Class information for:
Level 1: LEBER CONGENITAL AMAUROSIS//RPE65//LEBERS CONGENITAL AMAUROSIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9747 1124 46.1 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
360 3       RETINA//OPHTHALMOLOGY//PHOTORECEPTOR 34628
266 2             RETINITIS PIGMENTOSA//OPHTHALMOLOGY//RETINA 19390
9747 1                   LEBER CONGENITAL AMAUROSIS//RPE65//LEBERS CONGENITAL AMAUROSIS 1124

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEBER CONGENITAL AMAUROSIS authKW 954089 6% 56% 63
2 RPE65 authKW 700008 5% 49% 53
3 LEBERS CONGENITAL AMAUROSIS authKW 362188 2% 67% 20
4 EIE EYE address 329184 9% 12% 103
5 SUBRETINAL INJECTION authKW 253532 1% 67% 14
6 MCGILL OCULAR GENET address 233508 2% 36% 24
7 FM KIRBY MOL OPHTHALMOL address 190653 3% 19% 37
8 OCULAR GENE THERAPY authKW 166385 1% 88% 7
9 RETINAL GENE THERAPY authKW 158047 1% 73% 8
10 AIPL1 authKW 124176 1% 57% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Ophthalmology 32494 46% 0% 513
2 Medicine, Research & Experimental 7625 31% 0% 349
3 Genetics & Heredity 7280 34% 0% 380
4 Biotechnology & Applied Microbiology 2798 22% 0% 247
5 Biochemistry & Molecular Biology 546 22% 0% 246
6 Biology 31 2% 0% 25
7 Neurosciences 10 5% 0% 52
8 Pediatrics 7 2% 0% 22
9 Cell Biology 6 3% 0% 39
10 Cell & Tissue Engineering 4 0% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EIE EYE 329184 9% 12% 103
2 MCGILL OCULAR GENET 233508 2% 36% 24
3 FM KIRBY MOL OPHTHALMOL 190653 3% 19% 37
4 STELLAR CHANCE S 310 84887 0% 63% 5
5 MOL OPHTHALMOL 83704 1% 21% 15
6 ADV RETINAL OPHTHALM THER EUT 81495 0% 100% 3
7 OPHTHALMOL 75032 48% 1% 537
8 ADV RETINAL OCULAR THER EUT 72438 0% 67% 4
9 RECH THER EUT 1 62088 0% 57% 4
10 UNIT GENE THER Y STEM CELL BIOL 59939 1% 28% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENE THERAPY 28375 6% 2% 64
2 HUMAN GENE THERAPY 25496 5% 2% 56
3 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 20544 11% 1% 121
4 MOLECULAR VISION 19795 4% 1% 49
5 MOLECULAR THERAPY 19108 4% 1% 50
6 HUMAN GENE THERAPY CLINICAL DEVELOPMENT 16420 1% 9% 7
7 OPHTHALMIC GENETICS 8891 1% 2% 14
8 JOURNAL OF GENE MEDICINE 8491 2% 1% 21
9 CURRENT GENE THERAPY 4938 1% 2% 10
10 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 3879 4% 0% 49

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LEBER CONGENITAL AMAUROSIS 954089 6% 56% 63 Search LEBER+CONGENITAL+AMAUROSIS Search LEBER+CONGENITAL+AMAUROSIS
2 RPE65 700008 5% 49% 53 Search RPE65 Search RPE65
3 LEBERS CONGENITAL AMAUROSIS 362188 2% 67% 20 Search LEBERS+CONGENITAL+AMAUROSIS Search LEBERS+CONGENITAL+AMAUROSIS
4 SUBRETINAL INJECTION 253532 1% 67% 14 Search SUBRETINAL+INJECTION Search SUBRETINAL+INJECTION
5 OCULAR GENE THERAPY 166385 1% 88% 7 Search OCULAR+GENE+THERAPY Search OCULAR+GENE+THERAPY
6 RETINAL GENE THERAPY 158047 1% 73% 8 Search RETINAL+GENE+THERAPY Search RETINAL+GENE+THERAPY
7 AIPL1 124176 1% 57% 8 Search AIPL1 Search AIPL1
8 LEBER CONGENITAL AMAUROSIS LCA 122240 1% 75% 6 Search LEBER+CONGENITAL+AMAUROSIS+LCA Search LEBER+CONGENITAL+AMAUROSIS+LCA
9 LCA1 113186 0% 83% 5 Search LCA1 Search LCA1
10 GUCY2D 95071 1% 50% 7 Search GUCY2D Search GUCY2D

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 TRAPANI, I , PUPPO, A , AURICCHIO, A , (2014) VECTOR PLATFORMS FOR GENE THERAPY OF INHERITED RETINOPATHIES.PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 43. ISSUE . P. 108 -128 171 57% 22
2 COLELLA, P , AURICCHIO, A , (2012) GENE THERAPY OF INHERITED RETINOPATHIES: A LONG AND SUCCESSFUL ROAD FROM VIRAL VECTORS TO PATIENTS.HUMAN GENE THERAPY. VOL. 23. ISSUE 8. P. 796-807 105 68% 20
3 HUFNAGEL, RB , AHMED, ZM , CORREA, ZM , SISK, RA , (2012) GENE THERAPY FOR LEBER CONGENITAL AMAUROSIS: ADVANCES AND FUTURE DIRECTIONS.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. VOL. 250. ISSUE 8. P. 1117-1128 58 89% 23
4 TRAPANI, I , BANFI, S , SIMONELLI, F , SURACE, EM , AURICCHIO, A , (2015) GENE THERAPY OF INHERITED RETINAL DEGENERATIONS: PROSPECTS AND CHALLENGES.HUMAN GENE THERAPY. VOL. 26. ISSUE 4. P. 193 -200 66 69% 6
5 CIDECIYAN, AV , (2010) LEBER CONGENITAL AMAUROSIS DUE TO RPE65 MUTATIONS AND ITS TREATMENT WITH GENE THERAPY.PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 29. ISSUE 5. P. 398-427 92 50% 81
6 CIDECIYAN, AV , JACOBSON, SG , BELTRAN, WA , SUMAROKA, A , SWIDER, M , IWABE, S , ROMAN, AJ , OLIVARES, MB , SCHWARTZ, SB , KOMAROMY, AM , ET AL (2013) HUMAN RETINAL GENE THERAPY FOR LEBER CONGENITAL AMAUROSIS SHOWS ADVANCING RETINAL DEGENERATION DESPITE ENDURING VISUAL IMPROVEMENT.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 110. ISSUE 6. P. E517-E525 47 69% 116
7 BOYE, SE , BOYE, SL , LEWIN, AS , HAUSWIRTH, WW , (2013) A COMPREHENSIVE REVIEW OF RETINAL GENE THERAPY.MOLECULAR THERAPY. VOL. 21. ISSUE 3. P. 509 -519 81 43% 75
8 CARVALHO, LS , VANDENBERGHE, LH , (2015) PROMISING AND DELIVERING GENE THERAPIES FOR VISION LOSS.VISION RESEARCH. VOL. 111. ISSUE . P. 124 -133 64 65% 7
9 SMITH, AJ , BAINBRIDGE, JWB , ALI, RR , (2012) GENE SUPPLEMENTATION THERAPY FOR RECESSIVE FORMS OF INHERITED RETINAL DYSTROPHIES.GENE THERAPY. VOL. 19. ISSUE 2. P. 154 -161 66 66% 26
10 PETIT, L , KHANNA, H , PUNZO, C , (2016) ADVANCES IN GENE THERAPY FOR DISEASES OF THE EYE.HUMAN GENE THERAPY. VOL. 27. ISSUE 8. P. 563 -579 84 46% 2

Classes with closest relation at Level 1


Rank Class id link
1 16231 CELL DEV DIS//RETINAL DEGENERATION//N METHYL N NITROSOUREA
2 4434 RETINITIS PIGMENTOSA//RPGR//AUTOSOMAL DOMINANT RETINITIS PIGMENTOSA
3 21767 PROGRESSIVE RETINAL ATROPHY//PROGRESSIVE ROD CONE DEGENERATION//GENERALISED PROGRESSIVE RETINAL ATROPHY
4 9208 VISUAL CYCLE//INTERPHOTORECEPTOR RETINOID BINDING PROTEIN//FUNDUS ALBIPUNCTATUS
5 30188 TUBBY//TULP1//ORF PHAGE DISPLAY
6 1257 ADENO ASSOCIATED VIRUS//AAV//POWELL GENE THER Y
7 13019 UNIT REGULATORY MOL BIOL//NCS 1//RECOVERIN
8 25093 CHOROIDEREMIA//POU3F4//CHM GENE
9 6484 RETINAL TRANSPLANTATION//RETINAL PIGMENT EPITHELIUM//RPE TRANSPLANTATION
10 9993 TRICHROMACY//COLOR VISION//CONE PHOTOPIGMENTS

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