Class information for:
Level 1: PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1580 2585 47.8 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
636 3       TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN 12838
2172 2             PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B 4962
1580 1                   PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B 2585

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN TYROSINE PHOSPHATASE authKW 1520223 14% 35% 371
2 PTP1B authKW 1295638 7% 57% 192
3 PROTEIN TYROSINE PHOSPHATASE 1B authKW 578690 4% 51% 97
4 PTP1B INHIBITOR authKW 324527 2% 60% 46
5 TYROSINE PHOSPHATASE authKW 258684 3% 26% 84
6 TCPTP authKW 250246 1% 76% 28
7 RECEPTOR PROTEIN TYROSINE PHOSPHATASE authKW 225726 1% 66% 29
8 PTPIP51 authKW 200782 1% 100% 17
9 LAR authKW 160714 1% 39% 35
10 PROTEIN TYROSINE PHOSPHATASE 1B PTP1B authKW 118353 1% 48% 21

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 7860 46% 0% 1201
2 Chemistry, Medicinal 4275 13% 0% 326
3 Cell Biology 3930 21% 0% 549
4 Biophysics 711 7% 0% 182
5 Oncology 433 9% 0% 227
6 Chemistry, Organic 370 7% 0% 182
7 Developmental Biology 233 2% 0% 59
8 Genetics & Heredity 230 5% 0% 139
9 Endocrinology & Metabolism 206 5% 0% 122
10 Biochemical Research Methods 150 4% 0% 91

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EDMOND H FI ER SIGNAL TRANSDUCT 82856 1% 35% 20
2 MEDCHEM 1 36905 0% 63% 5
3 47R 31493 0% 67% 4
4 MEDCHEM 4 29522 0% 50% 5
5 MCGILL CANC 28177 1% 8% 31
6 MEDDORRANCE H HAMILTON S 22370 0% 32% 6
7 DRUG SCREENING 19649 1% 6% 28
8 CHEM GENOM CORE IL 19318 0% 27% 6
9 GOODMAN CANC 18806 1% 6% 28
10 MCGILL GOODMAN CANC 15746 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5024 4% 0% 105
2 JOURNAL OF BIOLOGICAL CHEMISTRY 5015 10% 0% 261
3 MOLECULAR AND CELLULAR NEUROSCIENCE 2604 1% 1% 25
4 METHODS 1679 1% 1% 21
5 BIOORGANIC & MEDICINAL CHEMISTRY 1609 2% 0% 43
6 MOLECULAR AND CELLULAR BIOLOGY 1459 2% 0% 54
7 ONCOGENE 1030 2% 0% 41
8 BIOCHEMISTRY 914 3% 0% 68
9 FEBS JOURNAL 843 1% 0% 20
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 699 3% 0% 68

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEIN TYROSINE PHOSPHATASE 1520223 14% 35% 371 Search PROTEIN+TYROSINE+PHOSPHATASE Search PROTEIN+TYROSINE+PHOSPHATASE
2 PTP1B 1295638 7% 57% 192 Search PTP1B Search PTP1B
3 PROTEIN TYROSINE PHOSPHATASE 1B 578690 4% 51% 97 Search PROTEIN+TYROSINE+PHOSPHATASE+1B Search PROTEIN+TYROSINE+PHOSPHATASE+1B
4 PTP1B INHIBITOR 324527 2% 60% 46 Search PTP1B+INHIBITOR Search PTP1B+INHIBITOR
5 TYROSINE PHOSPHATASE 258684 3% 26% 84 Search TYROSINE+PHOSPHATASE Search TYROSINE+PHOSPHATASE
6 TCPTP 250246 1% 76% 28 Search TCPTP Search TCPTP
7 RECEPTOR PROTEIN TYROSINE PHOSPHATASE 225726 1% 66% 29 Search RECEPTOR+PROTEIN+TYROSINE+PHOSPHATASE Search RECEPTOR+PROTEIN+TYROSINE+PHOSPHATASE
8 PTPIP51 200782 1% 100% 17 Search PTPIP51 Search PTPIP51
9 LAR 160714 1% 39% 35 Search LAR Search LAR
10 PROTEIN TYROSINE PHOSPHATASE 1B PTP1B 118353 1% 48% 21 Search PROTEIN+TYROSINE+PHOSPHATASE+1B+PTP1B Search PROTEIN+TYROSINE+PHOSPHATASE+1B+PTP1B

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BLASKOVICH, MAT , (2009) DRUG DISCOVERY AND PROTEIN TYROSINE PHOSPHATASES.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 17. P. 2095 -2176 347 48% 68
2 LOW, JL , CHAI, CLL , YAO, SQ , (2014) BIDENTATE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 20. ISSUE 14. P. 2225 -2250 102 70% 7
3 FELDHAMMER, M , UETANI, N , MIRANDA-SAAVEDRA, D , TREMBLAY, ML , (2013) PTP1B: A SIMPLE ENZYME FOR A COMPLEX WORLD.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 48. ISSUE 5. P. 430-445 103 60% 35
4 AHUJA, LG , GOPAL, B , (2014) BI-DOMAIN PROTEIN TYROSINE PHOSPHATASES REVEAL AN EVOLUTIONARY ADAPTATION TO OPTIMIZE SIGNAL TRANSDUCTION.ANTIOXIDANTS & REDOX SIGNALING. VOL. 20. ISSUE 14. P. 2141 -2159 99 73% 1
5 NUNES-XAVIER, CE , MARTIN-PEREZ, J , ELSON, A , PULIDO, R , (2013) PROTEIN TYROSINE PHOSPHATASES AS NOVEL TARGETS IN BREAST CANCER THERAPY.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1836. ISSUE 2. P. 211-226 132 51% 17
6 SHEN, K , QI, LX , STIFF, L , (2010) PEPTIDOMIMETIC COMPETITIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES.CURRENT PHARMACEUTICAL DESIGN. VOL. 16. ISSUE 28. P. 3101-3117 99 78% 4
7 DUBE, N , TREMBLAY, ML , (2005) INVOLVEMENT OF THE SMALL PROTEIN TYROSINE PHOSPHATASES TC-PTP AND PTP1B IN SIGNAL TRANSDUCTION AND DISEASES: FROM DIABETES, OBESITY TO CELL CYCLE, AND CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1754. ISSUE 1-2. P. 108-117 93 84% 79
8 TIGANIS, T , (2013) PTP1B AND TCPTP - NONREDUNDANT PHOSPHATASES IN INSULIN SIGNALING AND GLUCOSE HOMEOSTASIS.FEBS JOURNAL. VOL. 280. ISSUE 2. P. 445-458 87 66% 41
9 LABBE, DP , HARDY, S , TREMBLAY, ML , (2012) PROTEIN TYROSINE PHOSPHATASES IN CANCER: FRIENDS AND FOES!.PROTEIN PHOSPHORYLATION IN HEALTH AND DISEASE. VOL. 106. ISSUE . P. 253-306 150 45% 12
10 LESSARD, L , STUIBLE, M , TREMBLAY, ML , (2010) THE TWO FACES OF PTP1B IN CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1804. ISSUE 3. P. 613 -619 79 77% 79

Classes with closest relation at Level 1


Rank Class id link
1 20017 ACP1//BIOPATHOL IMAGING DIAGNOST//LMW PTP
2 9250 SHP2//SHP 2//SHP 1
3 26440 PRL 3//PHOSPHATASE OF REGENERATING LIVER 3//PRL 1
4 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
5 9463 CD45//CD45 ISOFORMS//LEUKOCYTE COMMON ANTIGEN
6 15937 CDC25B//CDC25 PHOSPHATASE//CDC25A
7 15666 PTPN22//PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 22//PTPN22 GENE
8 17383 BY KINASE//BACTERIAL PROTEIN KINASES//BACTERIAL PROTEIN PHOSPHORYLATION
9 30436 SYMPHYOCLADIA LATIUSCULA//BROMOPHENOLS//RHODOMELA CONFERVOIDES
10 12290 SH3 DOMAIN//SH2 DOMAIN//GRB2

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