Class information for:
Level 1: HEDGEHOG//GLI//SMOOTHENED

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
613 3247 49.6 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
642 3       POLYCYSTIC KIDNEY DISEASE//AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE//HEDGEHOG 12305
1658 2             HEDGEHOG//GLI//CILIOPATHY 6876
613 1                   HEDGEHOG//GLI//SMOOTHENED 3247

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HEDGEHOG authKW 1920500 16% 40% 513
2 GLI authKW 1142536 5% 69% 175
3 SMOOTHENED authKW 1000356 5% 70% 153
4 SONIC HEDGEHOG authKW 899481 10% 29% 328
5 HEDGEHOG SIGNALING authKW 892010 5% 56% 169
6 CYCLOPAMINE authKW 824099 4% 64% 136
7 GLI1 authKW 783252 4% 61% 136
8 PATCHED authKW 700412 4% 56% 134
9 HEDGEHOG PATHWAY authKW 635469 3% 68% 99
10 HEDGEHOG SIGNALING PATHWAY authKW 577816 3% 70% 88

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Developmental Biology 22470 17% 0% 550
2 Cell Biology 8372 27% 0% 875
3 Oncology 7507 26% 0% 846
4 Biochemistry & Molecular Biology 2338 25% 0% 826
5 Genetics & Heredity 1108 9% 0% 292
6 Chemistry, Medicinal 277 4% 0% 114
7 Medicine, Research & Experimental 269 5% 0% 149
8 Gastroenterology & Hepatology 258 4% 0% 114
9 Cell & Tissue Engineering 210 1% 0% 27
10 Dermatology 178 2% 0% 75

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DEV BIOL STEM CELL BIOL REGENERAT MED 37609 0% 100% 4
2 GENET DEV EVOLUT 37605 0% 67% 6
3 NEUROBIOL ALFRED FESSARD IFR2118 37605 0% 67% 6
4 INTERCELLULAR SIGNALLING GRP 33577 0% 71% 5
5 DEV GENET PROGRAM 32133 1% 13% 27
6 NICPB 26113 0% 56% 5
7 BRAIN TUMOR BIOL UNIT CIFA 21154 0% 75% 3
8 PHARMACOL TOXICOL THER EUT MED 21148 0% 38% 6
9 ALFRED FESSARD NEUROBIOL 18805 0% 100% 2
10 HEMATOL ONCOLWELLS PEDIAT 18805 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DEVELOPMENT 18132 5% 1% 157
2 VITAMINS AND HORMONES 17025 1% 9% 21
3 DEVELOPMENTAL BIOLOGY 6846 3% 1% 101
4 DEVELOPMENTAL CELL 4678 1% 1% 36
5 SACRED MUSIC 3249 0% 12% 3
6 GENES & DEVELOPMENT 2483 1% 1% 45
7 MECHANISMS OF DEVELOPMENT 1993 1% 1% 26
8 SCIENCE SIGNALING 1940 1% 1% 18
9 STUDIA CANONICA 1706 0% 9% 2
10 ONCOGENE 1597 2% 0% 57

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HEDGEHOG 1920500 16% 40% 513 Search HEDGEHOG Search HEDGEHOG
2 GLI 1142536 5% 69% 175 Search GLI Search GLI
3 SMOOTHENED 1000356 5% 70% 153 Search SMOOTHENED Search SMOOTHENED
4 SONIC HEDGEHOG 899481 10% 29% 328 Search SONIC+HEDGEHOG Search SONIC+HEDGEHOG
5 HEDGEHOG SIGNALING 892010 5% 56% 169 Search HEDGEHOG+SIGNALING Search HEDGEHOG+SIGNALING
6 CYCLOPAMINE 824099 4% 64% 136 Search CYCLOPAMINE Search CYCLOPAMINE
7 GLI1 783252 4% 61% 136 Search GLI1 Search GLI1
8 PATCHED 700412 4% 56% 134 Search PATCHED Search PATCHED
9 HEDGEHOG PATHWAY 635469 3% 68% 99 Search HEDGEHOG+PATHWAY Search HEDGEHOG+PATHWAY
10 HEDGEHOG SIGNALING PATHWAY 577816 3% 70% 88 Search HEDGEHOG+SIGNALING+PATHWAY Search HEDGEHOG+SIGNALING+PATHWAY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BRISCOE, J , THEROND, PP , (2013) THE MECHANISMS OF HEDGEHOG SIGNALLING AND ITS ROLES IN DEVELOPMENT AND DISEASE.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 14. ISSUE 7. P. 416-429 153 74% 320
2 TEGLUND, S , TOFTGARD, R , (2010) HEDGEHOG BEYOND MEDULLOBLASTOMA AND BASAL CELL CARCINOMA.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1805. ISSUE 2. P. 181 -208 268 64% 198
3 PANDOLFI, S , STECCA, B , (2015) COOPERATIVE INTEGRATION BETWEEN HEDGEHOG-GLI SIGNALLING AND OTHER ONCOGENIC PATHWAYS: IMPLICATIONS FOR CANCER THERAPY.EXPERT REVIEWS IN MOLECULAR MEDICINE. VOL. 17. ISSUE . P. - 231 79% 8
4 ROBBINS, DJ , FEI, DL , RIOBO, NA , (2012) THE HEDGEHOG SIGNAL TRANSDUCTION NETWORK.SCIENCE SIGNALING. VOL. 5. ISSUE 246. P. - 188 83% 98
5 VARJOSALO, M , TAIPALE, J , (2008) HEDGEHOG: FUNCTIONS AND MECHANISMS.GENES & DEVELOPMENT. VOL. 22. ISSUE 18. P. 2454-2472 157 61% 480
6 YANG, L , XIE, G , FAN, Q , XIE, J , (2010) ACTIVATION OF THE HEDGEHOG-SIGNALING PATHWAY IN HUMAN CANCER AND THE CLINICAL IMPLICATIONS.ONCOGENE. VOL. 29. ISSUE 4. P. 469 -481 156 80% 125
7 MIMEAULT, M , BATRA, SK , (2010) FREQUENT DEREGULATIONS IN THE HEDGEHOG SIGNALING NETWORK AND CROSS-TALKS WITH THE EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY INVOLVED IN CANCER PROGRESSION AND TARGETED THERAPIES.PHARMACOLOGICAL REVIEWS. VOL. 62. ISSUE 3. P. 497 -524 191 68% 60
8 JIANG, J , HUI, C , (2008) HEDGEHOG SIGNALING IN DEVELOPMENT AND CANCER.DEVELOPMENTAL CELL. VOL. 15. ISSUE 6. P. 801 -812 110 79% 466
9 HUI, CC , ANGERS, S , (2011) GLI PROTEINS IN DEVELOPMENT AND DISEASE.ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27. VOL. 27. ISSUE . P. 513-537 121 73% 193
10 JIA, YF , WANG, YS , XIE, JW , (2015) THE HEDGEHOG PATHWAY: ROLE IN CELL DIFFERENTIATION, POLARITY AND PROLIFERATION.ARCHIVES OF TOXICOLOGY. VOL. 89. ISSUE 2. P. 179 -191 149 72% 10

Classes with closest relation at Level 1


Rank Class id link
1 37394 SCUBE1//SIGNAL PEPTIDE CUB EGF DOMAIN CONTAINING PROTEIN 1//SCUBE3
2 37024 RAB23//CARPENTER SYNDROME//ACROCEPHALOPOLYSYNDACTYLY TYPE II
3 36130 GAS7//GAS1//GROWTH ARREST SPECIFIC 1
4 6523 ODONTOGENIC KERATOCYST//GORLIN SYNDROME//ODONTOGENIC CYSTS
5 13162 TWISTED GASTRULATION//BRINKER//DPP
6 27158 ACROCALLOSAL SYNDROME//VICI SYNDROME//GREIG CEPHALOPOLYSYNDACTYLY SYNDROME
7 12166 HOLOPROSENCEPHALY//TGIF//CYCLOPIA
8 1635 JOUBERT SYNDROME//CILIOPATHY//BARDET BIEDL SYNDROME
9 2019 MEDULLOBLASTOMA//CRANIOSPINAL IRRADIATION//PRIMITIVE NEUROECTODERMAL TUMOR
10 8749 ISTHMIC ORGANIZER//PITX3//OTX2

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