Class information for:
Level 1: IND BIOCHEM PROGRAM//BETA METHYLNORLEUCINE//CX 397

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
33129 129 23.0 59%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
350 3       COMPLEMENT//MANNOSE BINDING LECTIN//IMMUNOLOGY 35656
1655 2             BIOSIMILAR//FCRN//PROTEIN FORMULATION 6878
33129 1                   IND BIOCHEM PROGRAM//BETA METHYLNORLEUCINE//CX 397 129

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IND BIOCHEM PROGRAM address 561079 6% 30% 8
2 BETA METHYLNORLEUCINE authKW 473420 2% 100% 2
3 CX 397 authKW 315612 2% 67% 2
4 SEQUENCE VARIANT authKW 243463 5% 17% 6
5 AMINO ACID ABBREVIATIONS authKW 236710 1% 100% 1
6 AMINO ACID STRUCTURES authKW 236710 1% 100% 1
7 ANALYT DEV NA address 236710 1% 100% 1
8 AND REGRESSION ESTIMATION authKW 236710 1% 100% 1
9 BIOCHIM MICROBIOL IMMUNOL address 236710 1% 100% 1
10 BIOL PHARMA EARLY DEV address 236710 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biotechnology & Applied Microbiology 1162 40% 0% 52
2 Biochemical Research Methods 314 17% 0% 22
3 Pharmacology & Pharmacy 163 22% 0% 29
4 Chemistry, Analytical 162 16% 0% 21
5 Biochemistry & Molecular Biology 161 32% 0% 41
6 Education, Scientific Disciplines 150 5% 0% 7
7 Social Sciences, Interdisciplinary 20 2% 0% 3
8 Chemistry, Medicinal 8 3% 0% 4
9 Multidisciplinary Sciences 7 2% 0% 2
10 Biophysics 7 4% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IND BIOCHEM PROGRAM 561079 6% 30% 8
2 ANALYT DEV NA 236710 1% 100% 1
3 BIOCHIM MICROBIOL IMMUNOL 236710 1% 100% 1
4 BIOL PHARMA EARLY DEV 236710 1% 100% 1
5 BIOPROC DEV NA 236710 1% 100% 1
6 DISCOVERY TECH GRP 236710 1% 100% 1
7 EARLY STAGE CELL CULTURE DEV 236710 1% 100% 1
8 METAB ENDOCRINE DRUG PROD DRUG EVALUAT 236710 1% 100% 1
9 NEW DRUG CHEM 2 236710 1% 100% 1
10 PROC SCI ANALYT 236710 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPHARM INTERNATIONAL 36643 7% 2% 9
2 BIOCHEMICAL EDUCATION 11548 4% 1% 5
3 BIOPHARM-THE TECHNOLOGY & BUSINESS OF BIOPHARMACEUTICALS 9464 2% 2% 2
4 BIOPHARM INTERNATIONAL-THE APPLIED TECHNOLOGIES OF BIOPHARMACEUTICAL DEVELOPMENT 8765 1% 4% 1
5 MABS 8030 4% 1% 5
6 MICROBIAL CELL FACTORIES 2797 3% 0% 4
7 BIOLOGICALS 2779 3% 0% 4
8 BIO-TECHNOLOGY 1483 2% 0% 3
9 BIOPHARM-THE APPLIED TECHNOLOGIES OF BIOPHARMACEUTICAL DEVELOPMENT 1335 1% 1% 1
10 PHARMACOPEIAL FORUM 1136 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BETA METHYLNORLEUCINE 473420 2% 100% 2 Search BETA+METHYLNORLEUCINE Search BETA+METHYLNORLEUCINE
2 CX 397 315612 2% 67% 2 Search CX+397 Search CX+397
3 SEQUENCE VARIANT 243463 5% 17% 6 Search SEQUENCE+VARIANT Search SEQUENCE+VARIANT
4 AMINO ACID ABBREVIATIONS 236710 1% 100% 1 Search AMINO+ACID+ABBREVIATIONS Search AMINO+ACID+ABBREVIATIONS
5 AMINO ACID STRUCTURES 236710 1% 100% 1 Search AMINO+ACID+STRUCTURES Search AMINO+ACID+STRUCTURES
6 AND REGRESSION ESTIMATION 236710 1% 100% 1 Search AND+REGRESSION+ESTIMATION Search AND+REGRESSION+ESTIMATION
7 BIOPHARMACEUTICAL FERMENTATION 236710 1% 100% 1 Search BIOPHARMACEUTICAL+FERMENTATION Search BIOPHARMACEUTICAL+FERMENTATION
8 BL21 DE3 236710 1% 100% 1 Search BL21+DE3 Search BL21+DE3
9 CHEMICALLY DEFINED MEDIUM CDM 236710 1% 100% 1 Search CHEMICALLY+DEFINED+MEDIUM+CDM Search CHEMICALLY+DEFINED+MEDIUM+CDM
10 EARLY STAGE CELL LINE DEVELOPMENT 236710 1% 100% 1 Search EARLY+STAGE+CELL+LINE+DEVELOPMENT Search EARLY+STAGE+CELL+LINE+DEVELOPMENT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HARRIS, RP , KILBY, PM , (2014) AMINO ACID MISINCORPORATION IN RECOMBINANT BIOPHARMACEUTICAL PRODUCTS.CURRENT OPINION IN BIOTECHNOLOGY. VOL. 30. ISSUE . P. 45 -50 20 50% 7
2 NI, J , GAO, M , JAMES, A , YAO, JS , YUAN, T , CARPICK, B , D'AMORE, T , FARRELL, P , (2015) INVESTIGATION INTO THE MISINCORPORATION OF NORLEUCINE INTO A RECOMBINANT PROTEIN VACCINE CANDIDATE.JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY. VOL. 42. ISSUE 6. P. 971 -975 10 67% 2
3 HARRIS, RP , MATTOCKS, J , GREEN, PS , MOFFATT, F , KILBY, PM , (2012) DETERMINATION AND CONTROL OF LOW-LEVEL AMINO ACID MISINCORPORATION IN HUMAN THIOREDOXIN PROTEIN PRODUCED IN A RECOMBINANT ESCHERICHIA COLI PRODUCTION SYSTEM.BIOTECHNOLOGY AND BIOENGINEERING. VOL. 109. ISSUE 8. P. 1987-1995 10 71% 2
4 KHETAN, A , HUANG, YM , DOLNIKOVA, J , PEDERSON, NE , WEN, DY , YUSUF-MAKAGIANSAR, H , CHEN, P , RYLL, T , (2010) CONTROL OF MISINCORPORATION OF SERINE FOR ASPARAGINE DURING ANTIBODY PRODUCTION USING CHO CELLS.BIOTECHNOLOGY AND BIOENGINEERING. VOL. 107. ISSUE 1. P. 116-123 10 59% 23
5 ZHANG, S , BARTKOWIAK, L , NABISWA, B , MISHRA, P , FANN, J , OUELLETTE, D , CORREIA, I , REGIER, D , LIU, JJ , (2015) IDENTIFYING LOW-LEVEL SEQUENCE VARIANTS VIA NEXT GENERATION SEQUENCING TO AID STABLE CHO CELL LINE SCREENING.BIOTECHNOLOGY PROGRESS. VOL. 31. ISSUE 4. P. 1077 -1085 13 33% 2
6 BRADY, LJ , SCOTT, RA , BALLAND, A , (2015) AN OPTIMIZED APPROACH TO THE RAPID ASSESSMENT AND DETECTION OF SEQUENCE VARIANTS IN RECOMBINANT PROTEIN PRODUCTS.ANALYTICAL AND BIOANALYTICAL CHEMISTRY. VOL. 407. ISSUE 13. P. 3851 -3860 7 54% 3
7 SOINI, J , FALSCHLEHNER, C , LIEDERT, C , BERNHARDT, J , VUORISTO, J , NEUBAUER, P , (2008) NORVALINE IS ACCUMULATED AFTER A DOWN-SHIFT OF OXYGEN IN ESCHERICHIA COLI W3110.MICROBIAL CELL FACTORIES. VOL. 7. ISSUE . P. - 10 43% 25
8 WALSH, G , (2013) MILESTONES AND MODERATE PROGRESS IN 2012 DRUG APPROVALS.BIOPHARM INTERNATIONAL. VOL. 26. ISSUE 4. P. 54-56 4 100% 3
9 LIAN, ZR , WU, QD , WANG, TT , (2016) IDENTIFICATION AND CHARACTERIZATION OF A -1 READING FRAMESHIFT IN THE HEAVY CHAIN CONSTANT REGION OF AN IGG1 RECOMBINANT MONOCLONAL ANTIBODY PRODUCED IN CHO CELLS.MABS. VOL. 8. ISSUE 2. P. 358 -370 13 28% 0
10 HE, LH , FRYE, C , (2016) A RISK-BASED GENETIC CHARACTERIZATION STRATEGY FOR RECOMBINANT CHO CELL LINES USED FOR CLINICAL AND COMMERCIAL APPLICATIONS.BIOPHARM INTERNATIONAL. VOL. 29. ISSUE 3. P. 32 -40 8 44% 0

Classes with closest relation at Level 1


Rank Class id link
1 4824 AGALACTOSYL IGG//MABS//PROT ANALYT CHEM
2 35929 AGCY BIOSAFETY ASSESSMENT TECHNOL IMPACTS//INTELLECTUAL PROPERTY POLICY DIRECTORATE//AGCY BIOSAFETY ASSESSMENT TECHNOL
3 28501 PEAK HOMOGENEITY//ABSORBENCY RATIO//PEAK PURITY
4 11045 ISOASPARTATE//DEAMIDATION//PROTEIN L ISOASPARTYL METHYLTRANSFERASE
5 6542 HYDROPHOBIC INTERACTION CHROMATOGRAPHY//MODERN SEPARAT SCI//JOURNAL OF CHROMATOGRAPHY
6 11684 CHINESE HAMSTER OVARY CELLS//CELL LINE DEVELOPMENT//CHO
7 31806 HYDROPHILIC CARBON CLUSTERS//ANTISENSE BLOCKERS//BSAT1
8 25775 2 DIMENSIONAL DNA TYPING//ALTERED ENZYME//CI 1009
9 8820 ADV BIOCHEM ENGN//HOST CELL PROTEINS//HYDROPHOBIC CHARGE INDUCTION CHROMATOGRAPHY
10 2829 CODON USAGE//CODON USAGE BIAS//SYNONYMOUS CODON USAGE

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