Class information for:
Level 2: X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
536 14793 47.6 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
1558 1                   RHO GTPASES//TIAM1//RHOB 2595
5678 1                   PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA 1590
8654 1                   X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK 1231
9406 1                   INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1 1158
9431 1                   C ABL//BCR ABL//RIN1 1156
11502 1                   PAK1//P21 ACTIVATED KINASE//PAK4 977
12290 1                   SH3 DOMAIN//SH2 DOMAIN//GRB2 917
13570 1                   NEDD9//CRK//CRKL 828
13788 1                   SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING 813
14390 1                   CBL//CBL B//C CBL 772
14683 1                   SHIP2//SHIP1//DOK 756
17831 1                   P66SHC//SHC//SHC FAMILY 580
18972 1                   SYK//SPLEEN TYROSINE KINASE//FOSTAMATINIB 528
21034 1                   GRB7//GRB14//GRB10 436
22654 1                   VAV//VAV1//VAV PROTO ONCOGENE 373
36304 1                   SWAP 70//SWITCH ASSOCIATED PROTEIN 70//DEF6 83

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 X LINKED AGAMMAGLOBULINEMIA authKW 160605 1% 70% 112
2 BTK authKW 150439 1% 61% 119
3 SH2 DOMAIN authKW 145476 1% 45% 157
4 BRUTONS TYROSINE KINASE authKW 127345 1% 67% 92
5 RHO GTPASES authKW 126208 2% 25% 248
6 P66SHC authKW 125510 1% 66% 92
7 RAC authKW 104724 1% 28% 184
8 GRB2 authKW 94473 1% 42% 109
9 SH3 DOMAIN authKW 90397 1% 31% 144
10 PAK1 authKW 88532 1% 56% 77

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 48264 30% 1% 4441
2 Biochemistry & Molecular Biology 40118 44% 0% 6536
3 Oncology 9018 15% 0% 2153
4 Immunology 7816 13% 0% 1866
5 Hematology 3220 5% 0% 782
6 Biophysics 2697 6% 0% 882
7 Genetics & Heredity 2413 7% 0% 993
8 Medicine, Research & Experimental 1078 4% 0% 649
9 Endocrinology & Metabolism 936 4% 0% 644
10 Chemistry, Medicinal 524 3% 0% 379

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RAYMOND BEVERLY SACKLER GENET MOL MED 32469 0% 75% 21
2 LYMPHOCYTE SIGNALLING DEV 30123 0% 30% 49
3 CELL ADHES UNIT 24981 0% 61% 20
4 INOSITIDE 16322 0% 25% 32
5 LYMPHOCYTE SIGNALING DEV 14704 0% 36% 20
6 IMMUNOL 13404 5% 1% 749
7 MOL IMMUNOL PROGRAMME 13277 0% 32% 20
8 INFLAMMATORY CELL BIOL 12844 0% 69% 9
9 SECT LYMPHOCYTE SIGNALING 11224 0% 78% 7
10 CORE IL HLTH SCI 10311 0% 100% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 32808 11% 1% 1592
2 ONCOGENE 29482 3% 3% 514
3 MOLECULAR AND CELLULAR BIOLOGY 22369 3% 2% 499
4 CELLULAR SIGNALLING 13408 1% 4% 170
5 JOURNAL OF IMMUNOLOGY 6673 3% 1% 437
6 BLOOD 4838 2% 1% 298
7 CELL COMMUNICATION AND SIGNALING 3948 0% 7% 27
8 SCIENCE SIGNALING 3796 0% 4% 54
9 IMMUNITY 3707 1% 2% 80
10 EMBO JOURNAL 3390 1% 1% 175

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 X LINKED AGAMMAGLOBULINEMIA 160605 1% 70% 112 Search X+LINKED+AGAMMAGLOBULINEMIA Search X+LINKED+AGAMMAGLOBULINEMIA
2 BTK 150439 1% 61% 119 Search BTK Search BTK
3 SH2 DOMAIN 145476 1% 45% 157 Search SH2+DOMAIN Search SH2+DOMAIN
4 BRUTONS TYROSINE KINASE 127345 1% 67% 92 Search BRUTONS+TYROSINE+KINASE Search BRUTONS+TYROSINE+KINASE
5 RHO GTPASES 126208 2% 25% 248 Search RHO+GTPASES Search RHO+GTPASES
6 P66SHC 125510 1% 66% 92 Search P66SHC Search P66SHC
7 RAC 104724 1% 28% 184 Search RAC Search RAC
8 GRB2 94473 1% 42% 109 Search GRB2 Search GRB2
9 SH3 DOMAIN 90397 1% 31% 144 Search SH3+DOMAIN Search SH3+DOMAIN
10 PAK1 88532 1% 56% 77 Search PAK1 Search PAK1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KING, H , NICHOLAS, NS , WELLS, CM , (2014) ROLE OF P-21-ACTIVATED KINASES IN CANCER PROGRESSION.INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 309. VOL. 309. ISSUE . P. 347 -387 179 85% 19
2 KUMAR, R , LI, DQ , (2016) PAKS IN HUMAN CANCER PROGRESSION: FROM INCEPTION TO CANCER THERAPEUTIC TO FUTURE ONCOBIOLOGY.ADVANCES IN CANCER RESEARCH, VOL 130. VOL. 130. ISSUE . P. 137 -209 189 64% 4
3 FELLER, SM , (2001) CRK FAMILY ADAPTORS - SIGNALLING COMPLEX FORMATION AND BIOLOGICAL ROLES.ONCOGENE. VOL. 20. ISSUE 44. P. 6348 -6371 227 64% 319
4 SWAMINATHAN, G , TSYGANKOV, AY , (2006) THE CBL FAMILY PROTEINS: RING LEADERS IN REGULATION OF CELL SIGNALING.JOURNAL OF CELLULAR PHYSIOLOGY. VOL. 209. ISSUE 1. P. 21-43 201 65% 164
5 KUMAR, R , SANAWAR, R , LI, XD , LI, F , (2017) STRUCTURE, BIOCHEMISTRY, AND BIOLOGY OF PAK KINASES.GENE. VOL. 605. ISSUE . P. 20 -31 164 73% 0
6 SENAPEDIS, W , CROCHIERE, M , BALOGLU, E , LANDESMAN, Y , (2016) THERAPEUTIC POTENTIAL OF TARGETING PAK SIGNALING.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 1. P. 75 -88 145 67% 3
7 MOHAMED, AJ , YU, L , BACKESJO, CM , VARGAS, L , FARYAL, R , AINTS, A , CHRISTENSSON, B , BERGLOF, A , VIHINEN, M , NORE, BF , ET AL (2009) BRUTON'S TYROSINE KINASE (BTK): FUNCTION, REGULATION, AND TRANSFORMATION WITH SPECIAL EMPHASIS ON THE PH DOMAIN.IMMUNOLOGICAL REVIEWS. VOL. 228. ISSUE . P. 58 -73 129 82% 132
8 RADU, M , SEMENOVA, G , KOSOFF, R , CHERNOFF, J , (2014) PAK SIGNALLING DURING THE DEVELOPMENT AND PROGRESSION OF CANCER.NATURE REVIEWS CANCER. VOL. 14. ISSUE 1. P. 13 -25 103 74% 72
9 BOKOCH, GM , (2003) BIOLOGY OF THE P21-ACTIVATED KINASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 72. ISSUE . P. 743-781 136 62% 676
10 BERG, LJ , FINKELSTEIN, LD , LUCAS, JA , SCHWARTZBERG, PL , (2005) TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 23. ISSUE . P. 549 -600 151 73% 175

Classes with closest relation at Level 2


Rank Class id link
1 1911 FARNESYLTRANSFERASE//RAS//RAL
2 2228 C MYB//B MYB//SRC
3 1220 PTEN//MTOR//COWDEN SYNDROME
4 3948 SPROUTY//LRIG1//MIG 6
5 3960 IMP3//DLC1//DELETED IN LIVER CANCER 1
6 2254 PHOSPHOLIPASE D//DIACYLGLYCEROL KINASE//PHOSPHATIDIC ACID
7 2998 RGS PROTEINS//GIRDIN//RGS
8 1452 CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB
9 3713 A20//LAPTM4B//WWP1
10 1195 JNK//ERK5//MAP KINASE

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