TRAPS//SEVERE CONGENITAL NEUTROPENIA//NETOSIS

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