Class information for:
Level 1: XIAP//LIVIN//SMAC

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6794 1443 46.6 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
6794 1                   XIAP//LIVIN//SMAC 1443

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 XIAP authKW 1487632 13% 38% 186
2 LIVIN authKW 1448989 6% 80% 86
3 SMAC authKW 1109053 6% 56% 93
4 SMAC MIMETIC authKW 1052206 4% 84% 59
5 SMAC DIABLO authKW 577879 4% 53% 52
6 XAF1 authKW 456267 2% 74% 29
7 IAP authKW 416774 6% 24% 81
8 IAP ANTAGONIST authKW 333249 1% 75% 21
9 EXPT CANC PEDIAT address 289285 3% 33% 42
10 IAPS authKW 245735 4% 22% 54

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 7375 38% 0% 542
2 Cell Biology 3026 25% 0% 354
3 Biochemistry & Molecular Biology 1838 32% 0% 462
4 Chemistry, Medicinal 307 5% 0% 73
5 Medicine, Research & Experimental 219 6% 0% 83
6 Hematology 212 5% 0% 65
7 Biophysics 121 4% 0% 64
8 Genetics & Heredity 69 4% 0% 63
9 Pathology 66 3% 0% 38
10 Pharmacology & Pharmacy 19 5% 0% 72

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT CANC PEDIAT 289285 3% 33% 42
2 SOLANGE GAUTHIER KARSH MOL GENET 58868 1% 35% 8
3 PROGRAM OPTOSIS CELL DEATH 48248 1% 13% 18
4 FUNCT CANC GENOM 47607 0% 75% 3
5 OPTOSIS 45452 2% 8% 27
6 CANC ENDOCRINE PROGRAM 42319 0% 100% 2
7 SOLANGE G KARSH MOL GENET 42319 0% 100% 2
8 EARLY DISCOVERY BIOCHEM 34536 1% 12% 14
9 DIPARTIMENTO ONCOL SPERIMENTALE MED MOL 33110 0% 26% 6
10 EARLY ADME 28211 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL DEATH AND DIFFERENTIATION 6802 2% 1% 32
2 CELL DEATH & DISEASE 5132 2% 1% 24
3 PEZCOLLER FOUNDATION SYMPOSIA 4161 1% 1% 20
4 MOLECULAR CANCER THERAPEUTICS 1655 1% 0% 18
5 ONCOTARGET 1609 2% 0% 31
6 CLINICAL CANCER RESEARCH 1073 2% 0% 28
7 ONCOLOGY REPORTS 906 1% 0% 21
8 INTERNATIONAL JOURNAL OF ONCOLOGY 855 1% 0% 20
9 CANCER RESEARCH 804 3% 0% 40
10 ONCOGENE 691 2% 0% 25

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 XIAP 1487632 13% 38% 186 Search XIAP Search XIAP
2 LIVIN 1448989 6% 80% 86 Search LIVIN Search LIVIN
3 SMAC 1109053 6% 56% 93 Search SMAC Search SMAC
4 SMAC MIMETIC 1052206 4% 84% 59 Search SMAC+MIMETIC Search SMAC+MIMETIC
5 SMAC DIABLO 577879 4% 53% 52 Search SMAC+DIABLO Search SMAC+DIABLO
6 XAF1 456267 2% 74% 29 Search XAF1 Search XAF1
7 IAP 416774 6% 24% 81 Search IAP Search IAP
8 IAP ANTAGONIST 333249 1% 75% 21 Search IAP+ANTAGONIST Search IAP+ANTAGONIST
9 IAPS 245735 4% 22% 54 Search IAPS Search IAPS
10 CIAP2 245541 1% 55% 21 Search CIAP2 Search CIAP2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FULDA, S , VUCIC, D , (2012) TARGETING IAP PROTEINS FOR THERAPEUTIC INTERVENTION IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 2. P. 109 -124 167 75% 235
2 LACASSE, EC , MAHONEY, DJ , CHEUNG, HH , PLENCHETTE, S , BAIRD, S , KORNELUK, RG , (2008) IAP-TARGETED THERAPIES FOR CANCER.ONCOGENE. VOL. 27. ISSUE 48. P. 6252-6275 128 53% 272
3 STRAUB, CS , (2011) TARGETING IAPS AS AN APPROACH TO ANTI-CANCER THERAPY.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 3. P. 291 -316 119 72% 29
4 BAI, LC , SMITH, DC , WANG, SM , (2014) SMALL-MOLECULE SMAC MIMETICS AS NEW CANCER THERAPEUTICS.PHARMACOLOGY & THERAPEUTICS. VOL. 144. ISSUE 1. P. 82 -95 100 71% 26
5 VUCIC, D , (2008) TARGETING IAP (INHIBITOR OF APOPTOSIS) PROTEINS FOR THERAPEUTIC INTERVENTION IN TUMORS.CURRENT CANCER DRUG TARGETS. VOL. 8. ISSUE 2. P. 110 -117 109 73% 25
6 FLYGARE, JA , FAIRBROTHER, WJ , (2010) SMALL-MOLECULE PAN-IAP ANTAGONISTS: A PATENT REVIEW.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 20. ISSUE 2. P. 251-267 76 93% 41
7 FULDA, S , (2014) INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN HEMATOLOGICAL MALIGNANCIES: MOLECULAR MECHANISMS AND THERAPEUTIC OPPORTUNITIES.LEUKEMIA. VOL. 28. ISSUE 7. P. 1414 -1422 75 76% 20
8 HUNTER, AM , LACASSE, EC , KORNELUK, RG , (2007) THE INHIBITORS OF APOPTOSIS (IAPS) AS CANCER TARGETS.APOPTOSIS. VOL. 12. ISSUE 9. P. 1543 -1568 103 48% 317
9 FULDA, S , (2012) EXPLOITING INHIBITOR OF APOPTOSIS PROTEINS AS THERAPEUTIC TARGETS IN HEMATOLOGICAL MALIGNANCIES.LEUKEMIA. VOL. 26. ISSUE 6. P. 1155-1165 82 75% 14
10 DYNEK, JN , VUCIC, D , (2013) ANTAGONISTS OF IAP PROTEINS AS CANCER THERAPEUTICS.CANCER LETTERS. VOL. 332. ISSUE 2. P. 206-214 72 77% 19

Classes with closest relation at Level 1


Rank Class id link
1 3854 SURVIVIN//YM155//SURVIVIN EXPRESSION
2 14354 DRONC//DIAP1//REAPER
3 10004 NECROPTOSIS//RIP3//RIP1
4 25971 EMBELIN//EMBELIA RIBES//EMBELIA ANGUSTIFOLIA
5 1845 APAF 1//CASPASE 2//CASPASE
6 1157 TRAIL//DR5//TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND
7 14699 C FLIP//FADD//DEATH EFFECTOR DOMAIN
8 17952 TRAF4//TRAF6//TRAF2
9 15103 HTRA1//HTRA//HTRA2
10 25040 APOPTOSIS INDUCING FACTOR//AIF//AMID

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