Class information for:
Level 1: ASK1//PP5//PROTEIN PHOSPHATASE 5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22795 368 42.7 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
22795 1                   ASK1//PP5//PROTEIN PHOSPHATASE 5 368

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ASK1 authKW 2372520 21% 38% 76
2 PP5 authKW 995697 5% 67% 18
3 PROTEIN PHOSPHATASE 5 authKW 685125 5% 49% 17
4 APOPTOSIS SIGNAL REGULATING KINASE 1 authKW 571727 6% 33% 21
5 APOPTOSIS SIGNAL REGULATING KINASE 1 ASK1 authKW 519489 3% 52% 12
6 PPP5C authKW 248927 1% 100% 3
7 PHARMACEUT SCI STRATEG PROACH DRUG DIS address 186694 1% 75% 3
8 APOPTOSIS SIGNAL REGULATED KINASE 1 authKW 165952 1% 100% 2
9 ASK1 INHIBITOR authKW 165952 1% 100% 2
10 PHARMACEUT SCI CELL SIGNALINGBUNKYO address 165952 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1700 56% 0% 206
2 Cell Biology 1031 28% 0% 103
3 Biophysics 144 8% 0% 30
4 Oncology 45 8% 0% 29
5 Peripheral Vascular Diseases 27 3% 0% 12
6 Chemistry, Medicinal 26 3% 0% 12
7 Neurosciences 21 7% 0% 26
8 Endocrinology & Metabolism 19 4% 0% 15
9 Biochemical Research Methods 17 3% 0% 12
10 Pharmacology & Pharmacy 9 6% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUT SCI STRATEG PROACH DRUG DIS 186694 1% 75% 3
2 PHARMACEUT SCI CELL SIGNALINGBUNKYO 165952 1% 100% 2
3 CELL SIGNALING 159323 14% 4% 53
4 C TJ AN SCI TECHNOL CORPBUNKYO KU 110633 1% 67% 2
5 SECT ALLERGOL IMMUNOL 110633 1% 67% 2
6 BIOMATRIX BUNKYO KU 82976 0% 100% 1
7 BIOMATRIX CELL SIGNALING 82976 0% 100% 1
8 BIOMED SCI LIFE SCIMINIST EDUC 82976 0% 100% 1
9 BK BIOBC 21 82976 0% 100% 1
10 BOTNER 82976 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SLAS DISCOVERY 3949 0% 5% 1
2 ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 1087 1% 0% 3
3 JOURNAL OF BIOLOGICAL CHEMISTRY 1017 12% 0% 44
4 CELL DEATH AND DIFFERENTIATION 647 1% 0% 5
5 JOURNAL OF CELLULAR BIOCHEMISTRY 445 2% 0% 7
6 MOLECULAR AND CELLULAR BIOLOGY 435 3% 0% 11
7 ANTIOXIDANTS & REDOX SIGNALING 424 1% 0% 4
8 BMC CELL BIOLOGY 414 1% 0% 2
9 JOURNAL OF FOOD AND DRUG ANALYSIS 244 1% 0% 2
10 EXPERT OPINION ON THERAPEUTIC TARGETS 238 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ASK1 2372520 21% 38% 76 Search ASK1 Search ASK1
2 PP5 995697 5% 67% 18 Search PP5 Search PP5
3 PROTEIN PHOSPHATASE 5 685125 5% 49% 17 Search PROTEIN+PHOSPHATASE+5 Search PROTEIN+PHOSPHATASE+5
4 APOPTOSIS SIGNAL REGULATING KINASE 1 571727 6% 33% 21 Search APOPTOSIS+SIGNAL+REGULATING+KINASE+1 Search APOPTOSIS+SIGNAL+REGULATING+KINASE+1
5 APOPTOSIS SIGNAL REGULATING KINASE 1 ASK1 519489 3% 52% 12 Search APOPTOSIS+SIGNAL+REGULATING+KINASE+1+ASK1 Search APOPTOSIS+SIGNAL+REGULATING+KINASE+1+ASK1
6 PPP5C 248927 1% 100% 3 Search PPP5C Search PPP5C
7 APOPTOSIS SIGNAL REGULATED KINASE 1 165952 1% 100% 2 Search APOPTOSIS+SIGNAL+REGULATED+KINASE+1 Search APOPTOSIS+SIGNAL+REGULATED+KINASE+1
8 ASK1 INHIBITOR 165952 1% 100% 2 Search ASK1+INHIBITOR Search ASK1+INHIBITOR
9 ASK2 149354 1% 60% 3 Search ASK2 Search ASK2
10 APOPTOSIS SIGNAL REGULATING KINASE 110633 1% 67% 2 Search APOPTOSIS+SIGNAL+REGULATING+KINASE Search APOPTOSIS+SIGNAL+REGULATING+KINASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SAKAUCHI, C , WAKATSUKI, H , ICHIJO, H , HATTORI, K , (2017) PLEIOTROPIC PROPERTIES OF ASK1.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1861. ISSUE 1. P. 3030 -3038 59 55% 0
2 HONG, TJ , PARK, K , CHOI, EW , HAHN, JS , (2017) RO 90-7501 INHIBITS PP5 THROUGH A NOVEL, TPR-DEPENDENT MECHANISM.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. VOL. 482. ISSUE 2. P. 215 -220 22 71% 0
3 ZEKE, T , MORRICE, N , VAZQUEZ-MARTIN, C , COHEN, PTW , (2005) HUMAN PROTEIN PHOSPHATASE 5 DISSOCIATES FROM HEAT-SHOCK PROTEINS AND IS PROTEOLYTICALLY ACTIVATED IN RESPONSE TO ARACHIDONIC ACID AND THE MICROTUBULE-DEPOLYMERIZING DRUG NOCODAZOLE.BIOCHEMICAL JOURNAL. VOL. 385. ISSUE . P. 45-56 30 65% 22
4 YANG, J , ROE, SM , CLIFF, MJ , WILLIAMS, MA , LADBURY, JE , COHEN, PTW , BARFORD, D , (2005) MOLECULAR BASIS FOR TPR DOMAIN-MEDIATED REGULATION OF PROTEIN PHOSPHATASE.EMBO JOURNAL. VOL. 24. ISSUE 1. P. 1 -10 29 57% 104
5 FENG, L , SUN, P , LI, ZY , LIU, M , SUN, SB , (2015) KNOCKDOWN OF PPP5C INHIBITS GROWTH OF HEPATOCELLULAR CARCINOMA CELLS IN VITRO.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. VOL. 175. ISSUE 1. P. 526 -534 18 78% 1
6 KAWARAZAKI, Y , ICHIJO, H , NAGURO, I , (2014) APOPTOSIS SIGNAL-REGULATING KINASE 1 AS A THERAPEUTIC TARGET.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 18. ISSUE 6. P. 651 -664 34 37% 17
7 TAKEDA, K , NOGUCHI, T , NAGURO, I , ICHIJO, H , (2008) APOPTOSIS SIGNAL-REGULATING KINASE 1 IN STRESS AND IMMUNE RESPONSE.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 48. ISSUE . P. 199-225 40 35% 72
8 GOLDEN, T , SWINGLE, M , HONKANEN, RE , (2008) THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASE TYPE 5 (PP5) IN THE REGULATION OF STRESS-INDUCED SIGNALING NETWORKS AND CANCER.CANCER AND METASTASIS REVIEWS. VOL. 27. ISSUE 2. P. 169 -178 32 46% 28
9 CHEN, M , QU, XS , ZHANG, ZQ , WU, HY , QIN, X , LI, FJ , LIU, ZF , TIAN, LY , MIAO, JH , SHU, W , (2016) CROSS-TALK BETWEEN ARG METHYLATION AND SER PHOSPHORYLATION MODULATES APOPTOSIS SIGNAL-REGULATING KINASE 1 ACTIVATION IN ENDOTHELIAL CELLS.MOLECULAR BIOLOGY OF THE CELL. VOL. 27. ISSUE 8. P. 1358 -1366 19 56% 3
10 HAYAKAWA, R , HAYAKAWA, T , TAKEDA, K , ICHIJO, H , (2012) THERAPEUTIC TARGETS IN THE ASK1-DEPENDENT STRESS SIGNALING PATHWAYS.PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES. VOL. 88. ISSUE 8. P. 434 -453 42 30% 20

Classes with closest relation at Level 1


Rank Class id link
1 5457 JNK//MKK4//C JUN N TERMINAL KINASE
2 29710 DISABLED 2//DAB2IP//DOC 2
3 9167 CIP2A//PP2A//PROTEIN PHOSPHATASE 2A
4 24258 TAK1//TAB1//TGF BETA ACTIVATED KINASE 1
5 4034 THIOREDOXIN//BIOL PONSES//THIOREDOXIN REDUCTASE
6 36172 TLX//NR2E1//TAILLESS
7 24101 MIXED LINEAGE KINASE//RPM 1//DLK
8 17952 TRAF4//TRAF6//TRAF2
9 23185 WIP1//PPM1D//CELL CYCLE CONTROL TUMORIGENESIS GRP
10 23435 TOPK//PBK TOPK//MELK

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