Class information for:
Level 1: SPHEROID//3D CELL CULTURE//TUMOR SPHEROIDS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9229 1175 51.7 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
195 3       MATERIALS SCIENCE, BIOMATERIALS//HYDROXYAPATITE//TISSUE ENGINEERING 53996
149 2             TISSUE ENGINEERING//MATERIALS SCIENCE, BIOMATERIALS//SCAFFOLD 23120
9229 1                   SPHEROID//3D CELL CULTURE//TUMOR SPHEROIDS 1175

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SPHEROID authKW 293367 9% 11% 102
2 3D CELL CULTURE authKW 279942 4% 22% 50
3 TUMOR SPHEROIDS authKW 186840 2% 28% 26
4 3D TUMOR MODEL authKW 144357 1% 56% 10
5 3D CULTURE authKW 141092 3% 14% 39
6 MULTICELLULAR SPHEROIDS authKW 138277 2% 20% 26
7 CONCAVE MICROWELL ARRAY authKW 133640 1% 86% 6
8 THREE DIMENSIONAL CULTURE authKW 132060 3% 13% 38
9 THREE DIMENSIONAL CELL CULTURE authKW 122649 2% 20% 24
10 CANCER CELL SPHEROIDS authKW 92804 0% 71% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Materials Science, Biomaterials 7911 14% 0% 161
2 Cell & Tissue Engineering 3812 5% 0% 63
3 Engineering, Biomedical 3488 14% 0% 165
4 Cell Biology 2184 23% 0% 273
5 Oncology 1955 22% 0% 264
6 Biochemical Research Methods 1534 13% 0% 150
7 Biotechnology & Applied Microbiology 1148 14% 0% 169
8 Nanoscience & Nanotechnology 893 10% 0% 119
9 Pharmacology & Pharmacy 134 9% 0% 104
10 Multidisciplinary Sciences 107 2% 0% 22

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR BIOENGN 87691 1% 38% 9
2 SCI MEDICAMENT IFR71 51972 0% 100% 2
3 LIFE ENVIRONM ENGN 36369 1% 20% 7
4 ARTORG LUNG REGENERAT TECHNOL 34647 0% 67% 2
5 IRISH HIGH CONTENT SCREENING ANAL 34647 0% 67% 2
6 MED BIOTECHNOL KNOWLEDGE 34647 0% 67% 2
7 REGENERAT MED CANC PROGRAM 34647 0% 67% 2
8 A STAR BIOCHEM 25986 0% 100% 1
9 ADOLESCENCE MED PAEDIAT 25986 0% 100% 1
10 ADV ASSAYS 25986 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMATERIALS 12484 7% 1% 85
2 TISSUE ENGINEERING PART C-METHODS 8139 1% 2% 17
3 LAB ON A CHIP 8005 3% 1% 40
4 ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 6404 1% 2% 13
5 INTEGRATIVE BIOLOGY 6154 1% 2% 14
6 JOURNAL OF BIOMOLECULAR SCREENING 5442 2% 1% 19
7 BIOMICROFLUIDICS 3803 1% 1% 13
8 JALA 2947 1% 2% 7
9 ADVANCED HEALTHCARE MATERIALS 2939 1% 1% 11
10 BIOFABRICATION 2450 1% 2% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SPHEROID 293367 9% 11% 102 Search SPHEROID Search SPHEROID
2 3D CELL CULTURE 279942 4% 22% 50 Search 3D+CELL+CULTURE Search 3D+CELL+CULTURE
3 TUMOR SPHEROIDS 186840 2% 28% 26 Search TUMOR+SPHEROIDS Search TUMOR+SPHEROIDS
4 3D TUMOR MODEL 144357 1% 56% 10 Search 3D+TUMOR+MODEL Search 3D+TUMOR+MODEL
5 3D CULTURE 141092 3% 14% 39 Search 3D+CULTURE Search 3D+CULTURE
6 MULTICELLULAR SPHEROIDS 138277 2% 20% 26 Search MULTICELLULAR+SPHEROIDS Search MULTICELLULAR+SPHEROIDS
7 CONCAVE MICROWELL ARRAY 133640 1% 86% 6 Search CONCAVE+MICROWELL+ARRAY Search CONCAVE+MICROWELL+ARRAY
8 THREE DIMENSIONAL CULTURE 132060 3% 13% 38 Search THREE+DIMENSIONAL+CULTURE Search THREE+DIMENSIONAL+CULTURE
9 THREE DIMENSIONAL CELL CULTURE 122649 2% 20% 24 Search THREE+DIMENSIONAL+CELL+CULTURE Search THREE+DIMENSIONAL+CELL+CULTURE
10 CANCER CELL SPHEROIDS 92804 0% 71% 5 Search CANCER+CELL+SPHEROIDS Search CANCER+CELL+SPHEROIDS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LEE, GH , LEE, JS , WANG, XH , LEE, SH , (2016) BOTTOM-UP ENGINEERING OF WELL-DEFINED 3D MICROTISSUES USING MICROPLATFORMS AND BIOMEDICAL APPLICATIONS.ADVANCED HEALTHCARE MATERIALS. VOL. 5. ISSUE 1. P. 56 -74 46 41% 9
2 PRADHAN, S , HASSANI, I , CLARY, JM , LIPKE, EA , (2016) POLYMERIC BIOMATERIALS FOR IN VITRO CANCER TISSUE ENGINEERING AND DRUG TESTING APPLICATIONS.TISSUE ENGINEERING PART B-REVIEWS. VOL. 22. ISSUE 6. P. 470 -484 68 43% 0
3 GUO, WM , LOH, XJ , TAN, EY , LOO, JSC , HO, VHB , (2014) DEVELOPMENT OF A MAGNETIC 3D SPHEROID PLATFORM WITH POTENTIAL APPLICATION FOR HIGH-THROUGHPUT DRUG SCREENING.MOLECULAR PHARMACEUTICS. VOL. 11. ISSUE 7. P. 2182 -2189 35 73% 6
4 COSTA, EC , MOREIRA, AF , DE MELO-DIOGO, D , GASPAR, VM , CARVALHO, MP , CORREIA, IJ , (2016) 3D TUMOR SPHEROIDS: AN OVERVIEW ON THE TOOLS AND TECHNIQUES USED FOR THEIR ANALYSIS.BIOTECHNOLOGY ADVANCES. VOL. 34. ISSUE 8. P. 1427 -1441 54 45% 0
5 MARTINEZ, NJ , TITUS, SA , WAGNER, AK , SIMEONOV, A , (2015) HIGH-THROUGHPUT FLUORESCENCE IMAGING APPROACHES FOR DRUG DISCOVERY USING IN VITRO AND IN VIVO THREE-DIMENSIONAL MODELS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 10. ISSUE 12. P. 1347 -1361 44 48% 5
6 EDMONDSON, R , BROGLIE, JJ , ADCOCK, AF , YANG, LJ , (2014) THREE-DIMENSIONAL CELL CULTURE SYSTEMS AND THEIR APPLICATIONS IN DRUG DISCOVERY AND CELL-BASED BIOSENSORS.ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. VOL. 12. ISSUE 4. P. 207-218 38 46% 37
7 BRESLIN, S , O'DRISCOLL, L , (2013) THREE-DIMENSIONAL CELL CULTURE: THE MISSING LINK IN DRUG DISCOVERY.DRUG DISCOVERY TODAY. VOL. 18. ISSUE 5-6. P. 240 -249 26 52% 122
8 WEIGELT, B , GHAJAR, CM , BISSELL, MJ , (2014) THE NEED FOR COMPLEX 3D CULTURE MODELS TO UNRAVEL NOVEL PATHWAYS AND IDENTIFY ACCURATE BIOMARKERS IN BREAST CANCER.ADVANCED DRUG DELIVERY REVIEWS. VOL. 69. ISSUE . P. 42 -51 43 33% 63
9 LABARBERA, DV , REID, BG , YOO, BH , (2012) THE MULTICELLULAR TUMOR SPHEROID MODEL FOR HIGH-THROUGHPUT CANCER DRUG DISCOVERY.EXPERT OPINION ON DRUG DISCOVERY. VOL. 7. ISSUE 9. P. 819 -830 36 44% 62
10 ALEMANY-RIBES, M , SEMINO, CE , (2014) BIOENGINEERING 3D ENVIRONMENTS FOR CANCER MODELS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 79-80. ISSUE . P. 40 -49 43 38% 14

Classes with closest relation at Level 1


Rank Class id link
1 14991 MULTICELLULAR SPHEROIDS//MULTICELLULAR TUMOR SPHEROIDS//SPHEROID
2 2961 LAB ON A CHIP//MICROFLUIDICS//ORGAN ON A CHIP
3 14507 MODULAR TISSUE ENGINEERING//MICROVASCULAR TISSUE ENGINEERING//INOSCULATION
4 18330 CONTRACTILE FORCES//HOF NEIDER GRP LEUKOCYTE MIGRAT//THREE DIMENSIONAL CELL MIGRATION
5 37254 3D SPHEROID ASSAYS//BORTENAT//EARLY EVENTS IN BREAST TUMORIGENESIS
6 25952 CAM DR//CELL ADHESION MEDIATED DRUG RESISTANCE//RECEPTOR BIOL TUMOR METASTASIS
7 7275 CANCER ASSOCIATED FIBROBLASTS//JEFFERSON STEM CELL BIOL REGENERAT MED//MANCHESTER BREAST
8 3584 BIOARTIFICIAL LIVER//HEPATOCYTES//PORCINE HEPATOCYTES
9 30507 MESOTHELIAL CELLS//RAT MAMMARY CARCINOMA//ADHESION POLYPEPTIDES
10 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES

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