Class information for:
Level 2: INSULIN RECEPTOR//INSULIN DEGRADING ENZYME//INOSITOL PHOSPHOGLYCAN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1552 7396 34.7 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1552 2             INSULIN RECEPTOR//INSULIN DEGRADING ENZYME//INOSITOL PHOSPHOGLYCAN 7396
1594 1                   INSULIN RECEPTOR//LEPRECHAUNISM//DONOHUE SYNDROME 2574
9990 1                   INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE 1100
10931 1                   MONOMERIC INSULIN//INSULIN MUTANT//FAST ACTING INSULIN 1023
11092 1                   INOSITOL PHOSPHOGLYCAN//D CHIRO INOSITOL//CHIRO INOSITOL 1008
13259 1                   INSULIN AUTOIMMUNE SYNDROME//INSULIN ALLERGY//INSULIN ANTIBODIES 850
16270 1                   PLACENTAL INSULIN RECEPTORS//AARHUS KOMMUNE HOSP OBSTET GYNECOL//BLOOD GROUPING TISSUE TYPING 663
29870 1                   CHAIR INTERNAL MED DIABETOL//AURON MISHIEL THERAPY//CENTER PUBL HLTH GENOM 178

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INSULIN RECEPTOR authKW 227521 4% 21% 269
2 INSULIN DEGRADING ENZYME authKW 179445 1% 49% 88
3 INOSITOL PHOSPHOGLYCAN authKW 119251 0% 85% 34
4 LEPRECHAUNISM authKW 110151 0% 86% 31
5 INSULIN AUTOIMMUNE SYNDROME authKW 103733 0% 93% 27
6 INSULIN ALLERGY authKW 83218 0% 92% 22
7 D CHIRO INOSITOL authKW 74307 0% 51% 35
8 INSULIN ANTIBODIES authKW 65987 0% 44% 36
9 DONOHUE SYNDROME authKW 53920 0% 93% 14
10 INSULIN DEGRADATION authKW 51414 0% 69% 18

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Endocrinology & Metabolism 38988 28% 0% 2104
2 Biochemistry & Molecular Biology 16401 40% 0% 2994
3 Biophysics 4765 10% 0% 749
4 Cell Biology 1153 8% 0% 621
5 Medicine, Research & Experimental 396 4% 0% 292
6 Medicine, General & Internal 332 5% 0% 361
7 Physiology 300 3% 0% 240
8 Biology 215 2% 0% 167
9 CYTOLOGY & HISTOLOGY 37 0% 0% 10
10 Biochemical Research Methods 35 2% 0% 130

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABET PROT ENGN 21209 0% 43% 12
2 INSULIN 18561 0% 50% 9
3 RECEPTOR SYST BIOL 16044 0% 32% 12
4 MED INTERNAL MED 3731 HONGOBUNKYO KU 14735 0% 71% 5
5 MICHAEL CHEM 13204 0% 80% 4
6 EXPT BIOTECHNOL PLANT 12380 0% 100% 3
7 SCI PEDIAT ADOLESCENZA 12380 0% 100% 3
8 RECEPTOR CELL BIOL 11459 0% 56% 5
9 GRP CARBOHIDRATOS 10648 0% 17% 15
10 S MED PHYS 9284 0% 75% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES 33333 4% 3% 313
2 DIABETOLOGIA 12974 2% 2% 163
3 JOURNAL OF BIOLOGICAL CHEMISTRY 11028 9% 0% 659
4 ENDOCRINOLOGY 9891 3% 1% 248
5 HORMONE AND METABOLIC RESEARCH 8160 2% 2% 113
6 DIABETES CARE 7278 2% 1% 144
7 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 7009 1% 5% 37
8 BIOCHEMICAL JOURNAL 6390 3% 1% 218
9 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 5169 4% 0% 303
10 METABOLISM-CLINICAL AND EXPERIMENTAL 4966 1% 1% 105

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INSULIN RECEPTOR 227521 4% 21% 269 Search INSULIN+RECEPTOR Search INSULIN+RECEPTOR
2 INSULIN DEGRADING ENZYME 179445 1% 49% 88 Search INSULIN+DEGRADING+ENZYME Search INSULIN+DEGRADING+ENZYME
3 INOSITOL PHOSPHOGLYCAN 119251 0% 85% 34 Search INOSITOL+PHOSPHOGLYCAN Search INOSITOL+PHOSPHOGLYCAN
4 LEPRECHAUNISM 110151 0% 86% 31 Search LEPRECHAUNISM Search LEPRECHAUNISM
5 INSULIN AUTOIMMUNE SYNDROME 103733 0% 93% 27 Search INSULIN+AUTOIMMUNE+SYNDROME Search INSULIN+AUTOIMMUNE+SYNDROME
6 INSULIN ALLERGY 83218 0% 92% 22 Search INSULIN+ALLERGY Search INSULIN+ALLERGY
7 D CHIRO INOSITOL 74307 0% 51% 35 Search D+CHIRO+INOSITOL Search D+CHIRO+INOSITOL
8 INSULIN ANTIBODIES 65987 0% 44% 36 Search INSULIN+ANTIBODIES Search INSULIN+ANTIBODIES
9 DONOHUE SYNDROME 53920 0% 93% 14 Search DONOHUE+SYNDROME Search DONOHUE+SYNDROME
10 INSULIN DEGRADATION 51414 0% 69% 18 Search INSULIN+DEGRADATION Search INSULIN+DEGRADATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DUCKWORTH, WC , BENNETT, RG , HAMEL, FG , (1998) INSULIN DEGRADATION: PROGRESS AND POTENTIAL.ENDOCRINE REVIEWS. VOL. 19. ISSUE 5. P. 608 -624 160 77% 394
2 TAYLOR, SI , CAMA, A , ACCILI, D , BARBETTI, F , QUON, MJ , SIERRA, MD , SUZUKI, Y , KOLLER, E , LEVYTOLEDANO, R , WERTHEIMER, E , ET AL (1992) MUTATIONS IN THE INSULIN-RECEPTOR GENE.ENDOCRINE REVIEWS. VOL. 13. ISSUE 3. P. 566-595 151 93% 184
3 LEE, JS , PILCH, PF , (1994) THE INSULIN-RECEPTOR - STRUCTURE, FUNCTION, AND SIGNALING.AMERICAN JOURNAL OF PHYSIOLOGY. VOL. 266. ISSUE 2. P. C319-C334 143 72% 174
4 TAVARE, JM , SIDDLE, K , (1993) MUTATIONAL ANALYSIS OF INSULIN-RECEPTOR FUNCTION - CONSENSUS AND CONTROVERSY.BIOCHIMICA ET BIOPHYSICA ACTA. VOL. 1178. ISSUE 1. P. 21 -39 141 84% 82
5 VASHISTH, H , ABRAMS, CF , (2013) ALL-ATOM STRUCTURAL MODELS OF INSULIN BINDING TO THE INSULIN RECEPTOR IN THE PRESENCE OF A TANDEM HORMONE-BINDING ELEMENT.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. VOL. 81. ISSUE 6. P. 1017 -1030 77 86% 7
6 WARD, CW , MENTING, JG , LAWRENCE, MC , (2013) THE INSULIN RECEPTOR CHANGES CONFORMATION IN UNFORESEEN WAYS ON LIGAND BINDING: SHARPENING THE PICTURE OF INSULIN RECEPTOR ACTIVATION.BIOESSAYS. VOL. 35. ISSUE 11. P. 945 -954 70 88% 19
7 KAHN, CR , WHITE, MF , SHOELSON, SE , BACKER, JM , ARAKI, E , CHEATHAM, B , CSERMELY, P , FOLLI, F , GOLDSTEIN, BJ , HUERTAS, P , ET AL (1993) THE INSULIN-RECEPTOR AND ITS SUBSTRATE - MOLECULAR DETERMINANTS OF EARLY EVENTS IN INSULIN ACTION.RECENT PROGRESS IN HORMONE RESEARCH, VOL 48. VOL. 48. ISSUE . P. 291-339 142 76% 78
8 DE MEYTS, P , (2015) INSULIN/RECEPTOR BINDING: THE LAST PIECE OF THE PUZZLE?.BIOESSAYS. VOL. 37. ISSUE 4. P. 389 -397 57 90% 11
9 DUCKWORTH, WC , (1988) INSULIN DEGRADATION - MECHANISMS, PRODUCTS, AND SIGNIFICANCE.ENDOCRINE REVIEWS. VOL. 9. ISSUE 3. P. 319-345 176 62% 250
10 DE MEYTS, P , WHITTAKER, J , (2002) STRUCTURAL BIOLOGY OF INSULIN AND IGF1 RECEPTORS: IMPLICATIONS FOR DRUG DESIGN.NATURE REVIEWS DRUG DISCOVERY. VOL. 1. ISSUE 10. P. 769-783 89 68% 292

Classes with closest relation at Level 2


Rank Class id link
1 684 GLUT4//AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM//GLUCOSE TRANSPORT
2 2464 STREPTOZOTOCIN//KANGEN KARYU//HYPERCYTOLIPIDEMIA
3 3581 PHOSPHOENOLPYRUVATE CARBOXYKINASE//GLYCERONEOGENESIS//BROWN ADIPOSE TISSUE HEMIDENERVATION
4 1896 METFORMIN//ACARBOSE//REPAGLINIDE
5 1648 EPIDERMAL GROWTH FACTOR//HB EGF//TRANSFORMING GROWTH FACTOR ALPHA
6 3012 MANNOSE RECEPTOR//ENDO180//ASIALOGLYCOPROTEIN RECEPTOR
7 92 GROWTH HORMONE//GROWTH HORMONE & IGF RESEARCH//ENDOCRINOLOGY & METABOLISM
8 3219 OLEOYL ESTRONE//JCR LA CP RAT//HERITAGE MED 275
9 2228 C MYB//B MYB//SRC
10 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN

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