Class information for:
Level 1: NELFINAVIR//SAQUINAVIR NO//BECN1 PTDINS3K COMPLEX

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30421 169 41.6 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
29 3       HIV//VIROLOGY//HIV 1 108954
773 2             EFAVIRENZ//NEVIRAPINE//RALTEGRAVIR 12242
30421 1                   NELFINAVIR//SAQUINAVIR NO//BECN1 PTDINS3K COMPLEX 169

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NELFINAVIR authKW 602944 17% 12% 29
2 SAQUINAVIR NO authKW 406536 2% 75% 3
3 BECN1 PTDINS3K COMPLEX authKW 180683 1% 100% 1
4 CHEMOSENZITIZATION authKW 180683 1% 100% 1
5 CYTOL S address 180683 1% 100% 1
6 DIGEST COLORECTAL CANC address 180683 1% 100% 1
7 DRUG RADIOTHERAPY COMBINATIONS authKW 180683 1% 100% 1
8 EMAD FORMULA authKW 180683 1% 100% 1
9 GABRIELE MONASTERIO FONDAT address 180683 1% 100% 1
10 HEMATOLOGY HCT address 180683 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1603 50% 0% 85
2 Virology 107 7% 0% 11
3 Infectious Diseases 93 8% 0% 13
4 Pharmacology & Pharmacy 56 13% 0% 22
5 Immunology 51 10% 0% 17
6 Cell Biology 43 10% 0% 17
7 Hematology 37 5% 0% 9
8 Biochemistry & Molecular Biology 15 12% 0% 21
9 Chemistry, Medicinal 5 2% 0% 4
10 Respiratory System 3 2% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYTOL S 180683 1% 100% 1
2 DIGEST COLORECTAL CANC 180683 1% 100% 1
3 GABRIELE MONASTERIO FONDAT 180683 1% 100% 1
4 HEMATOLOGY HCT 180683 1% 100% 1
5 HLTH CARE MOTHER CHILD SERBIA DR VUKAN CUP 180683 1% 100% 1
6 INSERM E0 357 180683 1% 100% 1
7 MICROBIOL MED UNIT 180683 1% 100% 1
8 PARASIT INFECT IMMUNOMEDIATED DIS 180683 1% 100% 1
9 PLAST SURG OPERAT UNIT 180683 1% 100% 1
10 RETROVIRUS INFECT 180683 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANGIOGENESIS 3926 1% 2% 1
2 NEOPLASIA 961 2% 0% 3
3 MOLECULAR CANCER THERAPEUTICS 705 2% 0% 4
4 BLOOD CANCER JOURNAL 610 1% 0% 1
5 JOURNAL OF THORACIC ONCOLOGY 603 2% 0% 3
6 CANCER BIOLOGY & THERAPY 575 2% 0% 3
7 CANCER RESEARCH 548 7% 0% 11
8 JOURNAL OF NEURO-ONCOLOGY 530 2% 0% 4
9 JOURNAL OF MEDICAL BIOCHEMISTRY 522 1% 0% 1
10 AUTOPHAGY 473 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NELFINAVIR 602944 17% 12% 29 Search NELFINAVIR Search NELFINAVIR
2 SAQUINAVIR NO 406536 2% 75% 3 Search SAQUINAVIR+NO Search SAQUINAVIR+NO
3 BECN1 PTDINS3K COMPLEX 180683 1% 100% 1 Search BECN1+PTDINS3K+COMPLEX Search BECN1+PTDINS3K+COMPLEX
4 CHEMOSENZITIZATION 180683 1% 100% 1 Search CHEMOSENZITIZATION Search CHEMOSENZITIZATION
5 DRUG RADIOTHERAPY COMBINATIONS 180683 1% 100% 1 Search DRUG+RADIOTHERAPY+COMBINATIONS Search DRUG+RADIOTHERAPY+COMBINATIONS
6 EMAD FORMULA 180683 1% 100% 1 Search EMAD+FORMULA Search EMAD+FORMULA
7 HIV 1 PROTEASE INHIBITON 180683 1% 100% 1 Search HIV+1+PROTEASE+INHIBITON Search HIV+1+PROTEASE+INHIBITON
8 HIV PI LOPINAVIR 180683 1% 100% 1 Search HIV+PI+LOPINAVIR Search HIV+PI+LOPINAVIR
9 IN VITRO CELL PROLIFERATION ASSAY 180683 1% 100% 1 Search IN+VITRO+CELL+PROLIFERATION+ASSAY Search IN+VITRO+CELL+PROLIFERATION+ASSAY
10 ITRACONAZOLE ITCZ 180683 1% 100% 1 Search ITRACONAZOLE+ITCZ Search ITRACONAZOLE+ITCZ

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GANTT, S , CASPER, C , AMBINDER, RF , (2013) INSIGHTS INTO THE BROAD CELLULAR EFFECTS OF NELFINAVIR AND THE HIV PROTEASE INHIBITORS SUPPORTING THEIR ROLE IN CANCER TREATMENT AND PREVENTION.CURRENT OPINION IN ONCOLOGY. VOL. 25. ISSUE 5. P. 495-502 40 59% 19
2 SHIM, JS , LIU, JO , (2014) RECENT ADVANCES IN DRUG REPOSITIONING FOR THE DISCOVERY OF NEW ANTICANCER DRUGS.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. VOL. 10. ISSUE 7. P. 654 -663 20 33% 41
3 MAKSIMOVIC-IVANIC, D , MOJIC, M , BULATOVIC, M , RADOJKOVIC, M , KUZMANOVIC, M , RISTIC, S , STOSIC-GRUJICIC, S , MILJKOVIC, D , CAVALLI, E , LIBRA, M , ET AL (2015) THE NO-MODIFIED HIV PROTEASE INHIBITOR AS A VALUABLE DRUG FOR HEMATOLOGICAL MALIGNANCIES: ROLE OF P70S6K.LEUKEMIA RESEARCH. VOL. 39. ISSUE 10. P. 1088 -1095 18 47% 1
4 YOU, JL , HE, ZX , CHEN, LL , DENG, G , LIU, W , QIN, L , QIU, FY , CHEN, XP , (2010) CH05-10, A NOVEL INDINAVIR ANALOG, IS A BROAD-SPECTRUM ANTITUMOR AGENT THAT INDUCES CELL CYCLE ARREST, APOPTOSIS, ENDOPLASMIC RETICULUM STRESS AND AUTOPHAGY.CANCER SCIENCE. VOL. 101. ISSUE 12. P. 2644 -2651 19 48% 7
5 DRIESSEN, C , KRAUS, M , JOERGER, M , ROSING, H , BADER, J , HITZ, F , BERSET, C , XYRAFAS, A , HAWLE, H , BERTHOD, G , ET AL (2016) TREATMENT WITH THE HIV PROTEASE INHIBITOR NELFINAVIR TRIGGERS THE UNFOLDED PROTEIN RESPONSE AND MAY OVERCOME PROTEASOME INHIBITOR RESISTANCE OF MULTIPLE MYELOMA IN COMBINATION WITH BORTEZOMIB: A PHASE I TRIAL (SAKK 65/08).HAEMATOLOGICA. VOL. 101. ISSUE 3. P. 346 -355 17 46% 0
6 FAGONE, P , MANGANO, K , QUATTROCCHI, C , CAVALLI, E , MAMMANA, S , LOMBARDO, GAG , PENNISI, V , ZOCCA, MB , HE, MZ , AL-ABED, Y , ET AL (2015) EFFECTS OF NO-HYBRIDIZATION ON THE IMMUNOMODULATORY PROPERTIES OF THE HIV PROTEASE INHIBITORS LOPINAVIR AND RITONAVIR.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. VOL. 117. ISSUE 5. P. 306 -315 18 42% 0
7 BERNSTEIN, WB , DENNIS, PA , (2008) REPOSITIONING HIV PROTEASE INHIBITORS AS CANCER THERAPEUTICS.CURRENT OPINION IN HIV AND AIDS. VOL. 3. ISSUE 6. P. 666-675 21 34% 36
8 KRAUS, M , MULLER-IDE, H , RUCKRICH, T , BADER, J , OVERKLEEFT, H , DRIESSEN, C , (2014) RITONAVIR, NELFINAVIR, SAQUINAVIR AND LOPINAVIR INDUCE PROTEOTOXIC STRESS IN ACUTE MYELOID LEUKEMIA CELLS AND SENSITIZE THEM FOR PROTEASOME INHIBITOR TREATMENT AT LOW MICROMOLAR DRUG CONCENTRATIONS.LEUKEMIA RESEARCH. VOL. 38. ISSUE 3. P. 383-392 15 42% 8
9 KRAUS, M , BADER, J , OVERKLEEFT, H , DRIESSEN, C , (2013) NELFINAVIR AUGMENTS PROTEASOME INHIBITION BY BORTEZOMIB IN MYELOMA CELLS AND OVERCOMES BORTEZOMIB AND CARFILZOMIB RESISTANCE.BLOOD CANCER JOURNAL. VOL. 3. ISSUE . P. - 15 41% 13
10 XIANG, T , DU, LY , PHAM, P , ZHU, B , JIANG, SB , (2015) NELFINAVIR, AN HIV PROTEASE INHIBITOR, INDUCES APOPTOSIS AND CELL CYCLE ARREST IN HUMAN CERVICAL CANCER CELLS VIA THE ROS-DEPENDENT MITOCHONDRIAL PATHWAY.CANCER LETTERS. VOL. 364. ISSUE 1. P. 79 -88 14 36% 12

Classes with closest relation at Level 1


Rank Class id link
1 6181 ATAZANAVIR//RITONAVIR//LOPINAVIR
2 5140 PROTEASOME INHIBITOR//BORTEZOMIB//PROTEASOME
3 37234 PINELLIA TERNATA//HMC05//20 KD MYOSIN LIGHT CHAINS
4 3714 NON AIDS DEFINING CANCERS//AIDS RELATED LYMPHOMA//HIV ASSOCIATED LYMPHOMA
5 859 LIPODYSTROPHY//LIPOATROPHY//PROGRAM NUTR METAB
6 35160 TRIPEPTIDYL PEPTIDASE II//TPPII//TRIPEPTIDYL PEPTIDASE
7 16599 GRP78//GLUCOSE REGULATED PROTEIN 78//CELL SURFACE GRP78
8 17795 TCD50//TUMOR BED EFFECT//ONCORAY RADIAT
9 9126 NAIVE AND MEMORY CD4 T CELLS//SECC INMUNOPEDIAT//BIOSISTEMA 1
10 21370 NO NSAIDS//NCX 4016//NO ASPIRIN

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