Class information for:
Level 2: LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1071 9941 38.2 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1071 2             LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC 9941
201 1                   LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC 3943
2234 1                   PANITUMUMAB//CETUXIMAB//KRAS 2314
5374 1                   FAMILIAL ADENOMATOUS POLYPOSIS//APC GENE//MUTYH 1632
15816 1                   DCC GENE//BIOPHYS CYTOMETRY//DCC 690
16185 1                   APC//ADENOMATOUS POLYPOSIS COLI//MIN MOUSE 668
24187 1                   RHGP//WHOLE GENOMIC OLIGONUCLEOTIDE MICROARRAY//12 GENE COLON CANCER ASSAY 320
25206 1                   NONSPECIFIC STEROIDAL ESTERASE//V FES//TUMORICIDAL POTENTIAL 287
36036 1                   ABL B ALLELE//BLOKHIN CLIN ONCOL//CARDIOVASCULAR DISEASES RISK FACTORS EPIDEMIOLOGY PREVENTION 87

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 LYNCH SYNDROME authKW 1515938 7% 76% 651
2 MICROSATELLITE INSTABILITY authKW 1314179 9% 47% 918
3 HNPCC authKW 970209 4% 75% 423
4 HEREDITARY NONPOLYPOSIS COLORECTAL CANCER authKW 727148 3% 77% 309
5 PANITUMUMAB authKW 471334 2% 64% 240
6 COLORECTAL CANCER authKW 425248 17% 8% 1695
7 FAMILIAL ADENOMATOUS POLYPOSIS authKW 388727 3% 38% 334
8 CETUXIMAB authKW 377391 4% 28% 445
9 MLH1 authKW 376345 2% 56% 219
10 KRAS authKW 348790 4% 28% 403

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 90690 49% 1% 4908
2 Genetics & Heredity 15935 18% 0% 1752
3 Gastroenterology & Hepatology 14122 12% 0% 1195
4 Pathology 8145 9% 0% 862
5 Surgery 1537 9% 0% 880
6 Cell Biology 851 7% 0% 679
7 Medical Laboratory Technology 469 1% 0% 139
8 Medicine, Research & Experimental 449 4% 0% 371
9 Medicine, General & Internal 189 4% 0% 383
10 Biochemistry & Molecular Biology 82 8% 0% 760

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 DIGEST ONCOL UNIT 53614 1% 30% 59
2 NETHERLANDS FDN DETECT HEREDITARY TUMOURS 51837 0% 68% 25
3 MOL POPULAT GENET 50996 1% 24% 69
4 DANISH HNPCC REGISTER 50366 0% 86% 19
5 GRP HUMAN GENET 46911 0% 53% 29
6 FAMILIAL GASTROINTESTINAL CANC REGISTRY 44185 0% 60% 24
7 PATHOL 37181 24% 1% 2342
8 ONCOL SPERIMENTALE 1 30951 0% 92% 11
9 NEW ZEALAND FAMILIAL GASTROINTESTINAL CANC REGIST 29464 0% 80% 12
10 U434 28540 0% 25% 38

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FAMILIAL CANCER 185459 2% 26% 230
2 CLINICAL COLORECTAL CANCER 37517 1% 16% 76
3 HEREDITARY CANCER IN CLINICAL PRACTICE 24295 0% 21% 38
4 GENES CHROMOSOMES & CANCER 13528 1% 4% 119
5 HUMAN MUTATION 11689 1% 3% 124
6 JOURNAL OF MOLECULAR DIAGNOSTICS 10919 1% 6% 64
7 DISEASES OF THE COLON & RECTUM 10497 2% 2% 165
8 CANCER GENETICS AND CYTOGENETICS 10061 1% 2% 143
9 INTERNATIONAL JOURNAL OF CANCER 8984 2% 1% 248
10 BRITISH JOURNAL OF CANCER 6606 2% 1% 201

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 LYNCH SYNDROME 1515938 7% 76% 651 Search LYNCH+SYNDROME Search LYNCH+SYNDROME
2 MICROSATELLITE INSTABILITY 1314179 9% 47% 918 Search MICROSATELLITE+INSTABILITY Search MICROSATELLITE+INSTABILITY
3 HNPCC 970209 4% 75% 423 Search HNPCC Search HNPCC
4 HEREDITARY NONPOLYPOSIS COLORECTAL CANCER 727148 3% 77% 309 Search HEREDITARY+NONPOLYPOSIS+COLORECTAL+CANCER Search HEREDITARY+NONPOLYPOSIS+COLORECTAL+CANCER
5 PANITUMUMAB 471334 2% 64% 240 Search PANITUMUMAB Search PANITUMUMAB
6 COLORECTAL CANCER 425248 17% 8% 1695 Search COLORECTAL+CANCER Search COLORECTAL+CANCER
7 FAMILIAL ADENOMATOUS POLYPOSIS 388727 3% 38% 334 Search FAMILIAL+ADENOMATOUS+POLYPOSIS Search FAMILIAL+ADENOMATOUS+POLYPOSIS
8 CETUXIMAB 377391 4% 28% 445 Search CETUXIMAB Search CETUXIMAB
9 MLH1 376345 2% 56% 219 Search MLH1 Search MLH1
10 KRAS 348790 4% 28% 403 Search KRAS Search KRAS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 COLAS, C , COULET, F , SVRCEK, M , COLLURA, A , FLEJOU, JF , DUVAL, A , HAMELIN, R , (2012) LYNCH OR NOT LYNCH? IS THAT ALWAYS A QUESTION?.ADVANCES IN CANCER RESEARCH, VOL 113. VOL. 113. ISSUE . P. 121-166 192 87% 14
2 GIARDIELLO, FM , ALLEN, JI , AXILBUND, JE , BOLAND, CR , BURKE, CA , BURT, RW , CHURCH, JM , DOMINITZ, JA , JOHNSON, DA , KALTENBACH, T , ET AL (2014) GUIDELINES ON GENETIC EVALUATION AND MANAGEMENT OF LYNCH SYNDROME: A CONSENSUS STATEMENT BY THE US MULTI-SOCIETY TASK FORCE ON COLORECTAL CANCERE.AMERICAN JOURNAL OF GASTROENTEROLOGY. VOL. 109. ISSUE 8. P. 1159 -1179 116 85% 53
3 GIARDIELLO, FM , ALLEN, JI , AXILBUND, JE , BOLAND, CR , BURKE, CA , BURT, RW , CHURCH, JM , DOMINITZ, JA , JOHNSON, DA , KALTENBACH, T , ET AL (2014) GUIDELINES ON GENETIC EVALUATION AND MANAGEMENT OF LYNCH SYNDROME: A CONSENSUS STATEMENT BY THE US MULTI-SOCIETY TASK FORCE ON COLORECTAL CANCER.GASTROENTEROLOGY. VOL. 147. ISSUE 2. P. 502 -526 117 85% 46
4 BUZA, N , ZIAI, J , HUI, P , (2016) MISMATCH REPAIR DEFICIENCY TESTING IN CLINICAL PRACTICE.EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. VOL. 16. ISSUE 5. P. 591 -604 140 89% 0
5 SYNGAL, S , BRAND, RE , CHURCH, JM , GIARDIELLO, FM , HAMPEL, HL , BURT, RW , (2015) ACG CLINICAL GUIDELINE: GENETIC TESTING AND MANAGEMENT OF HEREDITARY GASTROINTESTINAL CANCER SYNDROMES.AMERICAN JOURNAL OF GASTROENTEROLOGY. VOL. 110. ISSUE 2. P. 223 -262 135 45% 82
6 LYNCH, HT , SNYDER, CL , SHAW, TG , HEINEN, CD , HITCHINS, MP , (2015) MILESTONES OF LYNCH SYNDROME: 1895-2015.NATURE REVIEWS CANCER. VOL. 15. ISSUE 3. P. 181 -194 121 68% 31
7 LADABAUM, U , FORD, JM , MARTEL, M , BARKUN, AN , (2015) AMERICAN GASTROENTEROLOGICAL ASSOCIATION TECHNICAL REVIEW ON THE DIAGNOSIS AND MANAGEMENT OF LYNCH SYNDROME.GASTROENTEROLOGY. VOL. 149. ISSUE 3. P. 783 -+ 125 87% 4
8 SIJMONS, RH , HOFSTRA, RMW , (2016) REVIEW: CLINICAL ASPECTS OF HEREDITARY DNA MISMATCH REPAIR GENE MUTATIONS.DNA REPAIR. VOL. 38. ISSUE . P. 155 -162 84 92% 6
9 HUXLEY, N , HOYLE, M , JONES-HUGHES, T , COELHO, H , COOPER, C , FRAYLING, I , HYDE, C , SNOWSILL, T , (2014) A SYSTEMATIC REVIEW AND ECONOMIC EVALUATION OF DIAGNOSTIC STRATEGIES FOR LYNCH SYNDROME.HEALTH TECHNOLOGY ASSESSMENT. VOL. 18. ISSUE 58. P. 1 -+ 141 66% 25
10 DESCHOOLMEESTER, V , BAAY, M , SPECENIER, P , LARDON, F , VERMORKEN, JB , (2010) A REVIEW OF THE MOST PROMISING BIOMARKERS IN COLORECTAL CANCER: ONE STEP CLOSER TO TARGETED THERAPY.ONCOLOGIST. VOL. 15. ISSUE 7. P. 699 -731 171 60% 70

Classes with closest relation at Level 2


Rank Class id link
1 3124 ANNALS OF SAUDI MEDICINE//NUTR HLTH STUDIES UNIT//SAUDI MEDICAL JOURNAL
2 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
3 2698 HETEROTOPIC PANCREAS//ECTOPIC PANCREAS//HETEROTOPIC GASTRIC MUCOSA
4 382 DNA METHYLATION//EPIGENETICS//METHYLATION
5 1425 WNT//BETA CATENIN//FRIZZLED
6 2606 FHIT//WWOX//FRAGILE SITES
7 2474 ABERRANT CRYPT FOCI//ANTINEOPLASTIC DRUGS//COLON CARCINOGENESIS
8 1717 GEFITINIB//EGFR MUTATION//MIDKINE
9 3290 HAND FOOT SYNDROME//HYPERSENSITIVITY REACTION//RADIATION RECALL
10 900 BRCA1//BRCA2//FANCONI ANEMIA

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