Class information for:
Level 2: PHAGE DISPLAY//ANTIBODY ENGINEERING//BISPECIFIC ANTIBODY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1834 6173 41.8 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
478 3       PHAGE DISPLAY//CELL FREE PROTEIN SYNTHESIS//ANTIBODY ENGINEERING 23687
1834 2             PHAGE DISPLAY//ANTIBODY ENGINEERING//BISPECIFIC ANTIBODY 6173
2141 1                   PHAGE DISPLAY//SCFV//ANTIBODY LIBRARY 2343
8251 1                   CANONICAL STRUCTURES//ANTIBODY MODELING//HUMANIZATION 1275
9947 1                   BISPECIFIC ANTIBODY//BISPECIFIC ANTIBODIES//CATUMAXOMAB 1105
14481 1                   NANOBODY//SINGLE DOMAIN ANTIBODY//VHH 767
18905 1                   REPEAT PROTEIN//FN3//ANKYRIN REPEAT 531
31515 1                   GANKYRIN//P28GANK//CUEDC2 152

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHAGE DISPLAY authKW 619474 9% 22% 579
2 ANTIBODY ENGINEERING authKW 541881 4% 48% 227
3 BISPECIFIC ANTIBODY authKW 499556 3% 55% 184
4 NANOBODY authKW 453293 3% 59% 155
5 SINGLE DOMAIN ANTIBODY authKW 441369 2% 74% 121
6 SCFV authKW 408040 4% 34% 243
7 SINGLE CHAIN FV authKW 290613 2% 47% 126
8 ANTIBODY LIBRARY authKW 277015 1% 68% 82
9 VHH authKW 240609 1% 62% 78
10 INTRABODY authKW 238139 1% 58% 83

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 17688 45% 0% 2794
2 Biochemical Research Methods 12513 16% 0% 966
3 Immunology 11469 22% 0% 1347
4 Biotechnology & Applied Microbiology 7543 16% 0% 981
5 Biophysics 2767 9% 0% 534
6 Oncology 1641 10% 0% 644
7 Medicine, Research & Experimental 943 6% 0% 356
8 Cell Biology 460 7% 0% 403
9 Virology 102 2% 0% 94
10 Mathematical & Computational Biology 62 1% 0% 56

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IG THER Y CO 49447 0% 100% 10
2 CHRISTIAN DOPPLER ANTIBODY ENGN 41877 0% 71% 12
3 LEHRSTUHL BIOL CHEM 36655 1% 21% 35
4 CELLULAIRE MOL IMMUNOL 28765 0% 73% 8
5 LARGE MOL 27129 0% 31% 18
6 ABT BIOTECHNOL 25854 0% 35% 15
7 CLIN COOPERAT GRP BISPECIF ANTIBODIES 24723 0% 100% 5
8 PROT ENGN ANTIBODY TECHNOL 21090 0% 53% 8
9 GDR2352 20601 0% 83% 5
10 BIOMOLEC ENGN 343 ROYAL PARADE 19779 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MABS 87119 2% 15% 114
2 PROTEIN ENGINEERING DESIGN & SELECTION 80279 2% 13% 130
3 PORTLAND PRESS PROCEEDINGS 74330 1% 40% 38
4 JOURNAL OF IMMUNOLOGICAL METHODS 39591 5% 3% 279
5 MOLECULAR IMMUNOLOGY 27580 3% 3% 199
6 PROTEIN ENGINEERING 25348 2% 5% 108
7 JOURNAL OF MOLECULAR BIOLOGY 24139 6% 1% 340
8 JOURNAL OF MOLECULAR RECOGNITION 9262 1% 4% 48
9 HYBRIDOMA 6521 1% 3% 53
10 HYBRIDOMA AND HYBRIDOMICS 5801 0% 7% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHAGE DISPLAY 619474 9% 22% 579 Search PHAGE+DISPLAY Search PHAGE+DISPLAY
2 ANTIBODY ENGINEERING 541881 4% 48% 227 Search ANTIBODY+ENGINEERING Search ANTIBODY+ENGINEERING
3 BISPECIFIC ANTIBODY 499556 3% 55% 184 Search BISPECIFIC+ANTIBODY Search BISPECIFIC+ANTIBODY
4 NANOBODY 453293 3% 59% 155 Search NANOBODY Search NANOBODY
5 SINGLE DOMAIN ANTIBODY 441369 2% 74% 121 Search SINGLE+DOMAIN+ANTIBODY Search SINGLE+DOMAIN+ANTIBODY
6 SCFV 408040 4% 34% 243 Search SCFV Search SCFV
7 SINGLE CHAIN FV 290613 2% 47% 126 Search SINGLE+CHAIN+FV Search SINGLE+CHAIN+FV
8 ANTIBODY LIBRARY 277015 1% 68% 82 Search ANTIBODY+LIBRARY Search ANTIBODY+LIBRARY
9 VHH 240609 1% 62% 78 Search VHH Search VHH
10 INTRABODY 238139 1% 58% 83 Search INTRABODY Search INTRABODY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MUYLDERMANS, S , (2013) NANOBODIES: NATURAL SINGLE-DOMAIN ANTIBODIES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82. VOL. 82. ISSUE . P. 775-797 116 79% 222
2 ROMAO, E , MORALES-YANEZ, F , HU, YZ , CRAUWELS, M , DE PAUW, P , HASSANZADEH, GG , DEVOOGDT, N , ACKAERT, C , VINCKE, C , MUYLDERMANS, S , (2016) IDENTIFICATION OF USEFUL NANOBODIES BY PHAGE DISPLAY OF IMMUNE SINGLE DOMAIN LIBRARIES DERIVED FROM CAMELID HEAVY CHAIN ANTIBODIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 22. ISSUE 43. P. 6500 -6518 196 66% 1
3 BRINKMANN, U , KONTERMANN, RE , (2017) THE MAKING OF BISPECIFIC ANTIBODIES.MABS. VOL. 9. ISSUE 2. P. 182 -212 176 66% 0
4 STEELAND, S , VANDENBROUCKE, RE , LIBERT, C , (2016) NANOBODIES AS THERAPEUTICS: BIG OPPORTUNITIES FOR SMALL ANTIBODIES.DRUG DISCOVERY TODAY. VOL. 21. ISSUE 7. P. 1076 -1113 157 52% 3
5 RAHBARIZADEH, F , AHMADVAND, D , SHARIFZADEH, Z , (2011) NANOBODY; AN OLD CONCEPT AND NEW VEHICLE FOR IMMUNOTARGETING.IMMUNOLOGICAL INVESTIGATIONS. VOL. 40. ISSUE 3. P. 299 -338 142 68% 31
6 VAN BOCKSTAELE, F , HOLZ, JB , REVETS, H , (2009) THE DEVELOPMENT OF NANOBODIES FOR THERAPEUTIC APPLICATIONS.CURRENT OPINION IN INVESTIGATIONAL DRUGS. VOL. 10. ISSUE 11. P. 1212 -1224 109 84% 72
7 DE MARCO, A , (2011) BIOTECHNOLOGICAL APPLICATIONS OF RECOMBINANT SINGLE-DOMAIN ANTIBODY FRAGMENTS.MICROBIAL CELL FACTORIES. VOL. 10. ISSUE . P. - 124 68% 49
8 EYER, L , HRUSKA, K , (2012) SINGLE-DOMAIN ANTIBODY FRAGMENTS DERIVED FROM HEAVY-CHAIN ANTIBODIES: A REVIEW.VETERINARNI MEDICINA. VOL. 57. ISSUE 9. P. 439 -513 110 79% 20
9 SPIESS, C , ZHAI, QT , CARTER, PJ , (2015) ALTERNATIVE MOLECULAR FORMATS AND THERAPEUTIC APPLICATIONS FOR BISPECIFIC ANTIBODIES.MOLECULAR IMMUNOLOGY. VOL. 67. ISSUE 2. P. 95 -106 73 66% 55
10 HOOGENBOOM, HR , (2005) SELECTING AND SCREENING RECOMBINANT ANTIBODY LIBRARIES.NATURE BIOTECHNOLOGY. VOL. 23. ISSUE 9. P. 1105-1116 101 64% 502

Classes with closest relation at Level 2


Rank Class id link
1 2154 PHAGE DISPLAY//FILAMENTOUS BACTERIOPHAGE//MIMOTOPE
2 2423 CATALYTIC ANTIBODIES//ABZYME//DIRECTED EVOLUTION
3 808 RADIOIMMUNOTHERAPY//NUCLEAR MEDICINE AND BIOLOGY//ANTIBODY DRUG CONJUGATE
4 1655 BIOSIMILAR//FCRN//PROTEIN FORMULATION
5 3451 HUMAN HUMAN HYBRIDOMA//IMMUNOGLOBULIN PRODUCTION STIMULATING FACTOR//HYBRIDOMA
6 1537 CELL FREE PROTEIN SYNTHESIS//INTEIN//PROTEIN SPLICING
7 1876 RIBOSOME INACTIVATING PROTEIN//RICIN//TRICHOSANTHIN
8 2591 HETEROPHILIC ANTIBODIES//HETEROPHILE ANTIBODIES//JOURNAL OF IMMUNOLOGICAL METHODS
9 3862 IGY//EGG YOLK ANTIBODIES//IMMUNOGLOBULIN Y
10 183 IMMUNOLOGY//JOURNAL OF IMMUNOLOGY//SOMATIC HYPERMUTATION

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