Class information for:
Level 1: TBRPDEB1//TARGET REPURPOSING//ANTIINFECT SCREENING CORE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24640 305 32.1 59%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
326 3       LEISHMANIA//TRYPANOSOMA CRUZI//PARASITIOLOGY 38360
108 2             TRYPANOSOMA CRUZI//CHAGAS DISEASE//PARASITIOLOGY 25255
24640 1                   TBRPDEB1//TARGET REPURPOSING//ANTIINFECT SCREENING CORE 305

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TBRPDEB1 authKW 600693 2% 100% 6
2 TARGET REPURPOSING authKW 400462 1% 100% 4
3 ANTIINFECT SCREENING CORE address 320368 1% 80% 4
4 CYCLIC NUCLEOTIDE SPECIFIC PHOSPHODIESTERASES authKW 200231 1% 100% 2
5 IOTA PHARMACEUT address 200231 1% 100% 2
6 METHOXY AMIDINE authKW 200231 1% 100% 2
7 OSWALDO ARANHA FDN address 200231 1% 100% 2
8 TBRPDEB2 authKW 200231 1% 100% 2
9 EGAN 417 address 200227 1% 50% 4
10 CYCLIC NUCLEOTIDE SIGNALLING authKW 133486 1% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Parasitiology 3865 22% 0% 66
2 Biochemistry & Molecular Biology 1202 52% 0% 159
3 Chemistry, Medicinal 295 10% 0% 30
4 Biophysics 198 10% 0% 31
5 Microbiology 171 11% 0% 34
6 CYTOLOGY & HISTOLOGY 114 1% 0% 3
7 Tropical Medicine 103 3% 0% 9
8 Mycology 86 2% 0% 7
9 Cell Biology 73 10% 0% 30
10 Zoology 21 4% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIINFECT SCREENING CORE 320368 1% 80% 4
2 IOTA PHARMACEUT 200231 1% 100% 2
3 OSWALDO ARANHA FDN 200231 1% 100% 2
4 EGAN 417 200227 1% 50% 4
5 ANDERSON WELLCOME UNIT MOLEC PARASITOL 100115 0% 100% 1
6 INSERMBIOSTRUCT DRUG DISCOVERY U761 100115 0% 100% 1
7 OSWLADO CRUZ 100115 0% 100% 1
8 BIOPHYS BIOCHEM PARASITOL SECT 50057 0% 50% 1
9 INVEST INGN GENET BIOL MOLEC 50057 0% 50% 1
10 SERV CHIM THER EUT 50057 0% 50% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 12839 9% 0% 27
2 REVIEWS IN BIOCHEMICAL TOXICOLOGY 4170 0% 4% 1
3 EXPERIMENTAL PARASITOLOGY 3938 5% 0% 14
4 EXPERIMENTAL MYCOLOGY 3829 2% 1% 5
5 SECOND MESSENGERS AND PHOSPHOPROTEINS 1667 0% 2% 1
6 ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES 1637 1% 1% 2
7 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 1280 2% 0% 5
8 MOLECULAR AND CELLULAR BIOCHEMISTRY 857 3% 0% 9
9 MOLECULAR INTERVENTIONS 839 0% 1% 1
10 JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY 835 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TBRPDEB1 600693 2% 100% 6 Search TBRPDEB1 Search TBRPDEB1
2 TARGET REPURPOSING 400462 1% 100% 4 Search TARGET+REPURPOSING Search TARGET+REPURPOSING
3 CYCLIC NUCLEOTIDE SPECIFIC PHOSPHODIESTERASES 200231 1% 100% 2 Search CYCLIC+NUCLEOTIDE+SPECIFIC+PHOSPHODIESTERASES Search CYCLIC+NUCLEOTIDE+SPECIFIC+PHOSPHODIESTERASES
4 METHOXY AMIDINE 200231 1% 100% 2 Search METHOXY+AMIDINE Search METHOXY+AMIDINE
5 TBRPDEB2 200231 1% 100% 2 Search TBRPDEB2 Search TBRPDEB2
6 CYCLIC NUCLEOTIDE SIGNALLING 133486 1% 67% 2 Search CYCLIC+NUCLEOTIDE+SIGNALLING Search CYCLIC+NUCLEOTIDE+SIGNALLING
7 1 6 17 BETA 3 METHOXYESTRA 1 3 510 TRIEN 17 YLAMINOHEXYI 1H PYRROLE 2 5 DIONE 100115 0% 100% 1 Search 1+6+17+BETA+3+METHOXYESTRA+1+3+510+TRIEN+17+YLAMINOHEXYI+1H+PYRROLE+2+5+DIONE Search 1+6+17+BETA+3+METHOXYESTRA+1+3+510+TRIEN+17+YLAMINOHEXYI+1H+PYRROLE+2+5+DIONE
8 1 O OCTADECYL 2 O METHYL RAE GLYCERO 3 PHOSPHORYLCHOLINE 100115 0% 100% 1 Search 1+O+OCTADECYL+2+O+METHYL+RAE+GLYCERO+3+PHOSPHORYLCHOLINE Search 1+O+OCTADECYL+2+O+METHYL+RAE+GLYCERO+3+PHOSPHORYLCHOLINE
9 8 CPT CAMP 100115 0% 100% 1 Search 8+CPT+CAMP Search 8+CPT+CAMP
10 ADENYLATE CYCLASE EXPRESSION 100115 0% 100% 1 Search ADENYLATE+CYCLASE+EXPRESSION Search ADENYLATE+CYCLASE+EXPRESSION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TAGOE, DNA , KALEJAIYE, TD , DE KONING, HP , (2015) THE EVER UNFOLDING STORY OF CAMP SIGNALING IN TRYPANOSOMATIDS: VIVE LA DIFFERENCE!.FRONTIERS IN PHARMACOLOGY. VOL. 6. ISSUE . P. - 53 46% 0
2 GOULD, MK , DE KONING, HP , (2011) CYCLIC-NUCLEOTIDE SIGNALLING IN PROTOZOA.FEMS MICROBIOLOGY REVIEWS. VOL. 35. ISSUE 3. P. 515 -541 51 40% 13
3 LAXMAN, S , BEAVO, JA , (2007) CYCLIC NUCLEOTIDE SIGNALING MECHANISMS IN TRYPANOSOMES: POSSIBLE TARGETS FOR THERAPEUTIC AGENTS.MOLECULAR INTERVENTIONS. VOL. 7. ISSUE 4. P. 203-215 28 40% 23
4 MALKI-FELDMAN, L , JAFFE, CL , (2009) LEISHMANIA MAJOR: EFFECT OF PROTEIN KINASE A AND PHOSPHODIESTERASE ACTIVITY ON INFECTIVITY AND PROLIFERATION OF PROMASTIGOTES.EXPERIMENTAL PARASITOLOGY. VOL. 123. ISSUE 1. P. 39-44 15 52% 10
5 MAKIN, L , GLUENZ, E , (2015) CAMP SIGNALLING IN TRYPANOSOMATIDS: ROLE IN PATHOGENESIS AND AS A DRUG TARGET.TRENDS IN PARASITOLOGY. VOL. 31. ISSUE 8. P. 373 -379 20 34% 0
6 VEERMAN, J , VAN DEN BERGH, T , ORRLING, KM , JANSEN, C , COS, P , MAES, L , CHATELAIN, E , IOSET, JR , EDINK, EE , TENOR, H , ET AL (2016) SYNTHESIS AND EVALUATION OF ANALOGS OF THE PHENYLPYRIDAZINONE NPD-001 AS POTENT TRYPANOSOMAL TBRPDEB1 PHOSPHODIESTERASE INHIBITORS AND IN VITRO TRYPANOCIDALS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 24. ISSUE 7. P. 1573 -1581 13 46% 1
7 JAGER, AV , DE GAUDENZI, JG , MILD, JG , MC CORMACK, B , PANTANO, S , ALTSCHULER, DL , EDREIRA, MM , (2014) IDENTIFICATION OF NOVEL CYCLIC NUCLEOTIDE BINDING PROTEINS IN TRYPANOSOMA CRUZI.MOLECULAR AND BIOCHEMICAL PARASITOLOGY. VOL. 198. ISSUE 2. P. 104 -112 14 45% 1
8 SEEBECK, T , SCHAUB, R , JOHNER, A , (2004) CAMP SIGNALLING IN THE KINETOPLASTID PROTOZOA.CURRENT MOLECULAR MEDICINE. VOL. 4. ISSUE 6. P. 585-599 28 28% 30
9 FLAWIA, MM , TELLEZINON, MT , TORRES, HN , (1997) SIGNAL TRANSDUCTION MECHANISMS IN TRYPANOSOMA CRUZI.PARASITOLOGY TODAY. VOL. 13. ISSUE 1. P. 30-33 16 62% 27
10 OCHIANA, SO , BLAND, ND , SETTIMO, L , CAMPBELL, RK , POLLASTRI, MP , (2015) REPURPOSING HUMAN PDE4 INHIBITORS FOR NEGLECTED TROPICAL DISEASES. EVALUATION OF ANALOGS OF THE HUMAN PDE4 INHIBITOR GSK-256066 AS INHIBITORS OF PDEB1 OF TRYPANOSOMA BRUCEI.CHEMICAL BIOLOGY & DRUG DESIGN. VOL. 85. ISSUE 5. P. 549 -564 12 48% 2

Classes with closest relation at Level 1


Rank Class id link
1 29829 YEASTLIKE CELLS//SPORANGIOSPORES//SYNTHETIC BROTH
2 17419 INFORMAT GENET DEV//BCY1//CDC25P
3 780 TRYPANOSOMA BRUCEI//MOLECULAR AND BIOCHEMICAL PARASITOLOGY//TRYPANOSOME
4 36141 ADENYLYL CYCLASE MECHANISM//QUOTIENT VELOCITY PLOT//ADENYLYL CYCLASE SYSTEM
5 13361 GLYCOSOME//UNIDAD BIOQUIM PARASITOS//TROP DIS UNIT
6 36244 ANTIBODIES CULTURE HEAT SHOCK PROTEIN//CDNA INSERTS//HSP 70 KDA HEAT SHOCK PROTEIN FAMILY
7 36246 ADPFE NADPH INDUCED LIPID PEROXIDATION//GEN MED PHYSIOL//PHYSIOLOGIA BOHEMOSLOVACA
8 34347 SYNCYTIAL CONNECTION//AUTOANTIBODIES TO GLUTAMATE RECEPTORS//COMMUNICATING SYNAPSES
9 8266 TRANS SIALIDASE//TRYPANOSOMA CRUZI//METACYCLIC TRYPOMASTIGOTES
10 15980 PHYTOMONAS//TRYPANOSOMATIDAE//TRYPANOSOMATIDS

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