Class information for:
Level 1: TPL2//TPL 2//COT TPL2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
29236 190 45.3 95%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
29236 1                   TPL2//TPL 2//COT TPL2 190

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TPL2 authKW 1446410 6% 75% 12
2 TPL 2 authKW 1124990 4% 100% 7
3 COT TPL2 authKW 964277 3% 100% 6
4 MAP3K8 authKW 867842 5% 60% 9
5 TPL2 KINASE authKW 803564 3% 100% 5
6 COT authKW 646660 7% 31% 13
7 TP12 authKW 642851 2% 100% 4
8 TUMOR PROGRESSION LOCUS 2 authKW 514280 2% 80% 4
9 INFLAMMAT SIGNALING address 361602 2% 75% 3
10 1 7NAPHTHYRIDINE 3 CARBONITRILES authKW 321426 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 795 34% 0% 64
2 Biochemistry & Molecular Biology 589 47% 0% 89
3 Immunology 258 19% 0% 36
4 Oncology 201 18% 0% 35
5 Chemistry, Medicinal 68 6% 0% 12
6 Medicine, Research & Experimental 29 6% 0% 11
7 Genetics & Heredity 21 6% 0% 11
8 Hematology 17 4% 0% 7
9 Biophysics 14 4% 0% 8
10 Endocrinology & Metabolism 11 4% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INFLAMMAT SIGNALING 361602 2% 75% 3
2 IMMUNE CELL BIOL 185272 9% 6% 18
3 1INSERMU1191IGF 160713 1% 100% 1
4 31 YAMADAOKA 160713 1% 100% 1
5 ANAT CELL BIOL MOL MED 160713 1% 100% 1
6 CNBCSICCEU 160713 1% 100% 1
7 DPTO ANAT HISTOL NEUROCIENCIA 160713 1% 100% 1
8 GENOM BIOL HEREDITARY BREAST CANC 160713 1% 100% 1
9 IISA 160713 1% 100% 1
10 INTRACELLULAR SIGNALLING GENE EXP S 160713 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND CELLULAR BIOLOGY 1028 6% 0% 12
2 ONCOGENE 559 4% 0% 8
3 SCIENCE SIGNALING 413 1% 0% 2
4 JOURNAL OF BIOLOGICAL CHEMISTRY 361 10% 0% 19
5 CANCER IMMUNOLOGY RESEARCH 356 1% 0% 1
6 JOURNAL OF IMMUNOLOGY 349 6% 0% 11
7 CELLULAR SIGNALLING 327 2% 0% 3
8 JOURNAL OF EXPERIMENTAL MEDICINE 321 3% 0% 5
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 303 4% 0% 7
10 BIOMEDICAL PAPERS-OLOMOUC 257 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TPL2 1446410 6% 75% 12 Search TPL2 Search TPL2
2 TPL 2 1124990 4% 100% 7 Search TPL+2 Search TPL+2
3 COT TPL2 964277 3% 100% 6 Search COT+TPL2 Search COT+TPL2
4 MAP3K8 867842 5% 60% 9 Search MAP3K8 Search MAP3K8
5 TPL2 KINASE 803564 3% 100% 5 Search TPL2+KINASE Search TPL2+KINASE
6 COT 646660 7% 31% 13 Search COT Search COT
7 TP12 642851 2% 100% 4 Search TP12 Search TP12
8 TUMOR PROGRESSION LOCUS 2 514280 2% 80% 4 Search TUMOR+PROGRESSION+LOCUS+2 Search TUMOR+PROGRESSION+LOCUS+2
9 1 7NAPHTHYRIDINE 3 CARBONITRILES 321426 1% 100% 2 Search 1+7NAPHTHYRIDINE+3+CARBONITRILES Search 1+7NAPHTHYRIDINE+3+CARBONITRILES
10 CANCER OSAKA THYROID COT 321426 1% 100% 2 Search CANCER+OSAKA+THYROID+COT Search CANCER+OSAKA+THYROID+COT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LEE, HW , CHOI, HY , JOO, KM , NAM, DH , (2015) TUMOR PROGRESSION LOCUS 2 (TPL2) KINASE AS A NOVEL THERAPEUTIC TARGET FOR CANCER: DOUBLE-SIDED EFFECTS OF TPL2 ON CANCER.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. VOL. 16. ISSUE 3. P. 4471 -4491 79 56% 2
2 VOUGIOUKALAKI, M , KANELLIS, DC , GKOUSKOU, K , ELIOPOULOS, AG , (2011) TP12 KINASE SIGNAL TRANSDUCTION IN INFLAMMATION AND CANCER.CANCER LETTERS. VOL. 304. ISSUE 2. P. 80 -89 59 74% 36
3 GANTKE, T , SRISKANTHARAJAH, S , LEY, SC , (2011) REGULATION AND FUNCTION OF TPL-2, AN I KAPPA B KINASE-REGULATED MAP KINASE KINASE KINASE.CELL RESEARCH. VOL. 21. ISSUE 1. P. 131 -145 56 56% 45
4 GEORGE, D , SALMERON, A , (2009) COT/TPL-2 PROTEIN KINASE AS A TARGET FOR THE TREATMENT OF INFLAMMATORY DISEASE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 7. P. 611-622 38 93% 26
5 GANTKE, T , SRISKANTHARAJAH, S , SADOWSKI, M , LEY, SC , (2012) I KAPPA B KINASE REGULATION OF THE TPL-2/ERK MAPK PATHWAY.IMMUNOLOGICAL REVIEWS. VOL. 246. ISSUE . P. 168-182 55 47% 39
6 BEN-ADDI, A , MAMBOLE-DEMA, A , BRENDER, C , MARTIN, SR , JANZEN, J , KJAER, S , SMERDON, SJ , LEY, SC , (2014) I KAPPA B KINASE-INDUCED INTERACTION OF TPL-2 KINASE WITH 14-3-3 IS ESSENTIAL FOR TOLL-LIKE RECEPTOR ACTIVATION OF ERK-1 AND-2 MAP KINASES.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 111. ISSUE 23. P. E2394-E2403 30 61% 5
7 LEE, JH , LEE, JH , LEE, SH , DO, SI , CHO, SD , FORSLUND, O , INN, KS , LEE, JS , DENG, FM , MELAMED, J , ET AL (2016) TPL2 IS AN ONCOGENIC DRIVER IN KERATOCANTHOMA AND SQUAMOUS CELL CARCINOMA.CANCER RESEARCH. VOL. 76. ISSUE 22. P. 6712 -6722 28 60% 1
8 CHO, JH , TSICHLIS, PN , (2005) PHOSPHORYLATION AT THR-290 REGULATES TPL2 BINDING TO NF-KAPPA B1/P105 AND TPL2 ACTIVATION AND DEGRADATION BY LIPOPOLYSACCHARIDE.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 102. ISSUE 7. P. 2350-2355 22 96% 37
9 ROBINSON, MJ , BEINKE, S , KOUROUMALIS, A , TSICHLIS, PN , LEY, SC , (2007) PHOPHORYLATION OF TPL-2 ON SERINE 400 IS ESSENTIAL FOR LIPOPOLYSACCHARIDE ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN MACROPHAGES.MOLECULAR AND CELLULAR BIOLOGY. VOL. 27. ISSUE 21. P. 7355-7364 27 68% 27
10 GUTMANN, S , HINNIGER, A , FENDRICH, G , DRUCKES, P , ANTZ, S , MATTES, H , MOBITZ, H , OFNER, S , SCHMIEDEBERG, N , STOJANOVIC, A , ET AL (2015) THE CRYSTAL STRUCTURE OF CANCER OSAKA THYROID KINASE REVEALS AN UNEXPECTED KINASE DOMAIN FOLD.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 290. ISSUE 24. P. 15210 -15218 22 63% 1

Classes with closest relation at Level 1


Rank Class id link
1 24258 TAK1//TAB1//TGF BETA ACTIVATED KINASE 1
2 500 NF KAPPA B//IKK//I KAPPA B
3 11748 RAF//LEO JENKINS CANC//KSR1
4 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5
5 10893 NFAT//NUCLEAR FACTOR OF ACTIVATED T CELLS//CALCINEURIN
6 17952 TRAF4//TRAF6//TRAF2
7 34857 LIPOPOLYSACCHARIDE INDUCED TNF ALPHA FACTOR//LITAF//LPS INDUCED TNF ALPHA FACTOR
8 19765 A20//RNF11//ZINC FINGER PROTEIN A20
9 5307 MK2//P38 INHIBITORS//P38 ALPHA
10 13288 IRAK 4//TIR DOMAIN//IRAK

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