Class information for:
Level 1: SH3 DOMAIN//SH2 DOMAIN//GRB2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12290 917 45.0 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
12290 1                   SH3 DOMAIN//SH2 DOMAIN//GRB2 917

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SH3 DOMAIN authKW 610003 10% 20% 93
2 SH2 DOMAIN authKW 467392 8% 20% 70
3 GRB2 authKW 462733 7% 23% 60
4 SH3 authKW 208344 4% 19% 33
5 SH2 authKW 201417 3% 21% 29
6 GRB2 SH2 DOMAIN authKW 138739 1% 83% 5
7 BIACORE X authKW 99893 0% 100% 3
8 INTERTWINED DIMER authKW 99893 0% 100% 3
9 SRC SH2 DOMAIN authKW 99893 0% 100% 3
10 GRB2 SH2 authKW 88791 0% 67% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5862 65% 0% 595
2 Chemistry, Medicinal 2043 15% 0% 133
3 Biophysics 1758 17% 0% 152
4 Cell Biology 1319 21% 0% 190
5 Chemistry, Organic 605 13% 0% 119
6 Biochemical Research Methods 430 8% 0% 74
7 Mathematical & Computational Biology 40 2% 0% 14
8 Crystallography 14 2% 0% 16
9 Spectroscopy 8 2% 0% 14
10 Oncology 6 4% 0% 34

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RAYMOND BEVERLY SACKLER GENET MOL MED 76098 1% 29% 8
2 GWEN JULES KN P BIOMED DISCOVERY 66595 0% 100% 2
3 VET ADM FDN 66595 0% 100% 2
4 VAKGRP COMP WETEN PEN 59933 0% 60% 3
5 USYLVESTER BRAMAN FAMILY BREAST CANC 44392 0% 33% 4
6 UM SYLVESTER BRAMAN FAMILY BREAST CANC 42808 0% 43% 3
7 TEXAS DRUG DIAGNOST DEV 36315 1% 18% 6
8 BECKMAN 3019 33298 0% 100% 1
9 BEVERLY SACKLER GENET MOL MED 33298 0% 100% 1
10 BIOCHEM OXFORD MOLEC SCI 33298 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3514 6% 0% 52
2 NATURE STRUCTURAL BIOLOGY 3023 1% 1% 12
3 JOURNAL OF MEDICINAL CHEMISTRY 2815 5% 0% 43
4 PROTEIN SCIENCE 2536 2% 0% 22
5 CHEMISTRY & BIOLOGY 2427 2% 1% 14
6 JOURNAL OF MOLECULAR BIOLOGY 2121 4% 0% 39
7 BIOCHEMISTRY 1958 6% 0% 57
8 JOURNAL OF BIOMOLECULAR NMR 1781 1% 0% 12
9 MOLECULAR & CELLULAR PROTEOMICS 1535 1% 0% 12
10 INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 1532 1% 1% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SH3 DOMAIN 610003 10% 20% 93 Search SH3+DOMAIN Search SH3+DOMAIN
2 SH2 DOMAIN 467392 8% 20% 70 Search SH2+DOMAIN Search SH2+DOMAIN
3 GRB2 462733 7% 23% 60 Search GRB2 Search GRB2
4 SH3 208344 4% 19% 33 Search SH3 Search SH3
5 SH2 201417 3% 21% 29 Search SH2 Search SH2
6 GRB2 SH2 DOMAIN 138739 1% 83% 5 Search GRB2+SH2+DOMAIN Search GRB2+SH2+DOMAIN
7 BIACORE X 99893 0% 100% 3 Search BIACORE+X Search BIACORE+X
8 INTERTWINED DIMER 99893 0% 100% 3 Search INTERTWINED+DIMER Search INTERTWINED+DIMER
9 SRC SH2 DOMAIN 99893 0% 100% 3 Search SRC+SH2+DOMAIN Search SRC+SH2+DOMAIN
10 GRB2 SH2 88791 0% 67% 4 Search GRB2+SH2 Search GRB2+SH2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PENG, D , ZHI, Y , XUE, T , GAO, HY , LONG, YQ , (2011) LIGAND-BASED STRUCTURAL OPTIMIZATION OF GRB2-SH2 INHIBITORS: HIGH AFFINITY, LOW CHARGE AND REDUCED PEPTIDIC NATURE.CHINESE JOURNAL OF ORGANIC CHEMISTRY. VOL. 31. ISSUE 12. P. 2019 -2033 49 98% 0
2 BURKE, TR , (2006) DEVELOPMENT OF GRB2 SH2 DOMAIN SIGNALING ANTAGONISTS: A POTENTIAL NEW CLASS OF ANTIPROLIFERATIVE AGENTS.INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. VOL. 12. ISSUE 1. P. 33-48 56 92% 23
3 MULLER, G , (2001) PEPTIDOMIMETIC SH2 DOMAIN ANTAGONISTS FOR TARGETING SIGNAL TRANSDUCTION.BIOORGANIC CHEMISTRY OF BIOLOGICAL SIGNAL TRANSDUCTION. VOL. 211. ISSUE . P. 17 -59 88 56% 24
4 GARCIA-ECHEVERRIA, C , (2001) ANTAGONISTS OF THE SRC HOMOLOGY 2 (SH2) DOMAINS OF GRB2, SRC, LCK AND ZAP-70.CURRENT MEDICINAL CHEMISTRY. VOL. 8. ISSUE 13. P. 1589-1604 67 63% 40
5 LADBURY, JE , AROLD, ST , (2011) ENERGETICS OF SRC HOMOLOGY DOMAIN INTERACTIONS IN RECEPTOR TYROSINE KINASE-MEDIATED SIGNALING.METHODS IN ENZYMOLOGY, VOL 488: BIOTHERMODYNAMICS, PT C. VOL. . ISSUE . P. 147-183 58 56% 7
6 VIDAL, M , GIGOUX, V , GARBAY, C , (2001) SH2 AND SH3 DOMAINS AS TARGETS FOR ANTI-PROLIFERATIVE AGENTS.CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. VOL. 40. ISSUE 2. P. 175-186 62 64% 49
7 LUNG, FDT , TSAI, JY , (2003) GRB2 SH2 DOMAIN-BINDING PEPTIDE ANALOGS AS POTENTIAL ANTICANCER AGENTS.BIOPOLYMERS. VOL. 71. ISSUE 2. P. 132-140 51 75% 16
8 KRASKOUSKAYA, D , DUODU, E , ARPIN, CC , GUNNING, PT , (2013) PROGRESS TOWARDS THE DEVELOPMENT OF SH2 DOMAIN INHIBITORS.CHEMICAL SOCIETY REVIEWS. VOL. 42. ISSUE 8. P. 3337 -3370 86 30% 24
9 FRETZ, H , FURET, P , GARCIA-ECHEVERRIA, C , RAHUEL, J , SCHOEPFER, J , (2000) STRUCTURE-BASED DESIGN OF COMPOUNDS INHIBITING GRB2-SH2 MEDIATED PROTEIN-PROTEIN INTERACTIONS IN SIGNAL TRANSDUCTION PATHWAYS.CURRENT PHARMACEUTICAL DESIGN. VOL. 6. ISSUE 18. P. 1777-1796 51 73% 55
10 MACHIDA, K , MAYER, BJ , (2005) THE SH2 DOMAIN: VERSATILE SIGNALING MODULE AND PHARMACEUTICAL TARGET.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1747. ISSUE 1. P. 1-25 85 33% 134

Classes with closest relation at Level 1


Rank Class id link
1 25087 PHOSPHOPEPTIDE SYNTHESIS//DI T BUTYL N N DIETHYLPHOSPHORAMIDITE//TYRP CONTAINING PEPTIDES
2 17831 P66SHC//SHC//SHC FAMILY
3 13788 SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING
4 21034 GRB7//GRB14//GRB10
5 13570 NEDD9//CRK//CRKL
6 3485 CSK//CSK HOMOLOGOUS KINASE//HEMATOL MED ENZYMOL
7 22610 WWP1//WW DOMAIN//CKIP 1
8 9250 SHP2//SHP 2//SHP 1
9 22654 VAV//VAV1//VAV PROTO ONCOGENE
10 11898 PDZ DOMAIN//SYNTENIN//MAGUK

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