Class information for:
Level 2: BIOSIMILAR//FCRN//PROTEIN FORMULATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1655 6878 38.0 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
350 3       COMPLEMENT//MANNOSE BINDING LECTIN//IMMUNOLOGY 35656
1655 2             BIOSIMILAR//FCRN//PROTEIN FORMULATION 6878
4824 1                   AGALACTOSYL IGG//MABS//PROT ANALYT CHEM 1719
8514 1                   PROTEIN FORMULATION//PROTEIN AGGREGATION//SUBVISIBLE PARTICLES 1246
10569 1                   FCRN//NEONATAL FC RECEPTOR//TARGET MEDIATED DRUG DISPOSITION 1052
11045 1                   ISOASPARTATE//DEAMIDATION//PROTEIN L ISOASPARTYL METHYLTRANSFERASE 1012
14993 1                   BIOSIMILAR//ANTI ERYTHROPOIETIN ANTIBODIES//CT P13 737
18498 1                   BIOANALYSIS//ANTI DRUG ANTIBODIES//LIGAND BINDING ASSAY 549
21074 1                   DYNAM MACROMOL ASSEMBLY SECT//ANALYTICAL ULTRACENTRIFUGATION//SEDIMENTATION VELOCITY 434
33129 1                   IND BIOCHEM PROGRAM//BETA METHYLNORLEUCINE//CX 397 129

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOSIMILAR authKW 728726 4% 58% 284
2 FCRN authKW 491819 2% 83% 134
3 PROTEIN FORMULATION authKW 434300 3% 55% 177
4 MABS journal 253090 3% 28% 205
5 NEONATAL FC RECEPTOR authKW 248985 1% 84% 67
6 DEAMIDATION authKW 212692 2% 35% 138
7 LATE STAGE PHARMACEUT DEV address 170386 1% 80% 48
8 ISOASPARTATE authKW 159133 1% 78% 46
9 PROTEIN AGGREGATION authKW 156083 4% 13% 274
10 PROT ANALYT CHEM address 139877 1% 52% 61

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemical Research Methods 12978 15% 0% 1041
2 Pharmacology & Pharmacy 12195 26% 0% 1794
3 Chemistry, Analytical 6800 15% 0% 1007
4 Biochemistry & Molecular Biology 4517 25% 0% 1688
5 Immunology 4041 13% 0% 907
6 Chemistry, Medicinal 3094 7% 0% 480
7 Biotechnology & Applied Microbiology 1306 7% 0% 500
8 Chemistry, Multidisciplinary 1232 12% 0% 795
9 Medicine, Research & Experimental 1039 6% 0% 395
10 Biophysics 840 5% 0% 351

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LATE STAGE PHARMACEUT DEV 170386 1% 80% 48
2 PROT ANALYT CHEM 139877 1% 52% 61
3 ANALYT FORMULAT SCI 118390 1% 68% 39
4 PROC PROD DEV 104295 1% 44% 54
5 MACROMOL VACCINE STABILIZAT 90640 1% 55% 37
6 FORMULAT ANALYT OURCES 87419 0% 73% 27
7 FORMULAT SCI 80393 1% 42% 43
8 LATE STAGE PHARMACEUT PROC DEV 73016 0% 69% 24
9 DYNAM MACROMOL ASSEMBLY SECT 67248 0% 63% 24
10 EARLY STAGE PHARMACEUT DEV 63229 0% 51% 28

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MABS 253090 3% 28% 205
2 BIOANALYSIS 125815 3% 14% 199
3 JOURNAL OF PHARMACEUTICAL SCIENCES 70188 6% 4% 422
4 AAPS JOURNAL 58234 2% 11% 122
5 PHARMACEUTICAL RESEARCH 21485 3% 2% 198
6 BIOLOGICALS 13673 1% 5% 65
7 BIOPHARM INTERNATIONAL 12834 1% 7% 39
8 JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 10827 1% 6% 38
9 MOLECULAR IMMUNOLOGY 9659 2% 2% 125
10 PROGRESS IN COLLOID AND POLYMER SCIENCE 8029 0% 13% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BIOSIMILAR 728726 4% 58% 284 Search BIOSIMILAR Search BIOSIMILAR
2 FCRN 491819 2% 83% 134 Search FCRN Search FCRN
3 PROTEIN FORMULATION 434300 3% 55% 177 Search PROTEIN+FORMULATION Search PROTEIN+FORMULATION
4 NEONATAL FC RECEPTOR 248985 1% 84% 67 Search NEONATAL+FC+RECEPTOR Search NEONATAL+FC+RECEPTOR
5 DEAMIDATION 212692 2% 35% 138 Search DEAMIDATION Search DEAMIDATION
6 ISOASPARTATE 159133 1% 78% 46 Search ISOASPARTATE Search ISOASPARTATE
7 PROTEIN AGGREGATION 156083 4% 13% 274 Search PROTEIN+AGGREGATION Search PROTEIN+AGGREGATION
8 SUBVISIBLE PARTICLES 111549 0% 93% 27 Search SUBVISIBLE+PARTICLES Search SUBVISIBLE+PARTICLES
9 TARGET MEDIATED DRUG DISPOSITION 102393 0% 77% 30 Search TARGET+MEDIATED+DRUG+DISPOSITION Search TARGET+MEDIATED+DRUG+DISPOSITION
10 ANTI ERYTHROPOIETIN ANTIBODIES 97811 0% 96% 23 Search ANTI+ERYTHROPOIETIN+ANTIBODIES Search ANTI+ERYTHROPOIETIN+ANTIBODIES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GIRAGOSSIAN, C , CLARK, T , PICHE-NICHOLAS, N , BOWMAN, CJ , (2013) NEONATAL FC RECEPTOR AND ITS ROLE IN THE ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF IMMUNOGLOBULIN G-BASED BIOTHERAPEUTICS.CURRENT DRUG METABOLISM. VOL. 14. ISSUE 7. P. 764-790 223 73% 14
2 SOCKOLOSKY, JT , SZOKA, FC , (2015) THE NEONATAL FC RECEPTOR, FCRN, AS A TARGET FOR DRUG DELIVERY AND THERAPY.ADVANCED DRUG DELIVERY REVIEWS. VOL. 91. ISSUE . P. 109 -124 132 84% 13
3 MANNING, MC , CHOU, DK , MURPHY, BM , PAYNE, RW , KATAYAMA, DS , (2010) STABILITY OF PROTEIN PHARMACEUTICALS: AN UPDATE.PHARMACEUTICAL RESEARCH. VOL. 27. ISSUE 4. P. 544 -575 190 38% 312
4 WARD, ES , DEVANABOYINA, SC , OBER, RJ , (2015) TARGETING FCRN FOR THE MODULATION OF ANTIBODY DYNAMICS.MOLECULAR IMMUNOLOGY. VOL. 67. ISSUE 2. P. 131 -141 117 84% 8
5 ROOPENIAN, DC , AKILESH, S , (2007) FCRN: THE NEONATAL FC RECEPTOR COMES OF AGE.NATURE REVIEWS IMMUNOLOGY. VOL. 7. ISSUE 9. P. 715 -725 75 87% 676
6 LIU, HC , PONNIAH, G , ZHANG, HM , NOWAK, C , NEILL, A , GONZALEZ-LOPEZ, N , PATEL, R , CHENG, GL , KITA, AZ , ANDRIEN, B , (2014) IN VITRO AND IN VIVO MODIFICATIONS OF RECOMBINANT AND HUMAN IGG ANTIBODIES.MABS. VOL. 6. ISSUE 5. P. 1145 -1154 122 79% 13
7 MARTINS, JP , KENNEDY, PJ , SANTOS, HA , BARRIAS, C , SARMENTO, B , (2016) A COMPREHENSIVE REVIEW OF THE NEONATAL FC RECEPTOR AND ITS APPLICATION IN DRUG DELIVERY.PHARMACOLOGY & THERAPEUTICS. VOL. 161. ISSUE . P. 22 -39 136 66% 1
8 KUO, TT , BAKER, K , YOSHIDA, M , QIAO, SW , AVESON, VG , LENCER, WI , BLUMBERG, RS , (2010) NEONATAL FC RECEPTOR: FROM IMMUNITY TO THERAPEUTICS.JOURNAL OF CLINICAL IMMUNOLOGY. VOL. 30. ISSUE 6. P. 777 -789 95 86% 88
9 VIDARSSON, G , DEKKERS, G , RISPENS, T , (2014) IGG SUBCLASSES AND ALLOTYPES: FROM STRUCTURE TO EFFECTOR FUNCTIONS.FRONTIERS IN IMMUNOLOGY. VOL. 5. ISSUE . P. - 101 52% 100
10 LIU, HC , GAZA-BULSECO, G , FALDU, D , CHUMSAE, C , SUN, J , (2008) HETEROGENEITY OF MONOCLONAL ANTIBODIES.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 97. ISSUE 7. P. 2426-2447 126 56% 172

Classes with closest relation at Level 2


Rank Class id link
1 2797 FC RECEPTOR//FC GAMMA RECEPTORS//FC GAMMA RECEPTOR
2 1834 PHAGE DISPLAY//ANTIBODY ENGINEERING//BISPECIFIC ANTIBODY
3 3191 SECRETORY COMPONENT//POLYMERIC IMMUNOGLOBULIN RECEPTOR//CD89
4 1067 ANGIOGENIN//RIBONUCLEASE//MOLTEN GLOBULE
5 321 N GLYCAN//GLYCOBIOLOGY//GLYCOPROTEOMICS
6 1592 TREHALOSE//SPRAY DRYING//FREEZE DRYING
7 1234 BACULOVIRUS//NUCLEOPOLYHEDROVIRUS//NUCLEAR POLYHEDROSIS VIRUS
8 2163 ION MOBILITY SPECTROMETRY//JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY//ION MOBILITY
9 3004 STAPHYLOCOCCAL PROTEIN A//PROTEIN A//ANIM PHYSIOL SECT
10 3862 IGY//EGG YOLK ANTIBODIES//IMMUNOGLOBULIN Y

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