Class information for:
Level 1: MPTP//MPP//1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3681 1932 38.7 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
124 3       PARKINSONS DISEASE//MOVEMENT DISORDERS//DEEP BRAIN STIMULATION 67777
332 2             PARKINSONS DISEASE//ALPHA SYNUCLEIN//PARKIN 18089
3681 1                   MPTP//MPP//1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE 1932

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MPTP authKW 1488433 20% 24% 389
2 MPP authKW 415082 6% 22% 120
3 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE authKW 370190 4% 29% 81
4 1 METHYL 4 PHENYLPYRIDINIUM authKW 274297 3% 35% 50
5 1 METHYL 4 PHENYLPYRIDINIUM ION MPP authKW 224801 1% 68% 21
6 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE MPTP authKW 190343 2% 38% 32
7 1 METHYL 4 PHENYLPYRIDINIUM ION authKW 162054 1% 49% 21
8 MPTP 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE authKW 86706 1% 37% 15
9 PARKINSONS DISEASE authKW 86434 21% 1% 406
10 ALTERNAT MED EXPT THER EUT address 70391 0% 64% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Neurosciences 18571 57% 0% 1092
2 Pharmacology & Pharmacy 2840 24% 0% 464
3 Toxicology 822 7% 0% 133
4 Biochemistry & Molecular Biology 765 20% 0% 392
5 Clinical Neurology 549 9% 0% 170
6 Medicine, Research & Experimental 272 6% 0% 108
7 Biophysics 214 5% 0% 95
8 Chemistry, Medicinal 135 3% 0% 63
9 Behavioral Sciences 97 2% 0% 40
10 Pathology 54 2% 0% 43

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALTERNAT MED EXPT THER EUT 70391 0% 64% 7
2 DRUG METAB THER EUT 33458 0% 35% 6
3 GEORGE MARYLOU BOONE PARKINSONS DIS MOVEMENT 31607 0% 100% 2
4 NEUROL SERV WARREN 408 31607 0% 100% 2
5 BEHAV NEUROSCI PATHOL 24686 0% 31% 5
6 BIOCHEM MOL BIOL NEUROL 21070 0% 67% 2
7 HARVEY W PETERS STUDY PARKINSONS DIS 21070 0% 67% 2
8 MEF FISIOL 21070 0% 67% 2
9 MED DENT NEUROBIOL ANAT 17775 0% 38% 3
10 PHARMACEUT SCI MED 15989 1% 7% 15

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROSCIENCE LETTERS 9980 7% 0% 141
2 BRAIN RESEARCH 8937 9% 0% 165
3 JOURNAL OF NEUROCHEMISTRY 7779 5% 0% 102
4 NEURODEGENERATION 6078 0% 5% 8
5 JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION 5697 0% 4% 9
6 NEUROCHEMISTRY INTERNATIONAL 5175 2% 1% 42
7 JOURNAL OF NEURAL TRANSMISSION 4428 2% 1% 34
8 LIFE SCIENCES 4076 4% 0% 73
9 NEUROTOXICOLOGY 3705 1% 1% 28
10 RESEARCH COMMUNICATIONS IN SUBSTANCES OF ABUSE 3578 0% 3% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MPTP 1488433 20% 24% 389 Search MPTP Search MPTP
2 MPP 415082 6% 22% 120 Search MPP Search MPP
3 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE 370190 4% 29% 81 Search 1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE Search 1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE
4 1 METHYL 4 PHENYLPYRIDINIUM 274297 3% 35% 50 Search 1+METHYL+4+PHENYLPYRIDINIUM Search 1+METHYL+4+PHENYLPYRIDINIUM
5 1 METHYL 4 PHENYLPYRIDINIUM ION MPP 224801 1% 68% 21 Search 1+METHYL+4+PHENYLPYRIDINIUM+ION+MPP Search 1+METHYL+4+PHENYLPYRIDINIUM+ION+MPP
6 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE MPTP 190343 2% 38% 32 Search 1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE+MPTP Search 1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE+MPTP
7 1 METHYL 4 PHENYLPYRIDINIUM ION 162054 1% 49% 21 Search 1+METHYL+4+PHENYLPYRIDINIUM+ION Search 1+METHYL+4+PHENYLPYRIDINIUM+ION
8 MPTP 1 METHYL 4 PHENYL 1 2 3 6 TETRAHYDROPYRIDINE 86706 1% 37% 15 Search MPTP+1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE Search MPTP+1+METHYL+4+PHENYL+1+2+3+6+TETRAHYDROPYRIDINE
9 PARKINSONS DISEASE 86434 21% 1% 406 Search PARKINSONS+DISEASE Search PARKINSONS+DISEASE
10 SLOW EVOLUTION OF DISEASE 50569 0% 80% 4 Search SLOW+EVOLUTION+OF+DISEASE Search SLOW+EVOLUTION+OF+DISEASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SAYRE, LM , (1989) BIOCHEMICAL-MECHANISM OF ACTION OF THE DOPAMINERGIC NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP).TOXICOLOGY LETTERS. VOL. 48. ISSUE 2. P. 121-149 190 89% 91
2 GERLACH, M , RIEDERER, P , PRZUNTEK, H , YOUDIM, MBH , (1991) MPTP MECHANISMS OF NEUROTOXICITY AND THEIR IMPLICATIONS FOR PARKINSONS-DISEASE.EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION. VOL. 208. ISSUE 4. P. 273-286 107 88% 197
3 SEDELIS, M , SCHWARTING, RKW , HUSTON, JP , (2001) BEHAVIORAL PHENOTYPING OF THE MPTP MOUSE MODEL OF PARKINSON'S DISEASE.BEHAVIOURAL BRAIN RESEARCH. VOL. 125. ISSUE 1-2. P. 109-125 81 63% 207
4 JAKOWEC, MW , PETZINGER, GM , (2004) 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MODEL OF PARKINSON'S DISEASE, WITH EMPHASIS ON MICE AND NONHUMAN PRIMATES.COMPARATIVE MEDICINE. VOL. 54. ISSUE 5. P. 497 -513 104 50% 55
5 TIPTON, KF , SINGER, TP , (1993) ADVANCES IN OUR UNDERSTANDING OF THE MECHANISMS OF THE NEUROTOXICITY OF MPTP AND RELATED-COMPOUNDS.JOURNAL OF NEUROCHEMISTRY. VOL. 61. ISSUE 4. P. 1191-1206 76 66% 452
6 MARET, G , TESTA, B , JENNER, P , ELTAYAR, N , CARRUPT, PA , (1990) THE MPTP STORY - MAO ACTIVATES TETRAHYDROPYRIDINE DERIVATIVES TO TOXINS CAUSING PARKINSONISM.DRUG METABOLISM REVIEWS. VOL. 22. ISSUE 4. P. 291-332 107 74% 42
7 MEREDITH, GE , RADEMACHER, DJ , (2011) MPTP MOUSE MODELS OF PARKINSON'S DISEASE: AN UPDATE.JOURNAL OF PARKINSONS DISEASE. VOL. 1. ISSUE 1. P. 19-33 73 49% 33
8 PIFL, C , SCHINGNITZ, G , HORNYKIEWICZ, O , (1991) EFFECT OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON THE REGIONAL DISTRIBUTION OF BRAIN MONOAMINES IN THE RHESUS-MONKEY.NEUROSCIENCE. VOL. 44. ISSUE 3. P. 591-605 65 81% 136
9 KINEMUCHI, H , FOWLER, CJ , TIPTON, KF , (1987) THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS RELEVANCE TO PARKINSONS-DISEASE.NEUROCHEMISTRY INTERNATIONAL. VOL. 11. ISSUE 4. P. 359-373 90 76% 55
10 LANGSTON, JW , IRWIN, I , (1986) MPTP - CURRENT CONCEPTS AND CONTROVERSIES.CLINICAL NEUROPHARMACOLOGY. VOL. 9. ISSUE 6. P. 485-507 64 90% 190

Classes with closest relation at Level 1


Rank Class id link
1 17570 SALSOLINOL//1 2 3 4 TETRAHYDROISOQUINOLINE//1 BENZYL 1 2 3 4 TETRAHYDROISOQUINOLINE
2 7381 NEUROMELANIN//AMINOCHROME//DOPAMINE QUINONE
3 24398 ROTENONE//AAV ALPHA SYNUCLEIN//PYRIMIDOTRIAZINEDIONE DERIVATIVES
4 8954 NEUROPHARMACOL SECT//MICROGLIA//PARKINSONS DISEASE
5 36616 BUDIPINE//1 TERT BUTYL 4 4 DIPHENYLPIPERIDINE//ADENOSINE A2 ANTAGONISTS
6 7937 SELEGILINE//RASAGILINE//DEPRENYL
7 4990 MONOAMINE OXIDASE//MAO B//MONOAMINE OXIDASE B
8 34469 BASE CATALYZED POLYMERIZATION//DEUTERATED ACRYLIC//EQUIACTIVE
9 21946 APOPTOSIS AND CEREBROVASCULAR INJURY//APOPTOSIS AND NEURODEGENERATION//BRAIN AGING DEMENTIA
10 29114 PRAMIPEXOLE//PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE//TALIPEXOLE

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