Class information for:
Level 1: RAP1//EPAC//EPAC1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11178 1002 50.2 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
1911 2             FARNESYLTRANSFERASE//RAS//RAL 5888
11178 1                   RAP1//EPAC//EPAC1 1002

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RAP1 authKW 997131 9% 35% 94
2 EPAC authKW 915976 7% 43% 70
3 EPAC1 authKW 529028 2% 69% 25
4 EPAC2 authKW 271040 1% 68% 13
5 RAP2B authKW 253937 1% 83% 10
6 RAP2 authKW 204837 1% 61% 11
7 EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP EPAC authKW 121884 1% 50% 8
8 PDZ GEF authKW 97512 0% 80% 4
9 RAP GTPASE authKW 97512 0% 80% 4
10 RAP1 GTPASE authKW 97512 0% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 3637 32% 0% 316
2 Biochemistry & Molecular Biology 3009 46% 0% 463
3 Oncology 297 11% 0% 109
4 Hematology 271 6% 0% 58
5 Physiology 259 6% 0% 65
6 Biophysics 252 7% 0% 68
7 Neurosciences 125 9% 0% 91
8 Endocrinology & Metabolism 115 5% 0% 54
9 Peripheral Vascular Diseases 74 3% 0% 33
10 Genetics & Heredity 36 4% 0% 40

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMED GENET 92699 7% 5% 66
2 UCCC DNA SEQUENCING ANAL CORE 91419 0% 100% 3
3 MOL CANC CANC GENOM NETHERLANDS 69649 0% 57% 4
4 SUSAN LEHMAN CULLEN CANC 68562 0% 75% 3
5 INTEGRAT BIOL PHARMACOLTEXAS THER EUT IN 60946 0% 100% 2
6 U PHYSIOPATHOL CARDIOVASC 637 60946 0% 100% 2
7 MOL IMMUNOL ALLERGY 54170 0% 44% 4
8 UMR S769 47607 0% 31% 5
9 TEXAS THER EUT 42855 1% 13% 11
10 CELLULAR MOL BIOL REPROD 40629 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 3770 14% 0% 139
2 CELLULAR SIGNALLING 3669 2% 1% 23
3 MOLECULAR AND CELLULAR BIOLOGY 1924 4% 0% 38
4 CELL ADHESION & MIGRATION 1286 0% 1% 5
5 SCIENCE SIGNALING 954 1% 0% 7
6 ISLETS 940 0% 1% 3
7 ONCOGENE 856 2% 0% 23
8 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 628 4% 0% 39
9 MOLECULAR BIOLOGY OF THE CELL 424 1% 0% 11
10 ACTA PHYSIOLOGICA 364 0% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RAP1 997131 9% 35% 94 Search RAP1 Search RAP1
2 EPAC 915976 7% 43% 70 Search EPAC Search EPAC
3 EPAC1 529028 2% 69% 25 Search EPAC1 Search EPAC1
4 EPAC2 271040 1% 68% 13 Search EPAC2 Search EPAC2
5 RAP2B 253937 1% 83% 10 Search RAP2B Search RAP2B
6 RAP2 204837 1% 61% 11 Search RAP2 Search RAP2
7 EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP EPAC 121884 1% 50% 8 Search EXCHANGE+PROTEIN+DIRECTLY+ACTIVATED+BY+CAMP+EPAC Search EXCHANGE+PROTEIN+DIRECTLY+ACTIVATED+BY+CAMP+EPAC
8 PDZ GEF 97512 0% 80% 4 Search PDZ+GEF Search PDZ+GEF
9 RAP GTPASE 97512 0% 80% 4 Search RAP+GTPASE Search RAP+GTPASE
10 RAP1 GTPASE 97512 0% 80% 4 Search RAP1+GTPASE Search RAP1+GTPASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BRECKLER, M , BERTHOUZE, M , LAURENT, AC , CROZATIER, B , MOREL, E , LEZOUALC'H, F , (2011) RAP-LINKED CAMP SIGNALING EPAC PROTEINS: COMPARTMENTATION, FUNCTIONING AND DISEASE IMPLICATIONS.CELLULAR SIGNALLING. VOL. 23. ISSUE 8. P. 1257-1266 111 71% 59
2 GLOERICH, M , BOS, JL , (2010) EPAC: DEFINING A NEW MECHANISM FOR CAMP ACTION.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 50. ISSUE . P. 355-375 88 63% 233
3 SCHMIDT, M , DEKKER, FJ , MAARSINGH, H , (2013) EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP (EPAC): A MULTIDOMAIN CAMP MEDIATOR IN THE REGULATION OF DIVERSE BIOLOGICAL FUNCTIONS.PHARMACOLOGICAL REVIEWS. VOL. 65. ISSUE 2. P. 670-709 159 39% 59
4 LEZOUALC'H, F , FAZAL, L , LAUDETTE, M , CONTE, C , (2016) CYCLIC AMP SENSOR EPAC PROTEINS AND THEIR ROLE IN CARDIOVASCULAR FUNCTION AND DISEASE.CIRCULATION RESEARCH. VOL. 118. ISSUE 5. P. 881 -897 95 68% 2
5 CHEN, HJ , WILD, C , ZHOU, XB , YE, N , CHENG, XD , ZHOU, J , (2014) RECENT ADVANCES IN THE DISCOVERY OF SMALL MOLECULES TARGETING EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPAC).JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 9. P. 3651 -3665 94 68% 5
6 BANERJEE, U , CHENG, XD , (2015) EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP ENCODED BY THE MAMMALIAN RAPGEF3 GENE: STRUCTURE, FUNCTION AND THERAPEUTICS.GENE. VOL. 570. ISSUE 2. P. 157 -167 73 79% 3
7 SUGAWARA, K , SHIBASAKI, T , TAKAHASHI, H , SEINO, S , (2016) STRUCTURE AND FUNCTIONAL ROLES OF EPAC2 (RAPGEF4).GENE. VOL. 575. ISSUE 2. P. 577 -583 67 70% 2
8 BORLAND, G , SMITH, BO , YARWOOD, SJ , (2009) EPAC PROTEINS TRANSDUCE DIVERSE CELLULAR ACTIONS OF CAMP.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 158. ISSUE 1. P. 70 -86 89 51% 72
9 GRANDOCH, M , ROSCIONI, SS , SCHMIDT, M , (2010) THE ROLE OF EPAC PROTEINS, NOVEL CAMP MEDIATORS, IN THE REGULATION OF IMMUNE, LUNG AND NEURONAL FUNCTION.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 159. ISSUE 2. P. 265 -284 94 45% 67
10 ALMAHARIQ, M , TSALKOVA, T , MEI, FC , CHEN, HJ , ZHOU, J , SASTRY, SK , SCHWEDE, F , CHENG, XD , (2013) A NOVEL EPAC-SPECIFIC INHIBITOR SUPPRESSES PANCREATIC CANCER CELL MIGRATION AND INVASION.MOLECULAR PHARMACOLOGY. VOL. 83. ISSUE 1. P. 122-128 41 84% 49

Classes with closest relation at Level 1


Rank Class id link
1 4031 RAS//RAS PROTEINS//ONCOGENIC RAS P21
2 14252 RAL//EXOCYST//RLIP76
3 13570 NEDD9//CRK//CRKL
4 11840 AKAP//A KINASE ANCHORING PROTEIN//GRAVIN
5 28520 MAP4K4//TNIK//MST3
6 11748 RAF//LEO JENKINS CANC//KSR1
7 6389 KINDLIN//KINDLIN 2//TALIN
8 24211 BRMS1//BREAST CANCER METASTASIS SUPPRESSOR 1//SIN3
9 3603 CELLULAR BIOCHEM SECT//CAMP DEPENDENT PROTEIN KINASE//8 CHLORO ADENOSINE
10 10163 ADENYLYL CYCLASE//ABT PHARMAZEUT BIOCHEM//ADENYLYL CYCLASE ISOFORMS

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