Class information for:
Level 2: PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2172 4962 40.2 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
636 3       TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 12838
2172 2             PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B 4962
1580 1                   PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B 2585
15484 1                   PURPLE ACID PHOSPHATASE//TARTRATE RESISTANT ACID PHOSPHATASE//SPECIAL HEMATOL 710
16020 1                   PROSTATIC ACID PHOSPHATASE//SECT UROL SURG//PROSTATIC PHOSPHATASE 677
20017 1                   ACP1//BIOPATHOL IMAGING DIAGNOST//LMW PTP 480
24694 1                   PARAVEINAL MESOPHYLL//ACID PHOSPHATASE//BRIX ACID RATIO 304
31738 1                   ACYLPHOSPHATASE//ACYLPHOSPHATASE MUTANT//ACYLPHOSPHATASE CATALYTIC MECHANISM 149
37458 1                   4 DIHYDROXYMETHYLPYRIDINE//COPPER NICKEL AND ZINC DETERMINATION//DIAMINEDICHLOROPALLADIUM 57

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN TYROSINE PHOSPHATASE authKW 879311 8% 37% 391
2 PTP1B authKW 674791 4% 57% 192
3 PROTEIN TYROSINE PHOSPHATASE 1B authKW 307629 2% 51% 98
4 PURPLE ACID PHOSPHATASE authKW 246995 1% 63% 64
5 ACP1 authKW 220542 1% 81% 44
6 PTP1B INHIBITOR authKW 169021 1% 60% 46
7 TYROSINE PHOSPHATASE authKW 158081 2% 28% 91
8 ACYLPHOSPHATASE authKW 134013 1% 68% 32
9 TCPTP authKW 130341 1% 76% 28
10 RECEPTOR PROTEIN TYROSINE PHOSPHATASE authKW 117566 1% 66% 29

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 11186 41% 0% 2023
2 Cell Biology 3589 15% 0% 763
3 Chemistry, Medicinal 2317 7% 0% 352
4 Biophysics 1941 8% 0% 405
5 Medical Laboratory Technology 946 3% 0% 126
6 Urology & Nephrology 668 4% 0% 205
7 Endocrinology & Metabolism 634 6% 0% 278
8 Oncology 534 8% 0% 373
9 Genetics & Heredity 270 5% 0% 226
10 Plant Sciences 197 4% 0% 220

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPATHOL IMAGING DIAGNOST 95672 1% 47% 33
2 SPECIAL HEMATOL 77464 0% 55% 23
3 EDMOND H FI ER SIGNAL TRANSDUCT 43146 0% 35% 20
4 PREVENT SOCIAL PEDIAT 33825 0% 50% 11
5 BIOPATHOL HUMAN POPULAT ENVIRONM PATHOL 32805 0% 67% 8
6 DIPARTIMENTO SCI BIOCHIM 28391 1% 9% 50
7 SECT UROL SURG 26040 0% 35% 12
8 KINOME PROFILING UNIT 19685 0% 80% 4
9 MEDCHEM 1 19221 0% 63% 5
10 BIOENSAIOS DINAM CELULAR 18456 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 4751 7% 0% 359
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2775 2% 0% 110
3 PROSTATE 2204 1% 1% 41
4 BIOCHEMISTRY 1464 2% 0% 120
5 MOLECULAR AND CELLULAR NEUROSCIENCE 1333 1% 1% 25
6 ACTA BIOCHIMICA POLONICA 1149 0% 1% 23
7 CLINICAL CHEMISTRY 1118 1% 0% 48
8 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1056 2% 0% 117
9 INVESTIGATIVE UROLOGY 1004 0% 3% 6
10 BIOORGANIC & MEDICINAL CHEMISTRY 963 1% 0% 47

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEIN TYROSINE PHOSPHATASE 879311 8% 37% 391 Search PROTEIN+TYROSINE+PHOSPHATASE Search PROTEIN+TYROSINE+PHOSPHATASE
2 PTP1B 674791 4% 57% 192 Search PTP1B Search PTP1B
3 PROTEIN TYROSINE PHOSPHATASE 1B 307629 2% 51% 98 Search PROTEIN+TYROSINE+PHOSPHATASE+1B Search PROTEIN+TYROSINE+PHOSPHATASE+1B
4 PURPLE ACID PHOSPHATASE 246995 1% 63% 64 Search PURPLE+ACID+PHOSPHATASE Search PURPLE+ACID+PHOSPHATASE
5 ACP1 220542 1% 81% 44 Search ACP1 Search ACP1
6 PTP1B INHIBITOR 169021 1% 60% 46 Search PTP1B+INHIBITOR Search PTP1B+INHIBITOR
7 TYROSINE PHOSPHATASE 158081 2% 28% 91 Search TYROSINE+PHOSPHATASE Search TYROSINE+PHOSPHATASE
8 ACYLPHOSPHATASE 134013 1% 68% 32 Search ACYLPHOSPHATASE Search ACYLPHOSPHATASE
9 TCPTP 130341 1% 76% 28 Search TCPTP Search TCPTP
10 RECEPTOR PROTEIN TYROSINE PHOSPHATASE 117566 1% 66% 29 Search RECEPTOR+PROTEIN+TYROSINE+PHOSPHATASE Search RECEPTOR+PROTEIN+TYROSINE+PHOSPHATASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BLASKOVICH, MAT , (2009) DRUG DISCOVERY AND PROTEIN TYROSINE PHOSPHATASES.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 17. P. 2095 -2176 361 50% 68
2 MACCARI, R , OTTANA, R , (2012) LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASES AS EMERGING TARGETS FOR THE DESIGN OF NOVEL THERAPEUTIC AGENTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 1. P. 2 -22 140 85% 9
3 JANCKILA, AJ , YAM, LT , (2009) BIOLOGY AND CLINICAL SIGNIFICANCE OF TARTRATE-RESISTANT ACID PHOSPHATASES: NEW PERSPECTIVES ON AN OLD ENZYME.CALCIFIED TISSUE INTERNATIONAL. VOL. 85. ISSUE 6. P. 465 -483 132 72% 30
4 LOW, JL , CHAI, CLL , YAO, SQ , (2014) BIDENTATE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 20. ISSUE 14. P. 2225 -2250 102 70% 7
5 SCHENK, G , MITIC, N , HANSON, GR , COMBA, P , (2013) PURPLE ACID PHOSPHATASE: A JOURNEY INTO THE FUNCTION AND MECHANISM OF A COLORFUL ENZYME.COORDINATION CHEMISTRY REVIEWS. VOL. 257. ISSUE 2. P. 473-482 91 75% 22
6 FELDHAMMER, M , UETANI, N , MIRANDA-SAAVEDRA, D , TREMBLAY, ML , (2013) PTP1B: A SIMPLE ENZYME FOR A COMPLEX WORLD.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 48. ISSUE 5. P. 430-445 103 60% 35
7 AHUJA, LG , GOPAL, B , (2014) BI-DOMAIN PROTEIN TYROSINE PHOSPHATASES REVEAL AN EVOLUTIONARY ADAPTATION TO OPTIMIZE SIGNAL TRANSDUCTION.ANTIOXIDANTS & REDOX SIGNALING. VOL. 20. ISSUE 14. P. 2141 -2159 99 73% 1
8 NUNES-XAVIER, CE , MARTIN-PEREZ, J , ELSON, A , PULIDO, R , (2013) PROTEIN TYROSINE PHOSPHATASES AS NOVEL TARGETS IN BREAST CANCER THERAPY.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1836. ISSUE 2. P. 211-226 132 51% 17
9 SHEN, K , QI, LX , STIFF, L , (2010) PEPTIDOMIMETIC COMPETITIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES.CURRENT PHARMACEUTICAL DESIGN. VOL. 16. ISSUE 28. P. 3101-3117 99 78% 4
10 DUBE, N , TREMBLAY, ML , (2005) INVOLVEMENT OF THE SMALL PROTEIN TYROSINE PHOSPHATASES TC-PTP AND PTP1B IN SIGNAL TRANSDUCTION AND DISEASES: FROM DIABETES, OBESITY TO CELL CYCLE, AND CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1754. ISSUE 1-2. P. 108-117 93 84% 79

Classes with closest relation at Level 2


Rank Class id link
1 3893 PRL 3//ATF3//ATF5
2 1574 TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN
3 2228 C MYB//B MYB//SRC
4 1195 JNK//ERK5//MAP KINASE
5 2142 VANADIUM//VANADIUM COMPLEXES//VANADATE
6 4012 N PHOSPHORYL AMINO ACID//BIOORGAN PHOSPHORUS CHEM//PHOSPHOPEPTIDE SYNTHESIS
7 1524 OSTEOCLAST//OSTEOPETROSIS//RANKL
8 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN
9 721 SUPERANTIGEN//IMMUNOLOGY//T CELL RECEPTOR
10 1552 INSULIN RECEPTOR//INSULIN DEGRADING ENZYME//INOSITOL PHOSPHOGLYCAN

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