Class information for:
Level 2: CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1452 7818 40.6 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
317 3       HER2//TRASTUZUMAB//CHRONIC MYELOID LEUKEMIA 39408
1452 2             CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB 7818
260 1                   CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB 3783
2490 1                   PLATELET DERIVED GROWTH FACTOR//PDGF//PDGF RECEPTOR 2228
11421 1                   ANILINOQUINAZOLINE//4 ANILINOQUINAZOLINE//VEGFR 2 INHIBITOR 983
23991 1                   REGORAFENIB//N DESETHYL SUNITINIB//N DESMETHYL IMATINIB 327
24850 1                   TYRPHOSTIN//AG957//INOSTAMYCIN 299
35107 1                   DIARYLAMIDE//DIARYLUREA//A375P 102
35514 1                   AG 1295//BONE CANC SMYELOMA//CAREGGI UNIV HOSP INTERNAL MEDAOU CAREGGI 96

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHRONIC MYELOID LEUKEMIA authKW 1643971 12% 45% 938
2 IMATINIB authKW 1297297 11% 38% 875
3 NILOTINIB authKW 851162 4% 71% 308
4 DASATINIB authKW 736084 4% 54% 348
5 BCR ABL authKW 681845 6% 37% 478
6 CML authKW 449088 5% 28% 405
7 IMATINIB MESYLATE authKW 277151 3% 31% 227
8 TYROSINE KINASE INHIBITORS authKW 247989 4% 21% 304
9 IMATINIB RESISTANCE authKW 237643 1% 67% 91
10 CHRONIC MYELOGENOUS LEUKEMIA authKW 234165 3% 26% 232

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Hematology 45026 24% 1% 1838
2 Oncology 22244 29% 0% 2239
3 Chemistry, Medicinal 7725 10% 0% 777
4 Cell Biology 2972 12% 0% 922
5 Biochemistry & Molecular Biology 1833 17% 0% 1320
6 Pharmacology & Pharmacy 1701 11% 0% 867
7 Medicine, Research & Experimental 416 4% 0% 308
8 Chemistry, Organic 407 5% 0% 390
9 Biochemical Research Methods 181 3% 0% 204
10 Pathology 131 2% 0% 148

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEUKEMIA 166497 4% 13% 323
2 HEMATOL ONCOL LA SERAGNOLI 49900 0% 47% 27
3 HEMATOL 45415 10% 2% 764
4 HEMATOPOIESE LEUCEM CIBLE THER EUT 43241 0% 92% 12
5 MED UNIV KLIN 3 43163 0% 38% 29
6 HEMATOL UNIT HELSINKI 40248 0% 54% 19
7 MED FAK MANNHEIM 38422 1% 15% 64
8 CANC DRUG 35129 0% 75% 12
9 PAUL OGORMAN LEUKAEMIA 33799 0% 33% 26
10 ONCOL HEMATOL CELL THER Y 31407 0% 62% 13

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 17748 1% 8% 59
2 LEUKEMIA 17055 2% 2% 183
3 LEUKEMIA RESEARCH 14698 2% 3% 152
4 BLOOD 12826 4% 1% 342
5 CURRENT HEMATOLOGIC MALIGNANCY REPORTS 9727 0% 9% 28
6 HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 9322 1% 4% 65
7 LEUKEMIA & LYMPHOMA 9018 2% 2% 134
8 INTERNATIONAL JOURNAL OF HEMATOLOGY 8428 1% 2% 91
9 CLINICAL LYMPHOMA & MYELOMA 5291 0% 7% 21
10 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5233 2% 1% 189

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CHRONIC MYELOID LEUKEMIA 1643971 12% 45% 938 Search CHRONIC+MYELOID+LEUKEMIA Search CHRONIC+MYELOID+LEUKEMIA
2 IMATINIB 1297297 11% 38% 875 Search IMATINIB Search IMATINIB
3 NILOTINIB 851162 4% 71% 308 Search NILOTINIB Search NILOTINIB
4 DASATINIB 736084 4% 54% 348 Search DASATINIB Search DASATINIB
5 BCR ABL 681845 6% 37% 478 Search BCR+ABL Search BCR+ABL
6 CML 449088 5% 28% 405 Search CML Search CML
7 IMATINIB MESYLATE 277151 3% 31% 227 Search IMATINIB+MESYLATE Search IMATINIB+MESYLATE
8 TYROSINE KINASE INHIBITORS 247989 4% 21% 304 Search TYROSINE+KINASE+INHIBITORS Search TYROSINE+KINASE+INHIBITORS
9 IMATINIB RESISTANCE 237643 1% 67% 91 Search IMATINIB+RESISTANCE Search IMATINIB+RESISTANCE
10 CHRONIC MYELOGENOUS LEUKEMIA 234165 3% 26% 232 Search CHRONIC+MYELOGENOUS+LEUKEMIA Search CHRONIC+MYELOGENOUS+LEUKEMIA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BACCARANI, M , DEININGER, MW , ROSTI, G , HOCHHAUS, A , SOVERINI, S , APPERLEY, JF , CERVANTES, F , CLARK, RE , CORTES, JE , GUILHOT, F , ET AL (2013) EUROPEAN LEUKEMIANET RECOMMENDATIONS FOR THE MANAGEMENT OF CHRONIC MYELOID LEUKEMIA: 2013.BLOOD. VOL. 122. ISSUE 6. P. 872 -884 130 95% 333
2 HELDIN, CH , WESTERMARK, B , (1999) MECHANISM OF ACTION AND IN VIVO ROLE OF PLATELET-DERIVED GROWTH FACTOR.PHYSIOLOGICAL REVIEWS. VOL. 79. ISSUE 4. P. 1283 -1316 296 60% 1328
3 BACCARANI, M , CORTES, J , PANE, F , NIEDERWIESER, D , SAGLIO, G , APPERLEY, J , CERVANTES, F , DEININGER, M , GRATWOHL, A , GUILHOT, F , ET AL (2009) CHRONIC MYELOID LEUKEMIA: AN UPDATE OF CONCEPTS AND MANAGEMENT RECOMMENDATIONS OF EUROPEAN LEUKEMIANET.JOURNAL OF CLINICAL ONCOLOGY. VOL. 27. ISSUE 35. P. 6041-6051 106 96% 511
4 STEEGMANN, JL , BACCARANI, M , BRECCIA, M , CASADO, LF , GARCIA-GUTIERREZ, V , HOCHHAUS, A , KIM, DW , KIM, TD , KHOURY, HJ , LE COUTRE, P , ET AL (2016) EUROPEAN LEUKEMIANET RECOMMENDATIONS FOR THE MANAGEMENT AND AVOIDANCE OF ADVERSE EVENTS OF TREATMENT IN CHRONIC MYELOID LEUKAEMIA.LEUKEMIA. VOL. 30. ISSUE 8. P. 1648 -1671 135 78% 6
5 BACCARANI, M , SAGLIO, G , GOLDMAN, J , HOCHHAUS, A , SIMONSSON, B , APPELBAUM, F , APPERLEY, J , CERVANTES, F , CORTES, J , DEININGER, M , ET AL (2006) EVOLVING CONCEPTS IN THE MANAGEMENT OF CHRONIC MYELOID LEUKEMIA: RECOMMENDATIONS FROM AN EXPERT PANEL ON BEHALF OF THE EUROPEAN LEUKEMIANET.BLOOD. VOL. 108. ISSUE 6. P. 1809 -1820 119 82% 539
6 O'BRIEN, S , ABBOUD, CN , AKHTARI, M , ALTMAN, J , BERMAN, E , DEANGELO, DJ , DEVINE, S , FATHI, AT , GOTLIB, J , JAGASIA, M , ET AL (2012) CHRONIC MYELOGENOUS LEUKEMIA.JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK. VOL. 10. ISSUE 1. P. 64 -110 170 80% 7
7 JABBOUR, EJ , CORTES, JE , KANTARJIAN, HM , (2013) RESISTANCE TO TYROSINE KINASE INHIBITION THERAPY FOR CHRONIC MYELOGENOUS LEUKEMIA: A CLINICAL PERSPECTIVE AND EMERGING TREATMENT OPTIONS.CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. VOL. 13. ISSUE 5. P. 515 -529 112 95% 23
8 DEININGER, M , BUCHDUNGER, E , DRUKER, BJ , (2005) THE DEVELOPMENT OF IMATINIB AS A THERAPEUTIC AGENT FOR CHRONIC MYELOID LEUKEMIA.BLOOD. VOL. 105. ISSUE 7. P. 2640 -2653 103 77% 708
9 DIRKS, RPH , BLOEMERS, HPJ , (1996) SIGNALS CONTROLLING THE EXPRESSION OF PDGF.MOLECULAR BIOLOGY REPORTS. VOL. 22. ISSUE 1. P. 1 -24 255 72% 15
10 APPERLEY, JF , (2015) CHRONIC MYELOID LEUKAEMIA.LANCET. VOL. 385. ISSUE 9976. P. 1447 -1459 80 84% 36

Classes with closest relation at Level 2


Rank Class id link
1 2228 C MYB//B MYB//SRC
2 1648 EPIDERMAL GROWTH FACTOR//HB EGF//TRANSFORMING GROWTH FACTOR ALPHA
3 3186 HYPEREOSINOPHILIC SYNDROME//IDIOPATHIC HYPEREOSINOPHILIC SYNDROME//EOSINOPHILIA
4 1717 GEFITINIB//EGFR MUTATION//MIDKINE
5 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN
6 1729 GASTROINTESTINAL STROMAL TUMOR//GIST//INTUSSUSCEPTION
7 56 MYELODYSPLASTIC SYNDROME//HEMATOLOGY//ACUTE MYELOID LEUKEMIA
8 361 ANGIOGENESIS//ENDOSTATIN//VEGF
9 3290 HAND FOOT SYNDROME//HYPERSENSITIVITY REACTION//RADIATION RECALL
10 2690 QUINAZOLINONE//43H QUINAZOLINONES//QUINAZOLINE

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