Class information for:
Level 1: VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
36490 80 47.7 95%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
3177 2             PROTEIN KINASE CK2//CK2//CASEIN KINASE 2 2149
36490 1                   VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM 80

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VRK1 authKW 7318599 26% 91% 21
2 VRK2 authKW 1870305 9% 70% 7
3 EXPT THER EUT TRANSLAT ONCOL PROGRAM address 1023894 16% 21% 13
4 VACCINIA RELATED KINASE 3 authKW 763392 3% 100% 2
5 INVEST BIOMED SALAMANCA IBSAL address 561300 13% 15% 10
6 BIOL MOL CELULAR CANCPROGRAMA ONCOL TRANS address 508926 3% 67% 2
7 NHK 1 authKW 508926 3% 67% 2
8 PROGRAMA ONCOL TRANSLAC address 508926 3% 67% 2
9 BIOL MOL CELULAR CANC address 451647 28% 5% 22
10 BIOL MOL CELULAR CANC INVEST CANC address 381696 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 901 54% 0% 43
2 Biochemistry & Molecular Biology 338 54% 0% 43
3 Developmental Biology 187 10% 0% 8
4 Genetics & Heredity 90 15% 0% 12
5 Oncology 75 18% 0% 14
6 Biophysics 37 9% 0% 7
7 Reproductive Biology 10 3% 0% 2
8 Respiratory System 4 3% 0% 2
9 Pathology 3 3% 0% 2
10 Biochemical Research Methods 2 3% 0% 2

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT THER EUT TRANSLAT ONCOL PROGRAM 1023894 16% 21% 13
2 INVEST BIOMED SALAMANCA IBSAL 561300 13% 15% 10
3 BIOL MOL CELULAR CANCPROGRAMA ONCOL TRANS 508926 3% 67% 2
4 PROGRAMA ONCOL TRANSLAC 508926 3% 67% 2
5 BIOL MOL CELULAR CANC 451647 28% 5% 22
6 BIOL MOL CELULAR CANC INVEST CANC 381696 1% 100% 1
7 BIOL MOL CELULAR CANCIBMCC INVEST CAN 381696 1% 100% 1
8 BIOL MOL CELULAR CANCPROGRAM ONCOL TRANSL 381696 1% 100% 1
9 BIOLOGI MOL CELULAR CANC 381696 1% 100% 1
10 CICCSIC 381696 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENESIS 1449 1% 0% 1
2 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 756 4% 0% 3
3 MOLECULAR AND CELLULAR BIOLOGY 612 8% 0% 6
4 JAMA NEUROLOGY 607 1% 0% 1
5 BIOMOLECULAR NMR ASSIGNMENTS 545 1% 0% 1
6 HEMATOLOGY 389 1% 0% 1
7 MOLECULAR CANCER RESEARCH 203 1% 0% 1
8 GENES & DEVELOPMENT 202 3% 0% 2
9 JOURNAL OF THORACIC DISEASE 200 1% 0% 1
10 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 198 4% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 VRK1 7318599 26% 91% 21 Search VRK1 Search VRK1
2 VRK2 1870305 9% 70% 7 Search VRK2 Search VRK2
3 VACCINIA RELATED KINASE 3 763392 3% 100% 2 Search VACCINIA+RELATED+KINASE+3 Search VACCINIA+RELATED+KINASE+3
4 NHK 1 508926 3% 67% 2 Search NHK+1 Search NHK+1
5 DDR DNA DAMAGE RESPONSE 381696 1% 100% 1 Search DDR+DNA+DAMAGE+RESPONSE Search DDR+DNA+DAMAGE+RESPONSE
6 LEM PROTEINS 381696 1% 100% 1 Search LEM+PROTEINS Search LEM+PROTEINS
7 NACRT 381696 1% 100% 1 Search NACRT Search NACRT
8 SMA PCH SPINAL MUSCULAR ATROPHY PONTOCEREBELLAR HYPOPLASIA 381696 1% 100% 1 Search SMA+PCH+SPINAL+MUSCULAR+ATROPHY+PONTOCEREBELLAR+HYPOPLASIA Search SMA+PCH+SPINAL+MUSCULAR+ATROPHY+PONTOCEREBELLAR+HYPOPLASIA
9 VACCINIA RELATED KINASE 1 P53 381696 1% 100% 1 Search VACCINIA+RELATED+KINASE+1+P53 Search VACCINIA+RELATED+KINASE+1+P53
10 VACCINIA RELATED KINASE 1 VRK1 381696 1% 100% 1 Search VACCINIA+RELATED+KINASE+1+VRK1 Search VACCINIA+RELATED+KINASE+1+VRK1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 BARCIA-SANJURJO, I , VAZQUEZ-CEDEIRA, M , BARCIA, R , LAZO, PA , (2013) SENSITIVITY OF THE KINASE ACTIVITY OF HUMAN VACCINIA-RELATED KINASE PROTEINS TO TOXIC METALS.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. VOL. 18. ISSUE 4. P. 473-482 38 63% 3
2 SALZANO, M , VAZQUEZ-CEDEIRA, M , SANZ-GARCIA, M , VALBUENA, A , BLANCO, S , FERNANDEZ, IF , LAZO, PA , (2014) VACCINIA-RELATED KINASE 1 (VRK1) CONFERS RESISTANCE TO DNA-DAMAGING AGENTS IN HUMAN BREAST CANCER BY AFFECTING DNA DAMAGE RESPONSE.ONCOTARGET. VOL. 5. ISSUE 7. P. 1770-1778 34 67% 4
3 LOPEZ-SANCHEZ, I , VALBUENA, A , VAZQUEZ-CEDEIRA, M , KHADAKE, J , SANZ-GARCIA, M , CARRILLO-JIMENEZ, A , LAZO, PA , (2014) VRK1 INTERACTS WITH P53 FORMING A BASAL COMPLEX THAT IS ACTIVATED BY UV-INDUCED DNA DAMAGE.FEBS LETTERS. VOL. 588. ISSUE 5. P. 692-700 32 48% 5
4 MONSALVE, DM , CAMPILLO-MARCOS, I , SALZANO, M , SANZ-GARCIA, M , CANTARERO, L , LAZO, PA , (2016) VRK1 PHOSPHORYLATES AND PROTECTS NBS1 FROM UBIQUITINATION AND PROTEASOMAL DEGRADATION IN RESPONSE TO DNA DAMAGE.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1863. ISSUE 4. P. 760 -769 28 50% 1
5 MOURA, DS , FERNANDEZ, IF , MARIN-ROYO, G , LOPEZ-SANCHEZ, I , MARTIN-DONCEL, E , VEGA, FM , LAZO, PA , (2016) ONCOGENIC SOX2 REGULATES AND COOPERATES WITH VRK1 IN CELL CYCLE PROGRESSION AND DIFFERENTIATION.SCIENTIFIC REPORTS. VOL. 6. ISSUE . P. - 30 46% 0
6 MONSALVE, DM , MERCED, T , FERNANDEZ, IF , BLANCO, S , VAZQUEZ-CEDEIRA, M , LAZO, PA , (2013) HUMAN VRK2 MODULATES APOPTOSIS BY INTERACTION WITH BCL-XL AND REGULATION OF BAX GENE EXPRESSION.CELL DEATH & DISEASE. VOL. 4. ISSUE . P. - 26 53% 11
7 CANTARERO, L , SANZ-GARCIA, M , VINOGRAD-BYK, H , RENBAUM, P , LEVY-LAHAD, E , LAZO, PA , (2015) VRK1 REGULATES CAJAL BODY DYNAMICS AND PROTECTS COILIN FROM PROTEASOMAL DEGRADATION IN CELL CYCLE.SCIENTIFIC REPORTS. VOL. 5. ISSUE . P. - 30 41% 0
8 MOLITOR, TP , TRAKTMAN, P , (2013) MOLECULAR GENETIC ANALYSIS OF VRK1 IN MAMMARY EPITHELIAL CELLS: DEPLETION SLOWS PROLIFERATION IN VITRO AND TUMOR GROWTH AND METASTASIS IN VIVO.ONCOGENESIS. VOL. 2. ISSUE . P. - 20 57% 13
9 KIM, W , CHAKRABORTY, G , KIM, S , SHIN, J , PARK, CH , JEONG, MW , BHARATHAM, N , YOON, HS , KIM, KT , (2012) MACRO HISTONE H2A1.2 (MACROH2A1) PROTEIN SUPPRESSES MITOTIC KINASE VRK1 DURING INTERPHASE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 287. ISSUE 8. P. 5278-5289 19 61% 17
10 KIM, SH , RYU, HG , LEE, J , SHIN, J , HARIKISHORE, A , JUNG, HY , KIM, YS , LYU, HN , OH, E , BAEK, NI , ET AL (2015) URSOLIC ACID EXERTS ANTI-CANCER ACTIVITY BY SUPPRESSING VACCINIA-RELATED KINASE 1-MEDIATED DAMAGE REPAIR IN LUNG CANCER CELLS.SCIENTIFIC REPORTS. VOL. 5. ISSUE . P. - 27 41% 1

Classes with closest relation at Level 1


Rank Class id link
1 26732 CASEIN KINASE 1//GRANULOVACUOLAR DEGENERATION//CK1 DELTA
2 18172 RHOMBENCEPHALOSYNAPSIS//PONTOCEREBELLAR HYPOPLASIA//CEREBELLAR AGENESIS
3 24808 TRIBBLES//TRB3//TRIB3
4 23563 LUTEOLIN//GLOSSOGYNE TENUIFOLIA//HLTH CARE TECHNOL DEV
5 16660 COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3
6 1053 LAMIN//LAMINOPATHY//NUCLEAR ENVELOPE
7 1860 MDM2//MDMX//MDM4
8 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
9 25952 CAM DR//CELL ADHESION MEDIATED DRUG RESISTANCE//RECEPTOR BIOL TUMOR METASTASIS
10 37662 NALCN//ABNORMAL RESPIRATORY RHYTHM//ADDIC MENTAL HLTH

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